메뉴 건너뛰기




Volumn 11, Issue 11, 2009, Pages 2685-2700

Mitochondrial glutathione, a key survival antioxidant

Author keywords

[No Author keywords available]

Indexed keywords

GLUTATHIONE; GLUTATHIONE PEROXIDASE; GLUTATHIONE TRANSFERASE; HYDROGEN PEROXIDE; LIPID HYDROPEROXIDE; XENOBIOTIC AGENT; ANTIOXIDANT;

EID: 73449124480     PISSN: 15230864     EISSN: None     Source Type: Journal    
DOI: 10.1089/ars.2009.2695     Document Type: Review
Times cited : (767)

References (154)
  • 1
    • 0346787815 scopus 로고    scopus 로고
    • Glutathione monoethyl ester provides neuroprotection in a rat model of stroke
    • Anderson MF, Nilsson M, Eriksson PS, and Sims NR. Glutathione monoethyl ester provides neuroprotection in a rat model of stroke. Neurosci Lett 354: 163-165, 2004.
    • (2004) Neurosci Lett , vol.354 , pp. 163-165
    • Anderson, M.F.1    Nilsson, M.2    Eriksson, P.S.3    Sims, N.R.4
  • 2
    • 0141991150 scopus 로고    scopus 로고
    • Glutathione monoethylester prevents mitochondrial glutathione depletion during focal cerebral ischemia
    • Anderson MF, Nilsson M, and Sims NR. Glutathione monoethylester prevents mitochondrial glutathione depletion during focal cerebral ischemia. Neurochem Int 44: 153-159, 2004.
    • (2004) Neurochem Int , vol.44 , pp. 153-159
    • Anderson, M.F.1    Nilsson, M.2    Sims, N.R.3
  • 3
    • 48649110601 scopus 로고    scopus 로고
    • Cholesterol as a risk factor for dementia and cognitive decline: A systematic review of prospective studies with meta-analysis
    • Anstey KJ, Lipnicki DM, and Low LF. Cholesterol as a risk factor for dementia and cognitive decline: a systematic review of prospective studies with meta-analysis. Am J Geriatr Psychiatry 16: 343-354, 2008.
    • (2008) Am J Geriatr Psychiatry , vol.16 , pp. 343-354
    • Anstey, K.J.1    Lipnicki, D.M.2    Low, L.F.3
  • 4
    • 0036673665 scopus 로고    scopus 로고
    • Glutathione depletion enforces the mitochondrial permeability transition and causes cell death in Bcl-2 overexpressing HL60 cells
    • Armstrong JS and Jones DP. Glutathione depletion enforces the mitochondrial permeability transition and causes cell death in Bcl-2 overexpressing HL60 cells. FASEB J 16: 1263-1265, 2002.
    • (2002) FASEB J , vol.16 , pp. 1263-1265
    • Armstrong, J.S.1    Jones, D.P.2
  • 5
    • 0023724778 scopus 로고    scopus 로고
    • I kappa B: A specific inhibitor of the NF-kappa B transcription factor
    • Baeuerle PA and Baltimore D. I kappa B: a specific inhibitor of the NF-kappa B transcription factor. Science 242: 540-548, 1998.
    • (1998) Science , vol.242 , pp. 540-548
    • Baeuerle, P.A.1    Baltimore, D.2
  • 6
    • 57149142495 scopus 로고    scopus 로고
    • The impact of O2 availability on human cancer
    • Bertout JA, Patel SA, and Simon MC. The impact of O2 availability on human cancer. Nat Rev Cancer 8: 967-975, 2008.
    • (2008) Nat Rev Cancer , vol.8 , pp. 967-975
    • Bertout, J.A.1    Patel, S.A.2    Simon, M.C.3
  • 7
    • 22044436635 scopus 로고    scopus 로고
    • Glutathione depletion in a midbrain-derived immortalized dopaminergic cell line results in limited tyrosine nitration of mitochondrial complex i subunits: Implications for Parkinson's disease
    • Bharath S and Andersen JK. Glutathione depletion in a midbrain-derived immortalized dopaminergic cell line results in limited tyrosine nitration of mitochondrial complex I subunits: implications for Parkinson's disease. Antioxid Redox Signal 7: 900-910, 2005.
    • (2005) Antioxid Redox Signal , vol.7 , pp. 900-910
    • Bharath, S.1    Andersen, J.K.2
  • 8
    • 0030011398 scopus 로고    scopus 로고
    • Involvement of MACH, a novel MORT1=FADD-interacting protease, in Fas=APO-1-and TNF receptor-induced cell death
    • Boldin MP, Goncharov TM, Goltsev YV, and Wallach D. Involvement of MACH, a novel MORT1=FADD-interacting protease, in Fas=APO-1-and TNF receptor-induced cell death. Cell 85: 803-815, 1996.
    • (1996) Cell , vol.85 , pp. 803-815
    • Boldin, M.P.1    Goncharov, T.M.2    Goltsev, Y.V.3    Wallach, D.4
  • 9
    • 16444379174 scopus 로고    scopus 로고
    • Gamma-glutamylcysteine ethyl ester-induced upregulation of glutathione protects neurons against Abeta (1-42)-mediated oxidative stress and neurotoxicity: Implications for Alzheimer's disease
    • Boyd-Kimball D, Sultana R, Abdul HM, and Butterfield DA. Gamma-glutamylcysteine ethyl ester-induced upregulation of glutathione protects neurons against Abeta (1-42)-mediated oxidative stress and neurotoxicity: implications for Alzheimer's disease. J NeurosciRes 79: 700-706, 2005.
    • (2005) J NeurosciRes , vol.79 , pp. 700-706
    • Boyd-Kimball, D.1    Sultana, R.2    Abdul, H.M.3    Butterfield, D.A.4
  • 11
    • 0035856980 scopus 로고    scopus 로고
    • Biochemistry and molecular cell biology of diabetic complications
    • Brownlee M. Biochemistry and molecular cell biology of diabetic complications. Nature 414: 813-820, 2001.
    • (2001) Nature , vol.414 , pp. 813-820
    • Brownlee, M.1
  • 12
    • 0017743745 scopus 로고
    • Giant mitochondria in hepatocytes: A diagnostic hint for alcoholic liver disease
    • Bruguera M, Bertran A, Bombi JA, Rodes J. Giant mitochondria in hepatocytes: a diagnostic hint for alcoholic liver disease. Gastroenterology 73: 1383-1387, 1977.
    • (1977) Gastroenterology , vol.73 , pp. 1383-1387
    • Bruguera, M.1    Bertran, A.2    Bombi, J.A.3    Rodes, J.4
  • 14
    • 0025774993 scopus 로고
    • Acetaminophen toxicity results in site-specific mitochondrial damage in isolated mouse hepatocytes
    • Burcham PC and Harman AW. Acetaminophen toxicity results in site-specific mitochondrial damage in isolated mouse hepatocytes. J Biol Chem 266: 5049-5054, 1991.
    • (1991) J Biol Chem , vol.266 , pp. 5049-5054
    • Burcham, P.C.1    Harman, A.W.2
  • 15
    • 0033796250 scopus 로고    scopus 로고
    • Mitochondrial free radical generation, oxidative stress, and aging
    • Cadenas E and Davies KJ. Mitochondrial free radical generation, oxidative stress, and aging. Free Radic Biol Med 29: 222-230, 2000.
    • (2000) Free Radic Biol Med , vol.29 , pp. 222-230
    • Cadenas, E.1    Davies, K.J.2
  • 16
    • 0000385805 scopus 로고    scopus 로고
    • Isoforms of mammalian peroxiredoxin that reduce peroxides in presence of thioredoxin
    • Chae HZ, Kang SW, and Rhee SG. Isoforms of mammalian peroxiredoxin that reduce peroxides in presence of thioredoxin. Methods Enzymol 300: 219-226, 1999.
