-
1
-
-
0036103602
-
Non-alcoholic fatty liver disease
-
doi: 10.1046/j.1440-1746.17.s1.10.x
-
Angulo P. Lindor K. D. (2002). Non-alcoholic fatty liver disease. J. Gastroenterol. Hepatol. 17(Suppl.) S186-S190. doi: 10.1046/j.1440-1746.17.s1.10.x
-
(2002)
J. Gastroenterol. Hepatol.
, vol.17
, Issue.SUPPL
-
-
Angulo, P.1
Lindor, K.D.2
-
2
-
-
79954624221
-
Mitochondrial glutathione transferases involving a new function for membrane permeability transition pore regulation
-
doi:10.3109/03602532.2011.552913
-
Aniya Y. Imaizumi N. (2011). Mitochondrial glutathione transferases involving a new function for membrane permeability transition pore regulation. Drug Metab. Rev. 43 292-299. doi: 10.3109/03602532.2011.552913
-
(2011)
Drug Metab. Rev.
, vol.43
, pp. 292-299
-
-
Aniya, Y.1
Imaizumi, N.2
-
3
-
-
48649110601
-
Cholesterol as a risk factor for dementia and cognitive decline: a systematic review of prospective studies with meta-analysis
-
doi:10.1097/JGP.0b013e31816b72d4
-
Anstey K. J. Lipnicki D. M. Low L. F. (2008). Cholesterol as a risk factor for dementia and cognitive decline: a systematic review of prospective studies with meta-analysis. Am. J. Geriatr. Psychiatry 16 343-354. doi: 10.1097/JGP.0b013e31816b72d4
-
(2008)
Am. J. Geriatr. Psychiatry
, vol.16
, pp. 343-354
-
-
Anstey, K.J.1
Lipnicki, D.M.2
Low, L.F.3
-
4
-
-
0031453141
-
Phosphorylation of steroidogenic acute regulatory protein (StAR) modulates its steroidogenic activity
-
doi:10.1074/jbc.272.51.32656
-
Arakane F. King S. R. Du Y. Kallen C. B. Walsh L. P. Watari H.et al. (1997). Phosphorylation of steroidogenic acute regulatory protein (StAR) modulates its steroidogenic activity. J. Biol. Chem. 272 32656-32662. doi: 10.1074/jbc.272.51.32656
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 32656-32662
-
-
Arakane, F.1
King, S.R.2
Du, Y.3
Kallen, C.B.4
Walsh, L.P.5
Watari, H.6
-
5
-
-
48549100652
-
Role of ganglioside metabolism in the pathogenesis of Alzheimer's disease - a review
-
doi:10.1194/jlr.R800007-JLR200
-
Ariga T. McDonald M. P. Yu R. K. (2008). Role of ganglioside metabolism in the pathogenesis of Alzheimer's disease - a review. J. Lipid Res. 49 1157-1175. doi: 10.1194/jlr.R800007-JLR200
-
(2008)
J. Lipid Res.
, vol.49
, pp. 1157-1175
-
-
Ariga, T.1
McDonald, M.P.2
Yu, R.K.3
-
7
-
-
0036673665
-
Glutathione depletion enforces the mitochondrial permeability transition and causes cell death in Bcl-2 overexpressing HL60 cells
-
doi:10.1096/fj.02-0097fje
-
Armstrong J. S. Jones D. P. (2002). Glutathione depletion enforces the mitochondrial permeability transition and causes cell death in Bcl-2 overexpressing HL60 cells. FASEB J. 16 1263-1265. doi: 10.1096/fj.02-0097fje
-
(2002)
FASEB J.
, vol.16
, pp. 1263-1265
-
-
Armstrong, J.S.1
Jones, D.P.2
-
8
-
-
77951920370
-
The cardiac mitochondrion: nexus of stress
-
doi:10.1146/annurev-physiol-021909-135929
-
Baines C. P. (2010). The cardiac mitochondrion: nexus of stress. Annu. Rev. Physiol. 72 61-80. doi: 10.1146/annurev-physiol-021909-135929
-
(2010)
Annu. Rev. Physiol.
, vol.72
, pp. 61-80
-
-
Baines, C.P.1
-
9
-
-
15844375853
-
Loss of cyclophilin D reveals a critical role for mitochondrial permeability transition in cell death
-
doi:10.1038/nature03434
-
Baines C. P. Kaiser R. A. Purcell N. H. Blair N. S. Osinska H. Hambleton M. A.et al. (2005). Loss of cyclophilin D reveals a critical role for mitochondrial permeability transition in cell death. Nature 434 658-662. doi: 10.1038/nature03434
-
(2005)
Nature
, vol.434
, pp. 658-662
-
-
Baines, C.P.1
Kaiser, R.A.2
Purcell, N.H.3
Blair, N.S.4
Osinska, H.5
Hambleton, M.A.6
-
10
-
-
17644386166
-
Human mitochondrial peroxiredoxin 5 protects from mitochondrial DNA damages induced by hydrogen peroxide
-
doi:10.1016/j.febslet.2005.03.027
-
Banmeyer I. Marchand C. Clippe A. Knoops B. (2005). Human mitochondrial peroxiredoxin 5 protects from mitochondrial DNA damages induced by hydrogen peroxide. FEBS Lett. 579 2327-2333. doi: 10.1016/j.febslet.2005.03.027
-
(2005)
FEBS Lett.
, vol.579
, pp. 2327-2333
-
-
Banmeyer, I.1
Marchand, C.2
Clippe, A.3
Knoops, B.4
-
11
-
-
84903197320
-
Endoplasmic reticulum stress mediates amyloid beta neurotoxicity via mitochondrial cholesterol trafficking
-
doi: 10.1016/j.ajpath.2014.03.014 [Epub ahead of print].
-
Barbero-Camps E. Fernandez A. Baulies A. Martinez L. Fernandez-Checa J. C. Colell A. (2014). Endoplasmic reticulum stress mediates amyloid beta neurotoxicity via mitochondrial cholesterol trafficking. Am. J. Pathol. doi: 10.1016/j.ajpath.2014.03.014 [Epub ahead of print].
-
(2014)
Am. J. Pathol.
-
-
Barbero-Camps, E.1
Fernandez, A.2
Baulies, A.3
Martinez, L.4
Fernandez-Checa, J.C.5
Colell, A.6
-
12
-
-
84881592640
-
APP/PS1 mice overexpressing SREBP-2 exhibit combined Abeta accumulation and tau pathology underlying Alzheimer's disease
-
doi:10.1093/hmg/ddt201
-
Barbero-Camps E. Fernandez A. Martinez L. Fernandez-Checa J. C. Colell A. (2013). APP/PS1 mice overexpressing SREBP-2 exhibit combined Abeta accumulation and tau pathology underlying Alzheimer's disease. Hum. Mol. Genet. 22 3460-3476. doi: 10.1093/hmg/ddt201
-
(2013)
Hum. Mol. Genet.
, vol.22
, pp. 3460-3476
-
-
Barbero-Camps, E.1
Fernandez, A.2
Martinez, L.3
Fernandez-Checa, J.C.4
Colell, A.5
-
13
-
-
21244446551
-
Properties of the permeability transition pore in mitochondria devoid of Cyclophilin D
-
doi:10.1074/jbc.C500089200
-
Basso E. Fante L. Fowlkes J. Petronilli V. Forte M. A. Bernardi P. (2005). Properties of the permeability transition pore in mitochondria devoid of Cyclophilin D. J. Biol. Chem. 280 18558-18561. doi: 10.1074/jbc.C500089200
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 18558-18561
-
-
Basso, E.1
Fante, L.2
Fowlkes, J.3
Petronilli, V.4
Forte, M.A.5
Bernardi, P.6
-
14
-
-
9144249116
-
Glutaredoxin 2 catalyzes the reversible oxidation and glutathionylation of mitochondrial membrane thiol proteins: implications for mitochondrial redox regulation and antioxidant DEFENSE
-
doi:10.1074/jbc.M408011200
-
Beer S. M. Taylor E. R. Brown S. E. Dahm C. C. Costa N. J. Runswick M. J.et al. (2004). Glutaredoxin 2 catalyzes the reversible oxidation and glutathionylation of mitochondrial membrane thiol proteins: implications for mitochondrial redox regulation and antioxidant DEFENSE. J. Biol. Chem. 279 47939-47951. doi: 10.1074/jbc.M408011200
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 47939-47951
-
-
Beer, S.M.1
Taylor, E.R.2
Brown, S.E.3
Dahm, C.C.4
Costa, N.J.5
Runswick, M.J.6
-
15
-
-
0028233494
-
Hydrogen peroxide mediates amyloid beta protein toxicity
-
doi:10.1016/0092-8674(94)90131-7
-
Behl C. Davis J. B. Lesley R. Schubert D. (1994). Hydrogen peroxide mediates amyloid beta protein toxicity. Cell 77 817-827. doi: 10.1016/0092-8674(94)90131-7
-
(1994)
Cell
, vol.77
, pp. 817-827
-
-
Behl, C.1
Davis, J.B.2
Lesley, R.3
Schubert, D.4
-
16
-
-
84875696605
-
Modulation of mitochondrial glutathione status and cellular energetics in primary cultures of proximal tubular cells from remnant kidney of uninephrectomized rats
-
doi:10.1016/j.bcp.2013.02.013
-
Benipal B. Lash L. H. (2013). Modulation of mitochondrial glutathione status and cellular energetics in primary cultures of proximal tubular cells from remnant kidney of uninephrectomized rats. Biochem. Pharmacol. 85 1379-1388. doi: 10.1016/j.bcp.2013.02.013
-
(2013)
Biochem. Pharmacol.
, vol.85
, pp. 1379-1388
-
-
Benipal, B.1
Lash, L.H.2
-
17
-
-
33845211116
-
Piplartine induces inhibition of leukemia cell proliferation triggering both apoptosis and necrosis pathways
-
doi:10.1016/j.tiv.2006.07.007
-
Bezerra D. P. Militao G. C. de Castro F. O. Pessoa C. de Moraes M. O. Silveira E. R.et al. (2007). Piplartine induces inhibition of leukemia cell proliferation triggering both apoptosis and necrosis pathways. Toxicol. In Vitro 21 1-8. doi: 10.1016/j.tiv.2006.07.007
-
(2007)
Toxicol. In Vitro
, vol.21
, pp. 1-8
-
-
Bezerra, D.P.1
Militao, G.C.2
de Castro, F.O.3
Pessoa, C.4
de Moraes, M.O.5
Silveira, E.R.6
-
18
-
-
84859799615
-
Caveolin-1: role in cell signaling
-
doi:10.1007/978-1-4614-1222-9_3
-
Boscher C. Nabi I. R. (2012). Caveolin-1: role in cell signaling. Adv. Exp. Med. Biol. 729 29-50. doi: 10.1007/978-1-4614-1222-9_3
-
(2012)
Adv. Exp. Med. Biol.
, vol.729
, pp. 29-50
-
-
Boscher, C.1
Nabi, I.R.2
-
19
-
-
79955471276
-
Caveolin-1 deficiency causes cholesterol-dependent mitochondrial dysfunction and apoptotic susceptibility
-
doi:10.1016/j.cub.2011.03.030
-
Bosch M. Mari M. Herms A. Fernandez A. Fajardo A. Kassan A.et al. (2011). Caveolin-1 deficiency causes cholesterol-dependent mitochondrial dysfunction and apoptotic susceptibility. Curr. Biol. 21 681-686. doi: 10.1016/j.cub.2011.03.030
-
(2011)
Curr. Biol.
, vol.21
, pp. 681-686
-
-
Bosch, M.1
Mari, M.2
Herms, A.3
Fernandez, A.4
Fajardo, A.5
Kassan, A.6
-
20
-
-
77952541558
-
The sites and topology of mitochondrial superoxide production
-
doi:10.1016/j.exger.2010.01.003
-
Brand M. D. (2010). The sites and topology of mitochondrial superoxide production. Exp. Gerontol. 45 466-472. doi: 10.1016/j.exger.2010.01.003
-
(2010)
Exp. Gerontol.
, vol.45
, pp. 466-472
-
-
Brand, M.D.1
-
21
-
-
84875697554
-
Glutathione peroxidases
-
doi:10.1016/j.bbagen.2012.11.020
-
Brigelius-Flohe R. Maiorino M. (2013). Glutathione peroxidases. Biochim. Biophys. Acta 1830 3289-3303. doi: 10.1016/j.bbagen.2012.11.020
-
(2013)
Biochim. Biophys. Acta
, vol.1830
, pp. 3289-3303
-
-
Brigelius-Flohe, R.1
Maiorino, M.2
-
22
-
-
1942454793
-
Nonalcoholic steatohepatitis
-
doi:10.1055/s-2004-823098
-
Brunt E. M. (2004). Nonalcoholic steatohepatitis. Semin. Liver Dis. 24 3-20. doi: 10.1055/s-2004-823098
-
(2004)
Semin. Liver Dis.
, vol.24
, pp. 3-20
-
-
Brunt, E.M.1
-
23
-
-
61849095626
-
Enhanced free cholesterol, SREBP-2 and StAR expression in human NASH
-
doi:10.1016/j.jhep.2008.12.016
-
Caballero F. Fernandez A. De Lacy A. M. Fernandez-Checa J. C. Caballeria J. Garcia-Ruiz C. (2009). Enhanced free cholesterol, SREBP-2 and StAR expression in human NASH. J. Hepatol. 50 789-796. doi: 10.1016/j.jhep.2008.12.016
-
(2009)
J. Hepatol.
, vol.50
, pp. 789-796
-
-
Caballero, F.1
Fernandez, A.2
De Lacy, A.M.3
Fernandez-Checa, J.C.4
Caballeria, J.5
Garcia-Ruiz, C.6
-
24
-
-
0033796250
-
Mitochondrial free radical generation, oxidative stress, and aging
-
doi:10.1016/S0891-5849(00)00317-8
-
Cadenas E. Davies K. J. (2000). Mitochondrial free radical generation, oxidative stress, and aging. Free Radic. Biol. Med. 29 222-230. doi: 10.1016/S0891-5849(00)00317-8
-
(2000)
Free Radic. Biol. Med.
, vol.29
, pp. 222-230
-
-
Cadenas, E.1
Davies, K.J.2
-
25
-
-
84896360551
-
Lysosomal sorting of amyloid-beta by the SORLA receptor is impaired by a familial Alzheimer's disease mutation
-
doi:10.1126/scitranslmed.3007747, 223ra20
-
Caglayan S. Takagi-Niidome S. Liao F. Carlo A. S. Schmidt V. Burgert T.et al. (2014). Lysosomal sorting of amyloid-beta by the SORLA receptor is impaired by a familial Alzheimer's disease mutation. Sci. Transl. Med. 6:223ra20. doi: 10.1126/scitranslmed.3007747
-
(2014)
Sci. Transl. Med.
