Evidence for mitochondrial uptake of glutathione by dicarboxylate and 2- oxoglutarate carriers

Journal of Pharmacology and Experimental Therapeutics

Volumn 285, Issue 2, 1998, Pages 608-618

  Chen, Zhifeng ^a   Lash, Lawrence H ^a  

^a WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 OXOGLUTARIC ACID; ADENINE NUCLEOTIDE TRANSLOCASE; ATRACTYLOSIDE; CARBOXYLIC ACID; DICARBOXYLIC ACID; GLUTAMIC ACID; GLUTATHIONE; MALIC ACID; PHOSPHATE; PHOSPHOENOLPYRUVATE; SUCCINIC ACID; SUCCINIC ACID DERIVATIVE; TRICARBOXYLIC ACID;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; KIDNEY CORTEX; MALE; MEMBRANE PERMEABILITY; MEMBRANE TRANSPORT; MITOCHONDRION; NONHUMAN; PRIORITY JOURNAL; RAT;

EID: 0031836944     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (38)

1. 2+ by liver mitochondria. J Biol Chem 259:1279-1287.
2. Broekemeier KM, Dempsey ME and Pfeiffer DR (1989) Cyclosporin A is a potent inhibitor of the inner membrane permeability transition in liver mitochondria. J Biol Chem 264:7826-7830.
3. Chen Z and Lash LH (1996) Role of mitochondrial anion transport, systems in glutathione transport in renal cortical mitochondria. FASEB J 10:A126.
4. Chen Z and Lash LH (1997) Kinetics and specificity of GSH transport in renal cortical mitochondria. Fund Appl Toxicol 36(Suppl):160.
5. 2+- dependent pore in heart mitochondria activated by inorganic phosphate and oxidative stress. Biochem J 255:357-360.
6. Estabrook RW (1967) Mitochondrial respiratory control and the polarographic measurement of ADP:O ratios. Methods Enzymol 10:41-47.
7. Fariss MW and Reed DJ (1987) High-performance liquid chromatography of thiols and disulfides: Dinitrophenyl derivatives. Methods Enzymol 143:101-109.
8. Fernandez-Checa JC, Garcia-Ruix C, Ookhtens M and Kaplowitz N (1991) Impaired uptake of glutathione by hepatic mitochondria from ethanol-fed rats. Tracer kinetic studies in vitro and in vivo and susceptibility to oxidant stress. J Clin Invest 87:397-405.
9. Garcia-Ruiz C, Morales A, Cole A, Rodes J, Kaplowitz N and Fernandez-Checa JC (1995) Evidence that the rat hepatic mitochondrial carrier is distinct from the sinusoidal and canalicular transporters for reduced glutathione. J Biol Chem 270:15946-15949.
10. Griffith OW and Meister A (1985) Origin and turnover of mitochondrial glutathione. Pnc Natl Acad Sci USA 82:4668-4672.
11. Gunter TE and Pfeiffer DR (1990) Mechanisms by which mitochondria transport calcium. Am J Physiol 258:C755-C786.
12. Halestrap AP(1975) The mitochondrial pyruvate carrier: Kinetics and specificity for substrates and inhibitors. Biochem J 148:85-96.
13. Inoue M and Morino Y (1985) Direct evidence for the role of the membrane potential in glutathione transport by renal brush-border membranes. J Biol Chem 260:326- 331.
14. Johnson D and Lardy H (1967) Isolation of liver or kidney mitochondria. Methods Enzymol 10:94-96.
15. Klingenberg M (1979) Overview on mitochondrial metabolite transport systems. Methods Enzymol 56:245-252.
16. Kurosawa K, Hayashi N, Sato N, Kamadu T and Tagawa K (1990) Transport of glutathione across the mitochondrial membranes. Biochem Biophys Res Commun 167:367-372.
17. Lash LH (1995) Intracellular distribution of thiols and disulfides: Assay of mitochondrial GSH transport. Methods Enzymol 252:14-26.
18. Lash LH and Anders MW (1987) Mechanism of S-(1,2-dichlorovinyl)-L-cysteine- and S-(1,2- dichlorovinyl)-L-homocysteine-induced renal mitochondrial toxicity. Mol Pharmacol 32:549-556.