    • (1999) Methods Enzymol , vol.300 , pp. 219-226
    • Chae, H.Z.1    Kang, S.W.2    Rhee, S.G.3
  • 17
    • 0034661990 scopus 로고    scopus 로고
    • Role of oxidants in NF-kappa B activation and TNFalpha gene transcription induced by hypoxia and endotoxin
    • Chandel NS, Trzyna WC, McClintock DS, and Schumacker PT. Role of oxidants in NF-kappa B activation and TNFalpha gene transcription induced by hypoxia and endotoxin. J Immunol 165: 1013-1021, 2000.
    • (2000) J Immunol , vol.165 , pp. 1013-1021
    • Chandel, N.S.1    Trzyna, W.C.2    McClintock, D.S.3    Schumacker, P.T.4
  • 18
    • 4744373181 scopus 로고    scopus 로고
    • Peroxiredoxin III a mitochondrion-specific peroxidase, regulates apoptotic signaling by mitochondria
    • Chang TS, Cho CS, Park S, Yu S, Kang SW, and Rhee SG. Peroxiredoxin III, a mitochondrion-specific peroxidase, regulates apoptotic signaling by mitochondria. J Biol Chem 279: 41975-41984, 2004.
    • (2004) J Biol Chem , vol.279 , pp. 41975-41984
    • Chang, T.S.1    Cho, C.S.2    Park, S.3    Yu, S.4    Kang, S.W.5    Rhee, S.G.6
  • 19
    • 0036667842 scopus 로고    scopus 로고
    • 4-Hydroxynonenal detoxification by mitochondrial glutathione S-transferase is compromised by short-term ethanol consumption in rats
    • Chen J, Schenker S, and Henderson GI. 4-Hydroxynonenal detoxification by mitochondrial glutathione S-transferase is compromised by short-term ethanol consumption in rats. Alcohol Clin Exp Res 26: 1252-1258, 2002.
    • (2002) Alcohol Clin Exp Res , vol.26 , pp. 1252-1258
    • Chen, J.1    Schenker, S.2    Henderson, G.I.3
  • 20
    • 0031836944 scopus 로고    scopus 로고
    • Evidence for mitochondrial uptake of glutathione by dicarboxylate and 2-oxoglutarate carriers
    • Chen Z and Lash LH. Evidence for mitochondrial uptake of glutathione by dicarboxylate and 2-oxoglutarate carriers. J Pharmacol Exp Ther 285: 608-618, 1998.
    • (1998) J Pharmacol Exp Ther , vol.285 , pp. 608-618
    • Chen, Z.1    Lash, L.H.2
  • 21
    • 0033963540 scopus 로고    scopus 로고
    • Enrichment and functional reconstitution of glutathione transport activity from rabbit kidney mitochondria: Further evidence for the role of the dicarboxylate and 2-oxoglutarate carriers in mitochondrial glutathione transport
    • Chen Z, Putt DA, and Lash LH. Enrichment and functional reconstitution of glutathione transport activity from rabbit kidney mitochondria: further evidence for the role of the dicarboxylate and 2-oxoglutarate carriers in mitochondrial glutathione transport. Arch Biochem Biophys 373: 193-202, 2000.
    • (2000) Arch Biochem Biophys , vol.373 , pp. 193-202
    • Chen, Z.1    Putt, D.A.2    Lash, L.H.3
  • 22
    • 33749047253 scopus 로고    scopus 로고
    • Reversible inhibition of mitochondrial complex i activity following chronic dopaminergic glutathione depletion in vitro: Implications for Parkinson's disease
    • Chinta SJ and Andersen JK. Reversible inhibition of mitochondrial complex I activity following chronic dopaminergic glutathione depletion in vitro: implications for Parkinson's disease. Free Radic Biol Med 41: 1442-1448, 2006.
    • (2006) Free Radic Biol Med , vol.41 , pp. 1442-1448
    • Chinta, S.J.1    Andersen, J.K.2
  • 23
    • 50849141073 scopus 로고    scopus 로고
    • Glutathione and apoptosis
    • Circu ML and Aw TY. Glutathione and apoptosis. Free Radic Res 42: 689-706, 2008.
    • (2008) Free Radic Res , vol.42 , pp. 689-706
    • Circu, M.L.1    Aw, T.Y.2
  • 25
    • 0030819482 scopus 로고    scopus 로고
    • Transport of reduced glutathione in hepatic mitochondria and mitoplasts from ethanol-treated rats: Effect of membrane physical properties and S-adenosyl-l-methionine
    • Colell A, Garcáa-Ruiz C, Morales A, Ballesta A, Ookhtens M, Rodés J, Kaplowitz N, and Fernández-Checa JC. Transport of reduced glutathione in hepatic mitochondria and mitoplasts from ethanol-treated rats: effect of membrane physical properties and S-adenosyl-l-methionine. Hepatology 26: 699-708, 1997.
    • (1997) Hepatology , vol.26 , pp. 699-708
    • Colell, A.1    Garcáa-Ruiz, C.2    Morales, A.3    Ballesta, A.4    Ookhtens, M.5    Rodés, J.6    Kaplowitz, N.7    Fernández-Checa, J.C.8
  • 26
    • 0041822088 scopus 로고    scopus 로고
    • Sensitivity of the 2-oxoglutarate carrier to alcohol intake contributes to mitochondrial glutathione depletion
    • Coll O, Colell A, Garcáa-Ruiz C, Kaplowitz N, and Fernández-Checa JC. Sensitivity of the 2-oxoglutarate carrier to alcohol intake contributes to mitochondrial glutathione depletion. Hepatology 38: 692-702, 2003.
    • (2003) Hepatology , vol.38 , pp. 692-702
    • Coll, O.1    Colell, A.2    Garcáa-Ruiz, C.3    Kaplowitz, N.4    Fernández- Checa, J.C.5
  • 27
    • 0033953170 scopus 로고    scopus 로고
    • GSH extrusion and the mitochondrial pathway of apoptotic signalling
    • Coppola S and Ghibelli L. GSH extrusion and the mitochondrial pathway of apoptotic signalling. Biochem Soc Trans 28: 56-61, 2000.
    • (2000) Biochem Soc Trans , vol.28 , pp. 56-61
    • Coppola, S.1    Ghibelli, L.2
  • 29
    • 0026387907 scopus 로고
    • Glutathione metabolism and its role in hepatotoxicity
    • DeLeve L and Kaplowitz N. Glutathione metabolism and its role in hepatotoxicity. Pharmacol Ther 52: 287-305, 1991.
    • (1991) Pharmacol Ther , vol.52 , pp. 287-305
    • Deleve, L.1    Kaplowitz, N.2
  • 31
    • 0037449777 scopus 로고    scopus 로고
    • Tyrosine phosphorylation of i kappa B alpha activates NF kappa B through a redox-regulated and c-Src-dependent mechanism following hypoxia=reoxygenation
    • Fan C, Li Q, Ross D, and Engelhardt JF. Tyrosine phosphorylation of I kappa B alpha activates NF kappa B through a redox-regulated and c-Src-dependent mechanism following hypoxia=reoxygenation. J Biol Chem 278: 2072-2080, 2003.
    • (2003) J Biol Chem , vol.278 , pp. 2072-2080
    • Fan, C.1    Li, Q.2    Ross, D.3    Engelhardt, J.F.4
  • 35
    • 66249083144 scopus 로고    scopus 로고
    • Mitochondrial cholesterol loading exacerbates amyloid beta peptide-induced inflammation and neurotoxicity
    • Fernández A, Llacuna L, Fernandez-Checa JC, and Colell A. Mitochondrial cholesterol loading exacerbates amyloid beta peptide-induced inflammation and neurotoxicity. J Neurosci 20: 6394-6405, 2009.