, vol.6
-
-
Caglayan, S.1
Takagi-Niidome, S.2
Liao, F.3
Carlo, A.S.4
Schmidt, V.5
Burgert, T.6
-
26
-
-
0030848810
-
Targeted disruption of the mouse gene encoding steroidogenic acute regulatory protein provides insights into congenital lipoid adrenal hyperplasia
-
doi:10.1073/pnas.94.21.11540
-
Caron K. M. Soo S. C. Wetsel W. C. Stocco D. M. Clark B. J. Parker K. L. (1997). Targeted disruption of the mouse gene encoding steroidogenic acute regulatory protein provides insights into congenital lipoid adrenal hyperplasia. Proc. Natl. Acad. Sci. U.S.A. 94 11540-11545. doi: 10.1073/pnas.94.21.11540
-
(1997)
Proc. Natl. Acad. Sci. U.S.A.
, vol.94
, pp. 11540-11545
-
-
Caron, K.M.1
Soo, S.C.2
Wetsel, W.C.3
Stocco, D.M.4
Clark, B.J.5
Parker, K.L.6
-
27
-
-
18444369324
-
Glutathionylation of human thioredoxin: a possible crosstalk between the glutathione and thioredoxin systems
-
doi:10.1073/pnas.152168599.
-
Casagrande S. Bonetto V. Fratelli M. Gianazza E. Eberini I. Massignan T.et al. (2002). Glutathionylation of human thioredoxin: a possible crosstalk between the glutathione and thioredoxin systems. Proc. Natl. Acad. Sci. U.S.A. 99 9745-9749. doi: 10.1073/pnas.152168599.
-
(2002)
Proc. Natl. Acad. Sci. U.S.A.
, vol.99
, pp. 9745-9749
-
-
Casagrande, S.1
Bonetto, V.2
Fratelli, M.3
Gianazza, E.4
Eberini, I.5
Massignan, T.6
-
28
-
-
0036272650
-
Beta-amyloid inhibits integrated mitochondrial respiration and key enzyme activities
-
doi:10.1046/j.0022-3042.2001.00681.x
-
Casley C. S. Canevari L. Land J. M. Clark J. B. Sharpe M. A. (2002). Beta-amyloid inhibits integrated mitochondrial respiration and key enzyme activities. J. Neurochem. 80 91-100. doi: 10.1046/j.0022-3042.2001.00681.x
-
(2002)
J. Neurochem.
, vol.80
, pp. 91-100
-
-
Casley, C.S.1
Canevari, L.2
Land, J.M.3
Clark, J.B.4
Sharpe, M.A.5
-
29
-
-
0000385805
-
Isoforms of mammalian peroxiredoxin that reduce peroxides in presence of thioredoxin
-
doi:10.1016/S0076-6879(99)00128-7
-
Chae H. Z. Kang S. W. Rhee S. G. (1999). Isoforms of mammalian peroxiredoxin that reduce peroxides in presence of thioredoxin. Methods Enzymol. 300 219-226. doi: 10.1016/S0076-6879(99)00128-7
-
(1999)
Methods Enzymol.
, vol.300
, pp. 219-226
-
-
Chae, H.Z.1
Kang, S.W.2
Rhee, S.G.3
-
30
-
-
0018776894
-
Hydroperoxide metabolism in mammalian organs
-
Chance B. Sies H. Boveris A. (1979). Hydroperoxide metabolism in mammalian organs. Physiol. Rev. 59 527-605.
-
(1979)
Physiol. Rev.
, vol.59
, pp. 527-605
-
-
Chance, B.1
Sies, H.2
Boveris, A.3
-
31
-
-
4744373181
-
Peroxiredoxin III, a mitochondrion-specific peroxidase, regulates apoptotic signaling by mitochondria
-
doi:10.1074/jbc.M407707200
-
Chang T. S. Cho C. S. Park S. Yu S. Kang S. W. Rhee S. G. (2004). Peroxiredoxin III, a mitochondrion-specific peroxidase, regulates apoptotic signaling by mitochondria. J. Biol. Chem. 279 41975-41984. doi: 10.1074/jbc.M407707200
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 41975-41984
-
-
Chang, T.S.1
Cho, C.S.2
Park, S.3
Yu, S.4
Kang, S.W.5
Rhee, S.G.6
-
32
-
-
80155134262
-
Inhibition of mitochondrial respiration and rapid depletion of mitochondrial glutathione by beta-phenethyl isothiocyanate: mechanisms for anti-leukemia activity
-
doi:10.1089/ars.2011.4170
-
Chen G. Chen Z. Hu Y. Huang P. (2011). Inhibition of mitochondrial respiration and rapid depletion of mitochondrial glutathione by beta-phenethyl isothiocyanate: mechanisms for anti-leukemia activity. Antioxid. Redox Signal. 15 2911-2921. doi: 10.1089/ars.2011.4170
-
(2011)
Antioxid. Redox Signal.
, vol.15
, pp. 2911-2921
-
-
Chen, G.1
Chen, Z.2
Hu, Y.3
Huang, P.4
-
33
-
-
0031836944
-
Evidence for mitochondrial uptake of glutathione by dicarboxylate and 2-oxoglutarate carriers
-
Chen Z. Lash L. H. (1998). Evidence for mitochondrial uptake of glutathione by dicarboxylate and 2-oxoglutarate carriers. J. Pharmacol. Exp. Ther. 285 608-618.
-
(1998)
J. Pharmacol. Exp. Ther.
, vol.285
, pp. 608-618
-
-
Chen, Z.1
Lash, L.H.2
-
34
-
-
0033963540
-
Enrichment and functional reconstitution of glutathione transport activity from rabbit kidney mitochondria: further evidence for the role of the dicarboxylate and 2-oxoglutarate carriers in mitochondrial glutathione transport
-
doi:10.1006/abbi.1999.1527
-
Chen Z. Putt D. A. Lash L. H. (2000). Enrichment and functional reconstitution of glutathione transport activity from rabbit kidney mitochondria: further evidence for the role of the dicarboxylate and 2-oxoglutarate carriers in mitochondrial glutathione transport. Arch. Biochem. Biophys. 373 193-202. doi: 10.1006/abbi.1999.1527
-
(2000)
Arch. Biochem. Biophys.
, vol.373
, pp. 193-202
-
-
Chen, Z.1
Putt, D.A.2
Lash, L.H.3
-
35
-
-
84879521441
-
Mitochondria and metabolic homeostasis
-
doi:10.1089/ars.2013.5255
-
Cheng Z. Ristow M. (2013). Mitochondria and metabolic homeostasis. Antioxid. Redox Signal. 19 240-242. doi: 10.1089/ars.2013.5255
-
(2013)
Antioxid. Redox Signal.
, vol.19
, pp. 240-242
-
-
Cheng, Z.1
Ristow, M.2
-
36
-
-
0032820358
-
Vitamin E regulates mitochondrial hydrogen peroxide generation
-
doi:10.1016/S0891-5849(99)00121-5
-
Chow C. K. Ibrahim W. Wei Z. Chan A. C. (1999). Vitamin E regulates mitochondrial hydrogen peroxide generation. Free Radic. Biol. Med. 27 580-587. doi: 10.1016/S0891-5849(99)00121-5
-
(1999)
Free Radic. Biol. Med.
, vol.27
, pp. 580-587
-
-
Chow, C.K.1
Ibrahim, W.2
Wei, Z.3
Chan, A.C.4
-
37
-
-
84857854776
-
The mammalian START domain protein family in lipid transport in health and disease
-
doi:10.1530/JOE-11-0313
-
Clark B. J. (2012). The mammalian START domain protein family in lipid transport in health and disease. J. Endocrinol. 212 257-275. doi: 10.1530/JOE-11-0313
-
(2012)
J. Endocrinol.
, vol.212
, pp. 257-275
-
-
Clark, B.J.1
-
38
-
-
84863435935
-
Glutathione peroxidase 4 has a major role in protecting mitochondria from oxidative damage and maintaining oxidative phosphorylation complexes in gut epithelial cells
-
doi:10.1016/j.freeradbiomed.2012.05.029
-
Cole-Ezea P. Swan D. Shanley D. Hesketh J. (2012). Glutathione peroxidase 4 has a major role in protecting mitochondria from oxidative damage and maintaining oxidative phosphorylation complexes in gut epithelial cells. Free Radic. Biol. Med. 53 488-497. doi: 10.1016/j.freeradbiomed.2012.05.029
-
(2012)
Free Radic. Biol. Med.
, vol.53
, pp. 488-497
-
-
Cole-Ezea, P.1
Swan, D.2
Shanley, D.3
Hesketh, J.4
-
39
-
-
0034761961
-
Tauroursodeoxycholic acid protects hepatocytes from ethanol-fed rats against tumor necrosis factor-induced cell death by replenishing mitochondrial glutathione
-
doi:10.1053/jhep.2001.28510
-
Colell A. Coll O. Garcia-Ruiz C. Paris R. Tiribelli C. Kaplowitz N.et al. (2001). Tauroursodeoxycholic acid protects hepatocytes from ethanol-fed rats against tumor necrosis factor-induced cell death by replenishing mitochondrial glutathione. Hepatology 34 964-971. doi: 10.1053/jhep.2001.28510
-
(2001)
Hepatology
, vol.34
, pp. 964-971
-
-
Colell, A.1
Coll, O.2
Garcia-Ruiz, C.3
Paris, R.4
Tiribelli, C.5
Kaplowitz, N.6
-
40
-
-
70449360014
-
Mitochondria, cholesterol and amyloid beta peptide: a dangerous trio in Alzheimer disease
-
doi:10.1007/s10863-009-9242-6
-
Colell A. Fernandez A. Fernandez-Checa J. C. (2009). Mitochondria, cholesterol and amyloid beta peptide: a dangerous trio in Alzheimer disease. J. Bioenerg. Biomembr. 41 417-423. doi: 10.1007/s10863-009-9242-6
-
(2009)
J. Bioenerg. Biomembr.
, vol.41
, pp. 417-423
-
-
Colell, A.1
Fernandez, A.2
Fernandez-Checa, J.C.3
-
41
-
-
0031789130
-
Selective glutathione depletion of mitochondria by ethanol sensitizes hepatocytes to tumor necrosis factor
-
doi:10.1016/S0016-5085(98)70034-4
-
Colell A. Garcia-Ruiz C. Miranda M. Ardite E. Mari M. Morales A.et al. (1998). Selective glutathione depletion of mitochondria by ethanol sensitizes hepatocytes to tumor necrosis factor. Gastroenterology 115 1541-1551. doi: 10.1016/S0016-5085(98)70034-4
-
(1998)
Gastroenterology
, vol.115
, pp. 1541-1551
-
-
Colell, A.1
Garcia-Ruiz, C.2
Miranda, M.3
Ardite, E.4
Mari, M.5
Morales, A.6
-
42
-
-
0030819482
-
Transport of reduced glutathione in hepatic mitochondria and mitoplasts from ethanol-treated rats: effect of membrane physical properties and S-adenosyl-L-methionine
-
doi:10.1002/hep.510260323
-
Colell A. Garcia-Ruiz C. Morales A. Ballesta A. Ookhtens M. Rodes J.et al. (1997). Transport of reduced glutathione in hepatic mitochondria and mitoplasts from ethanol-treated rats: effect of membrane physical properties and S-adenosyl-L-methionine. Hepatology 26 699-708. doi: 10.1002/hep.510260323
-
(1997)
Hepatology
, vol.26
, pp. 699-708
-
-
Colell, A.1
Garcia-Ruiz, C.2
Morales, A.3
Ballesta, A.4
Ookhtens, M.5
Rodes, J.6
-
43
-
-
0041822088
-
Sensitivity of the 2-oxoglutarate carrier to alcohol intake contributes to mitochondrial glutathione depletion
-
doi:10.1053/jhep.2003.50351
-
Coll O. Colell A. Garcia-Ruiz C. Kaplowitz N. Fernandez-Checa J. C. (2003). Sensitivity of the 2-oxoglutarate carrier to alcohol intake contributes to mitochondrial glutathione depletion. Hepatology 38 692-702. doi: 10.1053/jhep.2003.50351
-
(2003)
Hepatology
, vol.38
, pp. 692-702
-
-
Coll, O.1
Colell, A.2
Garcia-Ruiz, C.3
Kaplowitz, N.4
Fernandez-Checa, J.C.5
-
44
-
-
77951842594
-
Downregulation of adipose glutathione S-transferase A4 leads to increased protein carbonylation, oxidative stress, and mitochondrial dysfunction
-
doi:10.2337/db09-1105
-
Curtis J. M. Grimsrud P. A. Wright W. S. Xu X. Foncea R. E. Graham D. W.et al. (2010). Downregulation of adipose glutathione S-transferase A4 leads to increased protein carbonylation, oxidative stress, and mitochondrial dysfunction. Diabetes 59 1132-1142. doi: 10.2337/db09-1105
-
(2010)
Diabetes
, vol.59
, pp. 1132-1142
-
-
Curtis, J.M.1
Grimsrud, P.A.2
Wright, W.S.3
Xu, X.4
Foncea, R.E.5
Graham, D.W.6
-
45
-
-
2642573308
-
Resistance to cerebral ischemic injury in UCP2 knockout mice: evidence for a role of UCP2 as a regulator of mitochondrial glutathione levels
-
doi:10.1111/j.1471-4159.2004.02432.x
-
De Bilbao F. Arsenijevic D. Vallet P. Hjelle O. P. Ottersen O. P. Bouras C.et al. (2004). Resistance to cerebral ischemic injury in UCP2 knockout mice: evidence for a role of UCP2 as a regulator of mitochondrial glutathione levels. J. Neurochem. 89 1283-1292. doi: 10.1111/j.1471-4159.2004.02432.x
-
(2004)
J. Neurochem.
, vol.89
, pp. 1283-1292
-
-
De Bilbao, F.1
Arsenijevic, D.2
Vallet, P.3
Hjelle, O.P.4
Ottersen, O.P.5
Bouras, C.6
-
46
-
-
33748283747
-
Accumulation of amyloid precursor protein in the mitochondrial import channels of human Alzheimer's disease brain is associated with mitochondrial dysfunction
-
doi:10.1523/JNEUROSCI.1469-06.2006
-
Devi L. Prabhu B. M. Galati D. F. Avadhani N. G. Anandatheerthavarada H. K. (2006). Accumulation of amyloid precursor protein in the mitochondrial import channels of human Alzheimer's disease brain is associated with mitochondrial dysfunction. J. Neurosci. 26 9057-9068. doi: 10.1523/JNEUROSCI.1469-06.2006
-
(2006)
J. Neurosci.
, vol.26
, pp. 9057-9068
-
-
Devi, L.1
Prabhu, B.M.2
Galati, D.F.3
Avadhani, N.G.4
Anandatheerthavarada, H.K.5
-
49
-
-
67650685611
-
Mitochondrial S-adenosyl-L-methionine transport is insensitive to alcohol-mediated changes in membrane dynamics
-
doi: 10.1111/j.1530-0277.2009.00940.x
-
Fernandez A. Colell A. Caballero F. Matias N. Garcia-Ruiz C. Fernandez-Checa J. C. (2009a). Mitochondrial S-adenosyl-L-methionine transport is insensitive to alcohol-mediated changes in membrane dynamics. Alcohol. Clin. Exp. Res. 33 1169-1180. doi: 10.1111/j.1530-0277.2009.00940.x
-
(2009)
Alcohol. Clin. Exp. Res.
