The determination and analysis of site-specific rates of mitochondrial reactive oxygen species production

Methods in Enzymology

Volumn 526, Issue , 2013, Pages 189-217

  Quinlan, Casey L ^a   Perevoschikova, Irina V ^a   Goncalves, Renata L S ^a   Hey Mogensen, Martin ^a,b   Brand, Martin D ^a  

^a BUCK INSTITUTE FOR RESEARCH ON AGING   (United States)

^b UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

Complex; Electron transferring flavoprotein; Glycerol 3 phosphate dehydrogenase; Hydrogen peroxide; I; II; III; NADH; Superoxide; Ubiquinone

Indexed keywords

ANTIOXIDANT; CATALASE; GLYCEROL 3 PHOSPHATE DEHYDROGENASE; HYDROGEN PEROXIDE; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE); RESORUFIN; SUCCINATE DEHYDROGENASE (UBIQUINONE); SUPEROXIDE; UBIQUINOL CYTOCHROME C REDUCTASE;

ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; MEMBRANE PERMEABILITY; MITOCHONDRION; NONHUMAN; OXIDATION; PRIORITY JOURNAL; RESPIRATORY CHAIN; SIGNAL TRANSDUCTION; SKELETAL MUSCLE; STOICHIOMETRY;

EID: 84879774696     PISSN: 00766879     EISSN: 15577988     Source Type: Book Series    
DOI: 10.1016/B978-0-12-405883-5.00012-0     Document Type: Chapter

References (86)

