Mitochondrial GSH determines the toxic or therapeutic potential of superoxide scavenging in steatohepatitis

Journal of Hepatology

Volumn 57, Issue 4, 2012, Pages 852-859

  Montfort, Claudia Von ^a,b   Matias, Núria ^a,b   Fernandez, Anna ^a,b   Fucho, Raquel ^a,b   De La Rosa, Laura Conde ^a,b   Martinez Chantar, Maria Luz ^b,c   Mato, José M ^b,c   MacHida, Keigo ^d   Tsukamoto, Hidekazu ^d,e   Murphy, Michael P ^f   Mansouri, Abdellah ^g   Kaplowitz, Neil ^d   Garcia Ruiz, Carmen ^a,b   Fernandez Checa, Jose C ^a,b,d  

^a HOSPITAL CLÍNIC   (Spain)

^b INSTITUTO DE SALUD CARLOS III   (Spain)

^c CIC BIOGUNE   (Spain)

^d UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^e VA GREATER LOS ANGELES HEALTHCARE SYSTEM   (United States)

^f UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^g CENTRE DE RECHERCHE BIOMÉDICALE BICHAT BEAUJON CRB3   (France)

Author keywords

Antioxidant therapy; Cell death; Mitochondria; Necrosis; Oxidative stress; Steatohepatitis

Indexed keywords

3 NITROTYROSINE; CHOLINE; GLUTATHIONE; GLUTATHIONE ETHYL ESTER; HYDROGEN PEROXIDE; MANGANESE SUPEROXIDE DISMUTASE; METHIONINE; MITOCHONDRIAL GLUTATHIONE; PEROXYNITRITE; PROTEIN KINASE INHIBITOR; SUPEROXIDE; SUPEROXIDE DISMUTASE; THIOREDOXIN; UNCLASSIFIED DRUG;

AMINO ACID DEFICIENCY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; CELL DEATH; CELL ISOLATION; CONTROLLED STUDY; DEPLETION; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME PURIFICATION; FATTY LIVER; HEPATITIS; IMMUNOREACTIVITY; IN VIVO STUDY; LIVER CELL; LIVER FIBROSIS; LIVER INJURY; MALE; MITOCHONDRION; MOLECULAR MIMICRY; MOUSE; NONHUMAN; PRIORITY JOURNAL; RAT;

ALANINE TRANSAMINASE; ANIMALS; ANTIMYCIN A; APOPTOSIS; CHOLINE DEFICIENCY; DIET; DISEASE MODELS, ANIMAL; FATTY LIVER; FREE RADICAL SCAVENGERS; GLUTATHIONE; HEPATOCYTES; HYDROGEN PEROXIDE; MALE; METALLOPORPHYRINS; METHIONINE; METHIONINE ADENOSYLTRANSFERASE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICE, TRANSGENIC; MITOCHONDRIA, LIVER; OXIDATION-REDUCTION; PENTANOIC ACIDS; PEROXIREDOXIN III; PRIMARY CELL CULTURE; REACTIVE OXYGEN SPECIES; SUPEROXIDE DISMUTASE; SUPEROXIDES; THIOREDOXINS;

EID: 84866403209     PISSN: 01688278     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jhep.2012.05.024     Document Type: Article

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