메뉴 건너뛰기




Volumn 1762, Issue 2, 2006, Pages 256-265

Targeting antioxidants to mitochondria: A new therapeutic direction

Author keywords

Antioxidant; Mitochondria; Mitochondria membrane potential; Oxidative stress; Reactive oxygen species

Indexed keywords

2,4,6 TRIMETHYLPHENOL; ACETYLCYSTEINE CHOLINE ESTER; ALPHA TOCOPHEROL; ALPHA TOCOPHEROL DERIVATIVE; ANTINEOPLASTIC AGENT; ANTIOXIDANT; ASCORBIC ACID; BETA CAROTENE; BUTYLATED HYDROXYANISOLE; BUTYLCRESOL; CARBOXYAMIDOMETHYLATED MITOPEROXIDASE; EBSELEN; GALLIC ACID PROPYL ESTER; GLUTATHIONE CHOLINE ESTER; MITOPBN; MITOPEROXIDASE; MITOQ; MITOVIT E; N TERT BUTYL ALPHA PHENYLNITRONE; PHENOL DERIVATIVE; REACTIVE OXYGEN METABOLITE; SELENIUM; SS 02; SS 19; SS 20; SS 31; TETRAPEPTIDE; TROLOX C; UBIQUINONE; UBIQUINONE DERIVATIVE; UNCLASSIFIED DRUG;

EID: 29344446328     PISSN: 09254439     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbadis.2005.10.007     Document Type: Review
Times cited : (390)

References (63)
  • 2
    • 6344231842 scopus 로고    scopus 로고
    • Vascular endothelial growth factor-mediated induction of manganese superoxide dismutase occurs through redox-dependent regulation of forkhead and IκB/NF-κB
    • M.R. Abid, I.G. Schoots, K.C. Spokes, S.Q. Wu, C. Mawhinney, and W.C. Aird Vascular endothelial growth factor-mediated induction of manganese superoxide dismutase occurs through redox-dependent regulation of forkhead and IκB/NF-κB J. Biol. Chem. 279 2004 44030 44038
    • (2004) J. Biol. Chem. , vol.279 , pp. 44030-44038
    • Abid, M.R.1    Schoots, I.G.2    Spokes, K.C.3    Wu, S.Q.4    Mawhinney, C.5    Aird, W.C.6
  • 3
    • 0036132841 scopus 로고    scopus 로고
    • Redox regulation of adenovirus-induced AP-1 activation by overexpression of manganese-containing superoxide dismutase
    • H.J. Zhang, V.J. Drake, L. Xu, J. Hu, F.E. Domann, L.W. Oberley, and K.C. Kregel Redox regulation of adenovirus-induced AP-1 activation by overexpression of manganese-containing superoxide dismutase J. Virol. 76 2002 355 363
    • (2002) J. Virol. , vol.76 , pp. 355-363
    • Zhang, H.J.1    Drake, V.J.2    Xu, L.3    Hu, J.4    Domann, F.E.5    Oberley, L.W.6    Kregel, K.C.7
  • 4
    • 0034660880 scopus 로고    scopus 로고
    • The role of cellular glutathione peroxidase redox regulation in the suppression of tumor cell growth by manganese superoxide dismutase
    • S. Li, T. Yan, J.Q. Yang, T.D. Oberley, and L.W. Oberley The role of cellular glutathione peroxidase redox regulation in the suppression of tumor cell growth by manganese superoxide dismutase Cancer Res. 60 2000 3927 3939
    • (2000) Cancer Res. , vol.60 , pp. 3927-3939
    • Li, S.1    Yan, T.2    Yang, J.Q.3    Oberley, T.D.4    Oberley, L.W.5
  • 6
    • 0023891014 scopus 로고
    • The role of redox in the regulation of manganese-containing superoxide dismutase biosynthesis in Escherichia coli
    • J.R. Schiavone, and H.M. Hassan The role of redox in the regulation of manganese-containing superoxide dismutase biosynthesis in Escherichia coli J. Biol. Chem. 263 1988 4269 4273
    • (1988) J. Biol. Chem. , vol.263 , pp. 4269-4273
    • Schiavone, J.R.1    Hassan, H.M.2
  • 7
    • 0030766611 scopus 로고    scopus 로고
    • Low whole blood and erythrocyte levels of glutathione in hemodialysis and peritoneal dialysis patients
    • E.A. Ross, L.C. Koo, and J.B. Moberly Low whole blood and erythrocyte levels of glutathione in hemodialysis and peritoneal dialysis patients Am. J. Kidney Dis. 30 1997 489 494
    • (1997) Am. J. Kidney Dis. , vol.30 , pp. 489-494
    • Ross, E.A.1    Koo, L.C.2    Moberly, J.B.3
  • 8
    • 0002889135 scopus 로고    scopus 로고
    • Cellular sources and steady-state levels of reactive oxygen species
    • L.B. Clerch D.J. Massaro Marcel Dekker New York
    • A. Boveris, and E. Cadenas Cellular sources and steady-state levels of reactive oxygen species L.B. Clerch D.J. Massaro Oxygen, Gene Expression, and Cellular Function 1997 Marcel Dekker New York 1 25
