Caveolin-1 deficiency causes cholesterol-dependent mitochondrial dysfunction and apoptotic susceptibility

Current Biology

Volumn 21, Issue 8, 2011, Pages 681-686

  Bosch, Marta ^a   Marí, Montserrat ^b   Herms, Albert ^a   Fernández, Ana ^b   Fajardo, Alba ^a   Kassan, Adam ^a   Giralt, Albert ^a,c   Colell, Anna ^b   Balgoma, David ^d,e   Barbero, Elisabet ^b   González Moreno, Elena ^a   Matias, Nuria ^b   Tebar, Francesc ^a   Balsinde, Jesús ^d,e   Camps, Marta ^f   Enrich, Carlos ^a   Gross, Steven P ^g   García Ruiz, Carmen ^b   Pérez Navarro, Esther ^a,c   Fernández Checa, José C ^b,h   Pol, Albert ^a,i   more..

^a INSTITUT D INVESTIGACIONS BIOMÈDIQUES AUGUST PI I SUNYER IDIBAPS   (Spain)

^b HOSPITAL CLÍNIC   (Spain)

^c UNIVERSITY OF BARCELONA   (Spain)

^d Universidad de Valladolid y Consejo Superior de Investigaciones Científicas   (Spain)

^e INSTITUTO DE SALUD CARLOS III   (Spain)

^f INSTITUTE FOR RESEARCH IN BIOMEDICINE   (Spain)

^g UNIVERSITY OF CALIFORNIA   (United States)

^h UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

ⁱ INSTITUCIÓ CATALANA DE RECERCA I ESTUDIS AVANÇATS ICREA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

CAVEOLIN 1; CHOLESTEROL; GLUCOSE;

ANIMAL; APOPTOSIS; ARTICLE; CELL PROLIFERATION; FIBROBLAST; GENETICS; METABOLISM; MITOCHONDRIAL MEMBRANE; MITOCHONDRION; MOUSE; PHOSPHORYLATION;

ANIMALS; APOPTOSIS; CAVEOLIN 1; CELL PROLIFERATION; CHOLESTEROL; FIBROBLASTS; GLUCOSE; MICE; MITOCHONDRIA; MITOCHONDRIAL MEMBRANES; PHOSPHORYLATION;

ANIMALIA; CHICKEN ANEMIA VIRUS; MUS;

EID: 79955471276     PISSN: 09609822     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cub.2011.03.030     Document Type: Article

References (28)

