Adverse signaling of scavenger receptor class B1 and PGC1s in alcoholic hepatosteatosis and steatohepatitis and protection by betaine in rat

American Journal of Pathology

Volumn 184, Issue 7, 2014, Pages 2035-2044

  Varatharajalu, Ravi ^a   Garige, Mamatha ^a   Leckey, Leslie C ^a   Arellanes Robledo, Jaime ^a   Reyes Gordillo, Karina ^a   Shah, Ruchi ^a   Lakshman, M Raj ^a  

^a GEORGE WASHINGTON UNIVERSITY SCHOOL OF MEDICINE AND HEALTH SCIENCES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYL COENZYME A CARBOXYLASE; ADENYLATE KINASE; ADIPONECTIN; ALANINE AMINOTRANSFERASE; ALCOHOL; BETAINE; CHOLESTEROL; GLUTATHIONE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE; INTERLEUKIN 6; MESSENGER RNA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1BETA; POLYUNSATURATED FATTY ACID; SCAVENGER RECEPTOR BI; STEROL REGULATORY ELEMENT BINDING PROTEIN 1C; STEROL REGULATORY ELEMENT BINDING PROTEIN 2; TRIACYLGLYCEROL; TUMOR NECROSIS FACTOR ALPHA; PPARGC1A PROTEIN, RAT; SCARB1 PROTEIN, RAT; SCAVENGER RECEPTOR B; TRANSCRIPTION FACTOR;

ALCOHOLIC FATTY LIVER; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL MEMBRANE; CHOLESTEROL LIVER LEVEL; CHOLESTEROL TRANSPORT; CONTROLLED STUDY; DOWN REGULATION; FATTY ACID OXIDATION; FEMALE; GENE; GLYCOSYLATION; HISTOPATHOLOGY; HYPERLIPIDEMIA; LIPID OXIDATION; LIPOGENESIS; LIVER CELL; LIVER PROTECTION; NONALCOHOLIC FATTY LIVER; NONHUMAN; PRIORITY JOURNAL; PROTEIN LOCALIZATION; PROTEIN PROCESSING; RAT; REGULATOR GENE; SILENCE REGULATOR GENE 1; UPREGULATION; ANIMAL; BLOOD; FATTY LIVER; LIPID DIET; LIVER; METABOLISM; PATHOLOGY; PATHOPHYSIOLOGY; SIGNAL TRANSDUCTION; WISTAR RAT;

ADIPONECTIN; ALANINE TRANSAMINASE; ANIMALS; BETAINE; DIET, HIGH-FAT; ETHANOL; FATTY LIVER; FATTY LIVER, ALCOHOLIC; FEMALE; INTERLEUKIN-6; LIVER; PROTEIN PROCESSING, POST-TRANSLATIONAL; RATS, WISTAR; SCAVENGER RECEPTORS, CLASS B; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTORS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84903166509     PISSN: 00029440     EISSN: 15252191     Source Type: Journal    
DOI: 10.1016/j.ajpath.2014.03.005     Document Type: Article

References (45)