    • (1997) Oxygen, Gene Expression, and Cellular Function , pp. 1-25
    • Boveris, A.1    Cadenas, E.2
  • 10
    • 4744349398 scopus 로고    scopus 로고
    • Structure and regulation of the neutrophil respiratory burst oxidase: Comparison with nonphagocyte oxidases
    • M.T. Quinn, and K.A. Gauss Structure and regulation of the neutrophil respiratory burst oxidase: comparison with nonphagocyte oxidases J. Leukoc. Biol. 76 2004 760 781
    • (2004) J. Leukoc. Biol. , vol.76 , pp. 760-781
    • Quinn, M.T.1    Gauss, K.A.2
  • 11
    • 4244122702 scopus 로고    scopus 로고
    • Xanthine dehydrogenase and aldehyde oxidase
    • F.P. Guengerich Elsevier New York
    • K.V. Rajagopalan Xanthine dehydrogenase and aldehyde oxidase F.P. Guengerich Biotransformation 1997 Elsevier New York 165 178
    • (1997) Biotransformation , pp. 165-178
    • Rajagopalan, K.V.1
  • 12
    • 0003085358 scopus 로고    scopus 로고
    • Monoamine oxidase and flavin-containing monooxygenases
    • F.P. Guengerich Elsevier New York
    • J.R. Cashman Monoamine oxidase and flavin-containing monooxygenases F.P. Guengerich Biotransformation 1997 Elsevier New York 69 96
    • (1997) Biotransformation , pp. 69-96
    • Cashman, J.R.1
  • 13
    • 0029053451 scopus 로고
    • Superoxide radical and superoxide dismutases
    • I. Fridovich Superoxide radical and superoxide dismutases Annu. Rev. Biochem. 64 1995 97 112
    • (1995) Annu. Rev. Biochem. , vol.64 , pp. 97-112
    • Fridovich, I.1
  • 16
    • 0036086130 scopus 로고    scopus 로고
    • Free radicals in the physiological control of cell function
    • W. Dröge Free radicals in the physiological control of cell function Physiol. Rev. 82 2002 47 95
    • (2002) Physiol. Rev. , vol.82 , pp. 47-95
    • Dröge, W.1
  • 17
    • 0037972522 scopus 로고    scopus 로고
    • Mitochondrial respiratory-chain diseases
    • S. DiMauro, and E.A. Schon Mitochondrial respiratory-chain diseases N. Engl. J. Med. 348 2003 2656 2668
    • (2003) N. Engl. J. Med. , vol.348 , pp. 2656-2668
    • Dimauro, S.1    Schon, E.A.2
  • 21
    • 0031974274 scopus 로고    scopus 로고
    • Mitochondria in chemotherapy-induced apoptosis: A prospective novel target of cancer therapy
    • D. Decaudin, I. Marzo, C. Brenner, and G. Kroemer Mitochondria in chemotherapy-induced apoptosis: a prospective novel target of cancer therapy Int. J. Oncol. 12 1998 141 152
    • (1998) Int. J. Oncol. , vol.12 , pp. 141-152
    • Decaudin, D.1    Marzo, I.2    Brenner, C.3    Kroemer, G.4
  • 22
    • 34347389118 scopus 로고    scopus 로고
    • Mitochondria as targets for detection and treatment of cancer
    • J.S. Modica-Napolitano, and K. Singh Mitochondria as targets for detection and treatment of cancer Expert Rev. Mol. Med. 2002 2002 1 19
    • (2002) Expert Rev. Mol. Med. , vol.2002 , pp. 1-19
    • Modica-Napolitano, J.S.1    Singh, K.2
  • 23
    • 0032697363 scopus 로고    scopus 로고
    • Antioxidants in cancer therapy; Their actions and interactions with oncologic therapies
    • D.W. Lamson, and M.S. Brignall Antioxidants in cancer therapy; their actions and interactions with oncologic therapies Altern. Med. Rev. 4 1999 304 329
    • (1999) Altern. Med. Rev. , vol.4 , pp. 304-329
    • Lamson, D.W.1    Brignall, M.S.2
  • 24
    • 0043180531 scopus 로고    scopus 로고
    • Excitotoxic and excitoprotective mechanisms: Abundant targets for the prevention and treatment of neurodegenerative disorders
    • M.P. Mattson Excitotoxic and excitoprotective mechanisms: abundant targets for the prevention and treatment of neurodegenerative disorders Neuromol. Med. 3 2003 65 94
    • (2003) Neuromol. Med. , vol.3 , pp. 65-94
    • Mattson, M.P.1
  • 25
    • 13844281067 scopus 로고    scopus 로고
    • The powerhouse takes control of the cell: Is the mitochondrial permeability transition a viable therapeutic target against neuronal dysfunction and death?