, vol.33
, pp. 1169-1180
-
-
Fernandez, A.1
Colell, A.2
Caballero, F.3
Matias, N.4
Garcia-Ruiz, C.5
Fernandez-Checa, J.C.6
-
50
-
-
66249083144
-
Mitochondrial cholesterol loading exacerbates amyloid beta peptide-induced inflammation and neurotoxicity
-
doi:10.1523/JNEUROSCI.4909-08.2009
-
Fernandez A. Llacuna L. Fernandez-Checa J. C. Colell A. (2009b). Mitochondrial cholesterol loading exacerbates amyloid beta peptide-induced inflammation and neurotoxicity. J. Neurosci. 29 6394-6405. doi: 10.1523/JNEUROSCI.4909-08.2009
-
(2009)
J. Neurosci.
, vol.29
, pp. 6394-6405
-
-
Fernandez, A.1
Llacuna, L.2
Fernandez-Checa, J.C.3
Colell, A.4
-
51
-
-
84884412614
-
ASMase is required for chronic alcohol induced hepatic endoplasmic reticulum stress and mitochondrial cholesterol loading
-
doi:10.1016/j.jhep.2013.05.023
-
Fernandez A. Matias N. Fucho R. Ribas V. Von Montfort C. Nuno N.et al. (2013). ASMase is required for chronic alcohol induced hepatic endoplasmic reticulum stress and mitochondrial cholesterol loading. J. Hepatol. 59 805-813. doi: 10.1016/j.jhep.2013.05.023
-
(2013)
J. Hepatol.
, vol.59
, pp. 805-813
-
-
Fernandez, A.1
Matias, N.2
Fucho, R.3
Ribas, V.4
Von Montfort, C.5
Nuno, N.6
-
53
-
-
17444381536
-
Hepatic mitochondrial glutathione: transport and role in disease and toxicity
-
doi:10.1016/j.taap.2004.10.001
-
Fernandez-Checa J. C. Kaplowitz N. (2005). Hepatic mitochondrial glutathione: transport and role in disease and toxicity. Toxicol. Appl. Pharmacol. 204 263-273. doi: 10.1016/j.taap.2004.10.001
-
(2005)
Toxicol. Appl. Pharmacol.
, vol.204
, pp. 263-273
-
-
Fernandez-Checa, J.C.1
Kaplowitz, N.2
-
54
-
-
33646077891
-
Several glutathione S-transferase isozymes that protect against oxidative injury are expressed in human liver mitochondria
-
doi:10.1016/j.bcp.2006.02.018
-
Gallagher E. P. Gardner J. L. Barber D. S. (2006). Several glutathione S-transferase isozymes that protect against oxidative injury are expressed in human liver mitochondria. Biochem. Pharmacol. 71 1619-1628. doi: 10.1016/j.bcp.2006.02.018
-
(2006)
Biochem. Pharmacol.
, vol.71
, pp. 1619-1628
-
-
Gallagher, E.P.1
Gardner, J.L.2
Barber, D.S.3
-
55
-
-
64549106959
-
Mechanistic and kinetic details of catalysis of thiol-disulfide exchange by glutaredoxins and potential mechanisms of regulation
-
doi:10.1089/ARS.2008.2291
-
Gallogly M. M. Starke D. W. Mieyal J. J. (2009). Mechanistic and kinetic details of catalysis of thiol-disulfide exchange by glutaredoxins and potential mechanisms of regulation. Antioxid. Redox Signal. 11 1059-1081. doi: 10.1089/ARS.2008.2291
-
(2009)
Antioxid. Redox Signal.
, vol.11
, pp. 1059-1081
-
-
Gallogly, M.M.1
Starke, D.W.2
Mieyal, J.J.3
-
56
-
-
84885937939
-
Mitochondrial dysfunction in non-alcoholic fatty liver disease and insulin resistance: cause or consequence?
-
doi: 10.3109/10715762.2013.830717
-
Garcia-Ruiz C. Baulies A. Mari M. Garcia-Roves P. M. Fernandez-Checa J. C. (2013a). Mitochondrial dysfunction in non-alcoholic fatty liver disease and insulin resistance: cause or consequence? Free Radic. Res. 47 854-868. doi: 10.3109/10715762.2013.830717
-
(2013)
Free Radic.Res.
, vol.47
, pp. 854-868
-
-
Garcia-Ruiz, C.1
Baulies, A.2
Mari, M.3
Garcia-Roves, P.M.4
Fernandez-Checa, J.C.5
-
57
-
-
84899582553
-
Role of mitochondria in alcoholic liver disease
-
doi:10.1007/s40139-013-0021-z
-
Garcia-Ruiz C. Kaplowitz N. Fernandez-Checa J. C. (2013b). Role of mitochondria in alcoholic liver disease. Curr. Pathobiol. Rep. 1 159-168. doi: 10.1007/s40139-013-0021-z
-
(2013)
Curr. Pathobiol. Rep.
, vol.1
, pp. 159-168
-
-
Garcia-Ruiz, C.1
Kaplowitz, N.2
Fernandez-Checa, J.C.3
-
58
-
-
0037184085
-
Trafficking of ganglioside GD3 to mitochondria by tumor necrosis factor-alpha
-
doi:10.1074/jbc.M206021200M206021200
-
Garcia-Ruiz C. Colell A. Morales A. Calvo M. Enrich C. Fernandez-Checa J. C. (2002). Trafficking of ganglioside GD3 to mitochondria by tumor necrosis factor-alpha. J. Biol. Chem. 277 36443-36448. doi: 10.1074/jbc.M206021200M206021200
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 36443-36448
-
-
Garcia-Ruiz, C.1
Colell, A.2
Morales, A.3
Calvo, M.4
Enrich, C.5
Fernandez-Checa, J.C.6
-
59
-
-
33747618005
-
Mitochondrial glutathione: hepatocellular survival-death switch
-
doi: 10.1111/j.1440-1746.2006.04570.x
-
Garcia-Ruiz C. Fernandez-Checa J. C. (2006). Mitochondrial glutathione: hepatocellular survival-death switch. J. Gastroenterol. Hepatol. 21(Suppl. 3) S3-S6. doi: 10.1111/j.1440-1746.2006.04570.x
-
(2006)
J. Gastroenterol. Hepatol.
, vol.21
, Issue.SUPPL 3
-
-
Garcia-Ruiz, C.1
Fernandez-Checa, J.C.2
-
62
-
-
0028229899
-
Effect of chronic ethanol feeding on glutathione and functional integrity of mitochondria in periportal and perivenous rat hepatocytes
-
doi:10.1172/JCI117306
-
Garcia-Ruiz C. Morales A. Ballesta A. Rodes J. Kaplowitz N. Fernandez-Checa J. C. (1994). Effect of chronic ethanol feeding on glutathione and functional integrity of mitochondria in periportal and perivenous rat hepatocytes. J. Clin. Invest. 94 193-201. doi: 10.1172/JCI117306
-
(1994)
J. Clin. Invest.
, vol.94
, pp. 193-201
-
-
Garcia-Ruiz, C.1
Morales, A.2
Ballesta, A.3
Rodes, J.4
Kaplowitz, N.5
Fernandez-Checa, J.C.6
-
63
-
-
27244462713
-
Development of a peptide antibody specific to human glutathione S-transferase alpha 4-4 (hGSTA4-4) reveals preferential localization in human liver mitochondria
-
doi:10.1006/abbi.2001.2352
-
Gardner J. L. Gallagher E. P. (2001). Development of a peptide antibody specific to human glutathione S-transferase alpha 4-4 (hGSTA4-4) reveals preferential localization in human liver mitochondria. Arch. Biochem. Biophys. 390 19-27. doi: 10.1006/abbi.2001.2352
-
(2001)
Arch. Biochem. Biophys.
, vol.390
, pp. 19-27
-
-
Gardner, J.L.1
Gallagher, E.P.2
-
64
-
-
22744447211
-
Electron transfer between cytochrome c and p66Shc generates reactive oxygen species that trigger mitochondrial apoptosis
-
doi:10.1016/j.cell.2005.05.011
-
Giorgio M. Migliaccio E. Orsini F. Paolucci D. Moroni M. Contursi C.et al. (2005). Electron transfer between cytochrome c and p66Shc generates reactive oxygen species that trigger mitochondrial apoptosis. Cell 122 221-233. doi: 10.1016/j.cell.2005.05.011
-
(2005)
Cell
, vol.122
, pp. 221-233
-
-
Giorgio, M.1
Migliaccio, E.2
Orsini, F.3
Paolucci, D.4
Moroni, M.5
Contursi, C.6
-
65
-
-
0035839505
-
Identification and characterization of a new mammalian glutaredoxin (thioltransferase), Grx2
-
doi:10.1074/jbc.M100020200
-
Gladyshev V. N. Liu A. Novoselov S. V. Krysan K. Sun Q. A. Kryukov V. M.et al. (2001). Identification and characterization of a new mammalian glutaredoxin (thioltransferase), Grx2. J. Biol. Chem. 276 30374-30380. doi: 10.1074/jbc.M100020200
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 30374-30380
-
-
Gladyshev, V.N.1
Liu, A.2
Novoselov, S.V.3
Krysan, K.4
Sun, Q.A.5
Kryukov, V.M.6
-
66
-
-
34247482333
-
Cardiolipin: setting the beat of apoptosis
-
doi:10.1007/s10495-007-0718-8
-
Gonzalvez F. Gottlieb E. (2007). Cardiolipin: setting the beat of apoptosis. Apoptosis 12 877-885. doi: 10.1007/s10495-007-0718-8
-
(2007)
Apoptosis
, vol.12
, pp. 877-885
-
-
Gonzalvez, F.1
Gottlieb, E.2
-
67
-
-
0001547757
-
Origin and turnover of mitochondrial glutathione
-
doi:10.1073/pnas.82.14.4668
-
Griffith O. W. Meister A. (1985). Origin and turnover of mitochondrial glutathione. Proc. Natl. Acad. Sci. U.S.A. 82 4668-4672. doi: 10.1073/pnas.82.14.4668
-
(1985)
Proc. Natl. Acad. Sci. U.S.A.
, vol.82
, pp. 4668-4672
-
-
Griffith, O.W.1
Meister, A.2
-
68
-
-
1442264828
-
Take five - BACE and the gamma-secretase quartet conduct Alzheimer's amyloid beta-peptide generation
-
doi:10.1038/sj.emboj.7600061
-
Haass C. (2004). Take five - BACE and the gamma-secretase quartet conduct Alzheimer's amyloid beta-peptide generation. EMBO J. 23 483-488. doi: 10.1038/sj.emboj.7600061
-
(2004)
EMBO J.
, vol.23
, pp. 483-488
-
-
Haass, C.1
-
69
-
-
6344243173
-
Beginnings of a signal-transduction pathway for bioenergetic control of cell survival
-
doi:10.1016/j.tibs.2004.09.008
-
Hammerman P. S. Fox C. J. Thompson C. B. (2004). Beginnings of a signal-transduction pathway for bioenergetic control of cell survival. Trends Biochem. Sci. 29 586-592. doi: 10.1016/j.tibs.2004.09.008
-
(2004)
Trends Biochem. Sci.
, vol.29
, pp. 586-592
-
-
Hammerman, P.S.1
Fox, C.J.2
Thompson, C.B.3
-
70
-
-
84871910605
-
Cellular adaptation to anthrax lethal toxin-induced mitochondrial cholesterol enrichment, hyperpolarization, and reactive oxygen species generation through downregulating MLN64 in macrophages
-
doi:10.1128/MCB.00494-12
-
Ha S. D. Park S. Han C. Y. Nguyen M. L. Kim S. O. (2012). Cellular adaptation to anthrax lethal toxin-induced mitochondrial cholesterol enrichment, hyperpolarization, and reactive oxygen species generation through downregulating MLN64 in macrophages. Mol. Cell. Biol. 32 4846-4860. doi: 10.1128/MCB.00494-12
-
(2012)
Mol. Cell. Biol.
, vol.32
, pp. 4846-4860
-
-
Ha, S.D.1
Park, S.2
Han, C.Y.3
Nguyen, M.L.4
Kim, S.O.5
-
72
-
-
0036262945
-
The search for alpha-secretase and its potential as a therapeutic approach to Alzheimer s disease
-
doi:10.2174/0929867023370121
-
Hooper N. M. Turner A. J. (2002). The search for alpha-secretase and its potential as a therapeutic approach to Alzheimer s disease. Curr. Med. Chem. 9 1107-1119. doi: 10.2174/0929867023370121
-
(2002)
Curr. Med. Chem.
, vol.9
, pp. 1107-1119
-
-
Hooper, N.M.1
Turner, A.J.2
-
73
-
-
0030971057
-
Mice deficient in cellular glutathione peroxidase develop normally and show no increased sensitivity to hyperoxia
-
doi:10.1074/jbc.272.26.16644
-
Ho Y. S. Magnenat J. L. Bronson R. T. Cao J. Gargano M. Sugawara M.et al. (1997). Mice deficient in cellular glutathione peroxidase develop normally and show no increased sensitivity to hyperoxia. J. Biol. Chem. 272 16644-16651. doi: 10.1074/jbc.272.26.16644
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 16644-16651
-
-
Ho, Y.S.1
Magnenat, J.L.2
Bronson, R.T.3
Cao, J.4
Gargano, M.5
Sugawara, M.6
-
75
-
-
54049146740
-
Complex I within oxidatively stressed bovine heart mitochondria is glutathionylated on Cys-531 and Cys-704 of the 75-kDa subunit: potential role of CYS residues in decreasing oxidative damage
-
doi:10.1074/jbc.M803432200
-
Hurd T. R. Requejo R. Filipovska A. Brown S. Prime T. A. Robinson A. J.et al. (2008). Complex I within oxidatively stressed bovine heart mitochondria is glutathionylated on Cys-531 and Cys-704 of the 75-kDa subunit: potential role of CYS residues in decreasing oxidative damage. J. Biol. Chem. 283 24801-24815. doi: 10.1074/jbc.M803432200
-
(2008)
J. Biol. Chem.
, vol.283
, pp. 24801-24815
-
-
Hurd, T.R.1
Requejo, R.2
Filipovska, A.3
Brown, S.4
Prime, T.A.5
Robinson, A.J.6
-
76
-
-
38549141572
-
Cellular cholesterol trafficking and compartmentalization
-
doi:10.1038/nrm2336
-
Ikonen E. (2008). Cellular cholesterol trafficking and compartmentalization. Nat. Rev. Mol. Cell Biol. 9 125-138. doi: 10.1038/nrm2336
-
(2008)
Nat. Rev. Mol. Cell Biol.
, vol.9
, pp. 125-138
-
-
Ikonen, E.1
-
77
-
-
0037960128
-
Betaine decreases hyperhomocysteinemia, endoplasmic reticulum stress, and liver injury in alcohol-fed mice
-
doi:10.1016/S0016-5085(03)00276-2
-
Ji C. Kaplowitz N. (2003). Betaine decreases hyperhomocysteinemia, endoplasmic reticulum stress, and liver injury in alcohol-fed mice. Gastroenterology 124 1488-1499. doi: 10.1016/S0016-5085(03)00276-2
-
(2003)
Gastroenterology
, vol.124
, pp. 1488-1499
-
-
Ji, C.1
Kaplowitz, N.2
-
78
-
-
3142735995
-
Hyperhomocysteinemia, endoplasmic reticulum stress, and alcoholic liver injury
-
Ji C. Kaplowitz N. (2004). Hyperhomocysteinemia, endoplasmic reticulum stress, and alcoholic liver injury. World J. Gastroenterol. 10 1699-1708.
