CAVEOLIN-1: Role in cell signaling

Advances in Experimental Medicine and Biology

Volumn 729, Issue , 2012, Pages 29-50

  Boscher, Cécile ^a   Nabi, Ivan Robert ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

APOPTOSIS INDUCING FACTOR; APOPTOSIS REGULATORY PROTEIN; BETA CATENIN; CAVEOLIN 1; CYCLIN D1; EPIDERMAL GROWTH FACTOR RECEPTOR; INTEGRIN; LYMPHOID ENHANCER FACTOR 1; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE P60; RHO FACTOR; SCAFFOLD PROTEIN; T CELL FACTOR PROTEIN; TYROSINE KINASE RECEPTOR;

APOPTOSIS; ARTICLE; CAVEOLA; CELL COMPARTMENTALIZATION; CELL DIFFERENTIATION; CELL MIGRATION; CELL POLARITY; CELL PROLIFERATION; CELL SURVIVAL; COMPLEX FORMATION; DOWN REGULATION; FOCAL ADHESION; HUMAN; INTERNALIZATION; INTRACELLULAR SIGNALING; LIPID RAFT; MECHANOTRANSDUCTION; MEMBRANE STRUCTURE; NEGATIVE FEEDBACK; NEOPLASM; NONHUMAN; PHENOTYPIC VARIATION; POSITIVE FEEDBACK; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; UPREGULATION;

ANIMALS; CAVEOLAE; CAVEOLIN 1; CELL LINE; HUMANS; PROTEIN STRUCTURE, TERTIARY; RECEPTOR PROTEIN-TYROSINE KINASES; SIGNAL TRANSDUCTION;

EID: 84859799615     PISSN: 00652598     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-1-4614-1222-9_3     Document Type: Article

References (217)

1. Glenney JR Jr. Tyrosine phosphorylation of a 22-kDa protein is conelated with transformation by Rous sarcoma virus. J Biol Chem 1989; 264(34):20 163-20166.
2. Rothberg KG, Heuser JE, Donzell WC et al. Caveolin, a protein component of caveolae membrane coats. Cell 1992; 68(4):673-682.
3. Kurzchalia TV, Dupree P, Parton RG et al. VIP21, a 21-kD membrane protein is an integral component of trans-Golgi-network-derived transport vesicles. J Cell Biol 1992; 1 18(5):1003-1014.
4. Sargiacomo M, SudoiM, TangZetal. Signaltransducingmoleculesandglycosyl- phosphatidylinositol-linked proteins form a caveolin-rich insoluble complex in MDCK cells. J Cell Biol 1993; 122(4):789-807.
5. Scherer PE, Okamoto T, Chun M et al. Identification, sequence and expression of caveolin-2 defines a caveolin gene family. Proc Natl Acad Sci USA 1996; 930:131-135.
6. Tang Z, Scherer PE, Okamoto T et al. Molecular cloning of caveolin-3, a novel member of the caveolin gene family expressed predominantly in muscle. J Biol Chem 1996; 271(4):2255-2261.
7. Scherer PE, Lewis RY, Volonte D et al. Cell-type andtissue-specific expression ofcaveolin-2. Caveolins 1 and 2 colocalizeandforma stablehetero-oligomeric complexinvivo. JBiolChem 1997; 272(46):29337-29346.
8. Galbiati F, Volonte D, LiuJ et al. Caveolin- 1 expressionnegativelyregulates cell cycle progressionby inducing G(0) G(1) arrestviaaps3 p2 1(WAF 1 Cipl)-dependentmechanism. MolBiolCell2001; 12(8):2229-2244.
9. Woodman SE, Park DS, Cohen AW et al. Caveolin-3 knock-out mice develop a progressive cardiomyopathy and show hyperactivation of the p42 44 MAPK cascade. J Biol Chem 2002; 277(40:38988-38997.
10. Glenney JR Jr., Soppet D. Sequence and expression of caveolin, a protein component of caveolae plasma membrane domains phosphorylated on tyrosine in Rous sarcoma virus-transformed fibroblasts. Proc Natl Acad Sci USA 1992; 89(20:10517-10521.
11. Schlegel A, Lisanti MP. A molecular dissection of caveolin- 1 membrane attachment and oligomerization. Two separate regions of the caveolin- 1 C-terminal domain mediate membrane binding and oligomer oligomer interactions in vivo. J Biol Chem 2000; 275(28):21605-21617.
12. Li S, Seitz R, Lisanti MP. Phosphorylationofcaveolinby srctyrosinekinases. The alpha-isoformofcaveolin is selectively phosphorylated by v-Src in vivo. J Biol Chem 1996; 271(7):3863-3868.
13. Sanguinetti AR, Cao H, Corley Mastick C. Fyn is required for oxidative- and hyperosmotic-stress-induced tyrosine phosphorylation of caveolin-1. Biochem J 2003; 376(Pt 0:159-168.
14. Sanguinetti AR, Mastick CC. c-Abl is required for oxidative stress-induced phosphorylation of caveolin-1 ontyrosine 14. Cell Signal 2003; 15(3):289-298.
15. Lee H, Volonte D, Galbiati F et al. Constitutive and growth factor-regulated phosphorylation of caveolin- 1 occurs at the same site (Tyr- 14) in vivo: Identification of a c-Src Cay-i Grb7 signaling cassette. Molecular endocrinology (Baltimore, Md 2000; 14(11): 1750-1775.
16. Radel C. Rizzo V. Integrin mechanotransduction stimulates caveolin-1 phosphorylation and recruitment of Csk to mediate actin reorganization. Am J Physiol Heart Circ Physiol 2005; 288(2):H936-H945.
17. Schlegel A, Aryan P, Lisanti MP. Caveolin-1 binding to endoplasmic reticulum membranes and entry into the regulated secretory pathway are regulated by serine phosphorylation. Protein sorting at the level of the endoplasmic reticulum. J Biol Chem 2001; 276(6):4398-4408.
18. Fielding PE, Chau P, Liu D et al. Mechanism of platelet-derived growth factor-dependent caveolin-1 phosphorylation: Relationshiptosterolbindingandtheroleofserine-80. Biochemistry2004; 43(9):2578-2586.