1. H.H. Hobbs, M.S. Brown, and J.L. Goldstein Molecular genetics of the LDL receptor gene in familial hypercholesterolemia Hum Mutat 1 1992 445 466
2. A.D. Attie, J.P. Kastelein, and M.R. Hayden Pivotal role of ABCA1 in reverse cholesterol transport influencing HDL levels and susceptibility to atherosclerosis J Lipid Res 42 2001 1717 1726
3. D.L. Silver, N. Wang, X. Xiao, and A.R. Tall High density lipoprotein (HDL) particle uptake mediated by scavenger receptor class B type 1 results in selective sorting of HDL cholesterol from protein and polarized cholesterol secretion J Biol Chem 276 2001 25287 25293
4. S. Acton, A. Rigotti, K.T. Landschulz, S. Xu, H.H. Hobbs, and M. Krieger Identification of scavenger receptor SR-BI as a high density lipoprotein receptor Science 271 1996 518 520
5. H. Hauser, J.H. Dyer, A. Nandy, M.A. Vega, M. Werder, E. Bieliauskaite, F.E. Weber, S. Compassi, A. Gemperli, D. Boffelli, E. Wehrli, G. Schulthess, and M.C. Phillips Identification of a receptor mediating absorption of dietary cholesterol in the intestine Biochemistry 37 1998 17843 17850
6. R. Out, M. Hoekstra, J.A. Spijkers, J.K. Kruijt, M. van Eck, I.S. Bos, J. Twisk, and T.J. Van Berkel Scavenger receptor class B type I is solely responsible for the selective uptake of cholesteryl esters from HDL by the liver and the adrenals in mice J Lipid Res 45 2004 2088 2095
7. C.A. Casey, S.L. Kragskow, M.F. Sorrell, and D.J. Tuma Chronic ethanol administration impairs the binding and endocytosis of asialo-orosomucoid in isolated hepatocytes J Biol Chem 262 1987 2704 2710
8. M.R. Lakshman, S.J. Chirtel, L.C. Chambers, and B.S. Campbell Hepatic synthesis of apoproteins of very low density and high density lipoproteins in perfused rat liver: influence of chronic heavy and moderate doses of ethanol Alcohol Clin Exp Res 13 1989 554 559
9. D.J. Tuma, and M.F. Sorrell Effects of ethanol on protein trafficking in the liver Semin Liver Dis 8 1988 69 80
10. C.A. Casey, S.L. Kragskow, M.F. Sorrell, and D.J. Tuma Ethanol-induced impairments in receptor-mediated endocytosis of asialoorosomucoid in isolated rat hepatocytes: time course of impairments and recovery after ethanol withdrawal Alcohol Clin Exp Res 13 1989 258 263
11. L.E. Nagy, M.R. Lakshman, C.A. Casey, and C.F. Bearer Ethanol and membrane protein trafficking: diverse mechanisms of ethanol action Alcohol Clin Exp Res 26 2002 287 293
12. P. Ghosh, and M.R. Lakshman Chronic ethanol induced impairment of hepatic glycosylation machinery in rat is independent of dietary carbohydrate Alcohol Clin Exp Res 21 1997 76 81
13. B.L. Tworek, J.A. Oka, C.A. Casey, and P.H. Weigel Ethanol feeding causes inactivation of both state 1 and state 2 rat hepatic asialoglycoprotein receptors Alcohol Clin Exp Res 21 1997 1429 1434
14. B.L. Tworek, D.J. Tuma, and C.A. Casey Decreased binding of asialoglycoproteins to hepatocytes from ethanol-fed rats: consequence of both impaired synthesis and inactivation of the asialoglycoprotein receptor J Biol Chem 271 1996 2531 2538
15. P. Ghosh, S.J. Chirtel, and M.R. Lakshman Effect of chronic ethanol on apolipoprotein (Apo) E synthesis and glycosylation in rats Alcohol Clin Exp Res 15 1991 725 729
16. P. Ghosh, E.A. Hale, and R. Lakshman Long-term ethanol exposure alters the sialylation index of plasma apolipoprotein J (Apo J) in rats Alcohol Clin Exp Res 23 1999 720 725
17. P. Ghosh, Q.H. Liu, and M.R. Lakshman Long-term ethanol exposure impairs glycosylation of both N- and O-glycosylated proteins in rat liver Metabolism 44 1995 890 898
18. E. Baraona, M.A. Leo, S.A. Borowsky, and C.S. Lieber Pathogenesis of alcohol-induced accumulation of protein in the liver J Clin Invest 60 1977 546 554
19. C.S. Lieber, M.A. Leo, X. Wang, and L.M. Decarli Effect of chronic alcohol consumption on hepatic SIRT1 and PGC-1alpha in rats Biochem Biophys Res Commun 370 2008 44 48
20. M. You, Q. Cao, X. Liang, J.M. Ajmo, and G.C. Ness Mammalian sirtuin 1 is involved in the protective action of dietary saturated fat against alcoholic fatty liver in mice J Nutr 138 2008 497 501
21. C. Canto, and J. Auwerx PGC-1alpha, SIRT1 and AMPK, an energy sensing network that controls energy expenditure Curr Opin Lipidol 20 2009 98 105
22. J.D. Horton, J.L. Goldstein, and M.S. Brown SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver J Clin Invest 109 2002 1125 1131
23. S. Nemoto, M.M. Fergusson, and T. Finkel SIRT1 functionally interacts with the metabolic regulator and transcriptional coactivator PGC-1{alpha} J Biol Chem 280 2005 16456 16460