-
(2004)
World J. Gastroenterol.
, vol.10
, pp. 1699-1708
-
-
Ji, C.1
Kaplowitz, N.2
-
79
-
-
1542320094
-
Human mitochondrial glutaredoxin reduces S-glutathionylated proteins with high affinity accepting electrons from either glutathione or thioredoxin reductase
-
doi:10.1074/jbc.M312719200
-
Johansson C. Lillig C. H. Holmgren A. (2004). Human mitochondrial glutaredoxin reduces S-glutathionylated proteins with high affinity accepting electrons from either glutathione or thioredoxin reductase. J. Biol. Chem. 279 7537-7543. doi: 10.1074/jbc.M312719200
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 7537-7543
-
-
Johansson, C.1
Lillig, C.H.2
Holmgren, A.3
-
80
-
-
84864471159
-
A mutation in APP protects against Alzheimer's disease and age-related cognitive decline
-
doi:10.1038/nature11283
-
Jonsson T. Atwal J. K. Steinberg S. Snaedal J. Jonsson P. V. Bjornsson S.et al. (2012). A mutation in APP protects against Alzheimer's disease and age-related cognitive decline. Nature 488 96-99. doi: 10.1038/nature11283
-
(2012)
Nature
, vol.488
, pp. 96-99
-
-
Jonsson, T.1
Atwal, J.K.2
Steinberg, S.3
Snaedal, J.4
Jonsson, P.V.5
Bjornsson, S.6
-
81
-
-
84877914445
-
Microsomal triglyceride transfer protein inhibition induces endoplasmic reticulum stress and increases gene transcription via Ire1alpha/cJun to enhance plasma ALT/AST
-
doi:10.1074/jbc.M113.459602
-
Josekutty J. Iqbal J. Iwawaki T. Kohno K. Hussain M. M. (2013). Microsomal triglyceride transfer protein inhibition induces endoplasmic reticulum stress and increases gene transcription via Ire1alpha/cJun to enhance plasma ALT/AST. J. Biol. Chem. 288 14372-14383. doi: 10.1074/jbc.M113.459602
-
(2013)
J. Biol. Chem.
, vol.288
, pp. 14372-14383
-
-
Josekutty, J.1
Iqbal, J.2
Iwawaki, T.3
Kohno, K.4
Hussain, M.M.5
-
82
-
-
24144467846
-
ROS: really involved in oxygen sensing
-
doi:10.1016/j.cmet.2005.05.006
-
Kaelin W. G. Jr. (2005). ROS: really involved in oxygen sensing. Cell Metab. 1 357-358. doi: 10.1016/j.cmet.2005.05.006
-
(2005)
Cell Metab.
, vol.1
, pp. 357-358
-
-
Kaelin Jr, W.G.1
-
83
-
-
27744433524
-
Cytochrome c acts as a cardiolipin oxygenase required for release of proapoptotic factors
-
doi:10.1038/nchembio727
-
Kagan V. E. Tyurin V. A. Jiang J. Tyurina Y. Y. Ritov V. B. Amoscato A. A.et al. (2005). Cytochrome c acts as a cardiolipin oxygenase required for release of proapoptotic factors. Nat. Chem. Biol. 1 223-232. doi: 10.1038/nchembio727
-
(2005)
Nat. Chem. Biol.
, vol.1
, pp. 223-232
-
-
Kagan, V.E.1
Tyurin, V.A.2
Jiang, J.3
Tyurina, Y.Y.4
Ritov, V.B.5
Amoscato, A.A.6
-
84
-
-
77953240210
-
Increased expression of the lysosomal cholesterol transporter NPC1 in Alzheimer's disease
-
doi:10.1016/j.bbalip.2010.05.005
-
Kagedal K. Kim W. S. Appelqvist H. Chan S. Cheng D. Agholme L.et al. (2010). Increased expression of the lysosomal cholesterol transporter NPC1 in Alzheimer's disease. Biochim. Biophys. Acta 1801 831-838. doi: 10.1016/j.bbalip.2010.05.005
-
(2010)
Biochim. Biophys. Acta
, vol.1801
, pp. 831-838
-
-
Kagedal, K.1
Kim, W.S.2
Appelqvist, H.3
Chan, S.4
Cheng, D.5
Agholme, L.6
-
85
-
-
27744501797
-
Lipids as modulators of proteolytic activity of BACE: involvement of cholesterol, glycosphingolipids, and anionic phospholipids in vitro
-
doi:10.1074/jbc.M504484200
-
Kalvodova L. Kahya N. Schwille P. Ehehalt R. Verkade P. Drechsel D.et al. (2005). Lipids as modulators of proteolytic activity of BACE: involvement of cholesterol, glycosphingolipids, and anionic phospholipids in vitro. J. Biol. Chem. 280 36815-36823. doi: 10.1074/jbc.M504484200
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 36815-36823
-
-
Kalvodova, L.1
Kahya, N.2
Schwille, P.3
Ehehalt, R.4
Verkade, P.5
Drechsel, D.6
-
86
-
-
77955872512
-
Dicarboxylate carrier-mediated glutathione transport is essential for reactive oxygen species homeostasis and normal respiration in rat brain mitochondria
-
doi:10.1152/ajpcell.00058.2010
-
Kamga C. K. Zhang S. X. Wang Y. (2010). Dicarboxylate carrier-mediated glutathione transport is essential for reactive oxygen species homeostasis and normal respiration in rat brain mitochondria. Am. J. Physiol. Cell Physiol. 299 C497-C505. doi: 10.1152/ajpcell.00058.2010
-
(2010)
Am. J. Physiol. Cell Physiol.
, vol.299
-
-
Kamga, C.K.1
Zhang, S.X.2
Wang, Y.3
-
87
-
-
84902438348
-
Deficiency of sphingosine-1-phosphate lyase impairs lysosomal metabolism of the amyloid precursor protein
-
doi: 10.1074/jbc.M113.535500 [Epub ahead of print].
-
Karaca I. Tamboli I. Y. Glebov K. Richter J. Fell L. H. Grimm M. O.et al. (2014). Deficiency of sphingosine-1-phosphate lyase impairs lysosomal metabolism of the amyloid precursor protein. J. Biol. Chem. doi: 10.1074/jbc.M113.535500 [Epub ahead of print].
-
(2014)
J. Biol. Chem.
-
-
Karaca, I.1
Tamboli, I.Y.2
Glebov, K.3
Richter, J.4
Fell, L.H.5
Grimm, M.O.6
-
88
-
-
84861964383
-
Feedback control of adrenal steroidogenesis via H2O2-dependent, reversible inactivation of peroxiredoxin III in mitochondria
-
doi:10.1016/j.molcel.2012.05.030
-
Kil I. S. Lee S. K. Ryu K. W. Woo H. A. Hu M. C. Bae S. H.et al. (2012). Feedback control of adrenal steroidogenesis via H2O2-dependent, reversible inactivation of peroxiredoxin III in mitochondria. Mol. Cell 46 584-594. doi: 10.1016/j.molcel.2012.05.030
-
(2012)
Mol. Cell
, vol.46
, pp. 584-594
-
-
Kil, I.S.1
Lee, S.K.2
Ryu, K.W.3
Woo, H.A.4
Hu, M.C.5
Bae, S.H.6
-
89
-
-
2442439970
-
Targeted mutation of the MLN64 START domain causes only modest alterations in cellular sterol metabolism
-
doi:10.1074/jbc.M400717200
-
Kishida T. Kostetskii I. Zhang Z. Martinez F. Liu P. Walkley S. U.et al. (2004). Targeted mutation of the MLN64 START domain causes only modest alterations in cellular sterol metabolism. J. Biol. Chem. 279 19276-19285. doi: 10.1074/jbc.M400717200
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 19276-19285
-
-
Kishida, T.1
Kostetskii, I.2
Zhang, Z.3
Martinez, F.4
Liu, P.5
Walkley, S.U.6
-
90
-
-
80053954605
-
Vitamin E and the risk of prostate cancer: the Selenium and Vitamin E Cancer Prevention Trial (SELECT)
-
doi:10.1001/jama.2011.1437
-
Klein E. A. Thompson I. M. Jr., Tangen C. M. Crowley J. J. Lucia M. S. Goodman P. J.et al. (2011). Vitamin E and the risk of prostate cancer: the Selenium and Vitamin E Cancer Prevention Trial (SELECT). JAMA 306 1549-1556. doi: 10.1001/jama.2011.1437
-
(2011)
JAMA
, vol.306
, pp. 1549-1556
-
-
Klein, E.A.1
Thompson Jr, I.M.2
Tangen, C.M.3
Crowley, J.J.4
Lucia, M.S.5
Goodman, P.J.6
-
91
-
-
79960017554
-
Peroxiredoxin 5: structure, mechanism, and function of the mammalian atypical 2-Cys peroxiredoxin
-
doi:10.1089/ars.2010.3584
-
Knoops B. Goemaere J. Van Der Eecken V. Declercq J. P. (2011). Peroxiredoxin 5: structure, mechanism, and function of the mammalian atypical 2-Cys peroxiredoxin. Antioxid. Redox Signal. 15 817-829. doi: 10.1089/ars.2010.3584
-
(2011)
Antioxid. Redox Signal.
, vol.15
, pp. 817-829
-
-
Knoops, B.1
Goemaere, J.2
Van Der Eecken, V.3
Declercq, J.P.4
-
92
-
-
84864119697
-
Glutathione redox potential in the mitochondrial intermembrane space is linked to the cytosol and impacts the Mia40 redox state
-
doi:10.1038/emboj.2012.165
-
Kojer K. Bien M. Gangel H. Morgan B. Dick T. P. Riemer J. (2012). Glutathione redox potential in the mitochondrial intermembrane space is linked to the cytosol and impacts the Mia40 redox state. EMBO J. 31 3169-3182. doi: 10.1038/emboj.2012.165
-
(2012)
EMBO J.
, vol.31
, pp. 3169-3182
-
-
Kojer, K.1
Bien, M.2
Gangel, H.3
Morgan, B.4
Dick, T.P.5
Riemer, J.6
-
93
-
-
0842307483
-
The ADP/ATP translocator is not essential for the mitochondrial permeability transition pore
-
doi:10.1038/nature02229
-
Kokoszka J. E. Waymire K. G. Levy S. E. Sligh J. E. Cai J. Jones D. P.et al. (2004). The ADP/ATP translocator is not essential for the mitochondrial permeability transition pore. Nature 427 461-465. doi: 10.1038/nature02229
-
(2004)
Nature
, vol.427
, pp. 461-465
-
-
Kokoszka, J.E.1
Waymire, K.G.2
Levy, S.E.3
Sligh, J.E.4
Cai, J.5
Jones, D.P.6
-
94
-
-
0029145255
-
Reduced antioxidative capacity in liver mitochondria from bile duct ligated rats
-
doi:10.1016/0270-9139(95)90586-3
-
Krahenbuhl S. Talos C. Lauterburg B. H. Reichen J. (1995). Reduced antioxidative capacity in liver mitochondria from bile duct ligated rats. Hepatology 22 607-612. doi: 10.1016/0270-9139(95)90586-3
-
(1995)
Hepatology
, vol.22
, pp. 607-612
-
-
Krahenbuhl, S.1
Talos, C.2
Lauterburg, B.H.3
Reichen, J.4
-
95
-
-
33845977959
-
Mitochondrial membrane permeabilization in cell death
-
doi:10.1152/physrev.00013.2006
-
Kroemer G. Galluzzi L. Brenner C. (2007). Mitochondrial membrane permeabilization in cell death. Physiol. Rev. 87 99-163. doi: 10.1152/physrev.00013.2006
-
(2007)
Physiol. Rev.
, vol.87
, pp. 99-163
-
-
Kroemer, G.1
Galluzzi, L.2
Brenner, C.3
-
96
-
-
84875738395
-
The mitochondrial protein import machinery has multiple connections to the respiratory chain
-
doi:10.1016/j.bbabio.2012.12.004
-
Kulawiak B. Hopker J. Gebert M. Guiard B. Wiedemann N. Gebert N. (2013). The mitochondrial protein import machinery has multiple connections to the respiratory chain. Biochim. Biophys. Acta 1827 612-626. doi: 10.1016/j.bbabio.2012.12.004
-
(2013)
Biochim. Biophys. Acta
, vol.1827
, pp. 612-626
-
-
Kulawiak, B.1
Hopker, J.2
Gebert, M.3
Guiard, B.4
Wiedemann, N.5
Gebert, N.6
-
97
-
-
79953152683
-
Reconstitution of proapoptotic BAK function in liposomes reveals a dual role for mitochondrial lipids in the BAK-driven membrane permeabilization process
-
doi:10.1074/jbc.M110.165852
-
Landeta O. Landajuela A. Gil D. Taneva S. Di Primo C. Sot B.et al. (2011). Reconstitution of proapoptotic BAK function in liposomes reveals a dual role for mitochondrial lipids in the BAK-driven membrane permeabilization process. J. Biol. Chem. 286 8213-8230. doi: 10.1074/jbc.M110.165852
-
(2011)
J. Biol. Chem.
, vol.286
, pp. 8213-8230
-
-
Landeta, O.1
Landajuela, A.2
Gil, D.3
Taneva, S.4
Di Primo, C.5
Sot, B.6
-
98
-
-
33750011601
-
Mitochondrial glutathione transport: physiological, pathological and toxicological implications
-
doi:10.1016/j.cbi.2006.03.001
-
Lash L. H. (2006). Mitochondrial glutathione transport: physiological, pathological and toxicological implications. Chem. Biol. Interact. 163 54-67. doi: 10.1016/j.cbi.2006.03.001
-
(2006)
Chem. Biol. Interact.
, vol.163
, pp. 54-67
-
-
Lash, L.H.1
-
99
-
-
0036827706
-
Protection of NRK-52E cells, a rat renal proximal tubular cell line, from chemical-induced apoptosis by overexpression of a mitochondrial glutathione transporter
-
doi:10.1124/jpet.102.040220
-
Lash L. H. Putt D. A. Matherly L. H. (2002). Protection of NRK-52E cells, a rat renal proximal tubular cell line, from chemical-induced apoptosis by overexpression of a mitochondrial glutathione transporter. J. Pharmacol. Exp. Ther. 303 476-486. doi: 10.1124/jpet.102.040220
-
(2002)
J. Pharmacol. Exp. Ther.
, vol.303
, pp. 476-486
-
-
Lash, L.H.1
Putt, D.A.2
Matherly, L.H.3
-
101
-
-
49349116124
-
Glutaredoxin systems
-
doi:10.1016/j.bbagen.2008.06.003
-
Lillig C. H. Berndt C. Holmgren A. (2008). Glutaredoxin systems. Biochim. Biophys. Acta 1780 1304-1317. doi: 10.1016/j.bbagen.2008.06.003
-
(2008)
Biochim. Biophys. Acta
, vol.1780
, pp. 1304-1317
-
-
Lillig, C.H.1
Berndt, C.2
Holmgren, A.3
-
102
-
-
20444411531
-
Characterization of human glutaredoxin 2 as iron-sulfur protein: a possible role as redox sensor
-
doi:10.1073/pnas.0500735102
-
Lillig C. H. Berndt C. Vergnolle O. Lonn M. E. Hudemann C. Bill E.et al. (2005). Characterization of human glutaredoxin 2 as iron-sulfur protein: a possible role as redox sensor. Proc. Natl. Acad. Sci. U.S.A. 102 8168-8173. doi: 10.1073/pnas.0500735102
-
(2005)
Proc. Natl. Acad. Sci. U.S.A.
