Modulation of mitochondrial glutathione status and cellular energetics in primary cultures of proximal tubular cells from remnant kidney of uninephrectomized rats

Biochemical Pharmacology

Volumn 85, Issue 9, 2013, Pages 1379-1388

  Benipal, Bavneet ^a   Lash, Lawrence H ^a  

^a WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Compensatory renal hypertrophy; Glutathione; Mitochondria; Oxidative stress; Uninephrectomy

Indexed keywords

ANTIMYCIN A1; DICARBOXYLIC ACID; GLUTATHIONE; MITOCHONDRIAL DNA; OXOGLUTARATE DEHYDROGENASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL CULTURE; CELL ENERGY; CELL PROLIFERATION; CHEMICAL INJURY; CONTROLLED STUDY; CYTOTOXICITY; DISEASE PREDISPOSITION; EXPERIMENTAL ANIMAL; GENE OVEREXPRESSION; HYPERPOLARIZATION; KIDNEY HYPERTROPHY; KIDNEY PROXIMAL TUBULE; KIDNEY TUBULE CELL; MALE; MITOCHONDRIAL VOLUME DENSITY; MITOCHONDRION; MODULATION; NONHUMAN; PRIORITY JOURNAL; RAT; SPRAGUE DAWLEY RAT; UNINEPHRECTOMY;

ALKYLATING AGENTS; ANIMALS; ANTIMYCIN A; BUTANONES; CELLS, CULTURED; DICARBOXYLIC ACID TRANSPORTERS; ENERGY METABOLISM; GLUTATHIONE; HYPERTROPHY; KIDNEY; KIDNEY TUBULES, PROXIMAL; MALE; MEMBRANE POTENTIAL, MITOCHONDRIAL; MEMBRANE TRANSPORT PROTEINS; MITOCHONDRIA; NEPHRECTOMY; OXIDANTS; OXIDATION-REDUCTION; PRIMARY CELL CULTURE; PROTEIN TRANSPORT; RATS; RATS, SPRAGUE-DAWLEY; TERT-BUTYLHYDROPEROXIDE;

EID: 84875696605     PISSN: 00062952     EISSN: 18732968     Source Type: Journal    
DOI: 10.1016/j.bcp.2013.02.013     Document Type: Article

References (51)