19. Stahlhut M, van Dews B. Identification offilamin as anovel ligand for caveolin- 1: Evidence for the organization ofcaveolh-1-associatedmembrane domains by the actin cytoskeleton. Mol Biol Cell 2000; 1 lm:325-337.
20. Fernandez I, Ying Y, Albanesi Jet al. Mechanism of caveolin filament assembly. Proc Natl Acad Sci USA 2002; 99U7):lll93-lll98.
21. Richter T, Floetenmeyer M, Ferguson C et al. High-resolution 3D quantitative analysis of caveolar ultrastructure and caveola-cytoskeleton interactions. Traffic 2008; 9(6):893-909.
22. Mineo C, James OL, Smart EJ et al. Localization of epidermal growth factor-stimulated Ras Raf- 1 interaction to caveolae membrane. J Biol Chem 1996; 271(20): 11930-11935.
23. Couet J, Li S, Okamoto T et al. Identification of peptide and protein ligands for the caveolin-scaffolding domaim Jmplicationsfortheinteractionofcaveolinwithcaveolae-associatedproteins. JBiolChem 1997;272(10):6525-6533.
24. Yamamoto M, Toya Y, Schwencke C et al. Caveolin is an activator of insulin receptor signaling. J Biol Chem 1998; 273(40:26962-26968.
25. Venema VJ, Zou R, Ju H et al. Caveolin- 1 detergent solubility and association with endothelial nitric oxide synthaseismodulatedbytyrosinephosphorylation. BiochemBiophys Res Commun 1997; 2360: 155-161.
26. Murata M, Peranen J, Schreiner Ret al. VIP21 caveolin is a cholesterol-binding protein. Proc Natl Acad Sci USA 1995; 92(22): 10339-10343.
27. Uittenbogaard A, Ying Y, Smart EJ. Characterization of a cytosolic heat-shock protein-caveolin chaperone complex. Involvement in cholesterol trafficking. J Biol Chem 1998; 273(10):6525-6532.
28. Pol A, Luetterforst R, Lindsay M et al. A caveolin dominant negative mutant associates with lipid bodies and induces intracellular cholesterol imbalance. J Cell Biol 2001; 152(5):1057-1070.
29. Tagawa A, Mezzacasa A, Hayer A et al. Assembly and trafficking of caveolar domains in the cell: Caveolae as stable, cargo-triggered, vesicular transporters. J Cell Biol 2005; 170(5):769-779.
30. Uittenbogaard A, Smart EJ. Palmitoylation of caveolin-1 is required for cholesterol binding, chaperone complexformationandrapidtransportofcholesteroltocaveolae. JBiolChem2000; 275(33):25595-25599.
31. Lee H, Woodman SE, Engelman JA etal. Pahnitoylationofcaveolh-1 atasingle site (Cys-156) controls its coupling tothe c-Srctyrosinekinase: Targeting ofduallyacylatedmolecules (GPI-linlced,transmembrane, orcytoplasmic) to caveolae effectively uncouples c-Src and caveolin-1 (TYR-14). J Biol Chem 2001; 276(37):3S, 150-35158.
32. Parasassi T. Gratton E. YuWM et al. Two-photonfluorescencemicroscopy oflaurdangeneralizedpolarization domains in model and natural membranes. Biophys J 1997; 72(6):2413-2429.
33. Hope HR, Pike U. Phosphoinositides and phosphoinositide-utilizing enzymes in detergent-insoluble lipid domains. Mol Biol Cell 1996; 7(6):843-851.
34. WaughMG, LawsonD, TanSKetal. Phosphatidylinositol4-phosphate synthesis inirnmunoisolatedcaveolae-like vesicles and low buoyant density noncaveolar membranes. J Biol Chem 1998; 273(27): 17115-17121.
35. Huang S, Lifshitz L, Patki-Kamath Vetal. Phosphatidylinositol-4, 5-bisphosphate-rich plasmamembrane patches organizeactivezonesofendocytosisandrufflinginculturedadipocytes. MolCellBiol2004; 24(20):9102-9123.
36. Epand RM, Vuong P, Yip CM et al. Cholesterol-dependent partitioning of Ptdlns(4,5)P2 into membrane domains by the N-terminal fragment of NAP-22 (neuronal axonal myristoylated membrane protein of 22 kDa). Biochem J 2004; 379(Pt 3):527-532.
37. Rozelle AL, Machesky LM, Yamamoto Metal. Phosphatidylinositol 4,5-bisphosphate induces actin-based movement of rafi-enriched vesicles through WASP-Arp2 3. Cun Biol 2000; 10(6):31 1-320.
38. Dupree P, Parton RG, Raposo Get al. Caveolae and sorting in the trans-Golgi network of epithelial cells. EMBO J 1993; 12(4):1597-1605.
39. Parton RG, Hanzal-Bayer M, Hancock JF. Biogenesis of caveolae: A structural model for caveolin-induced domain formation. J Cell Sci 2006; 1 19(Pt 5):787-796.
40. Hayer A, Stoeber M, Bissig C et al. Biogenesis of Caveolae: Stepwise Assembly of Large Caveolin and Cavin Complexes. Traffic 2009.
41. Hill MM, Bastiani M, Luetterforst R et al. PTRF-Cavin, a conserved cytoplasmic protein required for caveola formation and ffinction. Cell 2008; 1320:1 13-124.
42. Nabi JR. Cavin fever: Regulating caveolae. Nat Cell Biol 2009; 1 1(7):789-791.
43. Lajoie P, Goetz JG, Dennis JW et al. Lattices, rafis and scaffolds: Domain regulation of receptor signaling at the plasma membrane. J Cell Biol 2009; 185(3):381-385.
44. Monier S, Parton RG, Vogel F et al. VIP21-caveolin, a membrane protein constituent of the caveolar coat, oligomerizes in vivo and in vitro. Mol Biol Cell 1995; 6(7):9 11-927.
45. Sargiacomo M, Scherer PE, Tang Z et al. Oligomeric structure of caveolin: Implications for caveolae membrane organization. Proc Natl Acad Sci USA 1995; 92(20):9407-941 1.
46. Bauer PM, Yu J, Chen Y et al. Endothelial-specific expression of caveolin-1 impairs microvascular permeability and angiogenesis. Proc Natl Acad Sci USA 2005; 1020:204-209.