, vol.102
, pp. 8168-8173
-
-
Lillig, C.H.1
Berndt, C.2
Vergnolle, O.3
Lonn, M.E.4
Hudemann, C.5
Bill, E.6
-
103
-
-
0035811496
-
Endonuclease G is an apoptotic DNase when released from mitochondria
-
doi:10.1038/35083620
-
Li L. Y. Luo X. Wang X. (2001). Endonuclease G is an apoptotic DNase when released from mitochondria. Nature 412 95-99. doi: 10.1038/35083620
-
(2001)
Nature
, vol.412
, pp. 95-99
-
-
Li, L.Y.1
Luo, X.2
Wang, X.3
-
104
-
-
33750683018
-
Alzheimer's APP mangles mitochondria
-
doi:10.1038/nm1106-1241
-
Lin M. T. Beal M. F. (2006). Alzheimer's APP mangles mitochondria. Nat. Med. 12 1241-1243. doi: 10.1038/nm1106-1241
-
(2006)
Nat. Med.
, vol.12
, pp. 1241-1243
-
-
Lin, M.T.1
Beal, M.F.2
-
105
-
-
78650796196
-
Mitochondrion as a novel site of dichloroacetate biotransformation by glutathione transferase zeta 1
-
doi:10.1124/jpet.110.173195
-
Li W. James M. O. McKenzie S. C. Calcutt N. A. Liu C. Stacpoole P. W. (2011). Mitochondrion as a novel site of dichloroacetate biotransformation by glutathione transferase zeta 1. J. Pharmacol. Exp. Ther. 336 87-94. doi: 10.1124/jpet.110.173195
-
(2011)
J. Pharmacol. Exp. Ther.
, vol.336
, pp. 87-94
-
-
Li, W.1
James, M.O.2
McKenzie, S.C.3
Calcutt, N.A.4
Liu, C.5
Stacpoole, P.W.6
-
106
-
-
34547616284
-
Dual role of mitochondrial reactive oxygen species in hypoxia signaling: activation of nuclear factor-{kappa}B via c-SRC and oxidant-dependent cell death
-
doi:10.1158/0008-5472.CAN-07-0515
-
Lluis J. M. Buricchi F. Chiarugi P. Morales A. Fernandez-Checa J. C. (2007). Dual role of mitochondrial reactive oxygen species in hypoxia signaling: activation of nuclear factor-{kappa}B via c-SRC and oxidant-dependent cell death. Cancer Res. 67 7368-7377. doi: 10.1158/0008-5472.CAN-07-0515
-
(2007)
Cancer Res.
, vol.67
, pp. 7368-7377
-
-
Lluis, J.M.1
Buricchi, F.2
Chiarugi, P.3
Morales, A.4
Fernandez-Checa, J.C.5
-
107
-
-
0037370152
-
Acetaldehyde impairs mitochondrial glutathione transport in HepG2 cells through endoplasmic reticulum stress
-
doi:10.1053/gast.2003.50089S0016508502159671
-
Lluis J. M. Colell A. Garcia-Ruiz C. Kaplowitz N. Fernandez-Checa J. C. (2003). Acetaldehyde impairs mitochondrial glutathione transport in HepG2 cells through endoplasmic reticulum stress. Gastroenterology 124 708-724. doi: 10.1053/gast.2003.50089S0016508502159671
-
(2003)
Gastroenterology
, vol.124
, pp. 708-724
-
-
Lluis, J.M.1
Colell, A.2
Garcia-Ruiz, C.3
Kaplowitz, N.4
Fernandez-Checa, J.C.5
-
108
-
-
13544254262
-
Critical role of mitochondrial glutathione in the survival of hepatocytes during hypoxia
-
doi:10.1074/jbc.M408244200
-
Lluis J. M. Morales A. Blasco C. Colell A. Mari M. Garcia-Ruiz C.et al. (2005). Critical role of mitochondrial glutathione in the survival of hepatocytes during hypoxia. J. Biol. Chem. 280 3224-3232. doi: 10.1074/jbc.M408244200
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 3224-3232
-
-
Lluis, J.M.1
Morales, A.2
Blasco, C.3
Colell, A.4
Mari, M.5
Garcia-Ruiz, C.6
-
109
-
-
34848883608
-
Role of calcium and cyclophilin D in the regulation of mitochondrial permeabilization induced by glutathione depletion
-
doi:10.1016/j.bbrc.2007.08.196
-
Lu C. Armstrong J. S. (2007). Role of calcium and cyclophilin D in the regulation of mitochondrial permeabilization induced by glutathione depletion. Biochem. Biophys. Res. Commun. 363 572-577. doi: 10.1016/j.bbrc.2007.08.196
-
(2007)
Biochem. Biophys. Res. Commun.
, vol.363
, pp. 572-577
-
-
Lu, C.1
Armstrong, J.S.2
-
110
-
-
39449130146
-
Bax activation and stress-induced apoptosis delayed by the accumulation of cholesterol in mitochondrial membranes
-
doi:10.1038/sj.cdd.4402280
-
Lucken-Ardjomande S. Montessuit S. Martinou J. C. (2008). Bax activation and stress-induced apoptosis delayed by the accumulation of cholesterol in mitochondrial membranes. Cell Death. Differ. 15 484-493. doi: 10.1038/sj.cdd.4402280
-
(2008)
Cell Death. Differ.
, vol.15
, pp. 484-493
-
-
Lucken-Ardjomande, S.1
Montessuit, S.2
Martinou, J.C.3
-
111
-
-
0035854785
-
Cloning and expression of a novel human glutaredoxin (Grx2) with mitochondrial and nuclear isoforms
-
doi:10.1074/jbc.M011605200
-
Lundberg M. Johansson C. Chandra J. Enoksson M. Jacobsson G. Ljung J.et al. (2001). Cloning and expression of a novel human glutaredoxin (Grx2) with mitochondrial and nuclear isoforms. J. Biol. Chem. 276 26269-26275. doi: 10.1074/jbc.M011605200
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 26269-26275
-
-
Lundberg, M.1
Johansson, C.2
Chandra, J.3
Enoksson, M.4
Jacobsson, G.5
Ljung, J.6
-
112
-
-
11144353586
-
ABAD directly links Abeta to mitochondrial toxicity in Alzheimer's disease
-
doi:10.1126/science.1091230
-
Lustbader J. W. Cirilli M. Lin C. Xu H. W. Takuma K. Wang N.et al. (2004). ABAD directly links Abeta to mitochondrial toxicity in Alzheimer's disease. Science 304 448-452. doi: 10.1126/science.1091230
-
(2004)
Science
, vol.304
, pp. 448-452
-
-
Lustbader, J.W.1
Cirilli, M.2
Lin, C.3
Xu, H.W.4
Takuma, K.5
Wang, N.6
-
113
-
-
84901445668
-
Glutaredoxin-2 is required to control oxidative phosphorylation in cardiac muscle by mediating deglutathionylation reactions. J. Biol. Chem.
-
doi: 10.1074/jbc.M114.550574 [Epub ahead of print].
-
Mailloux R. J. Xuan J. Y. McBride S. Maharsy W. Thorn S. Holterman C. E.et al. (2014). Glutaredoxin-2 is required to control oxidative phosphorylation in cardiac muscle by mediating deglutathionylation reactions. J. Biol. Chem. . doi: 10.1074/jbc.M114.550574 [Epub ahead of print].
-
(2014)
-
-
Mailloux, R.J.1
Xuan, J.Y.2
McBride, S.3
Maharsy, W.4
Thorn, S.5
Holterman, C.E.6
-
114
-
-
84866873131
-
Mitochondrial aquaporin-8 knockdown in human hepatoma HepG2 cells causes ROS-induced mitochondrial depolarization and loss of viability
-
doi:10.1016/j.taap.2012.08.005
-
Marchissio M. J. Frances D. E. Carnovale C. E. Marinelli R. A. (2012). Mitochondrial aquaporin-8 knockdown in human hepatoma HepG2 cells causes ROS-induced mitochondrial depolarization and loss of viability. Toxicol. Appl. Pharmacol. 264 246-254. doi: 10.1016/j.taap.2012.08.005
-
(2012)
Toxicol. Appl. Pharmacol.
, vol.264
, pp. 246-254
-
-
Marchissio, M.J.1
Frances, D.E.2
Carnovale, C.E.3
Marinelli, R.A.4
-
115
-
-
33747626511
-
Mitochondrial free cholesterol loading sensitizes to TNF- and Fas-mediated steatohepatitis
-
doi:10.1016/j.cmet.2006.07.006
-
Mari M. Caballero F. Colell A. Morales A. Caballeria J. Fernandez A.et al. (2006). Mitochondrial free cholesterol loading sensitizes to TNF- and Fas-mediated steatohepatitis. Cell Metab. 4 185-198. doi: 10.1016/j.cmet.2006.07.006
-
(2006)
Cell Metab.
, vol.4
, pp. 185-198
-
-
Mari, M.1
Caballero, F.2
Colell, A.3
Morales, A.4
Caballeria, J.5
Fernandez, A.6
-
116
-
-
43049095235
-
Mechanism of mitochondrial glutathione-dependent hepatocellular susceptibility to TNF despite NF-kappaB activation
-
doi:10.1053/j.gastro.2008.01.073
-
Mari M. Colell A. Morales A. Caballero F. Moles A. Fernandez A.et al. (2008). Mechanism of mitochondrial glutathione-dependent hepatocellular susceptibility to TNF despite NF-kappaB activation. Gastroenterology 134 1507-1520. doi: 10.1053/j.gastro.2008.01.073
-
(2008)
Gastroenterology
, vol.134
, pp. 1507-1520
-
-
Mari, M.1
Colell, A.2
Morales, A.3
Caballero, F.4
Moles, A.5
Fernandez, A.6
-
119
-
-
84875699765
-
Mitochondrial glutathione: features, regulation and role in disease
-
doi:10.1016/j.bbagen.2012.10.018
-
Mari M. Morales A. Colell A. Garcia-Ruiz C. Kaplowitz N. Fernandez-Checa J. C. (2013). Mitochondrial glutathione: features, regulation and role in disease. Biochim. Biophys. Acta 1830 3317-3328. doi: 10.1016/j.bbagen.2012.10.018
-
(2013)
Biochim. Biophys. Acta
, vol.1830
, pp. 3317-3328
-
-
Mari, M.1
Morales, A.2
Colell, A.3
Garcia-Ruiz, C.4
Kaplowitz, N.5
Fernandez-Checa, J.C.6
-
120
-
-
0025049139
-
High-affinity transport of glutathione is part of a multicomponent system essential for mitochondrial function
-
doi:10.1073/pnas.87.18.7185
-
Martensson J. Lai J. C. Meister A. (1990). High-affinity transport of glutathione is part of a multicomponent system essential for mitochondrial function. Proc. Natl. Acad. Sci. U.S.A. 87 7185-7189. doi: 10.1073/pnas.87.18.7185
-
(1990)
Proc. Natl. Acad. Sci. U.S.A.
, vol.87
, pp. 7185-7189
-
-
Martensson, J.1
Lai, J.C.2
Meister, A.3
-
121
-
-
0035235419
-
Breaking the mitochondrial barrier
-
doi:10.1038/35048069
-
Martinou J. C. Green D. R. (2001). Breaking the mitochondrial barrier. Nat. Rev. Mol. Cell Biol. 2 63-67. doi: 10.1038/35048069
-
(2001)
Nat. Rev. Mol. Cell Biol.
, vol.2
, pp. 63-67
-
-
Martinou, J.C.1
Green, D.R.2
-
122
-
-
80155169999
-
Hypercholesterolemia increases mitochondrial oxidative stress and enhances the MPT response in the porcine myocardium: beneficial effects of chronic exercise
-
doi:10.1152/ajpregu.00841.2010
-
McCommis K. S. McGee A. M. Laughlin M. H. Bowles D. K. Baines C. P. (2011). Hypercholesterolemia increases mitochondrial oxidative stress and enhances the MPT response in the porcine myocardium: beneficial effects of chronic exercise. Am. J. Physiol. Regul. Integr. Comp. Physiol. 301 R1250-R1258. doi: 10.1152/ajpregu.00841.2010
-
(2011)
Am. J. Physiol. Regul. Integr. Comp. Physiol.
, vol.301
-
-
McCommis, K.S.1
McGee, A.M.2
Laughlin, M.H.3
Bowles, D.K.4
Baines, C.P.5
-
123
-
-
34249787877
-
Steroidogenic acute regulatory protein (StAR), a novel mitochondrial cholesterol transporter
-
doi:10.1016/j.bbalip.2007.02.012
-
Miller W. L. (2007). Steroidogenic acute regulatory protein (StAR), a novel mitochondrial cholesterol transporter. Biochim. Biophys. Acta 1771 663-676. doi: 10.1016/j.bbalip.2007.02.012
-
(2007)
Biochim. Biophys. Acta
, vol.1771
, pp. 663-676
-
-
Miller, W.L.1
-
124
-
-
84884530635
-
Steroid hormone synthesis in mitochondria
-
doi:10.1016/j.mce.2013.04.014
-
Miller W. L. (2013). Steroid hormone synthesis in mitochondria. Mol. Cell. Endocrinol. 379 62-73. doi: 10.1016/j.mce.2013.04.014
-
(2013)
Mol. Cell. Endocrinol.
, vol.379
, pp. 62-73
-
-
Miller, W.L.1
-
125
-
-
77953745493
-
Cholesterol and peroxidized cardiolipin in mitochondrial membrane properties, permeabilization and cell death
-
doi:10.1016/j.bbabio.2010.02.010
-
Montero J. Mari M. Colell A. Morales A. Basanez G. Garcia-Ruiz C.et al. (2010). Cholesterol and peroxidized cardiolipin in mitochondrial membrane properties, permeabilization and cell death. Biochim. Biophys. Acta 1797 1217-1224. doi: 10.1016/j.bbabio.2010.02.010
-
(2010)
Biochim. Biophys. Acta
, vol.1797
, pp. 1217-1224
-
-
Montero, J.1
Mari, M.2
Colell, A.3
Morales, A.4
Basanez, G.5
Garcia-Ruiz, C.6
-
126
-
-
48549093785
-
Mitochondrial cholesterol contributes to chemotherapy resistance in hepatocellular carcinoma
-
doi:10.1158/0008-5472.CAN-07-6161
-
Montero J. Morales A. Llacuna L. Lluis J. M. Terrones O. Basanez G.et al. (2008). Mitochondrial cholesterol contributes to chemotherapy resistance in hepatocellular carcinoma. Cancer Res. 68 5246-5256. doi: 10.1158/0008-5472.CAN-07-6161
-
(2008)
Cancer Res.