    • I.G. Stavrovskaya, and B.S. Kristal The powerhouse takes control of the cell: is the mitochondrial permeability transition a viable therapeutic target against neuronal dysfunction and death? Free Radic. Biol. Med. 38 2005 687 697
    • (2005) Free Radic. Biol. Med. , vol.38 , pp. 687-697
    • Stavrovskaya, I.G.1    Kristal, B.S.2
  • 26
    • 0004897150 scopus 로고    scopus 로고
    • Antioxidants: The basics-What they are and how to evaluate them
    • B. Halliwell Antioxidants: the basics-What they are and how to evaluate them Adv. Pharmacol. 38 1997 3 20
    • (1997) Adv. Pharmacol. , vol.38 , pp. 3-20
    • Halliwell, B.1
  • 29
    • 0042711191 scopus 로고    scopus 로고
    • Mitochondrial-targeted drug and DNA delivery
    • V. Weissig Mitochondrial-targeted drug and DNA delivery Crit. Rev. Ther. Drug Carr. Syst. 20 2003 1 62
    • (2003) Crit. Rev. Ther. Drug Carr. Syst. , vol.20 , pp. 1-62
    • Weissig, V.1
  • 33
    • 22144432216 scopus 로고    scopus 로고
    • Mitochondrial reactive oxygen species regulate the temporal activation of nuclear factor κb to modulate tumour necrosis factor-induced apoptosis: Evidence from mitochondria-targeted antioxidants
    • G. Hughes, M.P. Murphy, and E.C. Ledgerwood Mitochondrial reactive oxygen species regulate the temporal activation of nuclear factor κB to modulate tumour necrosis factor-induced apoptosis: evidence from mitochondria-targeted antioxidants Biochem. J. 389 2005 83 89
    • (2005) Biochem. J. , vol.389 , pp. 83-89
    • Hughes, G.1    Murphy, M.P.2    Ledgerwood, E.C.3
  • 36
    • 0348136710 scopus 로고    scopus 로고
    • Mitochondria-targeted antioxidants protect Friedreich Ataxia fibroblasts from endogenous oxidative stress more effectively than untargeted antioxidants
    • M.L. Jauslin, T. Meier, R.A. Smith, and M.P. Murphy Mitochondria-targeted antioxidants protect Friedreich Ataxia fibroblasts from endogenous oxidative stress more effectively than untargeted antioxidants FASEB J. 17 2003 1972 1974
    • (2003) FASEB J. , vol.17 , pp. 1972-1974
    • Jauslin, M.L.1    Meier, T.2    Smith, R.A.3    Murphy, M.P.4
  • 37
    • 4444315545 scopus 로고    scopus 로고
    • Supplementation of endothelial cells with mitochondria-targeted antioxidants inhibit peroxide-induced mitochondrial iron uptake, oxidative damage, and apoptosis
    • A. Dhanasekaran, S. Kotamraju, S.V. Kalivendi, T. Matsunaga, T. Shang, A. Keszler, J. Joseph, and B. Kalyanaraman Supplementation of endothelial cells with mitochondria-targeted antioxidants inhibit peroxide-induced mitochondrial iron uptake, oxidative damage, and apoptosis J. Biol. Chem. 279 2004 37575 37587
    • (2004) J. Biol. Chem. , vol.279 , pp. 37575-37587
    • Dhanasekaran, A.1    Kotamraju, S.2    Kalivendi, S.V.3    Matsunaga, T.4    Shang, T.5    Keszler, A.6    Joseph, J.7    Kalyanaraman, B.8
  • 40
    • 20444392739 scopus 로고    scopus 로고
    • Interactions of mitochondria-targeted and untargeted ubiquinones with the mitochondrial respiratory chain and reactive oxygen species. Implications for the use of exogenous ubiquinones as therapies and experimental tools
    • A.M. James, H.M. Cocheme, R.A. Smith, and M.P. Murphy Interactions of mitochondria-targeted and untargeted ubiquinones with the mitochondrial respiratory chain and reactive oxygen species. Implications for the use of exogenous ubiquinones as therapies and experimental tools J. Biol. Chem. 280 2005 21295 21312
    • (2005) J. Biol. Chem. , vol.280 , pp. 21295-21312
