Piplartine induces inhibition of leukemia cell proliferation triggering both apoptosis and necrosis pathways

Toxicology in Vitro

Volumn 21, Issue 1, 2007, Pages 1-8

  Bezerra, Daniel Pereira ^a   Militão, Gardenia Carmen Gadelha ^a   de Castro, Fernanda Oliveira ^a   Pessoa, Cláudia ^a   de Moraes, Manoel Odorico ^a   Silveira, Edilberto Rocha ^a   Lima, Mary Anne Sousa ^a   Elmiro, Francisca Juliana Martins ^a   Costa Lotufo, Letícia Veras ^a  

^a FEDERAL UNIVERSITY OF CEARÁ   (Brazil)

Author keywords

Apoptosis; DNA synthesis; HL 60; K562; Necrosis; Piplartine

Indexed keywords

ANTINEOPLASTIC AGENT; BROXURIDINE; DOXORUBICIN; PIPLARTINE; PYRIDONE DERIVATIVE;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CELL PROLIFERATION; CELL STRAIN HL 60; CELL STRUCTURE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DNA SYNTHESIS; HUMAN; HUMAN CELL; INCUBATION TIME; LEUKEMIA CELL; PIPERACEAE;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; CASPASE 3; CELL LINE, TUMOR; CELL PROLIFERATION; CELL SURVIVAL; DNA; DNA, NEOPLASM; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME ACTIVATION; HL-60 CELLS; HUMANS; K562 CELLS; LEUKEMIA; LEUKEMIA, T-CELL; MICROSCOPY, FLUORESCENCE; MONOCYTES; NECROSIS; NUCLEIC ACID CONFORMATION; PIPER; PIPERIDONES; SIGNAL TRANSDUCTION;

EID: 33845211116     PISSN: 08872333     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tiv.2006.07.007     Document Type: Article

References (30)

