Stable over-expression of the 2-oxoglutarate carrier enhances neuronal cell resistance to oxidative stress via Bcl-2-dependent mitochondrial GSH transport

Journal of Neurochemistry

Volumn 130, Issue 1, 2014, Pages 75-86

  Wilkins, Heather M ^a   Brock, Samantha ^a   Gray, Josie J ^a   Linseman, Daniel A ^a,b,c  

^a UNIVERSITY OF DENVER   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

^c UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

Author keywords

2 oxoglutarate carrier; Bcl 2; glutathione; mitochondria; nitrosative stress; oxidative stress

Indexed keywords

2 OXOGLUTARATE CARRIER; ETACRYNIC ACID; GLUTATHIONE; HYDROGEN PEROXIDE; PEPTIDES AND PROTEINS; PROTEIN BCL 2; SMALL INTERFERING RNA; STAUROSPORINE; UNCLASSIFIED DRUG; CARRIER PROTEIN; MITOCHONDRIAL PROTEIN; OXIDIZING AGENT; OXOGLUTARATE TRANSLOCATOR;

APOPTOSIS; ARTICLE; CELL PROTECTION; CELL VIABILITY; CONTROLLED STUDY; CYTOTOXICITY; GENE SILENCING; MITOCHONDRION; MOTONEURON; NITROSATIVE STRESS; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN TRANSPORT; ANIMAL; BIOSYNTHESIS; CELL LINE; CELL SURVIVAL; GENE EXPRESSION REGULATION; METABOLISM; NERVE CELL; NEWBORN; PHYSIOLOGY; PROTEIN STABILITY; RAT; SPRAGUE DAWLEY RAT; TOXICITY;

RATTUS;

ANIMALS; ANIMALS, NEWBORN; CELL LINE; CELL SURVIVAL; GENE EXPRESSION REGULATION; GLUTATHIONE; MEMBRANE TRANSPORT PROTEINS; MITOCHONDRIAL PROTEINS; NEURONS; OXIDANTS; OXIDATIVE STRESS; PROTEIN STABILITY; PROTEIN TRANSPORT; PROTO-ONCOGENE PROTEINS C-BCL-2; RATS; RATS, SPRAGUE-DAWLEY;

EID: 84903215460     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/jnc.12709     Document Type: Article

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