    • (2009) J Neurosci , vol.20 , pp. 6394-6405
    • Fernández, A.1    Llacuna, L.2    Fernandez-Checa, J.C.3    Colell, A.4
  • 36
    • 0025979356 scopus 로고
    • Impaired uptake of glutathione by hepatic mitochondria from chronic ethanol-fed rats: Tracer kinetic studies in vitro and in vivo and susceptibility to oxidant stress
    • Fernández-Checa JC, Garcáa-Ruiz C, Ookhtens M, and Kaplowitz N. Impaired uptake of glutathione by hepatic mitochondria from chronic ethanol-fed rats: tracer kinetic studies in vitro and in vivo and susceptibility to oxidant stress. J Clin Invest 87: 397-405, 1991.
    • (1991) J Clin Invest , vol.87 , pp. 397-405
    • Fernández-Checa, J.C.1    Garcáa-Ruiz, C.2    Ookhtens, M.3    Kaplowitz, N.4
  • 38
    • 17444381536 scopus 로고    scopus 로고
    • Hepatic mitochondrial glutathione: Transport and role in disease and toxicity
    • Fernández-Checa JC and Kaplowitz N. Hepatic mitochondrial glutathione: transport and role in disease and toxicity. Toxicol Appl Pharmacol 204: 263-273, 2005.
    • (2005) Toxicol Appl Pharmacol , vol.204 , pp. 263-273
    • Fernández-Checa, J.C.1    Kaplowitz, N.2
  • 39
    • 0023274831 scopus 로고
    • Effect of chronic ethanol feeding on rat hepatocytic glutathione: Compartmentation, efflux, and response to incubation with ethanol
    • Fernández-Checa JC, Ookhtens M, and Kaplowitz N. Effect of chronic ethanol feeding on rat hepatocytic glutathione: compartmentation, efflux, and response to incubation with ethanol. J Clin Invest 80: 57-62, 1987.
    • (1987) J Clin Invest , vol.80 , pp. 57-62
    • Fernández-Checa, J.C.1    Ookhtens, M.2    Kaplowitz, N.3
  • 42
    • 1842330849 scopus 로고    scopus 로고
    • Direct effect of ceramide on the mitochondrial electron transport chain leads to generation of reactive oxygen species: Role of mitochondrial glutathione
    • Garcáa-Ruiz C, Colell A, Mará M, Morales A, and Fernández-Checa JC. Direct effect of ceramide on the mitochondrial electron transport chain leads to generation of reactive oxygen species: role of mitochondrial glutathione. J Biol Chem 272: 11369-11377, 1997.
    • (1997) J Biol Chem , vol.272 , pp. 11369-11377
    • Garcáa-Ruiz, C.1    Colell, A.2    Mará, M.3    Morales, A.4    Fernández-Checa, J.C.5
  • 43
    • 0343883506 scopus 로고    scopus 로고
    • Direct interaction of GD3 ganglioside with mitochondria generates reactive oxygen species followed by mitochondrial permeability transition, cytochrome c release, and caspase activation
    • Garcáa-Ruiz C, Colell A, Parás R, and Fernández- Checa JC. Direct interaction of GD3 ganglioside with mitochondria generates reactive oxygen species followed by mitochondrial permeability transition, cytochrome c release, and caspase activation. FASEB J 14: 847-858, 2000.
    • (2000) FASEB J , vol.14 , pp. 847-858
    • Garcáa-Ruiz, C.1    Colell, A.2    Parás, R.3    Fernández-Checa, J.C.4
  • 44
    • 0028229899 scopus 로고
    • Effect of chronic ethanol feeding on glutathione and functional integrity of mitochondria in periportal and perivenous rat hepatocytes
    • Garcia-Ruiz C, Morales A, Ballesta A, Rodes J, Kaplowitz N, and Fernandez-Checa JC. Effect of chronic ethanol feeding on glutathione and functional integrity of mitochondria in periportal and perivenous rat hepatocytes. J Clin Invest 94: 193-201, 1994.
    • (1994) J Clin Invest , vol.94 , pp. 193-201
    • Garcia-Ruiz, C.1    Morales, A.2    Ballesta, A.3    Rodes, J.4    Kaplowitz, N.5    Fernandez-Checa, J.C.6
  • 45
    • 0029052049 scopus 로고
    • Evidence that the rat hepatic mitochondrial carrier is distinct from the sinusoidal and canalicular transporters for reduced glutathione: Expression studies in Xenopus laevis oocytes
    • Garcáa-Ruiz C, Morales A, Colell A, Rodés J, Yi JR, Kaplowitz N, and Fernández-Checa JC. Evidence that the rat hepatic mitochondrial carrier is distinct from the sinusoidal and canalicular transporters for reduced glutathione: expression studies in Xenopus laevis oocytes. J Biol Chem 270: 15946-15949, 1995.
    • (1995) J Biol Chem , vol.270 , pp. 15946-15949
    • Garcáa-Ruiz, C.1    Morales, A.2    Colell, A.3    Rodés, J.4    Yi, J.R.5    Kaplowitz, N.6    Fernández-Checa, J.C.7
  • 47
    • 3442886811 scopus 로고    scopus 로고
    • The pathophysiology of mitochondrial cell death
    • Green DR and Kroemer G. The pathophysiology of mitochondrial cell death. Science 305: 626-629, 2004.
    • (2004) Science , vol.305 , pp. 626-629
    • Green, D.R.1    Kroemer, G.2
  • 48
    • 0001547757 scopus 로고
    • Origin and turnover of mitochondrial glutathione
    • Griffith OW and Meister A. Origin and turnover of mitochondrial glutathione. Proc Natl Acad Sci U S A 82: 4668-4672, 1985.
    • (1985) Proc Natl Acad Sci U S A , vol.82 , pp. 4668-4672
    • Griffith, O.W.1    Meister, A.2
  • 49
    • 24144493814 scopus 로고    scopus 로고
    • Mitochondrial complex III is required for hypoxiainduced ROS production and cellular oxygen sensing
    • Guzy RD, Hoyos B, Robin E, Chen H, Liu L, and Mansfield KD. Mitochondrial complex III is required for hypoxiainduced ROS production and cellular oxygen sensing. Cell Metab 1: 401-408, 2005.
    • (2005) Cell Metab , vol.1 , pp. 401-408
    • Guzy, R.D.1    Hoyos, B.2    Robin, E.3    Chen, H.4    Liu, L.5    Mansfield, K.D.6
  • 50
    • 33847662852 scopus 로고    scopus 로고
    • Soluble protein oligomers in neurodegeneration: Lessons from the Alzheimer's amyloid beta-peptide
    • Haass C and Selkoe DJ. Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid beta-peptide. Nat Rev Mol Cell Biol 8: 101-112, 2007.
    • (2007) Nat Rev Mol Cell Biol , vol.8 , pp. 101-112
    • Haass, C.1    Selkoe, D.J.2
  • 51
    • 0034955787 scopus 로고    scopus 로고
    • Novel roles for glutathione in gene expression, cell death, and membrane transport of organic solutes
    • Hammond CL, Lee TK, and Ballatori N. Novel roles for glutathione in gene expression, cell death, and membrane transport of organic solutes. J Hepatol 34: 946-954, 2001.
    • (2001) J Hepatol , vol.34 , pp. 946-954
    • Hammond, C.L.1    Lee, T.K.2    Ballatori, N.3
  • 55
    • 77049308856 scopus 로고
    • Aging: A theory based on free radical and radiation chemistry
    • Harman D. Aging: a theory based on free radical and radiation chemistry. J Gerontol 11: 298-300, 1956.
    • (1956) J Gerontol , vol.11 , pp. 298-300
    • Harman, D.1
  • 56
    • 0015319592 scopus 로고
    • The biologic clock: The mitochondria?
    • Harman D. The biologic clock: the mitochondria? J Am Geriatr Soc 20: 145-147, 1972.
    • (1972) J Am Geriatr Soc , vol.20 , pp. 145-147
    • Harman, D.1
  • 58
    • 0036359544 scopus 로고    scopus 로고
    • Glutaredoxins and oxidative stress defense in yeast
    • Herrero E and Ros J. Glutaredoxins and oxidative stress defense in yeast. Methods Enzymol 348: 136-146, 2002.
