Targeted Mutation of the MLN64 START Domain Causes only Modest Alterations in Cellular Sterol Metabolism

Journal of Biological Chemistry

Volumn 279, Issue 18, 2004, Pages 19276-19285

  Kishida, Tatsuro ^a   Kostetskii, Igor ^a   Zhang, Zhibing ^a   Martinez, Federico ^a   Liu, Pei ^a   Walkley, Steven U ^b   Dwyer, Nancy K ^a   Blanchette Mackie, E Joan ^c   Radice, Glenn L ^a   Strauss III, Jerome F ^a,d  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^c NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

^d Center for Research on Reproduction and Women's Health   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELLS; CHOLESTEROL; LIPIDS; PROTEINS;

STEROL DISTRIBUTION; TARGETED MUTATIONS;

BIOCHEMISTRY;

BINDING PROTEIN; CHOLESTEROL; PREGNENOLONE; PROTEIN MLN64; PROTEIN NPC1; PROTEIN NPC2; STEROIDOGENIC ACUTE REGULATORY PROTEIN; STEROL; UNCLASSIFIED DRUG;

ALLELE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CHOLESTEROL TRANSPORT; CONTROLLED STUDY; DEGENERATIVE DISEASE; ENDOSOME; FEMALE; FERTILITY; GENE EXPRESSION; GRANULOSA CELL; HOMOZYGOSITY; LIPID BLOOD LEVEL; LIPID DIET; LIPID LIVER LEVEL; LIPID TRANSPORT; LYSOSOME; MALE; MITOCHONDRION; MOUSE; MUTATION; NONHUMAN; NUCLEOTIDE SEQUENCE; PHENOTYPE; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN LOCALIZATION; STEROL METABOLISM;

ANIMALS; BIOLOGICAL TRANSPORT; CHOLESTEROL; FEMALE; FERTILITY; GENE EXPRESSION PROFILING; LIPIDS; LIVER; MICE; MICE, KNOCKOUT; MUTATION; PHENOTYPE; PHOSPHOPROTEINS; PROTEIN STRUCTURE, TERTIARY; RNA, MESSENGER; STEROLS;

ANIMALIA; MAMMALIA;

EID: 2442439970     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M400717200     Document Type: Article

References (37)

