메뉴 건너뛰기




Volumn 256, Issue 1, 2000, Pages 291-299

Accumulation of short telomeres in human fibroblasts prior to replicative senescence

Author keywords

Fibroblasts; Fluorescence in situ hybridization; Recombination; Replicative senescence; Telomere length

Indexed keywords

ARTICLE; CHROMOSOME; FETUS; FIBROBLAST; FLUORESCENCE IN SITU HYBRIDIZATION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; SENESCENCE; TELOMERE;

EID: 0034630432     PISSN: 00144827     EISSN: None     Source Type: Journal    
DOI: 10.1006/excr.2000.4823     Document Type: Article
Times cited : (198)

References (52)
  • 1
    • 0344622606 scopus 로고
    • The serial cultivation of human diploid strains
    • Hayflick L., Moorhead P. S. The serial cultivation of human diploid strains. Exp. Cell Res. 25:1961;585-621.
    • (1961) Exp. Cell Res. , vol.25 , pp. 585-621
    • Hayflick, L.1    Moorhead, P.S.2
  • 2
    • 0025145238 scopus 로고
    • Replicative senescence: The human fibroblast comes of age
    • Goldstein S. Replicative senescence: The human fibroblast comes of age. Science. 249:1990;1129-1133.
    • (1990) Science , vol.249 , pp. 1129-1133
    • Goldstein, S.1
  • 3
    • 0030038104 scopus 로고    scopus 로고
    • Replicative senescence: Implications for in vivo aging and tumor suppression
    • Smith J. R., Pereira-Smith O. M. Replicative senescence: Implications for in vivo aging and tumor suppression. Science. 273:1996;63-67.
    • (1996) Science , vol.273 , pp. 63-67
    • Smith, J.R.1    Pereira-Smith, O.M.2
  • 4
    • 0025279931 scopus 로고
    • Telomeres shorten during ageing of human fibroblasts
    • Harley C. B., Futcher A. B., Greider C. W. Telomeres shorten during ageing of human fibroblasts. Nature. 345:1990;458-460.
    • (1990) Nature , vol.345 , pp. 458-460
    • Harley, C.B.1    Futcher, A.B.2    Greider, C.W.3
  • 8
    • 0002149964 scopus 로고
    • Telomerase biochemistry and regulation
    • E. H. Blackburn, & C. W. Greider. Cold Spring Harbor: Cold Spring Harbor Laboratory Press
    • Greider C. W. Telomerase biochemistry and regulation. Blackburn E. H., Greider C. W. Telomeres. 1995;Cold Spring Harbor Laboratory Press, Cold Spring Harbor.
    • (1995) Telomeres
    • Greider, C.W.1
  • 11
    • 0029145379 scopus 로고
    • Evidence for a critical telomere length in senescent human fibroblasts
    • Allsopp R. C., Harley C. B. Evidence for a critical telomere length in senescent human fibroblasts. Exp. Cell Res. 219:1995;130-136.
    • (1995) Exp. Cell Res. , vol.219 , pp. 130-136
    • Allsopp, R.C.1    Harley, C.B.2
  • 15
    • 13144305133 scopus 로고    scopus 로고
    • The rate of telomere sequence loss in human leukocytes varies with age
    • Frenck R. W. Jr., Blackburn E. H., Shannon K. M. The rate of telomere sequence loss in human leukocytes varies with age. Proc. Natl. Acad. Sci. USA. 95:1998;5607-5610.
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 5607-5610
    • Frenck R.W., Jr.1    Blackburn, E.H.2    Shannon, K.M.3
  • 16
    • 0345643319 scopus 로고    scopus 로고
    • Telomere fluorescence measurements in granulocytes and T lymphocyte subsets point to a high turnover of hematopoietic stem cells and memory T cells in early childhood
    • Rufer N., Brummendorf T. H., Kolvraa S., Bischoff C., Christensen K., Wadsworth L., Schultzer M., Lansdorp P. M. Telomere fluorescence measurements in granulocytes and T lymphocyte subsets point to a high turnover of hematopoietic stem cells and memory T cells in early childhood. J. Exp. Med. 190:1999;157-167.
    • (1999) J. Exp. Med. , vol.190 , pp. 157-167
    • Rufer, N.1    Brummendorf, T.H.2    Kolvraa, S.3    Bischoff, C.4    Christensen, K.5    Wadsworth, L.6    Schultzer, M.7    Lansdorp, P.M.8
  • 17
    • 0015184804 scopus 로고