47. Bernatchez PN, Bauer PM, Yu J et al. Dissecting the molecular control of endothelial NO synthase by caveolin-1 using cell-permeable peptides. Proc Natl Acad Sci USA 2005; 102(3):761-766.
48. Bilderback TR, Gazula VR, Lisanti MP et al. Caveolin interacts with Trk A and p75(NTR) and regulates neurotrophin signaling pathways. J Biol Chem 1999; 2740:257-263.
49. Breuza L, Corby S, Arsanto JP et al. The scaffolding domain of caveolin 2 is responsible for its Golgi localization in Caco2 cells. J Cell Sci 2002; 115(Pt 23):4457-4467.
50. Lajoie P, Partridge EA, Quay O et al. Plasma membrane domain organization regulates EGFR signaling in tumor cells. J Cell Biol 2007; 179(2):341-356.
51. Kusumi A, Nakada C, Ritchie K etal. Paradigm shifi of the plasmamembrane concept fromthe two-dimensional continuum fluid to the partitioned fluid: High-speed single-molecule tracking of membrane molecules. Annual Review of Biophysics and Biomolecular Structure 2005; 34:351-378.
52. Suzuki K, Ritchie K, Kajikawa E et al. Rapid hop difffision of a 0-protein-coupled receptor in the plasma membrane as revealed by single-molecule techniques. Biophys J 2005; 88(5):3659-3680.
53. Li Y, Ying C, Zuo X et al. Green tea polyphenols down-regulate caveolin-1 expression via ERKI 2 and p38MAPK in endothelial cells. The Journal of Nutritional Biochemistry 2009; 20U2):1021-1027.
54. Tang PF, Burke GA, Li Get al. Patients with long bone fracture have altered Caveolin- 1 expression in their peripheralbloodmononuclear cells. Archives oforthopaedic andtrauma surgery 2009; 129(9): 1287-1292.
55. Zenklusen If, Weitzel IN, Ball HG et al. Allelic loss at 7q31.1 in human primary ovarian carcinomas suggests the existence of a tumor suppressor gene. Oncogene 1995; 1 1(2):359-363.
56. Engelman JA, Zhang XL, Lisanti MP. Genes encoding human caveolin-1 and -2 are colocalized to the D75522 locus (7q3 1.1), a known fragile site (FRA7G) that is frequently deleted in human cancers. FEBS Left 1998; 436(3):403-410.
57. Yang O, Truong LD, Wheeler TM et al. Caveolin- 1 expression in clinically confined human prostate cancer: A novel prognostic marker. Cancer Res 1999; 59(22):57 19-5723.
58. Savage K, Lambros MB, Robertson D et al. Caveolin 1 is overexpressed and amplified in a subset of basal-like and metaplastic breast carcinomas: A morphologic, ultrastructural, immunohistochemical and in situ hybridization analysis. Clin Cancer Res 2007; 130:90-101.
59. Joshi B, Strugnell SS, Goetz JO et al. Phosphorylated caveolin-1 regulates Rho ROCK-dependent focal adhesion dynamics and tumor cell migration and invasion. Cancer Res 2008; 68(20):8210-8220.
60. Hayashi K, Matsuda S, Machida K et al. Invasion activating caveolin- 1 mutation in human scinhous breast cancers. Cancer Res 2001; 61(6):2361-2364.
61. Lee H. Park DS. Razani B et al. Caveolin-1 mutations (P132L and null) and the pathogenesis of breast cancer: Caveolin-1 (P132L) behaves in a dominant-negative manner and caveolin-1 (- -) null mice show mammary epithelial cell hyperplasia. Am J Pathol 2002; 161(4): 1357-1369.
62. Shatz M, Lustig O, Reich R et al. Caveolin-1 mutants P132L andYl4F are dominant negative regulators of invasion, migration and aggregation in H 1299 lung cancer cells. Exp Cell Res. 10; 316(10):1748-1762.
63. Bonuccelli O, Casimiro MC, Sotgia F et al. Caveolin-1 (P 132L), a common breast cancer mutation, confers mammary cell invasiveness and defines a novel stem celllmetastasis-associated gene signature. Am J Pathol 2009; 174(5):1650-1662.
64. Li S, Couet J, Lisanti MP. Src tyrosine kinases, Galpha subunits and H-Ras share a common membrane-anchored scaffolding protein, caveolin. Caveolinbinding negatively regulates the auto-activation of Src tyrosine kinases. J Biol Chem 1996; 271(46):29182-29 190.
65. Couet J, Sargiacomo M, Lisanti MP. Interaction of a receptor tyrosine kinase, EGF-R, with caveolins. Caveolin binding negatively regulates tyrosine and serine threonine kinase activities. J Biol Chem 1997; 272(48):30429-30438.
66. Ju H, Zou R, Venema VJ et al. Direct interaction of endothelial nitric-oxide synthase and caveolin- 1 inhibits synthase activity. J Biol Chem 1997; 272(30):18522-18525.
67. Vihanto MM, Vindis C, Djonov V et al. Caveolin-1 is required for signaling and membrane targeting of EphBl receptortyrosinekinase. JCe11 Sci 2006; 119(Pt 10:2299-2309.
68. Razandi M, Alton O, Pedram A et al. Identification of a structural determinant necessary for the localization and ffinction of estrogen receptor alpha at the plasma membrane. Mol Cell Biol 2003; 23(5): 1633-1646.
69. Zhang W, Razani B, Altschuler Y et al. Caveolin-1 inhibits epidermal growth factor-stimulated lamellipod extension and cell migration in metastatic mammary adenocarcinoma cells (MTLn3). Transformation suppressor effects of adenovirus-mediated gene delivery of caveolin-1. J Biol Chem 2000; 275(27):20717-20725.
70. Cohen AW, Razani B, Wang XB et al. Caveolin-1-deficient mice show insulin resistance and defective insulinreceptorprotein expression in adipose tissue. Am J Physiol Cell Physiol 2003; 2850:C222-C235.
71. Sigismund S, Woellc T, Pun C et al. Clathrin-independent endocytosis of ubiquitinated cargos. Proc Natl Acad Sci USA 2005; 102(8):2760-2765.
72. Khan EM, Heidinger JM, Levy M et al. Epidermal growth factor receptor exposed to oxidative stress undergoes Src- andcaveolin-1- dependentperinucleartrafficking. JBiolChem2006; 281(20): 14486-14493.
