Mitochondrial aquaporin-8 knockdown in human hepatoma HepG2 cells causes ROS-induced mitochondrial depolarization and loss of viability

Toxicology and Applied Pharmacology

Volumn 264, Issue 2, 2012, Pages 246-254

  Marchissio, Maria Julia ^a   Francés, Daniel Eleazar Antonio ^a   Carnovale, Cristina Ester ^a   Marinelli, Raúl Alberto ^a  

^a UNIVERSIDAD NACIONAL DE ROSARIO   (Argentina)

Author keywords

Aquaporin 8; HepG2; Hydrogen peroxide; Mitochondria; ROS

Indexed keywords

CYCLOSPORIN A; DICHLORODIHYDROFLUORESCEIN DIACETATE; HYDROGEN PEROXIDE; REACTIVE OXYGEN METABOLITE; SMALL INTERFERING RNA; TETRAMETHYLRHODAMINE;

ARTICLE; CELL MEMBRANE PERMEABILITY; CELL STRAIN HEPG2; CELL VIABILITY; CONTROLLED STUDY; FLUORESCENCE MICROSCOPY; GENE; GENE EXPRESSION; GENE FUNCTION; GENE SILENCING; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IMMUNOBLOTTING; MITOCHONDRIAL AQUAPORIN 8 GENE; MITOCHONDRIAL MEMBRANE POTENTIAL; PROTEIN EXPRESSION; RNA INTERFERENCE;

ADENOSINE TRIPHOSPHATE; AQUAPORINS; BLOTTING, WESTERN; CELL SURVIVAL; CYCLOSPORINE; HEP G2 CELLS; HUMANS; HYDROGEN PEROXIDE; L-LACTATE DEHYDROGENASE; MEMBRANE POTENTIAL, MITOCHONDRIAL; MICROSCOPY, FLUORESCENCE; MITOCHONDRIA, LIVER; OXIDANTS; PERMEABILITY; REACTIVE OXYGEN SPECIES; RNA, SMALL INTERFERING; TETRAZOLIUM SALTS; THIAZOLES; TRYPAN BLUE;

EID: 84866873131     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2012.08.005     Document Type: Article

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