1. V. Adam-Vizi, and C. Chinopoulos Bioenergetics and the formation of mitochondrial reactive oxygen species Trends in Pharmacological Sciences 27 2006 639 645
2. C.L. Affourtit, C.L. Quinlan, and M.D. Brand Measurement of proton leak and electron leak in isolated mitochondria Methods in Molecular Biology 810 2012 165 182
3. o site of the mitochondrial complex III is required for the transduction of hypoxic signaling via reactive oxygen species production The Journal of Cell Biology 177 2007 1029 1036
4. M.J. Boden, A.E. Brandon, J.D. Tid-Ang, E. Preston, D. Wilks, and E. Stuart Overexpression of manganese superoxide dismutase ameliorates high-fat diet-induced insulin resistance in rat skeletal muscle American Journal of Physiology. Endocrinology and Metabolism 303 2012 E798 E805
5. A. Boveris, and E. Cadenas Mitochondrial production of superoxide anions and its relationship to the antimycin insensitive respiration FEBS Letters 54 1975 311 314
6. A. Boveris, E. Martino, and A.O.M. Stoppani Evaluation of the horseradish peroxidase-scopoletin method for the measurement of hydrogen peroxide formation in biological systems Analytical Biochemistry 80 1977 145 158
7. A. Boveris, N. Oshino, and B. Chance The cellular production of hydrogen peroxide The Biochemical Journal 128 1972 617 630
8. M.D. Brand The sites and topology of mitochondrial superoxide production Experimental Gerontology 45 2010 466 472
9. G.P. Brotea, and R.J. Thibert Fluorometric determination of hydrogen peroxide using resorufin and peroxidase Microchemical Journal 37 1988 368 376
10. G.C. Brown, and M.D. Brand Proton/electron stoichiometry of mitochondrial complex I estimated from the equilibrium thermodynamic force ratio The Biochemical Journal 252 1988 473 479
11. V.I. Bunik 2-Oxo acid dehydrogenase complexes in redox regulation European Journal of Biochemistry 270 2003 1036 1042
12. V.I. Bunik, and C. Sievers Inactivation of the 2-oxo acid dehydrogenase complexes upon generation of intrinsic radical species European Journal of Biochemistry 269 2002 5004 5015
13. A.R. Crofts The cytochrome bc1 complex: Function in the context of structure Annual Reviews of Physiology 66 2004 689 733
14. Z. Drahota, S.K. Chowdhury, D. Floryk, T. Mracek, J. Wilhelm, and H. Rauchova Glycerophosphate-dependent hydrogen peroxide production by brown adipose tissue mitochondria and its activation by ferricyanide Journal of Bioenergetics and Biomembranes 34 2002 105 113
15. 1 complex The Journal of Biological Chemistry 283 2008 21649 21654
16. S. Eaton Control of mitochondrial beta-oxidation flux Progress in Lipid Research 41 2002 197 239
17. M. Erecinska, D.F. Wilson, and Y. Miyata Mitochondrial cytochrome b-c complex: Its oxidation-reduction components and their stoichiometry Archives of Biochemistry and Biophysics 177 1976 133 143
18. W.R. Frisell, and C.G. Mackenzie Separation and purification of sarcosine dehydrogenase and dimethylglycine dehydrogenase The Journal of Biological Chemistry 237 1962 94 98
19. T. Golden, and S. Melov Mitochondrial DNA mutations, oxidative stress, and aging Mechanisms of Ageing and Development 122 2001 1577 1589
20. C.L. Hall, and J.D. Lambeth Studies on electron transfer from general acyl-CoA dehydrogenase to electron transfer flavoprotein The Journal of Biological Chemistry 255 1980 3591 3595
21. D. Han, R. Canali, D. Rettori, and N. Kaplowitz Effect of glutathione depletion on sites and topology of superoxide and hydrogen peroxide production in mitochondria Molecular Pharmacology 64 2003 1136 1144
22. 2 formation by rat heart mitochondria on substrate availability and donor age Journal of Bioenergetics and Biomembranes 29 1997 89 95
23. D. Harman Aging: A theory based on free radical and radiation chemistry Journal of Gerontology 11 1956 298 300
24. P.A. Hyslop, and L.A. Sklar A quantitative fluorimetric assay for the determination of oxidant production by polymorphonuclear leukocytes: Its use in the simultaneous fluorimetric assay of cellular activation processes Analytical Biochemistry 141 1984 280 286
25. Y. Ikeda, and K. Tanaka Purification and characterization of 2-methyl-branched chain acyl coenzyme A dehydrogenase, an enzyme involved in the isoleucine and valine metabolism, from rat liver mitochondria The Journal of Biological Chemistry 258 1983 9477 9487
26. Y. Ikeda, and K. Tanaka Purification and characterization of isovaleryl coenzyme A dehydrogenase from rat liver mitochondria The Journal of Biological Chemistry 258 1983 1077 1085
27. T. Klimova, and N.S. Chandel Mitochondrial complex III regulates hypoxic activation of HIF Cell Death and Differentiation 15 2008 660 666
28. M. Klingenberg Localization of the glycerol-phosphate dehydrogenase in the outer phase of the mitochondrial inner membrane European Journal of Biochemistry 13 1970 247 252
29. S.S. Korshunov, V.P. Skulachev, and A.A. Starkov High protonic potential actuates a mechanism of production of reactive oxygen species in mitochondria FEBS Letters 416 1997 15 18
30. Y. Kushnareva, A.N. Murphy, and A. Andreyev Complex I-mediated reactive oxygen species generation: Modulation by cytochrome c and NAD(P)+ oxidation-reduction state The Biochemical Journal 368 2002 545 553