, vol.68
, pp. 5246-5256
-
-
Montero, J.1
Morales, A.2
Llacuna, L.3
Lluis, J.M.4
Terrones, O.5
Basanez, G.6
-
127
-
-
84866403209
-
Mitochondrial GSH determines the toxic or therapeutic potential of superoxide scavenging in steatohepatitis
-
doi:10.1016/j.jhep.2012.05.024
-
Montfort C. Matias N. Fernandez A. Fucho R. Conde De La Rosa L. Martinez-Chantar M. L.et al. (2012). Mitochondrial GSH determines the toxic or therapeutic potential of superoxide scavenging in steatohepatitis. J. Hepatol. 57 852-859. doi: 10.1016/j.jhep.2012.05.024
-
(2012)
J. Hepatol.
, vol.57
, pp. 852-859
-
-
Montfort, C.1
Matias, N.2
Fernandez, A.3
Fucho, R.4
Conde De La Rosa, L.5
Martinez-Chantar, M.L.6
-
128
-
-
84891379545
-
Translocator protein/peripheral benzodiazepine receptor is not required for steroid hormone biosynthesis
-
doi:10.1210/en.2013-1556
-
Morohaku K. Pelton S. H. Daugherty D. J. Butler W. R. Deng W. Selvaraj V. (2014). Translocator protein/peripheral benzodiazepine receptor is not required for steroid hormone biosynthesis. Endocrinology 155 89-97. doi: 10.1210/en.2013-1556
-
(2014)
Endocrinology
, vol.155
, pp. 89-97
-
-
Morohaku, K.1
Pelton, S.H.2
Daugherty, D.J.3
Butler, W.R.4
Deng, W.5
Selvaraj, V.6
-
130
-
-
33746827856
-
Different mitochondrial intermembrane space proteins are released during apoptosis in a manner that is coordinately initiated but can vary in duration
-
doi:10.1073/pnas.0603007103
-
Munoz-Pinedo C. Guio-Carrion A. Goldstein J. C. Fitzgerald P. Newmeyer D. D. Green D. R. (2006). Different mitochondrial intermembrane space proteins are released during apoptosis in a manner that is coordinately initiated but can vary in duration. Proc. Natl. Acad. Sci. U.S.A. 103 11573-11578. doi: 10.1073/pnas.0603007103
-
(2006)
Proc. Natl. Acad. Sci. U.S.A.
, vol.103
, pp. 11573-11578
-
-
Munoz-Pinedo, C.1
Guio-Carrion, A.2
Goldstein, J.C.3
Fitzgerald, P.4
Newmeyer, D.D.5
Green, D.R.6
-
132
-
-
15844407874
-
Cyclophilin D-dependent mitochondrial permeability transition regulates some necrotic but not apoptotic cell death
-
doi:10.1038/nature03317
-
Nakagawa T. Shimizu S. Watanabe T. Yamaguchi O. Otsu K. Yamagata H.et al. (2005). Cyclophilin D-dependent mitochondrial permeability transition regulates some necrotic but not apoptotic cell death. Nature 434 652-658. doi: 10.1038/nature03317
-
(2005)
Nature
, vol.434
, pp. 652-658
-
-
Nakagawa, T.1
Shimizu, S.2
Watanabe, T.3
Yamaguchi, O.4
Otsu, K.5
Yamagata, H.6
-
133
-
-
34848866023
-
Hypoxia stimulates degradation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase through accumulation of lanosterol and hypoxia-inducible factor-mediated induction of insigs
-
doi:10.1074/jbc.M704976200
-
Nguyen A. D. McDonald J. G. Bruick R. K. DeBose-Boyd R. A. (2007). Hypoxia stimulates degradation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase through accumulation of lanosterol and hypoxia-inducible factor-mediated induction of insigs. J. Biol. Chem. 282 27436-27446. doi: 10.1074/jbc.M704976200
-
(2007)
J. Biol. Chem.
, vol.282
, pp. 27436-27446
-
-
Nguyen, A.D.1
McDonald, J.G.2
Bruick, R.K.3
DeBose-Boyd, R.A.4
-
134
-
-
0031976318
-
Serum total cholesterol, apolipoprotein E epsilon 4 allele, and Alzheimer's disease
-
doi:10.1159/000026149
-
Notkola I. L. Sulkava R. Pekkanen J. Erkinjuntti T. Ehnholm C. Kivinen P.et al. (1998). Serum total cholesterol, apolipoprotein E epsilon 4 allele, and Alzheimer's disease. Neuroepidemiology 17 14-20. doi: 10.1159/000026149
-
(1998)
Neuroepidemiology
, vol.17
, pp. 14-20
-
-
Notkola, I.L.1
Sulkava, R.2
Pekkanen, J.3
Erkinjuntti, T.4
Ehnholm, C.5
Kivinen, P.6
-
135
-
-
0035914342
-
Subcellular distribution of superoxide dismutases (SOD) in rat liver: Cu,Zn-SOD in mitochondria
-
doi:10.1074/jbc.M105395200
-
Okado-Matsumoto A. Fridovich I. (2001). Subcellular distribution of superoxide dismutases (SOD) in rat liver: Cu,Zn-SOD in mitochondria. J. Biol. Chem. 276 38388-38393. doi: 10.1074/jbc.M105395200
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 38388-38393
-
-
Okado-Matsumoto, A.1
Fridovich, I.2
-
136
-
-
0023846096
-
Retention of oxidized glutathione by isolated rat liver mitochondria during hydroperoxide treatment
-
doi:10.1016/0304-4165(88)90038-4
-
Olafsdottir K. Reed D. J. (1988). Retention of oxidized glutathione by isolated rat liver mitochondria during hydroperoxide treatment. Biochim. Biophys. Acta 964 377-382. doi: 10.1016/0304-4165(88)90038-4
-
(1988)
Biochim. Biophys. Acta
, vol.964
, pp. 377-382
-
-
Olafsdottir, K.1
Reed, D.J.2
-
137
-
-
33847045900
-
Mitochondrial oxidative stress: implications for cell death
-
doi:10.1146/annurev.pharmtox.47.120505.105122
-
Orrenius S. Gogvadze V. Zhivotovsky B. (2007). Mitochondrial oxidative stress: implications for cell death. Annu. Rev. Pharmacol. Toxicol. 47 143-183. doi: 10.1146/annurev.pharmtox.47.120505.105122
-
(2007)
Annu. Rev. Pharmacol. Toxicol.
, vol.47
, pp. 143-183
-
-
Orrenius, S.1
Gogvadze, V.2
Zhivotovsky, B.3
-
138
-
-
53049089639
-
Direct and potent regulation of gamma-secretase by its lipid microenvironment
-
doi:10.1074/jbc.M801925200
-
Osenkowski P. Ye W. Wang R. Wolfe M. S. Selkoe D. J. (2008). Direct and potent regulation of gamma-secretase by its lipid microenvironment. J. Biol. Chem. 283 22529-22540. doi: 10.1074/jbc.M801925200
-
(2008)
J. Biol. Chem.
, vol.283
, pp. 22529-22540
-
-
Osenkowski, P.1
Ye, W.2
Wang, R.3
Wolfe, M.S.4
Selkoe, D.J.5
-
139
-
-
33748069813
-
Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetes
-
doi:10.1126/science.1128294
-
Ozcan U. Yilmaz E. Ozcan L. Furuhashi M. Vaillancourt E. Smith R. O.et al. (2006). Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetes. Science 313 1137-1140. doi: 10.1126/science.1128294
-
(2006)
Science
, vol.313
, pp. 1137-1140
-
-
Ozcan, U.1
Yilmaz, E.2
Ozcan, L.3
Furuhashi, M.4
Vaillancourt, E.5
Smith, R.O.6
-
141
-
-
33847181297
-
The multiple faces of caveolae
-
doi:10.1038/nrm2122
-
Parton R. G. Simons K. (2007). The multiple faces of caveolae. Nat. Rev. Mol. Cell Biol. 8 185-194. doi: 10.1038/nrm2122
-
(2007)
Nat. Rev. Mol. Cell Biol.
, vol.8
, pp. 185-194
-
-
Parton, R.G.1
Simons, K.2
-
142
-
-
0035809933
-
A caveolin dominant negative mutant associates with lipid bodies and induces intracellular cholesterol imbalance
-
doi:10.1083/jcb.152.5.1057
-
Pol A. Luetterforst R. Lindsay M. Heino S. Ikonen E. Parton R. G. (2001). A caveolin dominant negative mutant associates with lipid bodies and induces intracellular cholesterol imbalance. J. Cell Biol. 152 1057-1070. doi: 10.1083/jcb.152.5.1057
-
(2001)
J. Cell Biol.
, vol.152
, pp. 1057-1070
-
-
Pol, A.1
Luetterforst, R.2
Lindsay, M.3
Heino, S.4
Ikonen, E.5
Parton, R.G.6
-
143
-
-
16344368798
-
Cholesterol and fatty acids regulate dynamic caveolin trafficking through the Golgi complex and between the cell surface and lipid bodies
-
doi:10.1091/mbc.E04-08-0737
-
Pol A. Martin S. Fernandez M. A. Ingelmo-Torres M. Ferguson C. Enrich C.et al. (2005). Cholesterol and fatty acids regulate dynamic caveolin trafficking through the Golgi complex and between the cell surface and lipid bodies. Mol. Biol. Cell 16 2091-2105. doi: 10.1091/mbc.E04-08-0737
-
(2005)
Mol. Biol. Cell
, vol.16
, pp. 2091-2105
-
-
Pol, A.1
Martin, S.2
Fernandez, M.A.3
Ingelmo-Torres, M.4
Ferguson, C.5
Enrich, C.6
-
144
-
-
0642283965
-
The changing faces of glutathione, a cellular protagonist
-
doi:10.1016/S0006-2952(03)00504-5
-
Pompella A. Visvikis A. Paolicchi A. De Tata V. Casini A. F. (2003). The changing faces of glutathione, a cellular protagonist. Biochem. Pharmacol. 66 1499-1503. doi: 10.1016/S0006-2952(03)00504-5
-
(2003)
Biochem. Pharmacol.
, vol.66
, pp. 1499-1503
-
-
Pompella, A.1
Visvikis, A.2
Paolicchi, A.3
De Tata, V.4
Casini, A.F.5
-
146
-
-
84896935583
-
The 2-oxoacid dehydrogenase complexes in mitochondria can produce superoxide/hydrogen peroxide at much higher rates than complex I
-
doi:10.1074/jbc.M113.545301
-
Quinlan C. L. Goncalves R. L. Hey-Mogensen M. Yadava N. Bunik V. I. Brand M. D. (2014). The 2-oxoacid dehydrogenase complexes in mitochondria can produce superoxide/hydrogen peroxide at much higher rates than complex I. J. Biol. Chem. 289 8312-8325. doi: 10.1074/jbc.M113.545301
-
(2014)
J. Biol. Chem.
, vol.289
, pp. 8312-8325
-
-
Quinlan, C.L.1
Goncalves, R.L.2
Hey-Mogensen, M.3
Yadava, N.4
Bunik, V.I.5
Brand, M.D.6
-
147
-
-
84864540083
-
Mitochondrial complex II can generate reactive oxygen species at high rates in both the forward and reverse reactions
-
doi:10.1074/jbc.M112.374629
-
Quinlan C. L. Orr A. L. Perevoshchikova I. V. Treberg J. R. Ackrell B. A. Brand M. D. (2012). Mitochondrial complex II can generate reactive oxygen species at high rates in both the forward and reverse reactions. J. Biol. Chem. 287 27255-27264. doi: 10.1074/jbc.M112.374629
-
(2012)
J. Biol. Chem.
, vol.287
, pp. 27255-27264
-
-
Quinlan, C.L.1
Orr, A.L.2
Perevoshchikova, I.V.3
Treberg, J.R.4
Ackrell, B.A.5
Brand, M.D.6
-
148
-
-
84879774696
-
The determination and analysis of site-specific rates of mitochondrial reactive oxygen species production
-
doi:10.1016/B978-0-12-405883-5.00012-0
-
Quinlan C. L. Perevoschikova I. V. Goncalves R. L. Hey-Mogensen M. Brand M. D. (2013). The determination and analysis of site-specific rates of mitochondrial reactive oxygen species production. Methods Enzymol. 526 189-217. doi: 10.1016/B978-0-12-405883-5.00012-0
-
(2013)
Methods Enzymol.
, vol.526
, pp. 189-217
-
-
Quinlan, C.L.1
Perevoschikova, I.V.2
Goncalves, R.L.3
Hey-Mogensen, M.4
Brand, M.D.5
-
150
-
-
84899907186
-
Mitochondrial pathology: stress signals from the energy factory
-
doi:10.1016/j.molmed.2014.01.005
-
Raimundo N. (2014). Mitochondrial pathology: stress signals from the energy factory. Trends Mol. Med. 20 282-292. doi: 10.1016/j.molmed.2014.01.005
-
(2014)
Trends Mol. Med.
, vol.20
, pp. 282-292
-
-
Raimundo, N.1
-
151
-
-
79960427057
-
Selective killing of cancer cells by a small molecule targeting the stress response to ROS
-
doi:10.1038/nature10167
-
Raj L. Ide T. Gurkar A. U. Foley M. Schenone M. Li X.et al. (2011). Selective killing of cancer cells by a small molecule targeting the stress response to ROS. Nature 475 231-234. doi: 10.1038/nature10167
-
(2011)
Nature
, vol.475
, pp. 231-234
-
-
Raj, L.1
Ide, T.2
Gurkar, A.U.3
Foley, M.4
Schenone, M.5
Li, X.6
-
152
-
-
73349094986
-
Curcumin and cancer cells: how many ways can curry kill tumor cells selectively?
-
doi: 10.1208/s12248-009-9128-x
-
Ravindran J. Prasad S. Aggarwal B. B. (2009). Curcumin and cancer cells: how many ways can curry kill tumor cells selectively? AAPS J. 11 495-510. doi: 10.1208/s12248-009-9128-x
-
(2009)
AAPS J.
, vol.11
, pp. 495-510
-
-
Ravindran, J.1
Prasad, S.2
Aggarwal, B.B.3
-
153
-
-
84885936559
-
Inter-organellar communication with mitochondria regulates both the intrinsic and extrinsic pathways of apoptosis
-
doi:10.4161/cib.22872
-
Renault T. T. Chipuk J. E. (2013). Inter-organellar communication with mitochondria regulates both the intrinsic and extrinsic pathways of apoptosis. Commun. Integr. Biol. 6:e22872. doi: 10.4161/cib.22872
-
(2013)
Commun. Integr. Biol.