    • James, A.M.1    Cocheme, H.M.2    Smith, R.A.3    Murphy, M.P.4
  • 41
    • 0037033039 scopus 로고    scopus 로고
    • Superoxide activates mitochondrial uncoupling protein 2 from the matrix side. Studies using targeted antioxidants
    • K.S. Echtay, M.P. Murphy, R.A. Smith, D.A. Talbot, and M.D. Brand Superoxide activates mitochondrial uncoupling protein 2 from the matrix side. Studies using targeted antioxidants J. Biol. Chem. 277 2002 47129 47135
    • (2002) J. Biol. Chem. , vol.277 , pp. 47129-47135
    • Echtay, K.S.1    Murphy, M.P.2    Smith, R.A.3    Talbot, D.A.4    Brand, M.D.5
  • 42
    • 0041419866 scopus 로고    scopus 로고
    • MitoQ counteracts telomere shortening and elongates lifespan of fibroblasts under mild oxidative stress
    • G. Saretzki, M.P. Murphy, and T. von Zglinicki MitoQ counteracts telomere shortening and elongates lifespan of fibroblasts under mild oxidative stress Aging Cell 2 2003 141 143
    • (2003) Aging Cell , vol.2 , pp. 141-143
    • Saretzki, G.1    Murphy, M.P.2    Von Zglinicki, T.3
  • 46
    • 0034122808 scopus 로고    scopus 로고
    • Do spin traps also act as classical chain-breaking antioxidants? a quantitative kinetic study of phenyl tert-butylnitrone (PBN) in solution and in liposomes
    • L.R. Barclay, and M.R. Vinqvist Do spin traps also act as classical chain-breaking antioxidants? A quantitative kinetic study of phenyl tert-butylnitrone (PBN) in solution and in liposomes Free Radic. Biol. Med. 28 2000 1079 1090
    • (2000) Free Radic. Biol. Med. , vol.28 , pp. 1079-1090
    • Barclay, L.R.1    Vinqvist, M.R.2
  • 47
    • 0033301895 scopus 로고    scopus 로고
    • Pharmacologic properties of phenyl N-tert-butylnitrone
    • Y. Kotake Pharmacologic properties of phenyl N-tert-butylnitrone Antioxid. Redox Signal. 1 1999 481 499
    • (1999) Antioxid. Redox Signal. , vol.1 , pp. 481-499
    • Kotake, Y.1
  • 48
    • 0032704101 scopus 로고    scopus 로고
    • Antioxidants, oxidative stress, and degenerative neurological disorders
    • R.A. Floyd Antioxidants, oxidative stress, and degenerative neurological disorders Proc. Soc. Exp. Biol. Med. 222 1999 236 245
    • (1999) Proc. Soc. Exp. Biol. Med. , vol.222 , pp. 236-245
    • Floyd, R.A.1
  • 50
    • 0035385139 scopus 로고    scopus 로고
    • Chemistry of biologically important synthetic organoselenium compounds
    • G. Mugesh, W.W. du Mont, and H. Sies Chemistry of biologically important synthetic organoselenium compounds Chem. Rev. 101 2001 2125 2179
    • (2001) Chem. Rev. , vol.101 , pp. 2125-2179
    • Mugesh, G.1    Du Mont, W.W.2    Sies, H.3
  • 51
    • 21244448078 scopus 로고    scopus 로고
    • Synthesis and characterization of a triphenylphosphonium-conjugated peroxidase mimetic: Insights into the interaction of ebselen with mitochondria
    • A. Filipovska, G.F. Kelso, S.E. Brown, S.M. Beer, R.A. Smith, and M.P. Murphy Synthesis and characterization of a triphenylphosphonium-conjugated peroxidase mimetic: insights into the interaction of ebselen with mitochondria J. Biol. Chem. 280 2005 24113 24126
    • (2005) J. Biol. Chem. , vol.280 , pp. 24113-24126
    • Filipovska, A.1    Kelso, G.F.2    Brown, S.E.3    Beer, S.M.4    Smith, R.A.5    Murphy, M.P.6
  • 52
    • 4544370680 scopus 로고    scopus 로고
    • Cell-permeable peptide antioxidants targeted to inner mitochondrial membrane inhibit mitochondrial swelling, oxidative cell death, and reperfusion injury