1. L. Fine The biology of renal hypertrophy Kidney Int 29 1985 619 634
2. S.S. Holcomb Evaluating chronic kidney disease risk Nurse Pract 30 2005 12 25
3. T.W. Meyer, K. Baboolal, and B.M. Brenner Nephron adaptation to renal injury B.M. Brenner, The kidney 5th ed. 1996 W.B. Saunders Company Philadelphia 2011 2048
4. D.G. Shirley, and S.J. Walter Acute and chronic changes in renal function following unilateral uninephrectomy Kidney Int 40 1991 62 68
5. G. Wolf, and E.G. Neilson Molecular mechanisms of tubulointerstitial hypertrophy and hyperplasia Kidney Int 39 1991 401 420
6. R.K. Zalups, and L.H. Lash Effects of uninephrectomy and mercuric chloride on renal glutathione homeostasis J Pharmacol Exp Ther 254 1990 962 970
7. L.H. Lash, and R.K. Zalups Activities of enzymes involved in renal cellular glutathione after uninephrectomy in rat Arch Biochem Biophys 309 1994 129 138
8. D.C.H. Harris, L. Chan, and R.W. Schrier Remnant kidney hypermetabolism and progression of chronic renal failure Am J Physiol 254 1988 F267 F276
9. L.H. Lash, D.A. Putt, S.J. Horky III, and R.K. Zalups Functional and toxicological characteristics of isolated renal mitochondria: impact of compensatory renal growth Biochem Pharmacol 62 2001 383 395
10. K.A. Nath, A.J. Croatt, and T.H. Hostetter Oxygen consumption and oxidative stress in surviving nephrons Am J Physiol 258 1990 F1354 F1362
11. J.I. Shapiro, N. Elkins, O.K. Reiss, G. Seleymanlar, H. Jin, and R.W. Schrier Energy metabolism following reduction of renal mass Kidney Int 45 Suppl. 1991 S100 S105
12. F.E. Cuppage, M. Chiga, and A. Tate Mitochondrial proliferation within the nephron. I. Comparison of mitochondrial hyperplasia of tubular regeneration with compensatory hypertrophy Am J Pathol 70 1973 119 130
13. H.A. Johnson, and F. Amendola Mitochondrial proliferation in compensatory growth of the kidney Am J Pathol 54 1969 35 45
14. S. Hwang, R. Bohman, P. Navas, J.T. Norman, T. Bradley, and L.G. Fine Hypertrophy of renal mitochondria J Am Soc Nephrol 1 1990 822 827
15. L.H. Lash, and R.K. Zalups Mercuric chloride-induced cytotoxicity and compensatory hypertrophy in rat kidney proximal tubular cells J Pharmacol Exp Ther 261 1992 819 829
16. L.H. Lash, D.A. Putt, and R.K. Zalups Influence of exogenous thiols on inorganic mercury-induced injury in renal proximal and distal tubular cells from normal and uninephrectomized rats J Pharmacol Exp Ther 291 1999 492 502
17. L.H. Lash Use of freshly isolated and primary cultures of proximal tubular and distal tubular cells from rat kidneys R.K. Zalups, L.H. Lash, Methods in renal toxicology 1996 CRC Press Boca Raton, FL 189 215
18. L.H. Lash In vitro methods of assessing renal damage Toxicol Pathol 26 1998 33 42
19. L.H. Lash, D.A. Putt, and R.K. Zalups Biochemical and functional characteristics of cultured renal epithelial cells from uninephrectomized rats: factors influencing nephrotoxicity J Pharmacol Exp Ther 296 2001 243 251
20. L.H. Lash, D.A. Putt, and R.K. Zalups Influence of compensatory renal growth on susceptibility of primary cultures of renal cells to chemical injury Toxicol Sci 94 2006 417 427
21. L.H. Lash, and M.W. Anders Mechanism of S-(1,2-dichlorovinyl)-l-cysteine- and S-(1,2-dichlorovinyl)-l-homocysteine-induced renal mitochondrial toxicity Mol Pharmacol 32 1987 549 556
22. Y. Chen, J. Cai, M.W. Anders, J.L. Stevens, and D.P. Jones Role of mitochondrial dysfunction and S-(1,2-dichlorovinyl)-l-cysteine induced apoptosis Toxicol Appl Pharmacol 170 2001 172 180
23. B. Benipal, and L.H. Lash Influence of renal compensatory hypertrophy on mitochondrial energetics and redox status Biochem Pharmacol 81 2011 295 303
24. L.H. Lash Mitochondrial glutathione transport: physiological, pathological and toxicological implications Chem-Biol Interact 163 2006 54 67
25. Z. Chen, and L.H. Lash Evidence for mitochondrial uptake of glutathione by dicarboxylate and 2-oxoglutarate carriers J Pharmacol Exp Ther 285 1998 608 618
26. Z. Chen, D.A. Putt, and L.H. Lash Enrichment and functional reconstitution of glutathione transport activity from rabbit kidney mitochondria: further evidence for the role of dicarboxylate and 2-oxoglutarate carriers in mitochondrial glutathione transport Arch Biochem Biophys 373 2000 193 202