    • (2002) Methods Enzymol , vol.348 , pp. 136-146
    • Herrero, E.1    Ros, J.2
  • 60
    • 0017396030 scopus 로고
    • The function of thioredoxin and glutathione in deoxyribonucleic acid synthesis
    • Holmgren A. The function of thioredoxin and glutathione in deoxyribonucleic acid synthesis. Biochem Soc Trans 5: 611-612, 1977.
    • (1977) Biochem Soc Trans , vol.5 , pp. 611-612
    • Holmgren, A.1
  • 61
    • 0026698060 scopus 로고
    • Oxidized redox state of glutathione in the endoplasmic reticulum
    • Hwang C, Sinskey AJ, and Lodish HF. Oxidized redox state of glutathione in the endoplasmic reticulum. Science 257: 1496-1502, 1992.
    • (1992) Science , vol.257 , pp. 1496-1502
    • Hwang, C.1    Sinskey, A.J.2    Lodish, H.F.3
  • 63
    • 41149144611 scopus 로고    scopus 로고
    • Preconditioning with death ligands FasL and TNF-alpha protects the cirrhotic mouse liver against ischaemic injury
    • Jang JH, Moritz W, Graf R, and Clavien PA. Preconditioning with death ligands FasL and TNF-alpha protects the cirrhotic mouse liver against ischaemic injury. Gut 57: 492-499, 2008.
    • (2008) Gut , vol.57 , pp. 492-499
    • Jang, J.H.1    Moritz, W.2    Graf, R.3    Clavien, P.A.4
  • 64
    • 62349116477 scopus 로고    scopus 로고
    • The mitochondrial theory of aging: Insight from transgenic and knockout mouse models
    • Jang YC and Remmen VH.The mitochondrial theory of aging: insight from transgenic and knockout mouse models. Exp Gerontol 44: 256-260, 2009.
    • (2009) Exp Gerontol , vol.44 , pp. 256-260
    • Jang, Y.C.1    Remmen, V.H.2
  • 65
    • 24144467846 scopus 로고    scopus 로고
    • ROS: Really involved in oxygen sensing
    • Kaelin WG Jr. ROS: really involved in oxygen sensing. Cell Metab 1: 357-358, 2005.
    • (2005) Cell Metab , vol.1 , pp. 357-358
    • Kaelin Jr., W.G.1
  • 67
    • 34948881208 scopus 로고    scopus 로고
    • Mitochondria: A hub of redox activities and cellular distress control
    • Kakkar P and Singh BK. Mitochondria: a hub of redox activities and cellular distress control. Mol Cell Biochem 305: 235-253, 2007.
    • (2007) Mol Cell Biochem , vol.305 , pp. 235-253
    • Kakkar, P.1    Singh, B.K.2
  • 68
    • 0033525830 scopus 로고    scopus 로고
    • Regulation of the hypoxia-inducible transcription factor 1alpha by the ubiquitin-proteasome pathway
    • Kallio PJ, Wilson WJ, O'Brien S, Makino Y, and Poellinger L. Regulation of the hypoxia-inducible transcription factor 1alpha by the ubiquitin-proteasome pathway. J Biol Chem 274: 6519-6525, 1999.
    • (1999) J Biol Chem , vol.274 , pp. 6519-6525
    • Kallio, P.J.1    Wilson, W.J.2    O'Brien, S.3    Makino, Y.4    Poellinger, L.5
  • 69
    • 27744501797 scopus 로고    scopus 로고
    • Lipids as modulators of proteolytic activity of BACE: Involvement of cholesterol, glycosphingolipids, and anionic phospholipids in vitro
    • Kalvodova L, Kahya N, Schwille P, Ehehalt R, Verkade P, Drechsel D, Simons K. Lipids as modulators of proteolytic activity of BACE: involvement of cholesterol, glycosphingolipids, and anionic phospholipids in vitro. J Biol Chem 280: 36815-36823, 2005.
    • (2005) J Biol Chem , vol.280 , pp. 36815-36823
    • Kalvodova, L.1    Kahya, N.2    Schwille, P.3    Ehehalt, R.4    Verkade, P.5    Drechsel, D.6    Simons, K.7
  • 70
  • 71
    • 34648825492 scopus 로고    scopus 로고
    • Oxidative damage in the retinal mitochondria of diabetic mice: Possible protection by superoxide dismutase
    • Kanwar M, Chan PS, Kern TS, and Kowluru RA. Oxidative damage in the retinal mitochondria of diabetic mice: possible protection by superoxide dismutase. Invest Ophthalmol Vis Sci 48: 3805-3811, 2007.
    • (2007) Invest Ophthalmol Vis Sci , vol.48 , pp. 3805-3811
    • Kanwar, M.1    Chan, P.S.2    Kern, T.S.3    Kowluru, R.A.4
  • 73
    • 0028268629 scopus 로고
    • Hypoxia causes the activation of nuclear factor kappa B through the phosphorylation of i kappa B alpha on tyrosine residues
    • Koong AC, Chen EY, and Giaccia AJ. Hypoxia causes the activation of nuclear factor kappa B through the phosphorylation of I kappa B alpha on tyrosine residues. Cancer Res 54: 1425-1430, 1994.
    • (1994) Cancer Res , vol.54 , pp. 1425-1430
    • Koong, A.C.1    Chen, E.Y.2    Giaccia, A.J.3
  • 74
    • 0026654982 scopus 로고
    • Reduced activity of the electron transport chain in liver mitochondria isolated from rats with secondary biliary cirrhosis
    • Krähenbühl S, Stucki J, and Reichen J. Reduced activity of the electron transport chain in liver mitochondria isolated from rats with secondary biliary cirrhosis. Hepatology 15, 1160-1166 1992.
    • (1992) Hepatology , vol.15 , pp. 1160-1166
    • Krähenbühl, S.1    Stucki, J.2    Reichen, J.3
  • 75
    • 0029145255 scopus 로고
    • Reduced antioxidative capacity in liver mitochondria from bile duct ligated rats
    • Krähenbühl S, Talos C, Lauterburg BH, and Reichen J. Reduced antioxidative capacity in liver mitochondria from bile duct ligated rats. Hepatology 22: 607-612, 1995.
    • (1995) Hepatology , vol.22 , pp. 607-612
    • Krähenbühl, S.T.1
  • 77
    • 0036827706 scopus 로고    scopus 로고
    • Protection of NRK-52E cells, a rat renal proximal tubular cell line, from chemical-induced apoptosis by overexpression of a mitochondrial glutathione transporter
    • Lash LH, Putt DA, and Matherly LH. Protection of NRK-52E cells, a rat renal proximal tubular cell line, from chemical-induced apoptosis by overexpression of a mitochondrial glutathione transporter. J Pharmacol Exp Ther 303: 476-486, 2002.
    • (2002) J Pharmacol Exp Ther , vol.303 , pp. 476-486
    • Lash, L.H.1    Putt, D.A.2    Matherly, L.H.3
  • 78
    • 33750011601 scopus 로고    scopus 로고
    • Mitochondrial glutathione transport: Physiological, pathological and toxicological implications
    • Lash LH. Mitochondrial glutathione transport: physiological, pathological and toxicological implications. Chem Biol Interact 163: 54-67, 2006.
    • (2006) Chem Biol Interact , vol.163 , pp. 54-67
    • Lash, L.H.1
  • 79
    • 0030715323 scopus 로고    scopus 로고
    • Cytochrome c and dATPdependent formation of Apaf-1=caspase-9 complex initiates an apoptotic protease cascade
    • Li P, Nijhawan D, Budihardjo I, Srinivasula SM, Ahmad M, Alnemri ES, and Wang X. Cytochrome c and dATPdependent formation of Apaf-1=caspase-9 complex initiates an apoptotic protease cascade. Cell 91: 479-489, 1997.