1. Anazetti M.C., Melo P.S., Duran N., and Haun M. Comparative cytotoxicity of dimethylamide-crotonin in the promyelocytic leukemia cell line (HL60) and human peripheral blood mononuclear cells. Toxicology 188 (2003) 261-274
2. Atal C.K., Dhar K.L., and Singh J. The chemistry of Indian Piper species. Lloydia 38 (1975) 256-264
3. Bezerra D.P., Pessoa C., Moraes M.O., Silveira E.R., Lima M.A.S., Elmiro F.J.M., and Costa-Lotufo L.V. Antiproliferative effects of two amides, piperine and piplartine, from Piper species. Zeitschrift für Naturforschung 60 (2005) 539-543
4. Braz-Filho R., Souza M.P., and Mattos M.E.O. Piplartine-dimer A, a new alkaloid from Piper tuberculatum. Phytochemistry 20 (1981) 345-346
5. Cao D.X., Qiao B., Ge Z.Q., and Yuan Y.J. Comparison of burst of reactive oxygen species and activation of caspase-3 in apoptosis of K562 and HL-60 cells induced by docetaxel. Cancer Letters 214 (2004) 103-113
6. Collins S.J., Gallo R.C., and Gallagher R.E. Continuous growth and differentiation of human myeloid leukaemic cells in suspension culture. Nature 270 (1977) 347-349
7. Czyz M., Szulawska A., Bednarek A.K., and Duchler M. Effects of anthracycline derivatives on human leukemia K562 cell growth and differentiation. Biochemical Pharmacology 70 (2005) 1431-1442
8. Dartsch D.C., Schaefer A., Boldt S., Kolch W., and Marquardt H. Comparison of anthracycline-induced death of human leukemia cells: programmed cell death versus necrosis. Apoptosis 7 (2002) 537-548
9. Duh C.Y., and Wu Y.C. Cytotoxic pyridone alkaloids from the leaves of Piper aborescens. Journal of Natural Products 53 (1990) 1575-1577
10. Duh C.Y., Wu Y.C., and Wang S.K. Cytotoxic pyridone alkaloids from Piper aborescens. Phytochemistry 29 (1990) 2689-2691
11. Guo R., Zou P., Song Y.P., Ma J., Lu H.Z., Cao Y.L., and Tong Y.J. Major histocompatibility complex class II transactivator (CIITA) hammer-head ribozyme transfer inhibits major histocompatibility complex class II (MHC-II) expression in Jukart cells. Zhonghua Er Ke Za Zhi 41 (2003) 925-928
12. Hengartner M.O. The biochemistry of apoptosis. Nature 407 (2000) 770-776
13. Hu W., and Kavanagh J.J. Anticancer therapy targeting the apoptotic pathway. Lancet Oncology 4 (2003) 721-729
14. Jacobs R.S., and Wilson L. Fertilized sea urchin egg as a model for detecting cell division inhibitors. In: Aszalos A. (Ed). Modern Analysis of Antibiotics (1986), Marcel Dekker, Inc, New York 481-493
15. Kaufmann S.H. Cell death induced by topoisomerase targeted drugs: more questions than answers. Biochimica et Biophysica Acta 1400 (1998) 195-211
16. Kerr J.F.R., Wyllie A.H., and Currie A.R. Apoptosis: a basic biological phenomenon with a wide-ranging implications in tissue kinetics. British Journal of Cancer 26 (1972) 239-257
17. Li T.K., and Liu L.F. Tumor cell death induced by topoisomerase-targeting drugs. Annual Review of Pharmacology and Toxicology 41 (2001) 53-77
18. Lozzio C.B., and Lozzio B.B. Human chronic myelogenous leukemia cell-line with positive Philadelphia-chromosome. Blood 45 (1975) 321-324
19. Mann J. Natural products in cancer chemotherapy: past, present and future. Nature Reviews/Cancer 2 (2002) 143-148
20. Masquelier M., Zhou Q.F., Gruber A., and Vitols S. Relationship between daunorubicin concentration and apoptosis induction in leukemic cells. Biochemical Pharmacology 67 (2004) 1047-1056
21. McGahon A.J., Martin S.J., Bissonnette R.P., Mahboubi A., Shi Y., Mogil R.J., Nishioka W.K., and Green D.R. The end of the (cell) line: methods for the study of apoptosis in vitro. Methods in Cell Biology 46 (1995) 153-185
22. Mehmet H. Apoptosis: caspase finds a new place to hide. Nature 403 (2002) 29-30
23. Mertens-Talcott S.U., and Percival S.S. Ellagic acid and quercetin interact synergistically with resveratrol in the induction of apoptosis and cause transient cell cycle arrest in human leukemia cells. Cancer Letters 218 (2005) 141-151
24. Navickiene H.M.D., Alécio A.C., Kato M.J., Bolzani V.S., Young M.C.M., Cavalheiro A.J., and Furlan M. Antifungal amides from Piper hispidum and Piper tuberculatum. Phytochemistry 55 (2000) 621-626
25. Parmar V.S., Jain S.C., Bisht K.S., Jain R., Taneja P., Jha A., Tyagi O.M., Prasad A.K., Wengel J., Olsen C.E., and Boll P.M. Phytochemistry of the genus Piper. Phytochemistry 46 (1997) 597-673
26. Reddy L., Odhav B., and Bhoola K.D. Natural products for cancer prevention: a global perspective. Pharmacology and Therapeutics 99 (2003) 1-13
27. Schempp C.M., Simon-Haarhaus B., Termeer C.C., and Simon J.C. Hypericin photo-induced apoptosis involves the tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and activation of caspase-8. FEBS Letters 493 (2001) 26-30
28. Silva R.V., Navickiene H.M.D., Kato M.J., Bolzani V.S., Méda C.I., Young M.C.M., and Furlan M. Antifungal amides from Piper arboreum and Piper tuberculatum. Phytochemistry 59 (2002) 521-527
29. Tsai I.L., Lee F.P., Wu C.C., Duh C.Y., Ishikawa T., Chen J.J., Chen Y.C., Seki H., and Chen I.S. New cytotoxic cyclobutanoid amides, a new furanoid lignan and anti-platelet aggregation constituents from Piper arborescens. Planta Medica 71 (2005) 535-542
30. Zuco V., Supino R., Righetti S.C., Cleris L., Marchesi E., Passerine-Gambacorti C., and Formelli F. Selective cytotoxicity of betulinic acid on tumor cell lines, but not on normal cells. Cancer Letters 175 (2002) 17-25