73. Fagerholm S, Ortegren U, Karlsson M et al. Rapid insulin-dependent endocytosis of the insulin receptor by caveolae in primary adipocytes. PLoS One 2009; 4(6):e5985.
74. Nabi IR, Le PU. Caveolae rafi-dependent endocytosis. J Cell Biol 2003; 161(4):673-677.
75. Lajoie P, Nabi JR. Regulation of rafi-dependent endocytosis. J Cell Mol Med 2007; 1 1(4):644-653.
76. Mineo C, Gill ON, Anderson RO. Regulated migration of epidermal growth factor receptor from caveolae. J Biol Chem 1999; 274(43):30636-30643.
77. Jang IH, Kim III, Lee BD et al. Localization of phospholipase C-gamma 1 signaling in caveolae: Importance in EGF- inducedphosphoinositidehydrolysisbutnotintyrosinephosphorylation. FEBS Lett200 1; 491(1-2):4-8.
78. Ringerike T, Blystad FD, Levy FO et al. Cholesterol is important in control of EGF receptor kinase activity but EGF receptors are not concentrated in caveolae. J Cell Sci 2002; 115(Pt 6):1331-1340.
79. Hofrian EG, Ruonala MO, Bader AN et al. EGF induces coalescence of different lipid rafis. J Cell Sci 2008; 121(Pt 15):2519-2528.
80. Lajoie P, Kojic LD, Nim S et al. Caveolin-1 regulation of dynamin-dependent, rafi-mediated endocytosis ofcholeratoxin-B sub-unit occurs independently of caveolae. J Cell Mol Med 2009; 13(9B):3218-3225.
81. Wang Y, Posner BI, Balbis A. Compartmentalization of epidermal growth factor receptor in liver plasma membrane. J Cell Biochem 2009; 1070:96-103.
82. Sigismund S, Argenzio E, Tosoni D et al. Clathrin-mediated internalization is essential for sustained EGFR signaling but dispensable for degradation. Dcv Cell 2008; 15(2):209-219.
83. Mattsson CL, Andersson ER, Nedergaard J. Differential involvement of caveolin-1 in brown adipocyte signaling: Impaired beta3-adrenergic, but unaffected LPA, PDGF and EGF receptor signaling. Biochim Biophys Acta; 1803(8):983-989.
84. Agelaki S, Spiliotaki M, Markomanolaki H et al. Caveolin-1 regulates EGFR signaling in MCF-7 breast cancer cells andenhances gefitinib-inducedtumor cell inhibition. Cancer Biology andTherapy 2009; 8U5): 1470-1477.
85. Park JH, Han HJ. Caveolin-1 plays important role in EGF-induced migration and proliferation of mouse embryonic stemcells: InvolvementofPl3KiAktandERK. AmJPhysiolCellPhysiol2009; 297(4):C935-C944.
86. Zhang B, Peng F, Wu D et al. Caveolin-1 phosphorylation is required for stretch-induced EGFR and Akt activation in mesangial cells. Cell Signal 2007; 19(8):1690-700.
87. Ushio-Fukai M, Griendling KK, Becker PL et al. Epidermal growth factor receptor transactivation by angiotensin II requires reactive oxygen species in vascular smooth muscle cells. Arterioscler Thromb Vasc Biol 2001; 21(4):489-495.
88. Park WY, Park JS, Cho KA et al. Up-regulation of caveolin attenuates epidermal growth factor signaling in senescent cells. J Biol Chem 2000; 275(27):20847-20852.
89. Engelman JA, Chu C, Lin Act al. Caveolin-mediated regulation of signaling along the p42 44 MAP kinase cascade in vivo. A role for the caveolin-scaffolding domain. FEBS Left 1998; 428(3):205-2 11.
90. Galbiati F, Volonte D, Engelman JA et al. Targeted downregulation of caveolin-1 is sufficient to drive cell transformation and hyperactivate the p42 44 MAP kinase cascade. EMBO J 1998; 17(22):6633-6648.
91. Zhuang L, Lin J, Lu ML et al. Cholesterol-rich lipid rafis mediate akt-regulated survival in prostate cancer cells. Cancer Res 2002; 62(8):2227-2231.
92. Sieg DJ, Hauck CR, Ilic D et al. FAK integrates growth-factor and integrin signals to promote cell migration. Nat Cell Biol 2000; 2(5):249-256.
93. Kim SH, Kim SH. Antagonistic effect of EGF on FAK phosphorylationldephosphorylation in a cell. Cell Biochemistry and Function 2008; 26(5):539-547.
94. del Pozo MA, Balasubramanian N, Alderson NB et al. Phospho-caveolin-1 mediates integrin-regulated membrane domain internalization. Nat Cell Biol 2005; 7(9):901-908.
95. Ning Y, Zeineldin R, Liu Y et al. Down-regulationofintegrinalpha2 surface expressionbymutant epidermal growth factor receptor (EGFRvIII) induces aberrant cell spreading and focal adhesion formation. Cancer Res 2005; 65(20):9280-9286.
96. Goetz JO, Joshi B, Lajoie P et al. Concerted regulation of focal adhesion dynamics by galectin-3 and tyrosine-phosphorylated caveolin-1. J Cell Biol 2008; 180(6):1261-1275.
97. Kudlow JE, Buss JE, Gill GN. Anti-pp60src antibodies are substrates for EGF-stimulated protein kinase. Nature 1981; 290(5806):519-521.
98. Kim YN, Wiepz GJ, Guadanama AG et al. Epidermal growth factor-stimulated tyrosine phosphorylation of caveolin- 1. Enhanced caveolin- 1 tyrosine phosphorylation following aberrant epidermal growth factor receptor status. J Biol Chem 2000; 275U1):7481-7491.
99. Mastick CC, Brady MJ, Saltiel AR. Insulin stimulates the tyrosine phosphorylation of caveolin. J Cell Biol 1995; 129(6):1523-1531.
100. Wang XQ, Sun P, Paller AS. Ganglioside induces caveolin-1 redistribution and interaction with the epidermal growth factor receptor. J Biol Chem 2002; 277(49):47028-47034.
101. Nomura R, Fujimoto T. Tyrosine-phosphorylated caveolin- 1: Immunolocalization and molecular characterization. Mol Biol Cell 1999; 10(4):975-986.