    • (1997) Cell , vol.91 , pp. 479-489
    • Li, P.1    Nijhawan, D.2    Budihardjo, I.3    Srinivasula, S.M.4    Ahmad, M.5    Alnemri, E.S.6    Wang, X.7
  • 80
    • 33750683018 scopus 로고    scopus 로고
    • Alzheimer's APP mangles mitochondria
    • Lin MT and Beal MF. Alzheimer's APP mangles mitochondria. Nat Med 12: 1241-1243, 2006.
    • (2006) Nat Med , vol.12 , pp. 1241-1243
    • Lin, M.T.1    Beal, M.F.2
  • 81
    • 33750347347 scopus 로고    scopus 로고
    • Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases
    • Lin MT and Beal MF. Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases. Nature 443: 787-795, 2006.
    • (2006) Nature , vol.443 , pp. 787-795
    • Lin, M.T.1    Beal, M.F.2
  • 82
    • 33748918887 scopus 로고    scopus 로고
    • Critical role of acidic sphingomyelinase in murine hepatic ischemia-reperfusion injury
    • Llacuna L, Mará M, Garcia-Ruiz C, Fernandez-Checa JC, and Morales A. Critical role of acidic sphingomyelinase in murine hepatic ischemia-reperfusion injury. Hepatology 44: 561-572, 2006.
    • (2006) Hepatology , vol.44 , pp. 561-572
    • Llacuna, L.1    Mará, M.2    Garcia-Ruiz, C.3    Fernandez-Checa, J.C.4    Morales, A.5
  • 83
    • 65649142014 scopus 로고    scopus 로고
    • Reactive oxygen species mediate liver injury through parenchymal NF-kB inactivation in prolonged ischemia=reperfusion
    • Llacuna L, Mará M, Lluis JM, Garcáa-Ruiz C, Fernández-Checa JC, and Morales A. Reactive oxygen species mediate liver injury through parenchymal NF-kB inactivation in prolonged ischemia=reperfusion. Am J Pathol 174: 1776-1785, 2009.
    • (2009) Am J Pathol , vol.174 , pp. 1776-1785
    • Llacuna, L.1    Mará, M.2    Lluis, J.M.3    Garcáa-Ruiz, C.4    Fernández-Checa, J.C.5    Morales, A.6
  • 84
    • 34547616284 scopus 로고    scopus 로고
    • Dual role of mitochondrial reactive oxygen species in hypoxia signalling: Activation of nuclear factor-{kappa}B via c-SRC and oxidant-dependent cell death
    • Lluis JM, Buricchi F, Chiarugi P, Morales A, and Fernandez-Checa JC. Dual role of mitochondrial reactive oxygen species in hypoxia signalling: activation of nuclear factor-{kappa}B via c-SRC and oxidant-dependent cell death. Cancer Res 67: 7368-7377, 2007.
    • (2007) Cancer Res , vol.67 , pp. 7368-7377
    • Lluis, J.M.1    Buricchi, F.2    Chiarugi, P.3    Morales, A.4    Fernandez-Checa, J.C.5
  • 85
    • 0037370152 scopus 로고    scopus 로고
    • Acetaldehyde impairs mitochondrial glutathione transport in HepG2 cells through endoplasmic reticulum stress
    • Lluis JM, Colell A, Garcáa-Ruiz C, Kaplowitz N, and Fernnandez-Checa JC. Acetaldehyde impairs mitochondrial glutathione transport in HepG2 cells through endoplasmic reticulum stress. Gastroenterology 124: 708-724, 2003.
    • (2003) Gastroenterology , vol.124 , pp. 708-724
    • Lluis, J.M.1    Colell, A.2    Garcáa-Ruiz, C.3    Kaplowitz, N.4    Fernnandez-Checa, J.C.5
  • 87
    • 35748961980 scopus 로고    scopus 로고
    • Glutathione depletion downregulates tumor necrosis factor alpha-induced NF-kappaB activity via IkappaB kinase-dependent and-independent mechanisms
    • Lou H and Kaplowitz N: Glutathione depletion downregulates tumor necrosis factor alpha-induced NF-kappaB activity via IkappaB kinase-dependent and -independent mechanisms. J Biol Chem 282: 29470-29481, 2007.
    • (2007) J Biol Chem , vol.282 , pp. 29470-29481
    • Lou, H.1    Kaplowitz, N.2
  • 88
    • 12844250694 scopus 로고    scopus 로고
    • Induction of hyperphosphorylated tau in primary rat cortical neuron cultures mediated by oxidative stress and glycogen synthase kinase-3
    • Lovell MA, Xiong S, Xie C, Davies P, and Markesbery WR. Induction of hyperphosphorylated tau in primary rat cortical neuron cultures mediated by oxidative stress and glycogen synthase kinase-3. J Alzheimers Dis 6: 659-671, 2004.
    • (2004) J Alzheimers Dis , vol.6 , pp. 659-671
    • Lovell, M.A.1    Xiong, S.2    Xie, C.3    Davies, P.4    Markesbery, W.R.5
  • 89
    • 20144388823 scopus 로고    scopus 로고
    • Deletion of IKK2 in hepatocytes does not sensitize these cells to TNF-induced apoptosis, but protects from ischemia= reperfusion injury
    • Luedde T, Assmus U, Wüstefeld T, Meyer zu Vilsendorf A, Roskams T, Schmidt-Supprian M, Rajewsky K, Brenner DA, Manns MP, Pasparakis M, and Trautwein C. Deletion of IKK2 in hepatocytes does not sensitize these cells to TNF-induced apoptosis, but protects from ischemia= reperfusion injury. J Clin Invest 115: 849-859, 2005.
    • (2005) J Clin Invest , vol.115 , pp. 849-859
    • Luedde, T.1
  • 91
    • 33646152108 scopus 로고    scopus 로고
    • Mitochondria are a direct site of A beta accumulation in Alzheimer's disease neurons: Implications for free radical generation and oxidative damage in disease progression
    • Manczak M, Anekonda TS, Henson E, Park BS, Quinn J, and Reddy PH. Mitochondria are a direct site of A beta accumulation in Alzheimer's disease neurons: implications for free radical generation and oxidative damage in disease progression. Hum Mol Genet 15: 1437-1449, 2006.
    • (2006) Hum Mol Genet , vol.15 , pp. 1437-1449
    • Manczak, M.1    Anekonda, T.S.2    Henson, E.3    Park, B.S.4    Quinn, J.5    Reddy, P.H.6
  • 94
    • 2142657911 scopus 로고    scopus 로고
    • Acidic sphingomyelinase downregulates the liver-specific methionine adenosyltransferase 1A, contributing to tumor necrosis factor-induced lethal hepatitis
    • Mará M, Colell A, Morales A, Pañeda C, Varela-Nieto I, Garcáa-Ruiz C, and Fernández-Checa JC. Acidic sphingomyelinase downregulates the liver-specific methionine adenosyltransferase 1A, contributing to tumor necrosis factor-induced lethal hepatitis. J Clin Invest 113: 895-904, 2004.
    • (2004) J Clin Invest , vol.113 , pp. 895-904
    • Mará, M.1    Colell, A.2    Morales, A.3    Pañeda, C.4    Varela-Nieto, I.5    Garcáa-Ruiz, C.6    Fernández-Checa, J.C.7
  • 96
    • 0025049139 scopus 로고
    • High-affinity transport of glutathione is part of a multicomponent system essential for mitochondrial function
    • Mårtensson J, Lai JC, and Meister A. High-affinity transport of glutathione is part of a multicomponent system essential for mitochondrial function. Proc Natl Acad Sci U S A 87: 7185-7189, 1990.
    • (1990) Proc Natl Acad Sci U S A , vol.87 , pp. 7185-7189
    • Mårtensson, J.1    Lai, J.C.2    Meister, A.3
  • 97
    • 0029033862 scopus 로고
    • Mitochondrial changes associated with glutathione deficiency
    • Meister A. Mitochondrial changes associated with glutathione deficiency. Biochim Biophys Acta 1271: 35-42, 1995.