1. Christenson, L. K., and Strauss, J. F., III (2000) Biochim. Biophys. Acta 1529, 175-187
2. Soccio, R. E., and Breslow, J. L. (2003) J. Biol. Chem. 278, 22183-22186
3. Hanada, K., Kumagai, K., Yasuda, S., Miura, Y., Kawano, M., Fukasawa, M., and Nishijima, M. (2003) Nature 426, 803-809
4. Soccio, R. E., Adams, R. M., Romanowski, M. J., Sehayek, E., Burley, S. K., and Breslow, J. L. (2002) Proc. Natl. Acad. Sci. U. S. A. 99, 6943-6948
5. Arakane, F., Kallen, C. B., Watari, H., Foster, J. A., Sepuri, N. B., Pain, D., Stayrook, S. E., Lewis, M., Gerton, G. L., and Strauss, J. F., III (1998) J. Biol. Chem. 273, 16339-16345
6. Kallen, C. B., Billheimer, J. T., Summers, S. A., Stayrook, S. E., Lewis, M., and Strauss, J. F., III (1998) J. Biol. Chem. 273, 26285-26288
7. Lin, D., Sugawara, T., Strauss, J. F., III, Clark, B. J., Stocco, D. M., Sanger, P., Rogol, A., and Miller, W. L. (1995) Science 267, 1828-1831
8. Caron, K. M., Soo, S. C., Wetsel, W. C., Stocco, D. M., Clark, B. J., and Parker, K. L. (1997) Proc. Natl. Acad. Sci. U. S. A. 94, 11540-11545
9. Ponting, C. P., and Aravind, L. (1999) Trends Biochem. Sci. 24, 130-132
10. Tsujishita, Y., and Hurley, J. H. (2000) Nat. Struct. Biol. 7, 408-414
11. Romanowski, M. J., Soccio, R. E., Breslow, J. L., and Burley, S. K. (2002) Proc. Natl. Acad. Sci. U. S. A. 99, 6949-6954
12. Roderick, S. L., Chan, W. W., Agate, D. S., Olsen, L. R., Vetting, M. W., Rajashankar, K. R., and Cohen, D. E. (2002) Nat. Struct. Biol. 9, 507-511
13. Moog-Lutz, C., Tomasetto, C., Regnier, C. H., Wendling, C., Lutz, Y., Muller, D., Chenard, M. P., Basset, P., and Rio, M. C. (1997) Int. J. Cancer 71, 183-191
14. Watari, H., Arakane, F., Moog-Lutz, C., Kallen, C. B., Tomasetto, C., Gerton, G. L., Rio, M. C., Baker, M. E., and Strauss, J. F., III (1997) Proc. Natl. Acad. Sci. U. S. A. 94, 8462-8467
15. Zhang, M., Liu, P., Dwyer, N. K., Christenson, L. K., Fujimoto, T., Martinez, F., Comly, M., Hanover, J. A., Blanchette-Mackie, E. J., and Strauss, J. F., III (2002) J. Biol. Chem. 277, 33300-33310
16. Alpy, F., Stoeckel, M. E., Dierich, A., Escola, J. M., Wendling, C., Chenard, M. P., Vanier, M. T., Gruenberg, J., Tomasetto, C., and Rio, M. C. (2001) J. Biol. Chem. 276, 4261-4269
17. Carstea, E. D., Morris, J. A., Coleman, K. G., Loftus, S. K., Zhang, D., Cummings, C., Gu, J., Rosenfeld, M. A., Pavan, W. J., Krizman, D. B., Nagle, J., Polymeropoulos, M. H., Sturley, S. L., Ioannou, Y. A., Higgins, M. E., Comly, M., Cooney, A., Brown, A., Kaneski, C. R., Blanchette-Mackie, E. J., Dwyer, N. K., Neufeld, E. B., Chang, T. Y., Liscum, L., et al. (1997) Science 277, 228-231
18. Loftus, S. K., Morris, J. A., Carstea, E. D., Gu, J. Z., Cummings, C., Brown, A., Ellison, J., Ohno, K., Rosenfeld, M. A., Tagle, D. A., Pentchev, P. G., and Pavan, W. J. (1997) Science 277, 232-235
19. Naureckiene, S., Sleat, D. E., Lackland, H., Fensom, A., Vanier, M. T., Wattiaux, R., Jadot, M., and Lobel, P. (2000) Science 290, 2298-2301
20. Frolov, A., Srivastava, K., Daphna-Iken, D., Traub, L. M., Schaffer, J. E., and Ory, D. S. (2001) J. Biol. Chem. 276, 46414-46421
21. Millard, E. E., Srivastava, K., Traub, L. M., Schaffer, J. E., and Ory, D. S. (2000) J. Biol. Chem. 275, 38445-38451
22. Cruz, J. C., and Chang, T. Y. (2000) J. Biol. Chem. 275, 41309-41316
23. Cruz, J. C., Sugii, S., Yu, C., and Chang, T. Y. (2000) J. Biol. Chem. 275, 4013-4021
24. Karten, B., Vance, D. E., Campenot, R. B., and Vance, J. E. (2002) J. Neurochem. 83, 1154-1163
25. Karten, B., Vance, D. E., Campenot, R. B., and Vance, J. E. (2003) J. Biol. Chem. 278, 4168-4175
26. Xie, C., Turley, S. D., Pentchev, P. G., and Dietschy, J. M. (1999) Am. J. Physiol. 276, E336-E344
27. Neufeld, E. B., Wastney, M., Patel, S., Suresh, S., Cooney, A. M., Dwyer, N. K., Roff, C. F., Ohno, K., Morris, J. A., Carstea, E. D., Incardona, J. P., Strauss, J. F., III, Vanier, M. T., Patterson, M. C., Brady, R. O., Pentchev, P. G., and Blanchette-Mackie, E. J. (1999) J. Biol. Chem. 274, 9627-9635
28. Mountford, P., Zevnik, B., Duwel, A., Nichols, J., Li, M., Dani, C., Robertson, M., Chambers, I., and Smith, A. (1994) Proc. Natl. Acad. Sci. U. S. A. 91, 4303-4307
29. Bartlett, E. M., and Lewis, D. H. (1970) Anal. Biochem. 36, 159-167
30. George, E. L., and Hynes, R. O. (1994) Methods Enzymol. 245, 386-420
31. Matsuo, H., and Strauss, J. F., III (1994) Endocrinology 135, 1135-1145
32. Zervas, M., Dobrenis, K., and Walkley, S. U. (2001) J. Neuropathol. Exp. Neurol. 60, 49-64
33. Cheema, S. K., Cikaluk, D., and Agellon, L. B. (1997) J. Lipid Res. 38, 315-323
34. Shen, W. J., Patel, S., Natu, V., Hong, R., Wang, J., Azhar, S., and Kraemer, F. B. (2003) J. Biol. Chem. 278, 43870-43876
35. Wiegand, V., Chang, T. Y., Strauss, J. F., III, Fahrenholz, F., and Gimpl, G. (2003) FASEB J. 17, 782-784
36. Alpy, F., Wendling, C., Rio, M. C., and Tomasetto, C. (2002) J. Biol. Chem. 277, 50780-50787
37. van Helvoort, A., de Brouwer, A., Ottenhoff, R., Brouwers, J. F., Wijnholds, J., Beijnen, J. H., Rijneveld, A., van der Poll, T., van der Valk, M. A., Majoor, D., Voorhout, W., Wirtz, K. W., Elferink, R. P., and Borst, P. (1999) Proc. Natl. Acad. Sci. U. S. A. 96, 11501-11506