27. L.H. Lash, D.A. Putt, and L.H. Matherly Protection of NRK-52E cells, a rat renal proximal tubular cell line, from chemical-induced apoptosis by overexpression of a mitochondrial glutathione transporter J Pharmacol Exp Ther 303 2002 476 486
28. F. Xu, D.A. Putt, L.H. Matherly, and L.H. Lash Modulation of expression of rat mitochondrial 2-oxoglutarate carrier in NRK-52E cells after mitochondrial transport and accumulation of glutathione and susceptibility to chemically induced apoptosis J Pharmacol Exp Ther 316 2006 1175 1186
29. R.K. Zalups Reductions in renal mass and the nephropathy induced by mercury Toxicol Appl Pharmacol 143 1987 366 379
30. D.P. Jones, G.B. Sundby, K. Ormstad, and S. Orrenius Use of isolated kidney cells for study of drug metabolism Biochem Pharmacol 28 1979 929 935
31. L.H. Lash, and J.J. Tokarz Isolation of two distinct populations of cells from rat kidney cortex and their use in the study of chemical-induced toxicity Anal Biochem 182 1989 271 279
32. L.H. Lash, J.J. Tokarz, and D.M. Pegouske Susceptibility of primary cultures of proximal tubular and distal tubular cells from rat kidney to chemically induced toxicity Toxicology 103 1995 85 103
33. T. Sorger, and R.J. Germinario A direct solubilization procedure for the determination of DNA and protein in cultured fibroblast monolayers Anal Biochem 131 1983 254 256
34. S.P. Bagby Maternal nutrition, low nephron number, and hypertension in later life: Pathways of nutritional programming J Nutr 137 2007 1066 1072
35. R.N. Douglas-Denton, B.J. McNamara, W.E. Hoy, M.D. Hughson, and J.F. Bertram Does nephron number matter in the development of kidney disease? Ethn Dis 16 Suppl. 2 2006 S2-40-5
36. B.L. Kasiske, J.Z. Ma, T.A. Louis, and S.K. Swan Long-term effects of reduced renal mass in humans Kidney Int 48 1995 814 819
37. R.K. Zalups Molecular interactions with mercury in the kidney Pharmacol Rev 52 2000 113 143
38. R.K. Zalups, and G.L. Diamond Mercuric chloride-induced nephrotoxicity in the rat following unilateral nephrectomy and compensatory renal growth Virchows Arch B 53 1987 336 346
39. R.K. Zalups, and L.H. Lash Recent advances in understanding the renal transport and toxicity of mercury J Toxicol Environ Health 42 1994 1 44
40. M.A. Henry, R.S. Sweet, and J.D. Tange A new reproducible experimental model of analgesic nephropathy J Pathol 139 1983 23 32
41. M.A. Henry, and J.D. Tange Chronic renal lesions in the uninephrectomized Gunn rat after analgesic mixtures Pathology 16 1984 278 284
42. R.K. Zalups, R.M. Gelein, and M.G. Cherian Shifts in the dose-effect relationship for the nephropathy induced by cadmium-metallothionein in rats after a reduction in renal mass J Pharmacol Exp Ther 262 1992 1256 1266
43. M. Gandhi, J.L. Olson, and T.W. Meyer Contribution of tubular injury to loss of remnant kidney function Kidney Int 54 1998 1157 1165
44. T.H. Hostetter Progression of renal disease and renal hypertrophy Annu Rev Physiol 57 1995 263 278
45. S.R. Pieczenik, and J. Neustadt Mitochondrial dysfunction and molecular pathways of disease Exp Mol Pathol 83 2007 84 92
46. D.C. Wallace A mitochondrial paradigm of metabolic and degenerative diseases, aging, and cancer: a dawn for evolutionary medicine Annu Rev Genet 39 2005 359 407
47. N. Ballatori, S.M. Krance, S. Notenboom, S. Shi, K. Tieu, and C.L. Hammond Glutathione dysregulation and the etiology and progression of human diseases Biol Chem 390 2009 191 214
48. I.P. Hargreaves, Y. Sheena, J.M. Land, and S.J.R. Heales Glutathione deficiency in patients with mitochondrial disease: Implications for pathogenesis and treatment J Inherit Metab Dis 28 2005 81 88
49. S. Krahenbuhl, J. Stucki, and J. Reichen Reduced activity of the electron transport chain in liver mitochondria isolated from rats with secondary biliary cirrhosis Hepatology 15 1992 1160 1166
50. R. Mastrocola, F. Restivo, I. Vercellinatto, O. Danni, E. Brignardello, and M. Aragno Oxidative and nitrosative stress in brain mitochondria of diabetic rats J Endocrinol 187 2005 37 44
51. D.L. Santos, C.M. Palmeira, R. Seica, J. Dias, J. Mesquita, and A.J. Moreno Diabetes and mitochondrial oxidative stress: a study using heart mitochondria from the diabetic Goto-Kakizaki rat Mol Cell Biochem 246 2003 163 170