102. Pol A, Calvo M, Lu Act al. EGF triggers caveolin redistribution from the plasma membrane to the early sorting endocytic compartment of hepatocytes. Cell Signal 2000; 12(8):537-540.
103. Orlichenko L, Huang B, Krueger E et al. Epithelial growth factor-induced phosphorylation of caveolin 1 at tyrosine 14 stimulates caveolae formation in epithelial cells. J Biol Chem 2006; 281(8):4570-4579.
104. Orlichenlco L, Weller SO, Cao H et al. Caveolae mediate growth factor-induced disassembly of adherens junctions to support tumor cell dissociation. Mol Biol Cell 2009; 20U9):4140-4152.
105. Lu Z, Ghosh S, Wang Z et al. Downregulation of caveolin-1 ffinction by EGF leads to the loss of E-cadherin, increased transcriptional activity of beta-catenin and enhanced tumor cell invasion. Cancer Cell 2003; 4(6):499-515.
106. Lee SW, Reimer CL, Oh P et al. Tumor cell growth inhibition by caveolin re-expression in human breast cancer cells. Oncogene 1998; 16U1):1391-1397.
107. Razani B, Engelman JA, Wang XB et al. Caveolin-1 null mice are viable but show evidence of hyperproliferative and vascular abnormalities. J Biol Chem 2001; 276(40:38121-38138.
108. Lavoie TN, L'AllemainG, BrunetAetal. CyclinDl expressionisregulatedpositivelybythep42 p44MAPK and negatively by the p38 HOGMAPK pathway. J Biol Chem 1996; 271(34):20608-20616.
109. Gille H, Downward J. Multiple ras effector pathways contribute to G(1) cell cycle progression. J Biol Chem 1999; 274(30:22033-22040.
110. Shtutman M, Zhurinsky J, Simcha Jet al. The cyclin Dl gene is a target of the beta-cateninlLEF-1 pathway. Proc Nati Acad Sci USA 1999; 96(10):5522-5527.
111. Williams TM, Lee H, Cheung MW et al. Combined loss of INK4a and caveolin-1 synergistically enhances cell proliferation and oncogene-induced tumorigenesis: Role of INK4a CAy- 1 in mammary epithelial cell hyperplasia. J Biol Chem 2004; 279(23):24745-24756.
112. Williams TM, Cheung MW, Park DS et al. Loss ofcaveolin- 1 gene expression accelerates the development of dysplastic mammary lesions in tumor-prone transgenic mice. Mol Biol Cell 2003; 14(3):1027-1042.
113. CohenAW, ParkDS, Woodman SEetal. Caveolin- 1 nulimicedevelop cardiac hypertrophywithhyperactivation of p42 44 MAP kinase in cardiac fibroblasts. Am J Physiol Cell Physiol 2003; 284(2):C457-C474.
114. Fiucci O, Ravid D, Reich R et al. Caveolin-1 inhibits anchorage-independent growth, anoikis and invasiveness in MCF-7 human breast cancer cells. Oncogene 2002; 21U5):2365-2375.
115. Park JH, Lee MY, Han HJ. A potential role for caveolin-1 in estradiol-l7beta-induced proliferation of mouse embryonic stem cells: Involvement of Src, PI3KJAkt and MAPKs pathways. Tnt J Biochem Cell Biol 2009; 41(3):659-665.
116. Lee MY. Lee SH. Park III et al. Interaction of galecth- 1 with caveolae hduces mouse embryonic stem cell proliferationthroughtheSrc,ERas, AktandmTORsignalingpathways. Cell MolLife Sci 2009; 66(8): 1467-1478.
117. Cerezo A, Guadamillas MC, Goetz JO et al. The absence ofcaveolin-1 increases proliferation and anchorage- independent growth byaRac-dependent, Erk-independentmechanism. Mol CellBiol 2009; 29U8):5046-5059.
118. Nelson WJ, Nusse R. Convergence of Wnt, beta-catenin and cadherin pathways. Science 2004; 303(5663): 1483-1487.
119. Galbiati F, Volonte D, BrownAM et al. Caveolin-1 expression inhibits Wnt/beta-cateninlLef-1 signaling by recruiting beta-catenin to caveolae membrane domains. J Biol Chem 2000; 275(30):23368-23377.
120. Hulit J, Bash T, Fu Metal. The cyclin Dl gene is transcriptionally repressed by caveolin-1. J Biol Chem 2000; 275(28):21203-21209.
121. Tones VA, TapiaJC, Rodriguez DA et al. E-cadherinis required for caveolin-1-mediated down-regulation of the inhibitor of apoptosis protein survivin via reduced beta-catenin-Tcf Lef-dependent transcription. Mol Cell Biol 2007; 27(20:7703-7717.
122. Tones VA, Tapia JC, Rodriguez DA et al. Caveolin-1 controls cell proliferation and cell death by suppressing expression ofthe inhibitor ofapoptosis protein survivin. JCe11 Sci 2006; 1 19(Pt 9): 1812-1823.
123. Ravid D, Maor S, Werner H et al. Caveolin-1 inhibits cell detachment-induced p53 activation and anoikis by upregulation ofinsulin-like growth factor-I receptors and signaling. Oncogene 2005; 24(8): 1338-1347.
124. Rodriguez DA, Tapia JC, Fernandez JO et al. Caveolin-1-mediated suppression of cyclooxygenase-2 via a beta-catenin-Tcf Lef-dependent transcriptional mechanism reduced prostaglandin E2 production and survivin expression. Mol Biol Cell 2009; 20(8):2297-23 10.
125. Liu J, Lee P, Galbiati F et al. Caveolin-1 expression sensitizes fibroblastic and epithelial cells to apoptotic stimulation. Am J Physiol Cell Physiol 2001; 280(4):C823-C835.
126. Wang S, Jia L, Zhou H et al. Caveolin-1 promotes the transformation and anti-apoptotic ability of mouse hepatoma cells. IUBMB Life 2008; 60(10):693-699.
127. Das M, Cui J, Das DK. Generation of survival signal by differential interaction ofp38MAPKalpha and p38MAPKbetawithcaveolin-1 andcaveolin-3 inthe adaptedheart. JMolCellCardiol2007; 42m:206-2 13.