    • (1995) Biochim Biophys Acta , vol.1271 , pp. 35-42
    • Meister, A.1
  • 98
    • 0020615123 scopus 로고
    • Depletion in vitro of mitochondrial glutathione in rat hepatocytes and enhancement of lipid peroxidation by Adriamycin and 1,3-bis (2-chloroethyl)-1- nitrosourea (BCNU)
    • Meredith MJ and Reed DJ. Depletion in vitro of mitochondrial glutathione in rat hepatocytes and enhancement of lipid peroxidation by Adriamycin and 1,3-bis (2-chloroethyl)-1-nitrosourea (BCNU). Biochem Pharmacol 32: 1383-1388, 1983.
    • (1983) Biochem Pharmacol , vol.32 , pp. 1383-1388
    • Meredith, M.J.1    Reed, D.J.2
  • 99
    • 0020478933 scopus 로고
    • Status of the mitochondrial pool of glutathione in the isolated hepatocyte
    • Meredith MJ and Reed DJ. Status of the mitochondrial pool of glutathione in the isolated hepatocyte. J Biol Chem 257: 3747-3753, 1982.
    • (1982) J Biol Chem , vol.257 , pp. 3747-3753
    • Meredith, M.J.1    Reed, D.J.2
  • 103
    • 0026585303 scopus 로고
    • Characterization of membrane fraction lipid composition and function of cirrhotic rat liver: Role of S-adenosyl-l-methionine
    • Muriel P and Mourelle M. Characterization of membrane fraction lipid composition and function of cirrhotic rat liver: role of S-adenosyl-l- methionine. J Hepatol 14: 16-21, 1992.
    • (1992) J Hepatol , vol.14 , pp. 16-21
    • Muriel, P.1    Mourelle, M.2
  • 104
    • 4644327947 scopus 로고    scopus 로고
    • Highly selective and prolonged depletion of mitochondrial glutathione in astrocytes markedly increases sensitivity to peroxynitrite
    • Muyderman H, Nilsson M, and Sims NR. Highly selective and prolonged depletion of mitochondrial glutathione in astrocytes markedly increases sensitivity to peroxynitrite. J Neurosci 24: 8019-8208, 2004.
    • (2004) J Neurosci , vol.24 , pp. 8019-8208
    • Muyderman, H.1    Nilsson, M.2    Sims, N.R.3
  • 106
    • 0036293621 scopus 로고    scopus 로고
    • Reduced glutathione depletion causes necrosis and sensitization to tumor necrosis factor-alpha-induced apoptosis in cultured mouse hepatocytes
    • Nagai H, Matsumaru K, Feng G, and Kaplowitz N. Reduced glutathione depletion causes necrosis and sensitization to tumor necrosis factor-alpha-induced apoptosis in cultured mouse hepatocytes. Hepatology 36: 55-64, 2002.
    • (2002) Hepatology , vol.36 , pp. 55-64
    • Nagai, H.1    Matsumaru, K.2    Feng, G.3    Kaplowitz, N.4
  • 107
    • 0025694879 scopus 로고
    • Molecular mechanisms of the hepatotoxicity caused by acetaminophen
    • Nelson SD. Molecular mechanisms of the hepatotoxicity caused by acetaminophen. Semin Liver Dis 10: 267-278, 1990.
    • (1990) Semin Liver Dis , vol.10 , pp. 267-278
    • Nelson, S.D.1
  • 108
    • 0033808753 scopus 로고    scopus 로고
    • Mitochondrial glutathione and oxidative stress: Implications for pulmonary oxygen toxicity in premature infants
    • O'Donovan DJ and Fernandes CJ. Mitochondrial glutathione and oxidative stress: implications for pulmonary oxygen toxicity in premature infants. Mol Genet Metab 71: 352-358, 2000.
    • (2000) Mol Genet Metab , vol.71 , pp. 352-358
    • O'Donovan, D.J.1    Fernandes, C.J.2
  • 110
    • 53049089639 scopus 로고    scopus 로고
    • Direct and potent regulation of gamma-secretase by its lipid microenvironment
    • Osenkowski P, Ye W, Wang R, Wolfe MS, and Selkoe DJ. Direct and potent regulation of gamma-secretase by its lipid microenvironment. J Biol Chem 283: 22529-22540, 2008.
    • (2008) J Biol Chem , vol.283 , pp. 22529-22540
    • Osenkowski, P.1    Ye, W.2    Wang, R.3    Wolfe, M.S.4    Selkoe, D.J.5
  • 112
    • 0028287860 scopus 로고
    • Mitochondrial carrier proteins
    • Palmieri F. Mitochondrial carrier proteins. FEBS Lett 346: 48-54, 1994.
    • (1994) FEBS Lett , vol.346 , pp. 48-54
    • Palmieri, F.1
  • 113
    • 0033525509 scopus 로고    scopus 로고
    • Identification and functional characterization of a novel mitochondrial thioredoxin system in Saccharomyces cerevisiae
    • Pedrajas JR, Kosmidou E,Miranda-Vizuete A, Gustafsson JA, Wright AP, and Spyrou G. Identification and functional characterization of a novel mitochondrial thioredoxin system in Saccharomyces cerevisiae. J Biol Chem 274: 6366-6373, 1999.
    • (1999) J Biol Chem , vol.274 , pp. 6366-6373
    • Pedrajas, J.R.1    Kosmidou Emiranda-Vizuete, A.2    Gustafsson, J.A.3    Wright, A.P.4    Spyrou, G.5
  • 114
    • 0141509869 scopus 로고    scopus 로고
    • Inhibition of mitochondrial respiration: A novel strategy to enhance druginduced apoptosis in human leukemia cells by a reactive oxygen species-mediated mechanism
    • Pelicano H, Feng L, Zhou Y, Carew JS, Hileman EO, Plunkett W, Keating MJ, and Huang P. Inhibition of mitochondrial respiration: a novel strategy to enhance druginduced apoptosis in human leukemia cells by a reactive oxygen species-mediated mechanism. J Biol Chem 278: 37832-37839, 2003.
    • (2003) J Biol Chem , vol.278 , pp. 37832-37839
    • Pelicano, H.1    Feng, L.2    Zhou, Y.3    Carew, J.S.4    Hileman, E.O.5    Plunkett, W.6    Keating, M.J.7    Huang, P.8
  • 115
    • 0022553605 scopus 로고
    • Idiopathic Parkinson's disease, progressive supranuclear palsy and glutathione metabolism in the substantia nigra of patients
    • Perry TL and Yong VW. Idiopathic Parkinson's disease, progressive supranuclear palsy and glutathione metabolism in the substantia nigra of patients. Neurosci Lett 67: 269-274, 1986.
    • (1986) Neurosci Lett , vol.67 , pp. 269-274
    • Perry, T.L.1    Yong, V.W.2
  • 116
    • 0038037735 scopus 로고    scopus 로고
    • Regulation of angiogenesis by hypoxia: Role of the HIF system
    • Pugh CW and Ratcliffe PJ. Regulation of angiogenesis by hypoxia: role of the HIF system. Nat Med 9: 677-684, 2003.
    • (2003) Nat Med , vol.9 , pp. 677-684
    • Pugh, C.W.1    Ratcliffe, P.J.2
  • 117
    • 0026781254 scopus 로고
    • Reversal of extrahepatic membrane cholesterol deposition in patients with chronic liver diseases by Sadenosyl-l-methionine
    • Rafique S, Guardascione M, Osman E, Burroughs AK, and Owen JS. Reversal of extrahepatic membrane cholesterol deposition in patients with chronic liver diseases by Sadenosyl-l-methionine. Clin Sci (Lond) 83: 353-356, 1992.
    • (1992) Clin Sci (Lond) , vol.83 , pp. 353-356
    • Rafique, S.1    Guardascione, M.2    Osman, E.3    Burroughs, A.K.4    Owen, J.S.5
  • 118
    • 0041326831 scopus 로고    scopus 로고
    • Effects of age and caloric restriction on glutathione redox state in mice
    • Rebrin I, Kamzalov S, and Sohal RS. Effects of age and caloric restriction on glutathione redox state in mice. Free Radic Biol Med 35: 626-635, 2003.