    • Principles of marginotomy in template synthesis of polynucleotides
    • Olovnikov A. M. Principles of marginotomy in template synthesis of polynucleotides. Dokl. Akad. Nauk. SSSR. 201:1971;1496-1499.
    • (1971) Dokl. Akad. Nauk. SSSR , vol.201 , pp. 1496-1499
    • Olovnikov, A.M.1
  • 18
    • 0029953557 scopus 로고    scopus 로고
    • Evidence for a new step in telomere maintenance
    • Wellinger R. J., Ethier K., Labrecque P., Zakian V. A. Evidence for a new step in telomere maintenance. Cell. 85:1996;423-433.
    • (1996) Cell , vol.85 , pp. 423-433
    • Wellinger, R.J.1    Ethier, K.2    Labrecque, P.3    Zakian, V.A.4
  • 20
    • 0032567967 scopus 로고    scopus 로고
    • Reconstitution of telomerase activity in normal human cells leads to elongation of telomeres and extended replicative life span
    • Vaziri H., Benchimol S. Reconstitution of telomerase activity in normal human cells leads to elongation of telomeres and extended replicative life span. Curr. Biol. 8:1998;279-282.
    • (1998) Curr. Biol. , vol.8 , pp. 279-282
    • Vaziri, H.1    Benchimol, S.2
  • 21
    • 0033616762 scopus 로고    scopus 로고
    • Telomerase extends the lifespan of virus-transformed human cells without net telomere lengthening
    • Zhu J., Wang H., Bishop J. M., Blackburn E. H. Telomerase extends the lifespan of virus-transformed human cells without net telomere lengthening. Proc. Natl. Acad. Sci. USA. 96:1999;3723-3728.
    • (1999) Proc. Natl. Acad. Sci. USA , vol.96 , pp. 3723-3728
    • Zhu, J.1    Wang, H.2    Bishop, J.M.3    Blackburn, E.H.4
  • 22
    • 0030964277 scopus 로고    scopus 로고
    • The biology of replicative senescence
    • Campisi J. The biology of replicative senescence. Eur. J. Cancer. 33:1997;703-709.
    • (1997) Eur. J. Cancer , vol.33 , pp. 703-709
    • Campisi, J.1
  • 23
    • 0027421043 scopus 로고
    • Loss of a yeast telomere: Arrest, recovery and chromosome loss
    • Sandell L. L., Zakian V. A. Loss of a yeast telomere: Arrest, recovery and chromosome loss. Cell. 75:1993;729-739.
    • (1993) Cell , vol.75 , pp. 729-739
    • Sandell, L.L.1    Zakian, V.A.2
  • 24
    • 0002309826 scopus 로고
    • Telomere dynamics and genome instability in human cancer
    • Cold Spring Harbor: Cold Spring Harbor Laboratory Press
    • de Lange T. Telomere dynamics and genome instability in human cancer. Telomeres. 1995;Cold Spring Harbor Laboratory Press, Cold Spring Harbor.
    • (1995) Telomeres
    • De Lange, T.1
  • 25
    • 0029741576 scopus 로고    scopus 로고
    • Silencing of genes at nontelomeric sites in yeast is controlled by sequestration of silencing factors at telomeres by Rap1 protein
    • Marcand S., Buck S. W., Moretti P., Gilson E., Shore D. Silencing of genes at nontelomeric sites in yeast is controlled by sequestration of silencing factors at telomeres by Rap1 protein. Genes Dev. 10:1996;1297-1309.
    • (1996) Genes Dev. , vol.10 , pp. 1297-1309
    • Marcand, S.1    Buck, S.W.2    Moretti, P.3    Gilson, E.4    Shore, D.5
  • 26
    • 0026682717 scopus 로고
    • Telomere positional effects and the regulation of cellular senescence
    • Wright W. E., Shay J. W. Telomere positional effects and the regulation of cellular senescence. Trends Genet. 8:1992;193-197.
    • (1992) Trends Genet. , vol.8 , pp. 193-197
    • Wright, W.E.1    Shay, J.W.2
  • 27
    • 0029817763 scopus 로고    scopus 로고
    • Spreading of transcriptional repressor SIR3 from telomeric heterochromatin
    • Hecht A., Strahl-Bolsinger S., Grunstein M. Spreading of transcriptional repressor SIR3 from telomeric heterochromatin. Nature. 383:1996;92-96.
    • (1996) Nature , vol.383 , pp. 92-96
    • Hecht, A.1    Strahl-Bolsinger, S.2    Grunstein, M.3
  • 28
    • 0028324442 scopus 로고
    • Sandwiching of a gene within 12 kb of a functional telomere and alpha satellite does not result in silencing
