Blood-brain barrier models and their relevance for a successful development of CNS drug delivery systems: A review

European Journal of Pharmaceutics and Biopharmaceutics

Volumn 87, Issue 3, 2014, Pages 409-432

  Bicker, Joana ^a,b   Alves, Gilberto ^b,c   Fortuna, Ana ^a,b   Falcão, Amílcar ^a,b  

^a UNIVERSITY OF COIMBRA   (Portugal)

^b UNIVERSITY OF COIMBRA   (Portugal)

^c UNIVERSITY OF BEIRA INTERIOR   (Portugal)

Author keywords

Brain uptake; Cell culture; CNS drugs; Drug discovery and development; In vitro; In vivo; Neurovascular unit; PAMPA; Permeability screening; Targeted drug delivery

Indexed keywords

CENTRAL NERVOUS SYSTEM AGENTS; DRUG;

ARTIFICIAL MEMBRANE; ASTROCYTE; AUTORADIOGRAPHY; BLOOD BRAIN BARRIER; BRAIN BLOOD VESSEL; BRAIN CAPILLARY; BRAIN PERFUSION; BRAIN PERICYTE; CELL CULTURE; CELL DIFFERENTIATION; CELL MEMBRANE PERMEABILITY; CEREBROSPINAL FLUID; DRUG DELIVERY SYSTEM; DRUG PENETRATION; DRUG TRANSPORT; DRUG UPTAKE; ENDOTHELIUM CELL; EXTRACELLULAR MATRIX; GASTROINTESTINAL ABSORPTION; GLIA CELL; HUMAN; IMMORTALIZED CELL LINE; LIPID BRAIN LEVEL; LIPID MEMBRANE; MACROPHAGE; MEMBRANE PERMEABILITY; MICROENVIRONMENT; MICROGLIA; NERVE CELL; NONHUMAN; PERICYTE; REVIEW; ANIMAL; CENTRAL NERVOUS SYSTEM; METABOLISM; PERMEABILITY; PHYSIOLOGY; PROCEDURES; TRANSPORT AT THE CELLULAR LEVEL;

ANIMALS; BIOLOGICAL TRANSPORT; BLOOD-BRAIN BARRIER; CENTRAL NERVOUS SYSTEM; DRUG DELIVERY SYSTEMS; HUMANS; PERMEABILITY; PHARMACEUTICAL PREPARATIONS;

EID: 84904264611     PISSN: 09396411     EISSN: 18733441     Source Type: Journal    
DOI: 10.1016/j.ejpb.2014.03.012     Document Type: Review

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