19. Lash LH and Jones DP (1983) Transport of glutathione by renal basal-lateral membrane vesicles. Biochem Biophys Res Commun 112:55-60.
20. Lash LH and Jones DP (1984) Renal glutathione transport: Characteristics of the sodium- dependent system in the basal-lateral membrane. J Biol Chem 259: 14508-14514.
21. Lash LH and Sall JM (1993) Mitochondrial isolation from liver and kidney: Strategy, techniques and criteria for purity, in Mitochondrial Dysfunction, Methods in Toxicology, vol 2 (Lash LH and Jones DP eds), pp 8-28, Academic Press, San Diego, CA.
22. Lash LH and Tokarz JJ (1990) Oxidative stress in isolated rat renal proximal and distal tubular cells. Am J Physiol 259:F338-F347.
23. Lê-Quôc K and Lê-Quôc D (1985) Crucial role of sulfhydryl groups in the mitochondrial inner membrane structure. J Biol Chem 260:7422-7428.
24. Lê-Quôc D and Lê-Quôc K (1989) Relationships between the NAD(P) redox state, fatty acid oxidation, and inner membrane permeability in rat liver mitochondria. Arch Biochem Biophys 273:466-478.
25. Martensson J, Lai JCK and Meister A (1990) High-affinity transport of glutathione is part of a multicomponent system essential for mitochondrial function. Proc Natl Acad Sci USA 87:7185-7189.
26. McKernan TB, Woods EB and Lash LH (1991) Uptake of glutathione by renal cortical mitochondria. Arch Biochem Biophys 288:653-663.
27. Meredith MJ and Reed DJ (1982) Status of the mitochondrial pool of glutathione in the isolated hepatocyte. J Biol Chem 257:3747-3753.
28. 2+ ionophore-induced injury to isolated hepatocytes. Arch Biochem Biophys 263:226-235.
29. Orlowski M and Meister A (1963) γ-Glutamyl-p-nitroanilide: A new convenient substrate for determination and study of L- and D-γ-glutamyltranspeptidase activities. Biochim Biophys Acta 73:679-681.
30. Palmieri F, Bisaccia F, Capobianco L, Dolce V, Fiermonte G, Iacobazzi V, Indiveri C and Palmieri L (1996) Mitochondrial metabolite transporters. Biochim Biophys Acta 1275:127-132.
31. Read SM and Northcote DH (1981) Minimization of variation in the response to different proteins of the Coomassie blue G dye-binding assay for protein. Anal Biochem 116:53-64.
32. Reed DJ (1990) Glutathione: Toxicological implications. Annu Rev Pharmacol Toxicol 30:603-631.
33. Reed DJ (1993) Assessment of mitochondrial glutathione as a measure of cell injury in Mitochondrial Dysfunction, Methods in Toxicology, vol 2 (Lash LH and Jones DP eds), pp 219-226, Academic Press, San Diego.
34. Schnellmann RG (1991) Renal mitochondrial glutathione transport. Life Sci 49:393-398.
35. Schnellmann RG, Gilchrist SM and Mandel LJ (1988) Intracellular distribution and depletion of glutathione in rabbit renal proximal tubules. Kidney Int 34:229-233.
36. Shan X, Jones DP, Hashmi M and Anders MW (1993) Selective depletion of mitochondrial glutathione concentrations by (R,S )-3-hydroxy-4-pentenoate potentiates oxidative cell death. Chem Res Toxicol 8:75-81.
37. Smith CV, Jones DP, Guenther TM, Lash LH and Lauterburg BH (1996) Compartmentation of glutathione: Implications for the study of toxicity and disease. Toxicol Appl Pharmacol 140:1-12.
38. Yagi T and Hatefi Y (1984) Thiols in oxidative phosphorylation: Inhibition and energy-potentiated uncoupling by monothiol and dithiol modifiers. Biochemistry 23:2449-2455.