Depletion of intracellular glutathione contributes to JNK-mediated death receptor 5 upregulation and apoptosis induction by the novel synthetic triterpenoid methyl-2-cyano-3, 12-dioxooleana-1, 9-dien-28-oate (CDDO-Me)

Cancer Biology and Therapy

Volumn 5, Issue 5, 2006, Pages 492-497

  Yue, Ping ^a   Zhou, Zhongmei ^a   Khuri, Fadlo R ^a   Sun, Shi Yong ^a  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Apoptosis; c Jun N terminal kinase (JNK); CDDO Me; Death receptor 5; Glutathione; Reactive oxygen species; Triterpenoids

Indexed keywords

ACETYLCYSTEINE; ANTIOXIDANT; ASCORBIC ACID; BUTYLATED HYDROXYANISOLE; CASPASE 8; DEATH RECEPTOR 5; DIETHYLMALEATE; DITHIOTHREITOL; GLUTATHIONE; MALEIC ACID DERIVATIVE; MANGANESE DERIVATIVE; MANGANESE TETRA(4 BENOIC ACID)PORPHYRIN CHLORIDE; MANNITOL; METHYL 2 CYANO 3,2 DIOXOOLEANA 1,9 DIEN 28 OATE; PORPHYRIN DERIVATIVE; REACTIVE OXYGEN METABOLITE; STRESS ACTIVATED PROTEIN KINASE; THIOL DERIVATIVE; TRITERPENOID; TROLOX C; UNCLASSIFIED DRUG;

ANTIOXIDANT ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CELLULAR DISTRIBUTION; DRUG ACTIVITY; DRUG MECHANISM; HUMAN; HUMAN CELL; OXIDATIVE STRESS; RECEPTOR UPREGULATION;

EID: 33646771034     PISSN: 15384047     EISSN: 15558576     Source Type: Journal    
DOI: 10.4161/cbt.5.5.2565     Document Type: Article

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