, vol.6
-
-
Renault, T.T.1
Chipuk, J.E.2
-
154
-
-
84856940017
-
Peroxiredoxin functions as a peroxidase and a regulator and sensor of local peroxides
-
doi:10.1074/jbc.R111.283432
-
Rhee S. G. Woo H. A. Kil I. S. Bae S. H. (2012). Peroxiredoxin functions as a peroxidase and a regulator and sensor of local peroxides. J. Biol. Chem. 287 4403-4410. doi: 10.1074/jbc.R111.283432
-
(2012)
J. Biol. Chem.
, vol.287
, pp. 4403-4410
-
-
Rhee, S.G.1
Woo, H.A.2
Kil, I.S.3
Bae, S.H.4
-
155
-
-
0034630258
-
Interactions between metabolism and intracellular distribution of cholesterol and sphingomyelin
-
doi:10.1016/S1388-1981(00)00006-8
-
Ridgway N. D. (2000). Interactions between metabolism and intracellular distribution of cholesterol and sphingomyelin. Biochim. Biophys. Acta 1484 129-141. doi: 10.1016/S1388-1981(00)00006-8
-
(2000)
Biochim. Biophys. Acta
, vol.1484
, pp. 129-141
-
-
Ridgway, N.D.1
-
156
-
-
20244381138
-
Lipophilic triphenylphosphonium cations as tools in mitochondrial bioenergetics and free radical biology
-
doi:10.1007/s10541-005-0104-5
-
Ross M. F. Kelso G. F. Blaikie F. H. James A. M. Cocheme H. M. Filipovska A.et al. (2005). Lipophilic triphenylphosphonium cations as tools in mitochondrial bioenergetics and free radical biology. Biochemistry (Mosc.) 70 222-230. doi: 10.1007/s10541-005-0104-5
-
(2005)
Biochemistry (Mosc.)
, vol.70
, pp. 222-230
-
-
Ross, M.F.1
Kelso, G.F.2
Blaikie, F.H.3
James, A.M.4
Cocheme, H.M.5
Filipovska, A.6
-
157
-
-
27744464884
-
2-Cyano-3,12-dioxooleana-1,9-dien-28-imidazolide (CDDO-Im) directly targets mitochondrial glutathione to induce apoptosis in pancreatic cancer
-
doi:10.1074/jbc.M507518200
-
Samudio I. Konopleva M. Hail N. Jr., Shi Y. X. McQueen T. Hsu T.et al. (2005). 2-Cyano-3,12-dioxooleana-1,9-dien-28-imidazolide (CDDO-Im) directly targets mitochondrial glutathione to induce apoptosis in pancreatic cancer. J. Biol. Chem. 280 36273-36282. doi: 10.1074/jbc.M507518200
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 36273-36282
-
-
Samudio, I.1
Konopleva, M.2
Hail Jr, N.3
Shi, Y.X.4
McQueen, T.5
Hsu, T.6
-
158
-
-
49849093594
-
Inhibition of mitochondrial metabolism by methyl-2-cyano-3,12-dioxooleana-1,9-diene-28-oate induces apoptotic or autophagic cell death in chronic myeloid leukemia cells
-
doi:10.1158/1535-7163.MCT-07-0553
-
Samudio I. Kurinna S. Ruvolo P. Korchin B. Kantarjian H. Beran M.et al. (2008). Inhibition of mitochondrial metabolism by methyl-2-cyano-3,12-dioxooleana-1,9-diene-28-oate induces apoptotic or autophagic cell death in chronic myeloid leukemia cells. Mol. Cancer Ther. 7 1130-1139. doi: 10.1158/1535-7163.MCT-07-0553
-
(2008)
Mol. Cancer Ther.
, vol.7
, pp. 1130-1139
-
-
Samudio, I.1
Kurinna, S.2
Ruvolo, P.3
Korchin, B.4
Kantarjian, H.5
Beran, M.6
-
159
-
-
1642482817
-
Modulation of amyloid precursor protein cleavage by cellular sphingolipids
-
doi:10.1074/jbc.M309832200
-
Sawamura N. Ko M. Yu W. Zou K. Hanada K. Suzuki T.et al. (2004). Modulation of amyloid precursor protein cleavage by cellular sphingolipids. J. Biol. Chem. 279 11984-11991. doi: 10.1074/jbc.M309832200
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 11984-11991
-
-
Sawamura, N.1
Ko, M.2
Yu, W.3
Zou, K.4
Hanada, K.5
Suzuki, T.6
-
162
-
-
24744460273
-
Cyclophilin D is a component of mitochondrial permeability transition and mediates neuronal cell death after focal cerebral ischemia
-
doi:10.1073/pnas.0505294102
-
Schinzel A. C. Takeuchi O. Huang Z. Fisher J. K. Zhou Z. Rubens J.et al. (2005). Cyclophilin D is a component of mitochondrial permeability transition and mediates neuronal cell death after focal cerebral ischemia. Proc. Natl. Acad. Sci. U.S.A. 102 12005-12010. doi: 10.1073/pnas.0505294102
-
(2005)
Proc. Natl. Acad. Sci. U.S.A.
, vol.102
, pp. 12005-12010
-
-
Schinzel, A.C.1
Takeuchi, O.2
Huang, Z.3
Fisher, J.K.4
Zhou, Z.5
Rubens, J.6
-
163
-
-
33748165596
-
Reactive oxygen species in cancer cells: live by the sword, die by the sword
-
doi:10.1016/j.ccr.2006.08.015
-
Schumacker P. T. (2006). Reactive oxygen species in cancer cells: live by the sword, die by the sword. Cancer Cell 10 175-176. doi: 10.1016/j.ccr.2006.08.015
-
(2006)
Cancer Cell
, vol.10
, pp. 175-176
-
-
Schumacker, P.T.1
-
164
-
-
84868007565
-
Physiological roles of mitochondrial reactive oxygen species
-
doi:10.1016/j.molcel.2012.09.025
-
Sena L. A. Chandel N. S. (2012). Physiological roles of mitochondrial reactive oxygen species. Mol. Cell 48 158-167. doi: 10.1016/j.molcel.2012.09.025
-
(2012)
Mol. Cell
, vol.48
, pp. 158-167
-
-
Sena, L.A.1
Chandel, N.S.2
-
165
-
-
46349087273
-
Uncoupling protein-2 (UCP2) induces mitochondrial proton leak and increases susceptibility of non-alcoholic steatohepatitis (NASH) liver to ischaemia-reperfusion injury
-
doi:10.1136/gut.2007.147496
-
Serviddio G. Bellanti F. Tamborra R. Rollo T. Capitanio N. Romano A. D.et al. (2008). Uncoupling protein-2 (UCP2) induces mitochondrial proton leak and increases susceptibility of non-alcoholic steatohepatitis (NASH) liver to ischaemia-reperfusion injury. Gut 57 957-965. doi: 10.1136/gut.2007.147496
-
(2008)
Gut
, vol.57
, pp. 957-965
-
-
Serviddio, G.1
Bellanti, F.2
Tamborra, R.3
Rollo, T.4
Capitanio, N.5
Romano, A.D.6
-
166
-
-
29344446328
-
Targeting antioxidants to mitochondria: a new therapeutic direction
-
doi:10.1016/j.bbadis.2005.10.007
-
Sheu S. S. Nauduri D. Anders M. W. (2006). Targeting antioxidants to mitochondria: a new therapeutic direction. Biochim. Biophys. Acta 1762 256-265. doi: 10.1016/j.bbadis.2005.10.007
-
(2006)
Biochim. Biophys. Acta
, vol.1762
, pp. 256-265
-
-
Sheu, S.S.1
Nauduri, D.2
Anders, M.W.3
-
167
-
-
84897444272
-
Role of Metabolic H2O2 Generation: REDOX SIGNALING AND OXIDATIVE STRESS
-
doi:10.1074/jbc.R113.544635
-
Sies H. (2014). Role of Metabolic H2O2 Generation: REDOX SIGNALING AND OXIDATIVE STRESS. J. Biol. Chem. 289 8735-8741. doi: 10.1074/jbc.R113.544635
-
(2014)
J. Biol. Chem.
, vol.289
, pp. 8735-8741
-
-
Sies, H.1
-
168
-
-
84901008605
-
Regulation of the mitochondrial permeability transition pore by the outer membrane does not involve the peripheral benzodiazepine receptor (TSPO)
-
doi: 10.1074/jbc.M114.549634 [Epub ahead of print].
-
Sileikyte J. Blachly-Dyson E. Sewell R. Carpi A. Menabo R. Di Lisa F.et al. (2014). Regulation of the mitochondrial permeability transition pore by the outer membrane does not involve the peripheral benzodiazepine receptor (TSPO). J. Biol. Chem. doi: 10.1074/jbc.M114.549634 [Epub ahead of print].
-
(2014)
J.Biol.Chem.
-
-
Sileikyte, J.1
Blachly-Dyson, E.2
Sewell, R.3
Carpi, A.4
Menabo, R.5
Di Lisa, F.6
-
169
-
-
0032840719
-
Sphingomyelin-cholesterol interactions in biological and model membranes
-
doi:10.1016/S0009-3084(99)00071-7
-
Slotte J. P. (1999). Sphingomyelin-cholesterol interactions in biological and model membranes. Chem. Phys. Lipids 102 13-27. doi: 10.1016/S0009-3084(99)00071-7
-
(1999)
Chem. Phys. Lipids
, vol.102
, pp. 13-27
-
-
Slotte, J.P.1
-
170
-
-
77955283395
-
Animal and human studies with the mitochondria-targeted antioxidant MitoQ
-
doi:10.1111/j.1749-6632.2010.05627.x
-
Smith R. A. Murphy M. P. (2010). Animal and human studies with the mitochondria-targeted antioxidant MitoQ. Ann. N. Y. Acad. Sci. 1201 96-103. doi: 10.1111/j.1749-6632.2010.05627.x
-
(2010)
Ann. N. Y. Acad. Sci.
, vol.1201
, pp. 96-103
-
-
Smith, R.A.1
Murphy, M.P.2
-
171
-
-
84865295946
-
Cytochrome c oxidase dysfunction in oxidative stress
-
doi:10.1016/j.freeradbiomed.2012.07.021
-
Srinivasan S. Avadhani N. G. (2012). Cytochrome c oxidase dysfunction in oxidative stress. Free Radic. Biol. Med. 53 1252-1263. doi: 10.1016/j.freeradbiomed.2012.07.021
-
(2012)
Free Radic. Biol. Med.
, vol.53
, pp. 1252-1263
-
-
Srinivasan, S.1
Avadhani, N.G.2
-
172
-
-
0038015010
-
Glutathione-thiyl radical scavenging and transferase properties of human glutaredoxin (thioltransferase)
-
doi:10.1074/jbc.M210434200
-
Starke D. W. Chock P. B. Mieyal J. J. (2003). Glutathione-thiyl radical scavenging and transferase properties of human glutaredoxin (thioltransferase). Potential role in redox signal transduction. J. Biol. Chem. 278 14607-14613. doi: 10.1074/jbc.M210434200
-
(2003)
Potential role in redox signal transduction. J. Biol. Chem.
, vol.278
, pp. 14607-14613
-
-
Starke, D.W.1
Chock, P.B.2
Mieyal, J.J.3
-
173
-
-
84865612521
-
The biological roles of glutaredoxins
-
doi:10.1042/BJ20112131
-
Stroher E. Millar A. H. (2012). The biological roles of glutaredoxins. Biochem. J. 446 333-348. doi: 10.1042/BJ20112131
-
(2012)
Biochem. J.
, vol.446
, pp. 333-348
-
-
Stroher, E.1
Millar, A.H.2
-
174
-
-
84881100615
-
Revealing various coupling of electron transfer and proton pumping in mitochondrial respiratory chain
-
doi:10.1016/j.sbi.2013.06.013
-
Sun F. Zhou Q. Pang X. Xu Y. Rao Z. (2013). Revealing various coupling of electron transfer and proton pumping in mitochondrial respiratory chain. Curr. Opin. Struct. Biol. 23 526-538. doi: 10.1016/j.sbi.2013.06.013
-
(2013)
Curr. Opin. Struct. Biol.
, vol.23
, pp. 526-538
-
-
Sun, F.1
Zhou, Q.2
Pang, X.3
Xu, Y.4
Rao, Z.5
-
175
-
-
39749182234
-
Apoptosis: controlled demolition at the cellular level
-
doi:10.1038/nrm2312
-
Taylor R. C. Cullen S. P. Martin S. J. (2008). Apoptosis: controlled demolition at the cellular level. Nat. Rev. Mol. Cell Biol. 9 231-241. doi: 10.1038/nrm2312
-
(2008)
Nat. Rev. Mol. Cell Biol.
, vol.9
, pp. 231-241
-
-
Taylor, R.C.1
Cullen, S.P.2
Martin, S.J.3
-
176
-
-
84872072831
-
beta-arrestin 2 regulates Abeta generation and gamma-secretase activity in Alzheimer's disease
-
doi:10.1038/nm.3023
-
Thathiah A. Horre K. Snellinx A. Vandewyer E. Huang Y. Ciesielska M.et al. (2013). beta-arrestin 2 regulates Abeta generation and gamma-secretase activity in Alzheimer's disease. Nat. Med. 19 43-49. doi: 10.1038/nm.3023
-
(2013)
Nat. Med.
, vol.19
, pp. 43-49
-
-
Thathiah, A.1
Horre, K.2
Snellinx, A.3
Vandewyer, E.4
Huang, Y.5
Ciesielska, M.6
-
177
-
-
0034676629
-
Cytokines in alcoholic and nonalcoholic steatohepatitis
-
doi:10.1056/NEJM200011163432007
-
Tilg H. Diehl A. M. (2000). Cytokines in alcoholic and nonalcoholic steatohepatitis. N. Engl. J. Med. 343 1467-1476. doi: 10.1056/NEJM200011163432007
-
(2000)
N. Engl. J. Med.
, vol.343
, pp. 1467-1476
-
-
Tilg, H.1
Diehl, A.M.2
-
178
-
-
33748146888
-
Selective killing of oncogenically transformed cells through a ROS-mediated mechanism by beta-phenylethyl isothiocyanate
-
doi:10.1016/j.ccr.2006.08.009
-
Trachootham D. Zhou Y. Zhang H. Demizu Y. Chen Z. Pelicano H.et al. (2006). Selective killing of oncogenically transformed cells through a ROS-mediated mechanism by beta-phenylethyl isothiocyanate. Cancer Cell 10 241-252. doi: 10.1016/j.ccr.2006.08.009
-
(2006)
Cancer Cell
, vol.10
, pp. 241-252
-
-
Trachootham, D.1
Zhou, Y.2
Zhang, H.3
Demizu, Y.4
Chen, Z.5
Pelicano, H.6
-
179
-
-
82755193704
-
Mitochondrial targeting of peroxiredoxin 5 is preserved from annelids to mammals but is absent in pig Sus scrofa domesticus
-
doi:10.1016/j.mito.2011.06.013
-
Van der Eecken V. Clippe A. Van Veldhoven P. P. Knoops B. (2011). Mitochondrial targeting of peroxiredoxin 5 is preserved from annelids to mammals but is absent in pig Sus scrofa domesticus. Mitochondrion 11 973-981. doi: 10.1016/j.mito.2011.06.013
-
(2011)
Mitochondrion
, vol.11
, pp. 973-981
-
-
Van der Eecken, V.1
Clippe, A.2
Van Veldhoven, P.P.3
Knoops, B.4
-
181
-
-
84903166509
-
Adverse signaling of scavenger receptor class B1, and PGC1s in alcoholic hepatosteatosis, and steatohepatitis, and protection by betaine in rat
-
doi: 10.1016/j.ajpath.2014.03.005 [Epub ahead of print].