128. Li L, Ren CH, Tahir SA et al. Caveolin- 1 maintains activated Akt in prostate cancer cells through scaffolding domain binding site interactions with and inhibition of serine threonine protein phosphatases PP 1 and PP2A. Mol Cell Biol 2003; 23(24):9389-9404.
129. Zhao X, Liu Y, Ma Q et al. Caveolin-1 negatively regulates TRAIL-induced apoptosis in human hepatocarcinoma cells. Biochem Biophys Res Commun 2009; 3780:21-26.
130. Percy CJ, Pat BK, Healy H et al. Phosphorylation of caveolin-1 is anti-apoptotic and promotes cell attachment during oxidative stress of kidney cells. Pathology 2008; 40(7):694-701.
131. Scherer PE, Lisanti MP, Baldini G et al. Induction of caveolin during adipogenesis and association of GLUT4 with caveolin-rich vesicles. J Cell Biol 1994; 127(5):1233-1243.
132. Gonzalez E, Nagiel A, Lin AJ et al. Small interfering RNA-mediated down-regulation of caveolin-1 differentially modulates signaling pathways in endothelial cells. JBiol Chem 2004; 279(39):40659-40669.
133. Fernandez-Real JM, Catalan V, Moreno-Navanete JM et al. Study of caveolin- 1 gene expression in whole adipose tissue and its subfractions and during differentiation ofhuman adipocytes. Nutrition and Metabolism 7:20.
134. Schmitz M, Kloppner S, Klopfleisch S et al. Mutual effects of caveolin and nerve growth factor signaling in pig oligodendrocytes. J Neurosci Res 88(3):572-588.
135. Massimino ML, Griffoni C, Spisni Eetal. Involvement of caveolae and caveolae-like domains in signalling, cell survival and angiogenesis. Cell Signal 2002; 14(2):93-98.
136. Albinsson S, Nordstrom I, Sward K et al. Differential dependence of stretch and shear stress signaling on caveolin-1 in the vascular wall. Am J Physiol Cell Physiol 2008; 2940:C271-C279.
137. Rubin J, Schwartz Z, Boyan BD et al. Caveolin-1 knockout mice have increased bone size and stifffiess. J Bone Miner Res 2007; 22(9):1408-1418.
138. Galbiati F, Volonte D, Gil 0 et al. Expression of caveolin-1 and -2 in differentiating PC12 cells and dorsal root ganglion neurons: Caveolin-2 is up-regulated in response to cell injury. Proc Natl Acad Sci USA 1998; 95(17):10257-10262.
139. Bu J, Bruckner SR, Sengoku let al. Glutamate regulates caveolin expression in rat hippocampal neurons. J Neurosci Res 2003; 72(2):185-190.
140. Cameron PL, Ruffin JW, Bollag R et al. Identification of caveolin and caveolin-related proteins in the brain. JNeurosci 1997; 17(24):9520-9535.
141. Bilderback TR, Grigsby RI, Dobrowsky RT. Association of p75(NTR) with caveolin and localization of neurotrophin-induced sphingomyelin hydrolysis to caveolae. J Biol Chem 1997; 272(16): 10922-10927.
142. Gaudreault SB, Blain JF, Grail on JP et al. A role for caveolin- 1 in post-injury reactive neuronal plasticity. J Neurochem 2005; 92(4):831-839.
143. Huang CS, Zhou J, Feng AK et al. Nerve growth factor signaling in caveolae-like domains at the plasma membrane. J Biol Chem 1999; 274(51):36707-36714.
144. Kang MJ, Seo JS, Park WY. Caveolin-1 inhibits neurite growth by blocking Raci Cdc42 and p21-activated kinase 1 interactions. Neuroreport 2006; 17(8):823-827.
145. Peiro S, ComellaJX, Enrichc etal. PC 12 cellshave caveolae thatcontainlrkA. Caveolae-disruptingdrugs inhibit nerve growth factor-induced, but not epidermal growth factor-induced, MAPK phosphorylation. J Biol Chem 2000; 275(48):37846-37852.
146. D'Orlando C, Guzzi F, Gravati Metal. Retinoic acid- and phorbol ester-induced neuronal differentiation down-regulates caveolin expression in GnRH neurons. J Neurochem 2008; 104(6):1577-1587.
147. Bailey KM, Liu J. Caveolin-1 up-regulation during epithelial to mesenchymal transition is mediated by focal adhesion kinase. J Biol Chem 2008; 283(20):13714-13724.
148. Zhang X, Ling MT, Wang Q et al. Identification of a novel inhibitor of differentiation-i (ID-i) binding partner, caveolin- 1 and its role in epithelial-mesenchymal transition and resistance to apoptosis in prostate cancer cells. J Biol Chem 2007; 282(46):33284-33294.
149. Dubash AD, Menold MM, Samson T et al. Chapter 1. Focal adhesions: New angles on an old structure. International Review of Cell and Molecular Biology 2009; 277:1-65.
150. Broussard JA, Webb DJ, Kaverina I. Asymmetric focal adhesion disassembly in motile cells. Cun Opin Cell Biol 2008; 201:85-90.
151. Beardsley A, Fang K, Mertz H et al. Loss of caveolin-1 polarity impedes endothelial cell polarization and directional movement. J Biol Chem 2005; 280(5):3541-3547.
152. Isshiki M, Ando J, Yamamoto K et al. Sites of CaQj wave initiation move with caveolae to the trailing edge of migrating cells. J Cell Sci 2002; 1 15(Pt 3):475-484.
153. Isshiki M, Ying YS, Fujita T et al. A molecular sensor detects signal transduction from caveolae in living cells. J Biol Chem 2002; 277(45):43389-43398.
154. ParatMO, Anand-Apte B, Fox PL. Differential caveolin-1 polarization in endothelial cells during migration in two and three dimensions. Mol Biol Cell 2003; 14(8):3156-3 168.
155. Sengupta P, Philip F, Scarlata S. Caveolin-1 alters CaQj signal durationthrough specific interactionwith the G alpha q family of G proteins. J Cell Sci 2008; 121(Pt 9):1363-1372.
156. Garcia-Cardena G, Martasek P, Masters BS et al. Dissecting the interaction between nitric oxide synthase (NOS) and caveolin. Functional significance of the nos caveolin binding domain in vivo. J Biol Chem 1997; 272(40:25437-25440.
