Induction of senescence with doxorubicin leads to increased genomic instability of HCT116 cells

Mechanisms of Ageing and Development

Volumn 130, Issue 1-2, 2009, Pages 24-32

  Sliwinska, Malgorzata A ^a   Mosieniak, Grazyna ^a   Wolanin, Kamila ^a   Babik, Aneta ^a   Piwocka, Katarzyna ^a   Magalska, Adriana ^a   Szczepanowska, Joanna ^a   Fronk, Jan ^b   Sikora, Ewa ^a  

^a NENCKI INSTITUTE OF EXPERIMENTAL BIOLOGY   (Poland)

^b UNIVERSITY OF WARSAW   (Poland)

Author keywords

Aneuploidy; Cancer; Endoreduplication; Polyploidy; Senescence

Indexed keywords

BETA GALACTOSIDASE; BIOLOGICAL MARKER; CYCLIN B1; CYCLIN D1; DOXORUBICIN; KI 67 ANTIGEN; PROTEIN P21; PROTEIN P53;

ANEUPLOIDY; ANTIGEN EXPRESSION; ARTICLE; CANCER INHIBITION; CARCINOMA CELL; CELL AGING; CELL PROLIFERATION; CELL STRAIN HCT116; CELL STRUCTURE; CENTROSOME; CHROMOSOME ANALYSIS; COLON CARCINOMA; CONTROLLED STUDY; DRUG ACTIVITY; DRUG EFFECT; DRUG RESPONSE; ENDOREDUPLICATION; ENZYME ACTIVITY; GENE LOCATION; GENOMIC INSTABILITY; GROWTH INHIBITION; HUMAN; HUMAN CELL; HYPERTROPHY; IN VITRO STUDY; MITOSIS; MITOSIS INDEX; MULTINUCLEAR CELL; POLYPLOIDY; PRIORITY JOURNAL; PROGENY; SENESCENCE;

ANTIBIOTICS, ANTINEOPLASTIC; APOPTOSIS; CELL AGING; COLONIC NEOPLASMS; DISEASE PROGRESSION; DNA REPLICATION; DOXORUBICIN; GENOMIC INSTABILITY; HCT116 CELLS; HUMANS; MITOSIS; POLYPLOIDY;

EID: 58149327460     PISSN: 00476374     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mad.2008.04.011     Document Type: Article

References (42)