    • K. Zhao, G.M. Zhao, D. Wu, Y. Soong, A.V. Birk, P.W. Schiller, and H.H. Szeto Cell-permeable peptide antioxidants targeted to inner mitochondrial membrane inhibit mitochondrial swelling, oxidative cell death, and reperfusion injury J. Biol. Chem. 279 2004 34682 34690
    • (2004) J. Biol. Chem. , vol.279 , pp. 34682-34690
    • Zhao, K.1    Zhao, G.M.2    Wu, D.3    Soong, Y.4    Birk, A.V.5    Schiller, P.W.6    Szeto, H.H.7
  • 53
    • 0030949450 scopus 로고    scopus 로고
    • Theoretical calculation of substituent effects on the OH bond strength of phenolic antioxidants related to vitamin e
    • J.S. Wright, D.J. Carpenter, D.J. McKay, and K.U. Ingold Theoretical calculation of substituent effects on the OH bond strength of phenolic antioxidants related to vitamin E J. Am. Chem. Soc. 119 1997 4245 4252
    • (1997) J. Am. Chem. Soc. , vol.119 , pp. 4245-4252
    • Wright, J.S.1    Carpenter, D.J.2    McKay, D.J.3    Ingold, K.U.4
  • 59
    • 0031836944 scopus 로고    scopus 로고
    • Evidence for mitochondrial uptake of glutathione by dicarboxylate and 2-oxoglutarate carriers
    • Z. Chen, and L.H. Lash Evidence for mitochondrial uptake of glutathione by dicarboxylate and 2-oxoglutarate carriers J. Pharmacol. Exp. Ther. 285 1998 608 618
    • (1998) J. Pharmacol. Exp. Ther. , vol.285 , pp. 608-618
    • Chen, Z.1    Lash, L.H.2
  • 60
    • 0033963540 scopus 로고    scopus 로고
    • Enrichment and functional reconstitution of glutathione transport activity from rabbit kidney mitochondria: Further evidence for the role of the dicarboxylate and 2-oxoglutarate carriers in mitochondrial glutathione transport
    • Z. Chen, D.A. Putt, and L.H. Lash Enrichment and functional reconstitution of glutathione transport activity from rabbit kidney mitochondria: further evidence for the role of the dicarboxylate and 2-oxoglutarate carriers in mitochondrial glutathione transport Arch. Biochem. Biophys. 373 2000 193 202
    • (2000) Arch. Biochem. Biophys. , vol.373 , pp. 193-202
    • Chen, Z.1    Putt, D.A.2    Lash, L.H.3
  • 61
    • 0020478933 scopus 로고
    • Status of the mitochondrial pool of glutathione in the isolated hepatocyte
    • M.J. Meredith, and D.J. Reed Status of the mitochondrial pool of glutathione in the isolated hepatocyte J. Biol. Chem. 257 1982 3747 3753
    • (1982) J. Biol. Chem. , vol.257 , pp. 3747-3753
    • Meredith, M.J.1    Reed, D.J.2
  • 62
    • 0020615123 scopus 로고
    • Depletion in vitro of mitochondrial glutathione in rat hepatocytes and enhancement of lipid peroxidation by adriamycin and 1,3-bis(2-chloroethyl)-1- nitrosourea (BCNU)
    • M.J. Meredith, and D.J. Reed Depletion in vitro of mitochondrial glutathione in rat hepatocytes and enhancement of lipid peroxidation by adriamycin and 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) Biochem. Pharmacol. 32 1982 1383 1388
    • (1982) Biochem. Pharmacol. , vol.32 , pp. 1383-1388
    • Meredith, M.J.1    Reed, D.J.2
  • 63
    • 0027475992 scopus 로고
    • Selective depletion of mitochondrial glutathione concentrations by (R,S)-3-hydroxy-4-pentenoate potentiates oxidative cell death
    • X. Shan, D.P. Jones, M. Hashmi, and M.W. Anders Selective depletion of mitochondrial glutathione concentrations by (R,S)-3-hydroxy-4-pentenoate potentiates oxidative cell death Chem. Res. Toxicol. 6 1993 75 81
    • (1993) Chem. Res. Toxicol. , vol.6 , pp. 75-81
    • Shan, X.1    Jones, D.P.2    Hashmi, M.3    Anders, M.W.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.