24. M.R. Lakshman Some novel insights into the pathogenesis of alcoholic steatosis Alcohol 34 2004 45 48
25. M. Sozio, and D.W. Crabb Alcohol and lipid metabolism Am J Physiol Endocrinol Metab 295 2008 E10 E16
26. A.J. Barak, H.C. Beckenhauer, S. Badakhsh, and D.J. Tuma The effect of betaine in reversing alcoholic steatosis Alcohol Clin Exp Res 21 1997 1100 1102
27. J. Balkan, S. Oztezcan, M. Kucuk, U. Cevikbas, N. Kocak-Toker, and M. Uysal The effect of betaine treatment on triglyceride levels and oxidative stress in the liver of ethanol-treated guinea pigs Exp Toxicol Pathol 55 2004 505 509
28. D. Graf, A.K. Kurz, R. Reinehr, R. Fischer, G. Kircheis, and D. Häussinger Prevention of bile acid-induced apoptosis by betaine in rat liver Hepatology 36 2002 829 839
29. A.J. Barak, H.C. Beckenhauer, M. Junnila, and D.J. Tuma Dietary betaine promotes generation of hepatic S-adenosylmethionine and protects the liver from ethanol-induced fatty infiltration Alcohol Clin Exp Res 17 1993 552 555
30. M. Garige, M. Gong, R. Varatharajalu, and M.R. Lakshman Quercetin up-regulates paraoxonase 1 gene expression via sterol regulatory element binding protein 2 that translocates from the endoplasmic reticulum to the nucleus where it specifically interacts with sterol responsive element-like sequence in paraoxonase 1 promoter in HuH7 liver cells Metabolism 59 2010 1372 1378
31. R.B. Shireman, and J. Durieux Microplate methods for determination of serum cholesterol, high density lipoprotein cholesterol, triglyceride and apolipoproteins Lipids 28 1993 151 155
32. L.I. Gidez, G.J. Miller, M. Burstein, S. Slagle, and H.A. Eder Separation and quantitation of subclasses of human plasma high density lipoproteins by a simple precipitation procedure J Lipid Res 23 1982 1206 1223
33. M.M. Bradford A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding Anal Biochem 72 1976 248 254
34. A. Zlatkis, and B. Zak Study of a new cholesterol reagent Anal Biochem 29 1969 143 148
35. S.K. Basu, J.L. Goldstein, G.W. Anderson, and M.S. Brown Degradation of cationized low density lipoprotein and regulation of cholesterol metabolism in homozygous familial hypercholesterolemia fibroblasts Proc Natl Acad Sci U S A 73 1976 3178 3182
36. M.R. Lakshman, R.A. Muesing, and J.C. LaRosa Regulation of cholesterol biosynthesis and 3-hydroxy-3-methylglutaryl coenzyme A reductase activity by chylomicron remnants in isolated hepatocytes and perfused liver J Biol Chem 256 1981 3037 3043
37. P. Marmillot, J. Munoz, S. Patel, M. Garige, R.B. Rosse, and M.R. Lakshman Long-term ethanol consumption impairs reverse cholesterol transport function of high-density lipoproteins by depleting high-density lipoprotein sphingomyelin both in rats and in humans Metabolism 56 2007 947 953
38. M. Gong, L. Castillo, R.S. Redman, M. Garige, K. Hirsch, M. Azuine, R.L. Amdur, D. Seth, P.S. Haber, and M.R. Lakshman Down-regulation of liver Galbeta1, 4GlcNAc alpha2, 6-sialyltransferase gene by ethanol significantly correlates with alcoholic steatosis in humans Metabolism 57 2008 1663 1668
39. L. Luna Manual of Histologic Staining Methods of the Armed Forces Institutes of Pathology ed 3. 1968 McGraw-Hill New York
40. P.A. Srere, and A. Bhaduri The citrate cleavage enzyme, III: citryl coenzyme a as a substrate and the stereospecificity of the enzyme J Biol Chem 239 1964 714 718
41. SAS Institute SAS/STAT User's Guide, Version 6 2000 SAS Institute Cary, NC
42. A.I. Cederbaum, Y. Lu, and D. Wu Role of oxidative stress in alcohol-induced liver injury Arch Toxicol 83 2009 519 548
43. A. Bertola, S. Mathews, S.H. Ki, H. Wang, and B. Gao Mouse model of chronic and binge ethanol feeding (the NIAAA model) Nat Protoc 8 2013 627 637
44. S.H. Ki, O. Park, M. Zheng, O. Morales-Ibanez, J. Kolls, R. Bataller, and B. Gao Interleukin-22 treatment ameliorates alcoholic liver injury in a murine model of chronic-binge ethanol feeding: role of signal transducer and activator of transcription 3 Hepatology 52 2010 1291 1300
45. A. Fernandez, N. Matias, R. Fucho, V. Ribas, C.V. Montfort, N. Nuno, A. Baulies, L. Martinez, N. Tarrats, M. Mari, A. Colell, A. Morales, L. Dubuquoy, P. Mathurin, R. Bataller, J. Caballeria, M. Elena, J. Balsinde, N. Kaplowitz, C. Garcia-Ruiz, and J.C. Fernandez-Checa Asmase is required for chronic alcohol induced hepatic endoplasmic reticulum stress and mitochondrial cholesterol loading J Hepatol 59 2013 805 813