31. L. Kussmaul, and J. Hirst The mechanism of superoxide production by NADH: Ubiquinone oxidoreductase (complex I) from bovine heart mitochondria Proceedings of the National Academy of Sciences of the United States of America 103 2006 7607 7612
32. A.J. Lambert, and M.D. Brand Inhibitors of the quinone-binding site allow rapid superoxide production from mitochondrial NADH:ubiquinone oxidoreductase (complex I) The Journal of Biological Chemistry 279 2004 39414 39420
33. A.J. Lambert, and M.D. Brand Superoxide production by NADH:ubiquinone oxidoreductase (complex I) depends on the pH gradient across the mitochondrial inner membrane The Biochemical Journal 382 2004 511 517
34. A.C. Lenich, and S.I. Goodman The purification and characterization of glutaryl-coenzyme A dehydrogenase from porcine and human liver The Journal of Biological Chemistry 261 1986 4090 4096
35. Y. Liu, G. Fiskum, and D. Schubert Generation of reactive oxygen species by the mitochondrial electron transport chain Journal of Neurochemistry 80 2002 780 787
36. J.M. McCord, and I. Fridovich Superoxide dismutase. An enzymic function for erythrocuprein (hemocuprein) The Journal of Biological Chemistry 244 1969 6049 6055
37. Y. Meng, K. High, J. Antonello, M.W. Washabaugh, and Q. Zhao Enhanced sensitivity and precision in an enzyme-linked immunosorbent assay with fluorogenic substrates compared with commonly used chromogenic substrates Analytical Biochemistry 345 2005 227 236
38. K.R. Messner, and J.A. Imlay Mechanism of superoxide and hydrogen peroxide formation by fumarate reductase, succinate dehydrogenase, and aspartate oxidase The Journal of Biological Chemistry 277 2002 42563 42571
39. P. Mitchell The protonmotive Q cycle: A general formulation FEBS Letters 59 1975 137 139
40. S. Miwa, J. St-Pierre, L. Partridge, and M.D. Brand Superoxide and hydrogen peroxide production by Drosophila mitochondria Free Radical Biology & Medicine 35 2003 938 948
41. 2 release from activated human leukocytes using a dihydroxyphenoxazine derivative Journal of Immunological Methods 202 1997 133 141
42. 1 complex Biochemistry 41 2002 7866 7874
43. F.L. Muller, Y. Liu, M.A. Abdul-Ghani, M.S. Lustgarten, A. Bhattacharya, and Y.C. Jang High rates of superoxide production in skeletal-muscle mitochondria respiring on both complex I- and complex II-linked substrates The Biochemical Journal 409 2008 491 499
44. o site of the cytochrome bc1 complex probed by superoxide production Biochemistry 42 2003 6493 6499
45. H. Nohl, and W. Jordan The metabolic fate of mitochondrial hydrogen peroxide European Journal of Biochemistry 111 1980 203 210
46. S.T. Ohnishi, K. Shinzawa-Itoh, K. Ohta, S. Yoshikawa, and T. Ohnishi New insights into the superoxide generation sites in bovine heart NADH-ubiquinone oxidoreductase (Complex I): The significance of protein-associated ubiquinone and the dynamic shifting of generation sites between semiflavin and semiquinone radicals Biochimica et Biophysica Acta 1797 2010 1901 1909
47. A.L. Orr, C.L. Quinlan, I.V. Perevoshchikova, and M.D. Brand A refined analysis of superoxide production by mitochondrial sn-glycerol 3-phosphate dehydrogenase The Journal of Biological Chemistry 287 2012 42921 42935
48. M.P. Paranagama, K. Sakamoto, H. Amino, M. Awano, H. Miyoshi, and K. Kita Contribution of the FAD and quinone binding sites to the production of reactive oxygen species from Ascaris suum mitochondrial complex II Mitochondrion 10 2010 158 165
49. I.V. Perevoshchikova, C.L. Quinlan, A.L. Orr, and M.D. Brand Sites of superoxide and hydrogen peroxide production during fatty acid oxidation in rat skeletal muscle Free Radical Biology & Medicine 2013 10.1016/j. freeradbiomed.2013.04.006 In press.
50. K.R. Pryde, and J. Hirst Superoxide is produced by the reduced flavin in mitochondrial complex I: A single, unified mechanism that applies during both forward and reverse electron transfer The Journal of Biological Chemistry 286 2011 18056 18065
51. C.L. Quinlan, A.A. Gerencser, J.R. Treberg, and M.D. Brand The mechanism of superoxide production by the antimycin-inhibited mitochondrial Q-cycle The Journal of Biological Chemistry 286 2011 31361 31372
52. C.L. Quinlan, A.L. Orr, I.V. Perevoshchikova, J.R. Treberg, B.A. Ackrell, and M.D. Brand Mitochondrial complex II can generate reactive oxygen species at high rates in both the forward and reverse reactions The Journal of Biological Chemistry 287 2012 27255 27264
53. C.L. Quinlan, J.R. Treberg, I.V. Perevoshchikova, A.L. Orr, and M.D. Brand Native rates of superoxide production from multiple sites in isolated mitochondria measured using endogenous reporters Free Radical Biology & Medicine 53 2012 1807 1817
54. S.J. Ralph, and J. Neuzil Mitochondria as targets for cancer therapy Molecular Nutrition & Food Research 53 2009 9 28
55. R.R. Ramsay, D.J. Steenkamp, and M. Husain Reactions of electron-transfer flavoprotein and electron-transfer flavoprotein: Ubiquinone oxidoreductase The Biochemical Journal 241 1987 883 892
56. M. Ristow, and S. Schmeisser Extending life span by increasing oxidative stress Free Radical Biology & Medicine 51 2011 327 336
57. J.V. Rodrigues, and C.M. Gomes Mechanism of superoxide and hydrogen peroxide generation by human electron-transfer flavoprotein and pathological variants Free Radical Biology & Medicine 53 2012 12 19