    • (2003) Free Radic Biol Med , vol.35 , pp. 626-635
    • Rebrin, I.1    Kamzalov, S.2    Sohal, R.S.3
  • 119
    • 6944220226 scopus 로고    scopus 로고
    • Comparison of thiol redox state of mitochondria and homogenates of various tissues between two strains of mice with different longevities
    • Rebrin I and Sohal RS. Comparison of thiol redox state of mitochondria and homogenates of various tissues between two strains of mice with different longevities. Exp Gerontol 39: 1513-1519, 2004.
    • (2004) Exp Gerontol , vol.39 , pp. 1513-1519
    • Rebrin, I.1    Sohal, R.S.2
  • 122
    • 33645765312 scopus 로고    scopus 로고
    • Diabetes and mitochondrial function: Role of hyperglycemia and oxidative stress
    • Rolo AP and Palmeira CM. Diabetes and mitochondrial function: role of hyperglycemia and oxidative stress. Toxicol Appl Pharmacol 212: 167-178, 2006.
    • (2006) Toxicol Appl Pharmacol , vol.212 , pp. 167-178
    • Rolo, A.P.1    Palmeira, C.M.2
  • 123
    • 0021824222 scopus 로고
    • The effect of temperature and chronic ethanol feeding on the proton electrochemical potential and phosphate potential in rat liver mitochondria
    • Rottenberg H, Robertson DE, and Rubin E. The effect of temperature and chronic ethanol feeding on the proton electrochemical potential and phosphate potential in rat liver mitochondria. Biochim Biophys Acta 809: 1-10, 1985.
    • (1985) Biochim Biophys Acta , vol.809 , pp. 1-10
    • Rottenberg, H.1    Robertson, D.E.2    Rubin, E.3
  • 124
    • 0036142543 scopus 로고    scopus 로고
    • Tumor necrosis factor alpha, but not Fas, mediates hepatocellular apoptosis in the murine ischemic liver
    • Rüdiger HA and Clavien PA. Tumor necrosis factor alpha, but not Fas, mediates hepatocellular apoptosis in the murine ischemic liver. Gastroenterology 122: 202-210, 2002.
    • (2002) Gastroenterology , vol.122 , pp. 202-210
    • Rüdiger Ha, C.1
  • 125
    • 0346874206 scopus 로고    scopus 로고
    • Sub-lethal oxidative stress triggers the protective effects of ischemic preconditioning in the mouse liver
    • Rüdiger HA, Graf R, and Clavien PA. Sub-lethal oxidative stress triggers the protective effects of ischemic preconditioning in the mouse liver. J Hepatol 39: 972-977, 2003.
    • (2003) J Hepatol , vol.39 , pp. 972-977
    • Rüdiger, H.A.1    Graf, R.2    Clavien, P.A.3
  • 126
    • 0037362890 scopus 로고    scopus 로고
    • HIF hydroxylation and the mammalian oxygen-sensing pathway
    • Safran M and Kaelin WG Jr. HIF hydroxylation and the mammalian oxygen-sensing pathway. J Clin Invest 111: 779-783, 2003.
    • (2003) J Clin Invest , vol.111 , pp. 779-783
    • Safran, M.1    Kaelin Jr., W.G.2
  • 127
    • 0038755458 scopus 로고    scopus 로고
    • Diabetes and mitochondrial oxidative stress: A study using heart mitochondria from the diabetic Goto-Kakizaki rat
    • Santos DL, Palmeira CM, Seica R, Dias J, Mesquita J, Moreno AJ, and Santos MS. Diabetes and mitochondrial oxidative stress: a study using heart mitochondria from the diabetic Goto-Kakizaki rat. Mol Cell Biochem 246: 163-170, 2003.
    • (2003) Mol Cell Biochem , vol.246 , pp. 163-170
    • Santos, D.L.1    Palmeira, C.M.2    Seica, R.3    Dias, J.4    Mesquita, J.5    Moreno, A.J.6    Santos, M.S.7
  • 128
    • 34347352096 scopus 로고    scopus 로고
    • Cisplatin-induced nephrotoxicity is associated with oxidative stress, redox state unbalance, impairment of energetic metabolism and apoptosis in rat kidney mitochondria
    • Santos NA, Catão CS, Martins NM, Curti C, Bianchi ML, and Santos AC. Cisplatin-induced nephrotoxicity is associated with oxidative stress, redox state unbalance, impairment of energetic metabolism and apoptosis in rat kidney mitochondria. Arch Toxicol 81: 495-504, 2007.
    • (2007) Arch Toxicol , vol.81 , pp. 495-504
    • Santos, N.A.1    Catão, C.S.2    Martins, N.M.3    Curti, C.4    Bianchi, M.L.5    Santos, A.C.6
  • 129
    • 35348916616 scopus 로고    scopus 로고
    • Molecular biology of glutathione peroxidase 4: From genomic structure to developmental expression and neural function
    • Savaskan NE, Ufer C, Kühn H, and Borchert A. Molecular biology of glutathione peroxidase 4: from genomic structure to developmental expression and neural function. Biol Chem 388: 1007-1017, 2007.
    • (2007) Biol Chem , vol.388 , pp. 1007-1017
    • Savaskan, N.E.1    Ufer, C.2    Kühn, H.3    Borchert, A.4
  • 130
    • 0032832881 scopus 로고    scopus 로고
    • Differences between CD95 type I and type II cells detected with the CD95 ligand [1]
    • Schmitz I, Walczak H, Krammer PH, and Peter ME. Differences between CD95 type I and II cells detected with the CD95 ligand. Cell Death Differ 6: 821-822, 1999. (Pubitemid 29488078)
    • (1999) Cell Death and Differentiation , vol.6 , Issue.9 , pp. 821-822
    • Schmitz, I.1    Walczak, H.2    Krammer, P.H.3    Peter, M.E.4
  • 132
    • 41149115123 scopus 로고    scopus 로고
    • The role of oxygen availability in embryonic development and stem cell function
    • Simon MC and Keith B. The role of oxygen availability in embryonic development and stem cell function. Nat Rev Mol Cell Biol 9: 285-296, 2008.
    • (2008) Nat Rev Mol Cell Biol , vol.9 , pp. 285-296
    • Simon, M.C.1    Keith, B.2
  • 133
    • 0036175596 scopus 로고    scopus 로고
    • Mitochondrial contributions to tissue damage in stroke
    • Sims NR and Anderson MF. Mitochondrial contributions to tissue damage in stroke. Neurochem Int 40: 511-526, 2002.
    • (2002) Neurochem Int , vol.40 , pp. 511-526
    • Sims, N.R.1    Anderson, M.F.2
  • 134
    • 10244261598 scopus 로고    scopus 로고
    • Mitochondrial glutathione: A modulator of brain cell death
    • Sims NR, Nilsson M, and Muyderman H. Mitochondrial glutathione: a modulator of brain cell death. J Bioenerg Biomembr 36: 329-333, 2004.
    • (2004) J Bioenerg Biomembr , vol.36 , pp. 329-333
    • Sims, N.R.1    Nilsson, M.2    Muyderman, H.3
  • 136
    • 4444276735 scopus 로고    scopus 로고
    • Clearance of Alzheimer's Ab peptide: The many roads to perdition
    • Tanzi RE, Moir RD, and Wagne SL. Clearance of Alzheimer's Ab peptide: the many roads to perdition. Neuron 43: 605-608, 2004.
    • (2004) Neuron , vol.43 , pp. 605-608
    • Tanzi, R.E.1    Moir, R.D.2    Wagne, S.L.3
  • 137
    • 1242336977 scopus 로고    scopus 로고
    • Dual role of tumor necrosis factor-alpha in hepatic ischemia-reperfusion injury: Studies in tumor necrosis factor-alpha gene knockout mice
    • Teoh N, Field J, Sutton J, and Farrell G. Dual role of tumor necrosis factor-alpha in hepatic ischemia-reperfusion injury: studies in tumor necrosis factor-alpha gene knockout mice. Hepatology 39: 412-421, 2004.