1. Arthur C.R., Gupton J.T., Kellogg G.E., Yeudall W.A., Cabot M.C., Newsham I.F., and Gewirtz D.A. Autophagic cell death, polyploidy and senescence induced in breast tumor cells by the substituted pyrrole JG-03-14, a novel microtubule poison. Biochem. Pharmacol. 74 (2007) 981-991
2. Burton D.G., Sheerin A.N., Ostler E.L., Smith K., Giles P.J., Lowe J., Rhys-Williams W., Kipling D.G., and Faragher R.G. Cyclin d1 overexpression permits the reproducible detection of senescent human vascular smooth muscle cells. Ann. N.Y. Acad. Sci. 1119 (2007) 20-31
3. Cahill D.P., Lengauer C., Yu J., Riggins G.J., Willson J.K., Markowitz S.D., Kinzler K.W., and Vogelstein B. Mutations of mitotic checkpoint genes in human cancers. Nature 392 (1998) 300-303
4. Chang B.D., Broude E.V., Dokmanovic M., Zhu H., Ruth A., Xuan Y., Kandel E.S., Lausch E., Christov K., and Roninson I.B. A senescence-like phenotype distinguishes tumor cells that undergo terminal proliferation arrest after exposure to anticancer agents. Cancer Res. 59 (1999) 3761-3767
5. Chang B.D., Broude E.V., Fang J., Kalinichenko T.V., Abdryashitov R., Poole J.C., and Roninson I.B. p21Waf1/Cip1/Sdi1-induced growth arrest is associated with depletion of mitosis-control proteins and leads to abnormal mitosis and endoreduplication in recovering cells. Oncogene 19 (2000) 2165-2170
6. Chang B.D., Swift M.E., Shen M., Fang J., Broude E.V., and Roninson I.B. Molecular determinants of terminal growth arrest induced in tumor cells by a chemotherapeutic agent. Proc. Natl. Acad. Sci. U.S.A. 99 (2002) 389-394
7. Chang B.D., Watanabe K., Broude E.V., Fang J., Poole J.C., Kalinichenko T.V., and Roninson I.B. Effects of p21Waf1/Cip1/Sdi1 on cellular gene expression: implications for carcinogenesis, senescence, and age-related diseases. Proc. Natl. Acad. Sci. U.S.A. 97 (2000) 4291-4296
8. Chang B.D., Xuan Y., Broude E.V., Zhu H., Schott B., Fang J., and Roninson I.B. Role of p53 and p21waf1/cip1 in senescence-like terminal proliferation arrest induced in human tumor cells by chemotherapeutic drugs. Oncogene 18 (1999) 4808-4818
9. Dimri G.P., Lee X., Basile G., Acosta M., Scott G., Roskelley C., Medrano E.E., Linskens M., Rubelj I., Pereira-Smith O., et al. A biomarker that identifies senescent human cells in culture and in aging skin in vivo. Proc. Natl. Acad. Sci. U.S.A. 92 (1995) 9363-9367
10. Eom Y.W., Kim M.A., Park S.S., Goo M.J., Kwon H.J., Sohn S., Kim W.H., Yoon G., and Choi K.S. Two distinct modes of cell death induced by doxorubicin: apoptosis and cell death through mitotic catastrophe accompanied by senescence-like phenotype. Oncogene 24 (2005) 4765-4777
11. Erenpreisa J., Kalejs M., and Cragg M.S. Mitotic catastrophe and endomitosis in tumour cells: an evolutionary key to a molecular solution. Cell Biol. Int. 29 (2005) 1012-1018
12. Erenpreisa J., Kalejs M., Ianzini F., Kosmacek E.A., Mackey M.A., Emzinsh D., Cragg M.S., Ivanov A., and Illidge T.M. Segregation of genomes in polyploid tumour cells following mitotic catastrophe. Cell Biol. Int. 29 (2005) 1005-1011
13. Gewirtz D.A. A critical evaluation of the mechanisms of action proposed for the antitumor effects of the anthracycline antibiotics adriamycin and daunorubicin. Biochem. Pharmacol. 57 (1999) 727-741
14. Gupta S. Hepatic polyploidy and liver growth control. Semin. Cancer Biol. 10 (2000) 161-171
15. Han Z., Wei W., Dunaway S., Darnowski J.W., Calabresi P., Sedivy J., Hendrickson E.A., Balan K.V., Pantazis P., and Wyche J.H. Role of p21 in apoptosis and senescence of human colon cancer cells treated with camptothecin. J. Biol. Chem. 277 (2002) 17154-17160
16. Hanselmann R.G., and Oberringer M. Polyploidization: a Janus-faced mechanism. Med. Hypotheses 56 (2001) 58-64
17. Kahlem P., Dorken B., and Schmitt C.A. Cellular senescence in cancer treatment: friend or foe?. J. Clin. Invest. 113 (2004) 169-174
18. Kim J.H., Kim J.H., Lee G.E., Kim S.W., and Chung I.K. Identification of a quinoxaline derivative that is a potent telomerase inhibitor leading to cellular senescence of human cancer cells. Biochem. J. 373 (2003) 523-529
19. Kurz D.J., Decary S., Hong Y., and Erusalimsky J.D. Senescence-associated (beta)-galactosidase reflects an increase in lysosomal mass during replicative ageing of human endothelial cells. J. Cell Sci. 113 Part 20 (2000) 3613-3622