    • Bayne R. A., Broccoli D., Taggart M. H., Thomson E. J., Farr C. J., Cooke H. J. Sandwiching of a gene within 12 kb of a functional telomere and alpha satellite does not result in silencing. Hum. Mol. Genet. 3:1994;539-546.
    • (1994) Hum. Mol. Genet. , vol.3 , pp. 539-546
    • Bayne, R.A.1    Broccoli, D.2    Taggart, M.H.3    Thomson, E.J.4    Farr, C.J.5    Cooke, H.J.6
  • 29
    • 0029969149 scopus 로고    scopus 로고
    • Effect of telomere length on telomeric gene expression
    • Sprung C. N., Sabatier L., Murnane J. P. Effect of telomere length on telomeric gene expression. Nucleic Acids Res. 24:1996;4336-4340.
    • (1996) Nucleic Acids Res. , vol.24 , pp. 4336-4340
    • Sprung, C.N.1    Sabatier, L.2    Murnane, J.P.3
  • 30
    • 0029924534 scopus 로고    scopus 로고
    • From telomere loss to p53 induction and activation of a DNA-damage pathway at senescence: The telomere loss/DNA damage model of cell aging
    • Vaziri H., Benchimol S. From telomere loss to p53 induction and activation of a DNA-damage pathway at senescence: The telomere loss/DNA damage model of cell aging. Exp. Gerontol. 31:1996;295-301.
    • (1996) Exp. Gerontol. , vol.31 , pp. 295-301
    • Vaziri, H.1    Benchimol, S.2
  • 32
    • 0033593814 scopus 로고    scopus 로고
    • Telomere length dynamics and chromosomal instability in cells derived from telomerase null mice
    • Hande M. P., Samper E., Lansdorp P., Blasco M. A. Telomere length dynamics and chromosomal instability in cells derived from telomerase null mice. J. Cell Biol. 144:1999;589-601.
    • (1999) J. Cell Biol. , vol.144 , pp. 589-601
    • Hande, M.P.1    Samper, E.2    Lansdorp, P.3    Blasco, M.A.4
  • 34
    • 0028007237 scopus 로고
    • Telomere dynamics in an immortal human cell line
    • Murnane J. P., Sabatier L., Marder B. A., Morgan W. F. Telomere dynamics in an immortal human cell line. EMBO J. 13:1994;4953-4962.
    • (1994) EMBO J. , vol.13 , pp. 4953-4962
    • Murnane, J.P.1    Sabatier, L.2    Marder, B.A.3    Morgan, W.F.4
  • 37
    • 0033178240 scopus 로고    scopus 로고
    • Telomere length measurements using digital fluorescence microscopy
    • Poon S. S. S., Martens U. M., Ward R. K., Lansdorp P. M. Telomere length measurements using digital fluorescence microscopy. Cytometry. 36:1999;267-278.
    • (1999) Cytometry , vol.36 , pp. 267-278
    • Poon, S.S.S.1    Martens, U.M.2    Ward, R.K.3    Lansdorp, P.M.4
  • 38
    • 0026553826 scopus 로고
    • Which measures of skewness and kurtosis are best
    • Royston P. Which measures of skewness and kurtosis are best. Stat. Med. 11:1992;333-343.
    • (1992) Stat. Med. , vol.11 , pp. 333-343
    • Royston, P.1
  • 39
    • 0032554360 scopus 로고    scopus 로고
    • Telomere length distribution and Southern blot analysis
    • Oexle K. Telomere length distribution and Southern blot analysis. J. Theor. Biol. 190:1998;369-377.
    • (1998) J. Theor. Biol. , vol.190 , pp. 369-377
    • Oexle, K.1
  • 40
    • 0016787766 scopus 로고
    • Equality of dependent correlation coefficients
    • Neill J. J., Dunn O. J. Equality of dependent correlation coefficients. Biometrics. 31:1975;531-543.
    • (1975) Biometrics , vol.31 , pp. 531-543
    • Neill, J.J.1    Dunn, O.J.2
  • 41
    • 0026523228 scopus 로고
    • Telomere shortening associated with chromosome instability is arrested in immortal cells which express telomerase activity
    • Counter C. M., Avilion A. A., LeFeuvre C. E., Stewart N. G., Greider C. W., Harley C. B., Bacchetti S. Telomere shortening associated with chromosome instability is arrested in immortal cells which express telomerase activity. EMBO J. 11:1992;1921-1929.
    • (1992) EMBO J. , vol.11 , pp. 1921-1929