-
Varatharajalu R. Garige M. Leckey L. C. Arellanes-Robledo J. Reyes-Gordillo K. Shah R.et al. (2014). Adverse signaling of scavenger receptor class B1, and PGC1s in alcoholic hepatosteatosis, and steatohepatitis, and protection by betaine in rat. Am. J. Pathol. doi: 10.1016/j.ajpath.2014.03.005 [Epub ahead of print].
-
(2014)
Am. J. Pathol.
-
-
Varatharajalu, R.1
Garige, M.2
Leckey, L.C.3
Arellanes-Robledo, J.4
Reyes-Gordillo, K.5
Shah, R.6
-
182
-
-
84874575715
-
Mitochondrial metabolism of reactive oxygen species
-
doi:10.1016/j.mito.2013.01.008
-
Venditti P. Di Stefano L. Di Meo S. (2013). Mitochondrial metabolism of reactive oxygen species. Mitochondrion 13 71-82. doi: 10.1016/j.mito.2013.01.008
-
(2013)
Mitochondrion
, vol.13
, pp. 71-82
-
-
Venditti, P.1
Di Stefano, L.2
Di Meo, S.3
-
183
-
-
67749147469
-
Absence of nitric-oxide synthase in sequentially purified rat liver mitochondria
-
doi:10.1074/jbc.M109.003301
-
Venkatakrishnan P. Nakayasu E. S. Almeida I. C. Miller R. T. (2009). Absence of nitric-oxide synthase in sequentially purified rat liver mitochondria. J. Biol. Chem. 284 19843-19855. doi: 10.1074/jbc.M109.003301
-
(2009)
J. Biol. Chem.
, vol.284
, pp. 19843-19855
-
-
Venkatakrishnan, P.1
Nakayasu, E.S.2
Almeida, I.C.3
Miller, R.T.4
-
184
-
-
21844448354
-
Spatial segregation of gamma-secretase and substrates in distinct membrane domains
-
doi:10.1074/jbc.M503570200
-
Vetrivel K. S. Cheng H. Kim S. H. Chen Y. Barnes N. Y. Parent A. T.et al. (2005). Spatial segregation of gamma-secretase and substrates in distinct membrane domains. J. Biol. Chem. 280 25892-25900. doi: 10.1074/jbc.M503570200
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 25892-25900
-
-
Vetrivel, K.S.1
Cheng, H.2
Kim, S.H.3
Chen, Y.4
Barnes, N.Y.5
Parent, A.T.6
-
185
-
-
64349086819
-
Mitochondrial glutathione uptake: characterization in isolated brain mitochondria and astrocytes in culture
-
doi: 10.1111/j.1471-4159.2009.05936.x
-
Wadey A. L. Muyderman H. Kwek P. T. Sims N. R. (2009). Mitochondrial glutathione uptake: characterization in isolated brain mitochondria and astrocytes in culture. J. Neurochem. 109(Suppl. 1) 101-108. doi: 10.1111/j.1471-4159.2009.05936.x
-
(2009)
J. Neurochem.
, vol.109
, Issue.SUPPL 1
, pp. 101-108
-
-
Wadey, A.L.1
Muyderman, H.2
Kwek, P.T.3
Sims, N.R.4
-
186
-
-
0036180950
-
Cholesterol-dependent gamma-secretase activity in buoyant cholesterol-rich membrane microdomains
-
doi:10.1006/nbdi.2001.0470
-
Wahrle S. Das P. Nyborg A. C. McLendon C. Shoji M. Kawarabayashi T.et al. (2002). Cholesterol-dependent gamma-secretase activity in buoyant cholesterol-rich membrane microdomains. Neurobiol. Dis. 9 11-23. doi: 10.1006/nbdi.2001.0470
-
(2002)
Neurobiol. Dis.
, vol.9
, pp. 11-23
-
-
Wahrle, S.1
Das, P.2
Nyborg, A.C.3
McLendon, C.4
Shoji, M.5
Kawarabayashi, T.6
-
187
-
-
84875181661
-
Oxidants, antioxidants and the current incurability of metastatic cancers
-
doi:10.1098/rsob.120144
-
Watson J. (2013). Oxidants, antioxidants and the current incurability of metastatic cancers. Open Biol. 3:120144. doi: 10.1098/rsob.120144
-
(2013)
Open Biol.
, vol.3
, pp. 120144
-
-
Watson, J.1
-
188
-
-
34247335248
-
Steroidogenic acute regulatory protein (StAR): evidence of gonadotropin-induced steroidogenesis in Alzheimer disease
-
doi:10.1186/1750-1326-1-14
-
Webber K. M. Stocco D. M. Casadesus G. Bowen R. L. Atwood C. S. Previll L. A.et al. (2006). Steroidogenic acute regulatory protein (StAR): evidence of gonadotropin-induced steroidogenesis in Alzheimer disease. Mol. Neurodegener. 1:14. doi: 10.1186/1750-1326-1-14
-
(2006)
Mol. Neurodegener.
, vol.1
, pp. 14
-
-
Webber, K.M.1
Stocco, D.M.2
Casadesus, G.3
Bowen, R.L.4
Atwood, C.S.5
Previll, L.A.6
-
189
-
-
84903215460
-
Stable over-expression of the 2-oxoglutarate carrier enhances neuronal cell resistance to oxidative stress via Bcl-2-dependent mitochondrial GSH transport
-
doi: 10.1111/jnc.12709 [Epub ahead of print].
-
Wilkins H. M. Brock S. Gray J. J. Linseman D. A. (2014). Stable over-expression of the 2-oxoglutarate carrier enhances neuronal cell resistance to oxidative stress via Bcl-2-dependent mitochondrial GSH transport. J. Neurochem. doi: 10.1111/jnc.12709 [Epub ahead of print].
-
(2014)
J. Neurochem.
-
-
Wilkins, H.M.1
Brock, S.2
Gray, J.J.3
Linseman, D.A.4
-
190
-
-
84874045170
-
Mitochondrial glutathione transport is a key determinant of neuronal susceptibility to oxidative and nitrosative stress
-
doi:10.1074/jbc.M112.405738
-
Wilkins H. M. Kirchhof D. Manning E. Joseph J. W. Linseman D. A. (2013). Mitochondrial glutathione transport is a key determinant of neuronal susceptibility to oxidative and nitrosative stress. J. Biol. Chem. 288 5091-5101. doi: 10.1074/jbc.M112.405738
-
(2013)
J. Biol. Chem.
, vol.288
, pp. 5091-5101
-
-
Wilkins, H.M.1
Kirchhof, D.2
Manning, E.3
Joseph, J.W.4
Linseman, D.A.5
-
191
-
-
84855469557
-
Bcl-2 is a novel interacting partner for the 2-oxoglutarate carrier and a key regulator of mitochondrial glutathione
-
doi:10.1016/j.freeradbiomed.2011.10.495
-
Wilkins H. M. Marquardt K. Lash L. H. Linseman D. A. (2012). Bcl-2 is a novel interacting partner for the 2-oxoglutarate carrier and a key regulator of mitochondrial glutathione. Free Radic. Biol. Med. 52 410-419. doi: 10.1016/j.freeradbiomed.2011.10.495
-
(2012)
Free Radic. Biol. Med.
, vol.52
, pp. 410-419
-
-
Wilkins, H.M.1
Marquardt, K.2
Lash, L.H.3
Linseman, D.A.4
-
192
-
-
0033772113
-
Decreased prevalence of Alzheimer disease associated with 3-hydroxy-3-methyglutaryl coenzyme A reductase inhibitors
-
doi:10.1001/archneur.57.10.1439
-
Wolozin B. Kellman W. Ruosseau P. Celesia G. G. Siegel G. (2000). Decreased prevalence of Alzheimer disease associated with 3-hydroxy-3-methyglutaryl coenzyme A reductase inhibitors. Arch. Neurol. 57 1439-1443. doi: 10.1001/archneur.57.10.1439
-
(2000)
Arch. Neurol.
, vol.57
, pp. 1439-1443
-
-
Wolozin, B.1
Kellman, W.2
Ruosseau, P.3
Celesia, G.G.4
Siegel, G.5
-
193
-
-
33644769263
-
Modulation of expression of rat mitochondrial 2-oxoglutarate carrier in NRK-52E cells alters mitochondrial transport and accumulation of glutathione and susceptibility to chemically induced apoptosis
-
doi:10.1124/jpet.105.094599
-
Xu F. Putt D. A. Matherly L. H. Lash L. H. (2006). Modulation of expression of rat mitochondrial 2-oxoglutarate carrier in NRK-52E cells alters mitochondrial transport and accumulation of glutathione and susceptibility to chemically induced apoptosis. J. Pharmacol. Exp. Ther. 316 1175-1186. doi: 10.1124/jpet.105.094599
-
(2006)
J. Pharmacol. Exp. Ther.
, vol.316
, pp. 1175-1186
-
-
Xu, F.1
Putt, D.A.2
Matherly, L.H.3
Lash, L.H.4
-
195
-
-
84900299463
-
The intrinsic apoptosis pathway mediates the pro-longevity response to mitochondrial ROS in C
-
doi:10.1016/j.cell.2014.02.055
-
Yee C. Yang W. Hekimi S. (2014). The intrinsic apoptosis pathway mediates the pro-longevity response to mitochondrial ROS in C. elegans. Cell 157 897-909. doi: 10.1016/j.cell.2014.02.055
-
(2014)
elegans. Cell
, vol.157
, pp. 897-909
-
-
Yee, C.1
Yang, W.2
Hekimi, S.3
-
196
-
-
84867725042
-
Mitochondrial thiols in the regulation of cell death pathways
-
doi:10.1089/ars.2012.4639
-
Yin F. Sancheti H. Cadenas E. (2012). Mitochondrial thiols in the regulation of cell death pathways. Antioxid. Redox Signal. 17 1714-1727. doi: 10.1089/ars.2012.4639
-
(2012)
Antioxid. Redox Signal.
, vol.17
, pp. 1714-1727
-
-
Yin, F.1
Sancheti, H.2
Cadenas, E.3
-
197
-
-
37549048249
-
The BCL-2 protein family: opposing activities that mediate cell death
-
doi:10.1038/nrm2308
-
Youle R. J. Strasser A. (2008). The BCL-2 protein family: opposing activities that mediate cell death. Nat. Rev. Mol. Cell Biol. 9 47-59. doi: 10.1038/nrm2308
-
(2008)
Nat. Rev. Mol. Cell Biol.
, vol.9
, pp. 47-59
-
-
Youle, R.J.1
Strasser, A.2
-
198
-
-
33646771034
-
Depletion of intracellular glutathione contributes to JNK-mediated death receptor 5 upregulation and apoptosis induction by the novel synthetic triterpenoid methyl-2-cyano-3, 12-dioxooleana-1, 9-dien-28-oate (CDDO-Me)
-
doi:10.4161/cbt.5.5.2565
-
Yue P. Zhou Z. Khuri F. R. Sun S. Y. (2006). Depletion of intracellular glutathione contributes to JNK-mediated death receptor 5 upregulation and apoptosis induction by the novel synthetic triterpenoid methyl-2-cyano-3, 12-dioxooleana-1, 9-dien-28-oate (CDDO-Me). Cancer Biol. Ther. 5 492-497. doi: 10.4161/cbt.5.5.2565
-
(2006)
Cancer Biol. Ther.
, vol.5
, pp. 492-497
-
-
Yue, P.1
Zhou, Z.2
Khuri, F.R.3
Sun, S.Y.4
-
199
-
-
15744378799
-
Altered cholesterol metabolism in Niemann-Pick type C1 mouse brains affects mitochondrial function
-
doi:10.1074/jbc.M412898200
-
Yu W. Gong J. S. Ko M. Garver W. S. Yanagisawa K. Michikawa M. (2005). Altered cholesterol metabolism in Niemann-Pick type C1 mouse brains affects mitochondrial function. J. Biol. Chem. 280 11731-11739. doi: 10.1074/jbc.M412898200
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 11731-11739
-
-
Yu, W.1
Gong, J.S.2
Ko, M.3
Garver, W.S.4
Yanagisawa, K.5
Michikawa, M.6
-
200
-
-
34548048824
-
Mitochondrial thioredoxin-2/peroxiredoxin-3 system functions in parallel with mitochondrial GSH system in protection against oxidative stress
-
doi:10.1016/j.abb.2007.05.001
-
Zhang H. Go Y. M. Jones D. P. (2007). Mitochondrial thioredoxin-2/peroxiredoxin-3 system functions in parallel with mitochondrial GSH system in protection against oxidative stress. Arch. Biochem. Biophys. 465 119-126. doi: 10.1016/j.abb.2007.05.001
-
(2007)
Arch. Biochem. Biophys.
, vol.465
, pp. 119-126
-
-
Zhang, H.1
Go, Y.M.2
Jones, D.P.3
-
201
-
-
0036322172
-
Selective mitochondrial glutathione depletion by ethanol enhances acetaminophen toxicity in rat liver
-
doi:10.1053/jhep.2002.34943
-
Zhao P. Kalhorn T. F. Slattery J. T. (2002). Selective mitochondrial glutathione depletion by ethanol enhances acetaminophen toxicity in rat liver. Hepatology 36 326-335. doi: 10.1053/jhep.2002.34943
-
(2002)
Hepatology
, vol.36
, pp. 326-335
-
-
Zhao, P.1
Kalhorn, T.F.2
Slattery, J.T.3
-
202
-
-
43949146899
-
Hepatic mitochondrial transport of glutathione: studies in isolated rat liver mitochondria and H4IIE rat hepatoma cells
-
doi:10.1016/j.abb.2008.03.008
-
Zhong Q. Putt D. A. Xu F. Lash L. H. (2008). Hepatic mitochondrial transport of glutathione: studies in isolated rat liver mitochondria and H4IIE rat hepatoma cells. Arch. Biochem. Biophys. 474 119-127. doi: 10.1016/j.abb.2008.03.008
-
(2008)
Arch. Biochem. Biophys.
, vol.474
, pp. 119-127
-
-
Zhong, Q.1
Putt, D.A.2
Xu, F.3
Lash, L.H.4
-
203
-
-
84863116196
-
The antioxidant enzyme peroxiredoxin and its protective role in neurological disorders
-
doi:10.1258/ebm.2011.011152
-
Zhu H. Santo A. Li Y. (2012). The antioxidant enzyme peroxiredoxin and its protective role in neurological disorders. Exp. Biol. Med. (Maywood) 237 143-149. doi: 10.1258/ebm.2011.011152
-
(2012)
Exp. Biol. Med. (Maywood)
, vol.237
, pp. 143-149
-
-
Zhu, H.1
Santo, A.2
Li, Y.3
|