20. Laemmli U.K. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227 (1970) 680-685
21. Lindqvist A., van Zon W., Karlsson Rosenthal C., and Wolthuis R.M. Cyclin B1-Cdk1 activation continues after centrosome separation to control mitotic progression. PLoS Biol. 5 (2007) e123
22. Matsumoto-Taniura N., Pirollet F., Monroe R., Gerace L., and Westendorf J.M. Identification of novel M phase phosphoproteins by expression cloning. Mol. Biol. Cell 7 (1996) 1455-1469
23. Morales C., Ribas M., Aiza G., and Peinado M.A. Genetic determinants of methotrexate responsiveness and resistance in colon cancer cells. Oncogene 24 (2005) 6842-6847
24. Myohanen S.K., Baylin S.B., and Herman J.G. Hypermethylation can selectively silence individual p16ink4A alleles in neoplasia. Cancer Res. 58 (1998) 591-593
25. Narita M., and Lowe S.W. Senescence comes of age. Nat. Med. 11 (2005) 920-922
26. Nguyen H.G., and Ravid K. Tetraploidy/aneuploidy and stem cells in cancer promotion: the role of chromosome passenger proteins. J. Cell Physiol. 208 (2006) 12-22
27. Nigg E.A. Origins and consequences of centrosome aberrations in human cancers. Int. J. Cancer 119 (2006) 2717-2723
28. Ota H., Tokunaga E., Chang K., Hikasa M., Iijima K., Eto M., Kozaki K., Akishita M., Ouchi Y., and Kaneki M. Sirt1 inhibitor, Sirtinol, induces senescence-like growth arrest with attenuated Ras-MAPK signaling in human cancer cells. Oncogene 25 (2006) 176-185
29. Park J.I., Jeong J.S., Han J.Y., Kim D.I., Gao Y.H., Park S.C., Rodgers G.P., and Kim I.H. Hydroxyurea induces a senescence-like change of K562 human erythroleukemia cell. J. Cancer Res. Clin. Oncol. 126 (2000) 455-460
30. Rebbaa A., Zheng X., Chu F., and Mirkin B.L. The role of histone acetylation versus DNA damage in drug-induced senescence and apoptosis. Cell Death Differ. 13 (2006) 1960-1967
31. Roberson R.S., Kussick S.J., Vallieres E., Chen S.Y., and Wu D.Y. Escape from therapy-induced accelerated cellular senescence in p53-null lung cancer cells and in human lung cancers. Cancer Res. 65 (2005) 2795-2803
32. Roninson I.B. Tumor cell senescence in cancer treatment. Cancer Res. 63 (2003) 2705-2715
33. Roninson I.B., Broude E.V., and Chang B.D. If not apoptosis, then what? Treatment-induced senescence and mitotic catastrophe in tumor cells. Drug Resist. Updat. 4 (2001) 303-313
34. Shay J.W., and Roninson I.B. Hallmarks of senescence in carcinogenesis and cancer therapy. Oncogene 23 (2004) 2919-2933
35. Storchova Z., and Pellman D. From polyploidy to aneuploidy, genome instability and cancer. Nat. Rev. Mol. Cell Biol. 5 (2004) 45-54
36. te Poele R.H., Okorokov A.L., Jardine L., Cummings J., and Joel S.P. DNA damage is able to induce senescence in tumor cells in vitro and in vivo. Cancer Res. 62 (2002) 1876-1883
37. Tse A.N., and Schwartz G.K. Potentiation of cytotoxicity of topoisomerase i poison by concurrent and sequential treatment with the checkpoint inhibitor UCN-01 involves disparate mechanisms resulting in either p53-independent clonogenic suppression or p53-dependent mitotic catastrophe. Cancer Res. 64 (2004) 6635-6644
38. Vigneron A., Roninson I.B., Gamelin E., and Coqueret O. Src inhibits adriamycin-induced senescence and G2 checkpoint arrest by blocking the induction of p21waf1. Cancer Res. 65 (2005) 8927-8935
39. Wagner M., Hampel B., Bernhard D., Hala M., Zwerschke W., and Jansen-Durr P. Replicative senescence of human endothelial cells in vitro involves G1 arrest, polyploidization and senescence-associated apoptosis. Exp. Gerontol. 36 (2001) 1327-1347
40. Wang X., Wong S.C., Pan J., Tsao S.W., Fung K.H., Kwong D.L., Sham J.S., and Nicholls J.M. Evidence of cisplatin-induced senescent-like growth arrest in nasopharyngeal carcinoma cells. Cancer Res. 58 (1998) 5019-5022
41. Xu W.S., Perez G., Ngo L., Gui C.Y., and Marks P.A. Induction of polyploidy by histone deacetylase inhibitor: a pathway for antitumor effects. Cancer Res. 65 (2005) 7832-7839
42. Yang D., McCrann D.J., Nguyen H., St Hilaire C., DePinho R.A., Jones M.R., and Ravid K. Increased polyploidy in aortic vascular smooth muscle cells during aging is marked by cellular senescence. Aging Cell 6 (2007) 257-260