    • Counter, C.M.1    Avilion, A.A.2    Lefeuvre, C.E.3    Stewart, N.G.4    Greider, C.W.5    Harley, C.B.6    Bacchetti, S.7
  • 43
    • 0021999880 scopus 로고
    • Intramitotic variation in proliferative potential: Stochastic events in cellular aging
    • Jones R. B., Whitney R. G., Smith J. R. Intramitotic variation in proliferative potential: Stochastic events in cellular aging. Mech. Ageing Dev. 29:1985;143-149.
    • (1985) Mech. Ageing Dev. , vol.29 , pp. 143-149
    • Jones, R.B.1    Whitney, R.G.2    Smith, J.R.3
  • 44
    • 0029778954 scopus 로고    scopus 로고
    • A novel mechanism for telomere size control in Saccharomyces cerevisiae
    • Li B., Lustig A. J. A novel mechanism for telomere size control in Saccharomyces cerevisiae. Genes Dev. 10:1996;1310-1326.
    • (1996) Genes Dev. , vol.10 , pp. 1310-1326
    • Li, B.1    Lustig, A.J.2
  • 45
    • 0033519630 scopus 로고    scopus 로고
    • Repression of an alternative mechanism for lengthening of telomeres in somatic cell hybrids
    • Perrem K., Bryan T. M., Englezou A., Hackl T., Moy E. L., Reddel R. R. Repression of an alternative mechanism for lengthening of telomeres in somatic cell hybrids. Oncogene. 18:1999;3383-3390.
    • (1999) Oncogene , vol.18 , pp. 3383-3390
    • Perrem, K.1    Bryan, T.M.2    Englezou, A.3    Hackl, T.4    Moy, E.L.5    Reddel, R.R.6
  • 46
    • 0032937038 scopus 로고    scopus 로고
    • Stochastic models of telomere shortening
    • Olofsson P., Kimmel M. Stochastic models of telomere shortening. Math. Biosci. 158:1999;75-92.
    • (1999) Math. Biosci. , vol.158 , pp. 75-92
    • Olofsson, P.1    Kimmel, M.2
  • 47
    • 0033590952 scopus 로고    scopus 로고
    • Stochastic mechanism of cellular aging - Abrupt telomere shortening as a model for stochastic nature of cellular aging
    • Rubelj I., Vondracek Z. Stochastic mechanism of cellular aging - Abrupt telomere shortening as a model for stochastic nature of cellular aging. J. Theor. Biol. 197:1999;425-438.
    • (1999) J. Theor. Biol. , vol.197 , pp. 425-438
    • Rubelj, I.1    Vondracek, Z.2
  • 48
    • 0033362027 scopus 로고    scopus 로고
    • Accelerated telomere shortening in the human inactive X chromosome
    • Surralles J., Hande M. P., Marcos R., Lansdorp P. M. Accelerated telomere shortening in the human inactive X chromosome. Am. J. Hum. Genet. 65:1999;1617-1622.
    • (1999) Am. J. Hum. Genet. , vol.65 , pp. 1617-1622
    • Surralles, J.1    Hande, M.P.2    Marcos, R.3    Lansdorp, P.M.4
  • 50
    • 0029746495 scopus 로고    scopus 로고
    • Cap-prevented recombination between terminal telomeric repeat arrays (telomere CPR) maintains telomeres in Kluyveromyces lactis lacking telomerase
    • McEachern M. J., Blackburn E. H. Cap-prevented recombination between terminal telomeric repeat arrays (telomere CPR) maintains telomeres in Kluyveromyces lactis lacking telomerase. Genes Dev. 10:1996;1822-1834.
    • (1996) Genes Dev. , vol.10 , pp. 1822-1834
    • McEachern, M.J.1    Blackburn, E.H.2
  • 51
    • 0027944347 scopus 로고
    • TLC1: Template RNA component of Saccharomyces cerevisiae telomerase
    • Singer M. S., Gottschling D. E. TLC1: Template RNA component of Saccharomyces cerevisiae telomerase. Science. 266:1994;404-409.
    • (1994) Science , vol.266 , pp. 404-409
    • Singer, M.S.1    Gottschling, D.E.2
  • 52
    • 0032959506 scopus 로고    scopus 로고
    • RAD50 and RAD51 define two pathways that collaborate to maintain telomeres in the absence of telomerase
    • Le S., Moore J. K., Haber J. E., Greider C. W. RAD50 and RAD51 define two pathways that collaborate to maintain telomeres in the absence of telomerase. Genetics. 152:1999;143-152.
    • (1999) Genetics , vol.152 , pp. 143-152
    • Le, S.1    Moore, J.K.2    Haber, J.E.3    Greider, C.W.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.