58. H. Rottenberg, R. Covian, and B.L. Trumpower Membrane potential greatly enhances superoxide generation by the cytochrome bc1 complex reconstituted into phospholipid vesicles The Journal of Biological Chemistry 284 2009 19203 19210
59. 2 production by macrophages and neutrophils with homovanillic acid and horse-radish peroxidase Journal of Immunological Methods 63 1983 347 357
60. F.J. Ruzicka, and H. Beinert A new iron-sulfur flavoprotein of the respiratory chain. A component of the fatty acid beta oxidation pathway The Journal of Biological Chemistry 252 1977 8440 8445
61. J. Rydstrom Mitochondrial NADPH, transhydrogenase and disease Biochimica et Biophysica Acta 1757 2006 721 726
62. F.Q. Schafer, and G.R. Buettner Redox environment of the cell as viewed through the redox state of the glutathione disulfide/glutathione couple Free Radical Biology & Medicine 30 2001 1191 1212
63. T.J. Schulz, K. Zarse, A. Voigt, N. Urban, M. Birringer, and M. Ristow Glucose restriction extends Caenorhabditis elegans life span by inducing mitochondrial respiration and increasing oxidative stress Cell Metabolism 6 2007 280 293
64. K. Staniek, and H. Nohl H2O2 detection from intact mitochondria as a measure for one-electron reduction of dioxygen requires a non-invasive assay system Biochimica et Biophysica Acta: Bioenergetics 1413 1999 70 80
65. 2 production by membrane potential and NAD(P)H redox state Journal of Neurochemistry 86 2003 1101 1107
66. A.A. Starkov, G. Fiskum, C. Chinopoulos, B.J. Lorenzo, S.E. Browne, and M.S. Patel Mitochondrial alpha-ketoglutarate dehydrogenase complex generates reactive oxygen species The Journal of Neuroscience 24 2004 7779 7788
67. J. St-Pierre, J.A. Buckingham, S.J. Roebuck, and M.D. Brand Topology of superoxide production from different sites in the mitochondrial electron transport chain The Journal of Biological Chemistry 277 2002 44784 44790
68. F. Sun, X. Huo, Y. Zhai, A. Wang, J. Xu, and D. Su Crystal structure of mitochondrial respiratory membrane protein complex II Cell 121 2005 1043 1057
69. 2 for platelet-derived growth factor signal transduction Science 270 1995 296 299
70. J.R. Treberg, and M.D. Brand A model of the proton translocation mechanism of complex I The Journal of Biological Chemistry 286 2011 17579 17584
71. J.R. Treberg, C.L. Quinlan, and M.D. Brand Hydrogen peroxide efflux from muscle mitochondria underestimates matrix superoxide production - A correction using glutathione depletion The FEBS Journal 277 2010 2766 2778
72. J.R. Treberg, C.L. Quinlan, and M.D. Brand Evidence for two sites of superoxide production by mitochondrial NADH-ubiquinone oxidoreductase (complex I) The Journal of Biological Chemistry 286 2011 27103 27110
73. 2 generation in brain mitochondria Journal of Neurochemistry 100 2007 650 663
74. 1 complex The Journal of Biological Chemistry 265 1990 11409 11412
75. W.H. Van den Berg, R.C. Prince, C.L. Bashford, K.I. Takamiya, W.D. Bonner Jr., and P.L. Dutton Electron and proton transport in the ubiquinone cytochrome b-c2 oxidoreductase of Rhodopseudomonas sphaeroides. Patterns of binding and inhibition by antimycin The Journal of Biological Chemistry 254 1979 8594 8604
76. A.D. Vinogradov, and V.G. Grivennikova Generation of superoxide-radical by the NADH:ubiquinone oxidoreductase of heart mitochondria Biochemistry (Moscow) 70 2005 120 127
77. T.V. Votyakova, and I.J. Reynolds DeltaPsi(m)-Dependent and -independent production of reactive oxygen species by rat brain mitochondria Journal of Neurochemistry 79 2001 266 277
78. N.J. Watmough, and F.E. Frerman The electron transfer flavoprotein: Ubiquinone oxidoreductases Biochimica et Biophysica Acta 1797 2010 1910 1916
79. 2 + stimulation of rat liver mitochondrial glycerophosphate dehydrogenase The Journal of Biological Chemistry 256 1981 12767 12771
80. I.C. West, P. Mitchell, and P.R. Rich Electron conduction between b cytochromes of the mitochondrial respiratory chain in the presence of antimycin plus myxothiazol Biochimica et Biophysica Acta 933 1988 35 41
81. M.E. Witte, J.J. Geurts, H.E. de Vries, P. van der Valk, and J. van Horssen Mitochondrial dysfunction: A potential link between neuroinflammation and neurodegeneration? Mitochondrion 10 2010 411 418
82. V. Yankovskaya, R. Horsefield, S. Tornroth, C. Luna-Chavez, H. Miyoshi, and C. Leger Architecture of succinate dehydrogenase and reactive oxygen species generation Science 299 2003 700 704
83. K. Zarse, S. Schmeisser, M. Groth, S. Priebe, G. Beuster, and D. Kuhlow Impaired insulin/IGF1 signaling extends life span by promoting mitochondrial L-proline catabolism to induce a transient ROS signal Cell Metabolism 15 2012 451 465
84. J. Zhang, F.E. Frerman, and J.J. Kim Structure of electron transfer flavoprotein-ubiquinone oxidoreductase and electron transfer to the mitochondrial ubiquinone pool Proceedings of the National Academy of Sciences of the United States America 103 2006 16212 16217
85. L. Zhang, L. Yu, and C.A. Yu Generation of superoxide anion by succinate-cytochrome c reductase from bovine heart mitochondria The Journal of Biological Chemistry 273 1998 33972 33976
86. M. Zhou, Z. Diwu, N. Panchuk-Voloshina, and R.P. Haugland A stable nonfluorescent derivative of resorufin for the fluorometric determination of trace hydrogen peroxide: Applications in detecting the activity of phagocyte NADPH oxidase and other oxidases Analytical Biochemistry 253 1997 162 168