    • (2004) Hepatology , vol.39 , pp. 412-421
    • Teoh, N.1    Field, J.2    Sutton, J.3    Farrell, G.4
  • 138
    • 0023160654 scopus 로고
    • Effects of ethanol on proteins of mitochondrial membranes
    • Thayer WS. Effects of ethanol on proteins of mitochondrial membranes. Ann N Y Acad Sci 492: 193-206, 1987.
    • (1987) Ann N y Acad Sci , vol.492 , pp. 193-206
    • Thayer, W.S.1
  • 139
    • 0024345539 scopus 로고
    • Subcellular binding and effects on calcium homeostasis produced by acetaminophen and a nonhepatotoxic regioisomer, 3′-hydroxyacetanilide, in mouse liver
    • Tirmenstein MA and Nelson SD. Subcellular binding and effects on calcium homeostasis produced by acetaminophen and a nonhepatotoxic regioisomer, 3′-hydroxyacetanilide, in mouse liver. J Biol Chem 264: 9814-9819, 1989.
    • (1989) J Biol Chem , vol.264 , pp. 9814-9819
    • Tirmenstein, M.A.1    Nelson, S.D.2
  • 140
    • 0028978032 scopus 로고
    • Phosphorylation of human i kappa Balpha on serines 32 and 36 controls i kappa B-alpha proteolysis and NF-kappa B activation in response to diverse stimuli
    • Traenckner EB, Pahl HL, Henkel T, Schmidt KN, Wilk S, and Baeuerle PA. Phosphorylation of human I kappa Balpha on serines 32 and 36 controls I kappa B-alpha proteolysis and NF-kappa B activation in response to diverse stimuli. EMBO J 14: 2876-2883, 1995.
    • (1995) EMBO J , vol.14 , pp. 2876-2883
    • Traenckner, E.B.1    Pahl, H.L.2    Henkel, T.3    Schmidt, K.N.4    Wilk, S.5    Baeuerle, P.A.6
  • 142
    • 0030601829 scopus 로고    scopus 로고
    • Effect of acetaminophen administration on hepatic glutathione compartmentation and mitochondrial energy metabolism in the rat
    • Vendemiale G, Grattagliano I, Altomare E, Turturro N, and Guerrieri F. Effect of acetaminophen administration on hepatic glutathione compartmentation and mitochondrial energy metabolism in the rat. Biochem Pharmacol 52: 1147-1154, 1996.
    • (1996) Biochem Pharmacol , vol.52 , pp. 1147-1154
    • Vendemiale, G.1    Grattagliano, I.2    Altomare, E.3    Turturro, N.4    Guerrieri, F.5
  • 143
    • 0036320934 scopus 로고    scopus 로고
    • Cellular adaptation to hypoxia: O2-sensing protein hydroxylases, hypoxia-inducible transcription factors, and O2-regulated gene expression
    • Wenger RH. Cellular adaptation to hypoxia: O2-sensing protein hydroxylases, hypoxia-inducible transcription factors, and O2-regulated gene expression. FASEB J 16: 1151-1162, 2002.
    • (2002) FASEB J , vol.16 , pp. 1151-1162
    • Wenger, R.H.1
  • 145
    • 0033772113 scopus 로고    scopus 로고
    • Decreased prevalence of Alzheimer disease associated with 3-hydroxy-3-methyglutaryl coenzyme A reductase inhibitors
    • Wolozin B, Kellman W, Ruosseau P, Celesia GG, and Siegel G. Decreased prevalence of Alzheimer disease associated with 3-hydroxy-3-methyglutaryl coenzyme A reductase inhibitors. Arch Neurol 57: 1439-1443, 2000.
    • (2000) Arch Neurol , vol.57 , pp. 1439-1443
    • Wolozin, B.1    Kellman, W.2    Ruosseau, P.3    Celesia, G.G.4    Siegel, G.5
  • 146
    • 0344603640 scopus 로고    scopus 로고
    • Glutathione depletion and neuronal cell death: The role of reactive oxygen intermediates and mitochondrial function
    • Wüllner U, Seyfried J, Groscurth P, Beinroth S, Winter S, Gleichmann M, Heneka M, Löschmann P, Schulz JB, Weller M, and Klockgether T. Glutathione depletion and neuronal cell death: the role of reactive oxygen intermediates and mitochondrial function. Brain Res 826: 53-62, 1999.
    • (1999) Brain Res , vol.826 , pp. 53-62
    • Wüllner, U.S.1
  • 149
    • 33846418007 scopus 로고    scopus 로고
    • Characterization of intracellular elevation of glutathione (GSH) with glutathione monoethyl ester and GSH in brain and neuronal cultures: Relevance to Parkinson's disease
    • Zeevalk GD, Manzino L, Sonsalla PK, and Bernard LP. Characterization of intracellular elevation of glutathione (GSH) with glutathione monoethyl ester and GSH in brain and neuronal cultures: relevance to Parkinson's disease. Exp Neurol 203: 512-520, 2007.
    • (2007) Exp Neurol , vol.203 , pp. 512-520
    • Zeevalk, G.D.1    Manzino, L.2    Sonsalla, P.K.3    Bernard, L.P.4
  • 150
    • 0036322172 scopus 로고    scopus 로고
    • Selective mitochondrial glutathione depletion by ethanol enhances acetaminophen toxicity in rat liver
    • Zhao P, Kalhorn TF, and Slattery JT. Selective mitochondrial glutathione depletion by ethanol enhances acetaminophen toxicity in rat liver. Hepatology 36: 326-335, 2002.
    • (2002) Hepatology , vol.36 , pp. 326-335
    • Zhao, P.1    Kalhorn, T.F.2    Slattery, J.T.3
  • 151
    • 0036891947 scopus 로고    scopus 로고
    • Effects of ethanol dose and ethanol withdrawal on rat liver mitochondrial glutathione: Implication of potentiated acetaminophen toxicity in alcoholics
    • Zhao P and Slattery JT. Effects of ethanol dose and ethanol withdrawal on rat liver mitochondrial glutathione: implication of potentiated acetaminophen toxicity in alcoholics. Drug Metab Dispos 30: 1413-1417, 2002.
    • (2002) Drug Metab Dispos , vol.30 , pp. 1413-1417
    • Zhao, P.1    Slattery, J.T.2
  • 152
    • 0344153290 scopus 로고    scopus 로고
    • Caspases: The enzymes of death
    • Zhivotovsky B. Caspases: the enzymes of death. Essays Biochem 39: 25-40, 2003.
    • (2003) Essays Biochem , vol.39 , pp. 25-40
    • Zhivotovsky, B.1
  • 153
    • 43949146899 scopus 로고    scopus 로고
    • Hepatic mitochondrial transport of glutathione: Studies in isolated rat liver mitochondria and H4IIE rat hepatoma cells
    • Zhong Q, Putt DA, Xu F, and Lash LH. Hepatic mitochondrial transport of glutathione: studies in isolated rat liver mitochondria and H4IIE rat hepatoma cells. Arch Biochem Biophys 474: 119-127, 2008.
    • (2008) Arch Biochem Biophys , vol.474 , pp. 119-127
    • Zhong, Q.1    Putt, D.A.2    Xu, F.3    Lash, L.H.4
  • 154
    • 0031706322 scopus 로고    scopus 로고
    • Ischemia=reperfusion injury in the liver of BALB=c mice activates AP-1 and nuclear factor kB independently of IkB degradation
    • Zwaka R, Zhang Y, Zhou W, Halldorson J, and Engelhardt JE. Ischemia=reperfusion injury in the liver of BALB=c mice activates AP-1 and nuclear factor kB independently of IkB degradation. Hepatology 28: 1022-1030, 1998.
    • (1998) Hepatology , vol.28 , pp. 1022-1030
    • Zwaka, R.1    Zhang, Y.2    Zhou, W.3    Halldorson, J.4    Engelhardt, J.E.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.