157. Feron O, Saldana F, Michel JB et al. The endothelial nitric-oxide synthase-caveolin regulatory cycle. J Biol Chem 1998; 273(6):3125-3128.
158. Sun XH, Flynn DC, Castranova Vet al. Identification of a novel domain at the N terminus ofcaveolin- 1 that controls rear polarization of the protein and caveolae formation. J Biol Chem 2007; 282(10):7232-7241.
159. Wary KK, Mainiero F, Isakoff SJ et al. The adaptor protein Shc couples a class of integrins to the control of cell cycle progression. Cell 1996; 87(4):733-743.
160. Wei Y, Yang X, Liu Q et al. A role for caveolin and the urokinase receptor in integrin-mediated adhesion and signaling. J Cell Biol 1999; 144(6):1285-1294.
161. Wei Y, Eble JA, Wang Z et al. Urokinase receptors promote beta 1 integrin function through interactions with integrin alpha3betal. Mol Biol Cell 2001; 12(10):2975-2986.
162. Tang CH, Hill ML, Brurnwell AN et al. Signaling through urokinase and urokinase receptor in lung cancer cells requires interactions with betal integrins. J Cell Sci 2008; 121(Pt 22):3747-3756.
163. Blasi F, Carmeliet P. uPAR: Aversatile signalling orchestrator. Nat Rev Mol CellBiol2002; 3U2):932-943.
164. Hill MM, Scherbakov N, Schiefermeier Net al. Reassessing the role ofphosphocaveolin-1 in cell adhesion and migration. Traffic 2007; 8U2): 1695-1705.
165. Oaus K, Le Lay S, Balasubramanian N et al. Integrin-mediated adhesion regulates membrane order. J Cell Biol 2006; 174(5):725-734.
166. Lingwood D, Simons K. Lipid rafis as a membrane-organizing principle. Science. 1;327(5961):46-50.
167. Huveneers S, Danen EH. Adhesion signaling-crosstalk between integrins, Src and Rho. J Cell Sci 2009; 122(Pt 8): 1059-1069.
168. Etienne-Manneville S, Hall A. Rho OTPases in cell biology. Nature 2002; 420(6916):629-635.
169. Clark EA, King WO, Brugge JS et al. Integrin-mediated signals regulated by members of the rho family of GTPases. J Cell Biol 1998; 142(2):573-586.
170. Arthur WT, Petch LA, Bunidge K. Integrin engagement suppresses RhoA activity via a c-Src-dependent mechanism. Cun Biol 2000; 10U2):719-722.
171. Nobes CD, Hall A. Rho, rac and cdc42 OTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia and filopodia. Cell 1995; 81(1):53-62.
172. Rottner K, Hall A, Small TV. Interplay between Rac and Rho in the control of substrate contact dynamics. Cun Biol 1999; 9U2):640-648.
173. Kiosses WB, Shattil SJ, Pampori N et al. Rac recruits high-affinity integrin alphavbeta3 to lamellipodia in endothelial cell migration. Nat Cell Biol 2001; 3(3):316-320.
174. Ballestrem C. Hinz B. Imbof BA et al. Marching at the front and dragging behind: Differential alphavbeta3-integrin turnover regulates focal adhesion behavior. J Cell Biol 2001; 155(7): 1319-1332.
175. Nethe M, Anthony EC, Fernandez-Borja M et al. Focal-adhesion targeting links caveolin-1 to a Raci-degradation pathway. J Cell Sci; 123(Pt 10:1948-1958.
176. Grande-Garcia A, Echarri A, de Rooij J et al. Caveolin-1 regulates cell polarization and directional migration through Src kinase and Rho OTPases. J Cell Biol 2007; 177(4):683-694.
177. Cao H, Courchesne WE, Mastick CC. A phosphotyrosine-dependent protein interaction screen reveals a role for phosphorylation of caveolin-1 on tyrosine 14: Recruitment of C-terminal Src kinase. J Biol Chem 2002; 277(10):8771-8774.
178. Rizzo V, McIntosh DP, Oh P et al. In situ flow activates endothelial nitric oxide synthase in luminal caveolae of endothelium with rapid caveolin dissociation and calmodulin association. J Biol Chem 1998; 273(52):34724-34729.
179. Rizzo V, Morton C, DePaola N et al. Recruitment of endothelial caveolae into mechanotransduction pathways by flow conditioning in vitro. Am J Physiol Heart Circ Physiol 2003; 285(4):H1720-H 1729.
180. Oh P, Schnitzer JE. Segregation of heterotrimeric 0 proteins in cell surface microdomains. 0(q) binds caveolin to concentrate in caveolae, whereas 0(i) and 0(s) target lipid rafis by default. Mol Biol Cell 2001; 12(3):685-698.
181. Boyd NL, Park H, Yi H et al. Chronic shear induces caveolae formation and alters ERK and Akt responses in endothelial cells. Am J Physiol Heart Circ Physiol 2003; 285(3):H1 113-H1122.
182. Radel C, Carlile-Klusacek M, Rizzo V. Participation of caveolae in beta 1 integrin-mediated mechanotransduction. Biochem Biophys Res Commun 2007; 358(2):626-631.
183. Lowry WE, Huang J, MaYC et al. Csk, a critical link ofg protein signals to actin cytoskeletal reorganization. Dcv Cell 2002; 2(6):733-744.
184. Liu L, Pilch PF. A critical role of cavin (PTRF) in caveolae formation and organization. J Biol Chem 2007.
185. Hansen CO, Bright NA, Howard O et al. SDPR induces membrane curvature and ffinctions in the formation of caveolae. Nat Cell Biol 2009; 1 1(7):807-814.
186. McMahon KA, Zajicek H, Li WP et al. SRBC cavin-3 is a caveolin adapter protein that regulates caveolae function. EMBO J 2009; 28(8):1001-1015.
187. Bastiani M, Liu L, Hill MM et al. MURC Cavin-4 and cavin family members form tissue-specific caveolar complexes. J Cell Biol 2009; 185(7):1259-1273.
188. Razani B, Zhang XL, Bitzer Metal. Caveolin-1 regulates transforming growth factor (TOF)-beta SMAD signaling through an interaction with the TOF-betatype I receptor. J Biol Chem 2001; 276(9):6727-6738.
189. Schlegel A, Wang C, Pestell RO et al. Ligand-independent activation of oestrogen receptor alpha by caveolin-1. Biochem J 2001; 359(Pt 0:203-210.