1. R.G. Parton, and K. Simons The multiple faces of caveolae Nat. Rev. Mol. Cell Biol. 8 2007 185 194
2. A. Pol, R. Luetterforst, M. Lindsay, S. Heino, E. Ikonen, and R.G. Parton A caveolin dominant negative mutant associates with lipid bodies and induces intracellular cholesterol imbalance J. Cell Biol. 152 2001 1057 1070 (Pubitemid 34286080)
3. A. Pol, S. Martin, M.A. Fernández, M. Ingelmo-Torres, C. Ferguson, C. Enrich, and R.G. Parton Cholesterol and fatty acids regulate dynamic caveolin trafficking through the Golgi complex and between the cell surface and lipid bodies Mol. Biol. Cell 16 2005 2091 2105 (Pubitemid 40471974)
4. H. Cao, L. Alston, J. Ruschman, and R.A. Hegele Heterozygous CAV1 frameshift mutations (MIM 601047) in patients with atypical partial lipodystrophy and hypertriglyceridemia Lipids Health Dis. 7 2008 3
5. C.A. Kim, M. Delépine, E. Boutet, H. El Mourabit, S. Le Lay, M. Meier, M. Nemani, E. Bridel, C.C. Leite, and D.R. Bertola Association of a homozygous nonsense caveolin-1 mutation with Berardinelli-Seip congenital lipodystrophy J. Clin. Endocrinol. Metab. 93 2008 1129 1134 (Pubitemid 351540679)
6. H. Lee, D.S. Park, B. Razani, R.G. Russell, R.G. Pestell, and M.P. Lisanti Caveolin-1 mutations (P132L and null) and the pathogenesis of breast cancer: caveolin-1 (P132L) behaves in a dominant-negative manner and caveolin-1 (-/-) null mice show mammary epithelial cell hyperplasia Am. J. Pathol. 161 2002 1357 1369
7. I. Mercier, J.F. Jasmin, S. Pavlides, C. Minetti, N. Flomenberg, R.G. Pestell, P.G. Frank, F. Sotgia, and M.P. Lisanti Clinical and translational implications of the caveolin gene family: Lessons from mouse models and human genetic disorders Lab. Invest. 89 2009 614 623
8. S. Le Lay, and T.V. Kurzchalia Getting rid of caveolins: Phenotypes of caveolin-deficient animals Biochim. Biophys. Acta 1746 2005 322 333 (Pubitemid 41815026)
9. A.W. Cohen, R. Hnasko, W. Schubert, and M.P. Lisanti Role of caveolae and caveolins in health and disease Physiol. Rev. 84 2004 1341 1379 (Pubitemid 39287953)
10. M.A. Fernández, C. Albor, M. Ingelmo-Torres, S.J. Nixon, C. Ferguson, T. Kurzchalia, F. Tebar, C. Enrich, R.G. Parton, and A. Pol Caveolin-1 is essential for liver regeneration Science 313 2006 1628 1632 (Pubitemid 44414035)
11. D.C. Wallace, W. Fan, and V. Procaccio Mitochondrial energetics and therapeutics Annu. Rev. Pathol. 5 2010 297 348
12. B. Razani, J.A. Engelman, X.B. Wang, W. Schubert, X.L. Zhang, C.B. Marks, F. Macaluso, R.G. Russell, M. Li, and R.G. Pestell Caveolin-1 null mice are viable but show evidence of hyperproliferative and vascular abnormalities J. Biol. Chem. 276 2001 38121 38138
13. M.G. Vander Heiden, L.C. Cantley, and C.B. Thompson Understanding the Warburg effect: The metabolic requirements of cell proliferation Science 324 2009 1029 1033
14. S. Bonnet, S.L. Archer, J. Allalunis-Turner, A. Haromy, C. Beaulieu, R. Thompson, C.T. Lee, G.D. Lopaschuk, L. Puttagunta, and S. Bonnet A mitochondria-K+ channel axis is suppressed in cancer and its normalization promotes apoptosis and inhibits cancer growth Cancer Cell 11 2007 37 51 (Pubitemid 46054520)
15. M. Marí, F. Caballero, A. Colell, A. Morales, J. Caballeria, A. Fernandez, C. Enrich, J.C. Fernandez-Checa, and C. García-Ruiz Mitochondrial free cholesterol loading sensitizes to TNF- and Fas-mediated steatohepatitis Cell Metab. 4 2006 185 198 (Pubitemid 44307975)
16. M. Drab, P. Verkade, M. Elger, M. Kasper, M. Lohn, B. Lauterbach, J. Menne, C. Lindschau, F. Mende, and F.C. Luft Loss of caveolae, vascular dysfunction, and pulmonary defects in caveolin-1 gene-disrupted mice Science 293 2001 2449 2452 (Pubitemid 32917325)
17. E. Ikonen Cellular cholesterol trafficking and compartmentalization Nat. Rev. Mol. Cell Biol. 9 2008 125 138 (Pubitemid 351158918)
18. T. Hayashi, R. Rizzuto, G. Hajnoczky, and T.P. Su MAM: More than just a housekeeper Trends Cell Biol. 19 2009 81 88
19. R. Sano, I. Annunziata, A. Patterson, S. Moshiach, E. Gomero, J. Opferman, M. Forte, and A. d'Azzo GM1-ganglioside accumulation at the mitochondria-associated ER membranes links ER stress to Ca(2+)-dependent mitochondrial apoptosis Mol. Cell 36 2009 500 511
20. E.J. Smart, Y. Ying, W.C. Donzell, and R.G. Anderson A role for caveolin in transport of cholesterol from endoplasmic reticulum to plasma membrane J. Biol. Chem. 271 1996 29427 29435 (Pubitemid 26382662)
21. C. Jefcoate High-flux mitochondrial cholesterol trafficking, a specialized function of the adrenal cortex J. Clin. Invest. 110 2002 881 890
22. J. Montero, M. Mari, A. Colell, A. Morales, G. Basañez, C. Garcia-Ruiz, and J.C. Fernández-Checa Cholesterol and peroxidized cardiolipin in mitochondrial membrane properties, permeabilization and cell death Biochim. Biophys. Acta 1797 2010 1217 1224
23. A. Grande-García, A. Echarri, J. de Rooij, N.B. Alderson, C.M. Waterman-Storer, J.M. Valdivielso, and M.A. del Pozo Caveolin-1 regulates cell polarization and directional migration through Src kinase and Rho GTPases J. Cell Biol. 177 2007 683 694 (Pubitemid 46799839)
24. M.T. Lin, and M.F. Beal Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases Nature 443 2006 787 795 (Pubitemid 44622683)
25. H.W. Querfurth, and F.M. LaFerla Alzheimer's disease N. Engl. J. Med. 362 2010 329 344
26. E. Brouillet, C. Jacquard, N. Bizat, and D. Blum 3-Nitropropionic acid: a mitochondrial toxin to uncover physiopathological mechanisms underlying striatal degeneration in Huntington's disease J. Neurochem. 95 2005 1521 1540 (Pubitemid 41804051)
27. E. Gonzalez-Munoz, C. Lopez-Iglesias, M. Calvo, M. Palacin, A. Zorzano, and M. Camps Caveolin-1 loss-of-function accelerates GLUT4 and insulin receptor degradation in 3T3-L1 adipocytes Endocrinology 150 2009 3493 3502
28. M. Charman, B.E. Kennedy, N. Osborne, and B. Karten MLN64 mediates egress of cholesterol from endosomes to mitochondria in the absence of functional Niemann-Pick Type C1 protein J. Lipid Res. 51 2010 1023 1034