190. Ishizaka N, Oriendling KK, Lassegue B et al. Angiotensin II type 1 receptor: Relationship with caveolae and caveolin afler initial agonist stimulation. Hypertension 1998; 32(3):459-466.
191. Wyse BD, Prior IA, Qian H et al. Caveolin interacts with the angiotensin II type 1 receptor during exocytic transport but not at the plasma membrane. J Biol Chem 2003; 278(26):23738-23746.
192. HongYH, Kim TV, Lee JH et al. Agonist-induced internalizationofm0luRlalpha is mediatedby caveolin. JNeurochem 2009; 1110:61-71.
193. Song KS, Li S, Okamoto T et al. Co-purification and direct interaction of Ras with caveolin, an integral membrane protein of caveolae microdomains. Detergent-free purification of caveolae microdomains. J Biol Chem 1996; 271U6):9690-9697.
194. Huang C, Hepler JR, Chen LT et al. Organization of 0 proteins and adenylyl cyclase at the plasma membrane. Mol Biol Cell 1997; 8(12):2365-2378.
195. Allen JA, Yu JZ, Dave RH et al. Caveolin-1 and lipid microdomains regulate Os trafficking and attenuate Os adenylyl cyclase signaling. Molecular pharmacology 2009; 76(5):1082-1093.
196. Razani B, Lisanti MP. Two distinct caveolin-1 domains mediate the ffinctional interaction of caveolin-1 with protein kinase A. Am J Physiol Cell Physiol 2001; 281(4):C1241-C1250.
197. Razani B, Rubin CS, Lisanti MP. Regulation of cAMP-mediated signal transduction via interaction of caveolins with the catalytic subunit of protein kinase A. J Biol Chem 1999; 274(37):26353-26360.
198. Waschke J, Golenhofen N, Kurzchalia TV et al. Protein kinase C-mediated endothelial bather regulation is caveolin-1-dependent. Histochem Cell Biol 2006; 1260:17-26.
199. Wang Q, Zhu F, Wang Z. Identification of EOF receptor C-terminal sequences 1005-1017 and di-leucine motif 1O1OLL1O 11 as essential in EOF receptor endocytosis. Exp Cell Res 2007; 313(1 5):3349-3363.
200. Prevostel C, Alice V, Joubert D et al. Protein kinase C(alpha) actively downregulates through caveolae-dependent traffic to an endosomal compartment. J Cell Sci 2000; 113 (Pt 14):2575-2584.
201. Czarny M, Fiucci O, Lavie Yet al. Phospholipase D2: Functional interaction with caveolin in low-density membrane microdomains. FEBS Left 2000; 467(2-3):326-332.
202. Czarny M, Lavie Y, Fiucci O., et al. Localization of phospholipase D in detergent-insoluble, caveolin-rich membrane domains. Modulation by caveolin-1 expression and caveolin-182-101. J Biol Chem 1999; 274(5):27 17-2724.
203. Kim III, Han JM, Lee S et al. Phospholipase Dl in caveolae: Regulation by protein kinase Calpha and caveolin- 1. Biochemistry 1999; 38( 12):3763-3769.
204. Toya Y, Schwencke C, Couet Jet al. Inhibition of adenylyl cyclase by caveolin peptides. Endocrinology 1998; 139(4):2025-2031.
205. Roy S, Luetterforst R, Harding Act al. Dominant-negative caveolin inhibits H-Ras ffinction by disrupting cholesterol-rich plasma membrane domains. Nat Cell Biol 1999; 1(2):98-105.
206. Kranenburg O, Verlaan L, Moolenaar WH. Regulating c-Ras ffinction. cholesterol depletion affects caveolin association, OTP loading and signaling. Cun Biol 2001; 11(23):1880-1884.
207. Cao H, Sanguinetti AR, Mastick CC. Oxidative stress activates both Src-kinases and their negative regulator Csk and induces phosphorylation of two targeting proteins for Csk: Caveolin- 1 and paxillin. Exp Cell Res 2004; 2940:159-171.
208. Panetta D, Biedi C, Repetto S et al. IGF-I regulates caveolin 1 and IRS 1 interaction in caveolae. Biochem Biophys Res Commun 2004; 3160:240-243.
209. Biedi C, PanettaD, SegatD etal. Specificity ofinsulin-likegrowthfactorl andinsulinonShcphosphorylation and Grb2 recruitment in caveolae. Endocrinology 2003; 144(12):5497-5503.
210. Perdue N, Yan Q. Caveolin-1 is up-regulated in transdifferentiated lens epithelial cells but minimal in normal human and murine lenses. Exp Eye Res 2006; 83(5): 1154-1161.
211. Dittmann K, Mayer C, Kehlbach Ret al. Radiation-induced caveolin-1 associated EGFR internalization is linked with nuclear EGFR transport and activation of DNA-PK. Molecular Cancer 2008; 7:69.
212. Shin J, Jo H, Park H. Caveolin- 1 is transiently dephosphorylated by shear stress-activated protein tyrosine phosphatase mu. Biochem Biophys Res Commun 2006; 339(3):737-741.
213. Nystrom FH, Chen H, Cong LN et al. Caveolin- 1 interacts with the insulin receptor and can differentially modulate insulin signaling in transfected Cos-7 cells and rat adipose cells. Molecular endocrinology (Baltimore, Md 1999; 13U2):20 13-2024.
214. Gustavsson J, Parpal S, Karlsson M et al. Localization of the insulin receptor in caveolae of adipocyte plasma membrane. FASEB J 1999; 13U4): 1961-1971.
215. Parpal S, Karisson M, Thorn H et al. Cholesterol depletion disrupts caveolae and insulin receptor signaling for metabolic control via insulin receptor substrate-i, but not for mitogen-activated protein kinase control. J Biol Chem 2001; 276U3):9670-9678.
216. Loza-Coll MA, Perera S, Shi Wet al. A transient increase in the activity of Src-family kinases induced by cell detachment delays anoikis of intestinal epithelial cells. Oncogene 2005; 24(10): 1727-1737.
217. Park H, Go YM, Darji R et al. Caveolin-1 regulates shear stress-dependent activation of extracellular signal-regulated kinase. Am J Physiol Heart Circ Physiol 2000; 278(4):H1285-H1293.