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Volumn 72, Issue 5, 2012, Pages 648-672

The blood-brain barrier in health and disease

Author keywords

[No Author keywords available]

Indexed keywords

CELL ADHESION MOLECULE; COLLAGEN TYPE 4; ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1; ENTACTIN; GLUCOSE TRANSPORTER 1; GLYCOPROTEIN; JUNCTIONAL ADHESION MOLECULE; LAMININ; LEUKOCYTE ADHESION MOLECULE; NERVE CELL ADHESION MOLECULE; OCCLUDIN; PADGEM PROTEIN; TETRASPANIN; UNCLASSIFIED DRUG;

EID: 84870408539     PISSN: 03645134     EISSN: 15318249     Source Type: Journal    
DOI: 10.1002/ana.23648     Document Type: Article
Times cited : (485)

References (341)
  • 1
    • 33846849237 scopus 로고    scopus 로고
    • Phenotypic heterogeneity of the endothelium: II. Representative vascular beds
    • DOI 10.1161/01.RES.0000255690.03436.ae, PII 0000301220070202000005
    • Aird WC,. Phenotypic heterogeneity of the endothelium: II. Representative vascular beds. Circ Res 2007; 100: 174-190. (Pubitemid 46208718)
    • (2007) Circulation Research , vol.100 , Issue.2 , pp. 174-190
    • Aird, W.C.1
  • 2
    • 33846798106 scopus 로고    scopus 로고
    • Phenotypic heterogeneity of the endothelium: I. Structure, function, and mechanisms
    • DOI 10.1161/01.RES.0000255691.76142.4a, PII 0000301220070202000004
    • Aird WC,. Phenotypic heterogeneity of the endothelium: I. Structure, function, and mechanisms. Circ Res 2007; 100: 158-173. (Pubitemid 46208717)
    • (2007) Circulation Research , vol.100 , Issue.2 , pp. 158-173
    • Aird, W.C.1
  • 3
    • 0034750810 scopus 로고    scopus 로고
    • Molecular and cellular permeability control at the blood-brain barrier
    • DOI 10.1016/S0165-0173(01)00102-3, PII S0165017301001023
    • Gloor SM, Wachtel M, Bolliger MF, et al. Molecular and cellular permeability control at the blood-brain barrier. Brain Res Brain Res Rev 2001; 36: 258-264. (Pubitemid 33020756)
    • (2001) Brain Research Reviews , vol.36 , Issue.2-3 , pp. 258-264
    • Gloor, S.M.1    Wachtel, M.2    Bolliger, M.F.3    Ishihara, H.4    Landmann, R.5    Frei, K.6
  • 4
    • 0032936851 scopus 로고    scopus 로고
    • The cell biology of the blood-brain barrier
    • DOI 10.1146/annurev.neuro.22.1.11
    • Rubin LL, Staddon JM,. The cell biology of the blood-brain barrier. Annu Rev Neurosci 1999; 22: 11-28. (Pubitemid 29144879)
    • (1999) Annual Review of Neuroscience , vol.22 , pp. 11-28
    • Rubin, L.L.1    Staddon, J.M.2
  • 6
    • 38149090292 scopus 로고    scopus 로고
    • The blood-brain barrier in health and chronic neurodegenerative disorders
    • Zlokovic BV,. The blood-brain barrier in health and chronic neurodegenerative disorders. Neuron 2008; 57: 178-201.
    • (2008) Neuron , vol.57 , pp. 178-201
    • Zlokovic, B.V.1
  • 7
    • 78650173611 scopus 로고    scopus 로고
    • Disruption of central nervous system barriers in multiple sclerosis
    • Alvarez JI, Cayrol R, Prat A,. Disruption of central nervous system barriers in multiple sclerosis. Biochim Biophys Acta 2011; 1812: 252-264.
    • (2011) Biochim Biophys Acta , vol.1812 , pp. 252-264
    • Alvarez, J.I.1    Cayrol, R.2    Prat, A.3
  • 8
    • 53749096762 scopus 로고    scopus 로고
    • Blood-brain barrier tight junction permeability and ischemic stroke
    • Sandoval KE, Witt KA,. Blood-brain barrier tight junction permeability and ischemic stroke. Neurobiol Dis 2008; 32: 200-219.
    • (2008) Neurobiol Dis , vol.32 , pp. 200-219
    • Sandoval, K.E.1    Witt, K.A.2
  • 9
    • 34249040510 scopus 로고    scopus 로고
    • Blood-brain barrier impairment in Alzheimer disease: Stability and functional significance
    • DOI 10.1212/01.wnl.0000262031.18018.1a, PII 0000611420070522000008
    • Bowman GL, Kaye JA, Moore M, et al. Blood-brain barrier impairment in Alzheimer disease: stability and functional significance. Neurology 2007; 68: 1809-1814. (Pubitemid 46791393)
    • (2007) Neurology , vol.68 , Issue.21 , pp. 1809-1814
    • Bowman, G.L.1    Kaye, J.A.2    Moore, M.3    Waichunas, D.4    Carlson, N.E.5    Quinn, J.F.6
  • 10
    • 78649518938 scopus 로고    scopus 로고
    • The case for blood-brain barrier dysfunction in the pathogenesis of Alzheimer's disease
    • Jeynes B, Provias J,. The case for blood-brain barrier dysfunction in the pathogenesis of Alzheimer's disease. J Neurosci Res 2011; 89: 22-28.
    • (2011) J Neurosci Res , vol.89 , pp. 22-28
    • Jeynes, B.1    Provias, J.2
  • 12
    • 77953501722 scopus 로고    scopus 로고
    • The role of neuroinflammation on the pathogenesis of Parkinson's disease
    • Chung YC, Ko HW, Bok E, et al. The role of neuroinflammation on the pathogenesis of Parkinson's disease. BMB Rep 2010; 43: 225-232.
    • (2010) BMB Rep , vol.43 , pp. 225-232
    • Chung, Y.C.1    Ko, H.W.2    Bok, E.3
  • 13
    • 0033586471 scopus 로고    scopus 로고
    • Blood vessels change in the mesencephalon of patients with Parkinson's disease
    • Faucheux BA, Bonnet AM, Agid Y, Hirsch EC,. Blood vessels change in the mesencephalon of patients with Parkinson's disease. Lancet 1999; 353: 981-982. (Pubitemid 29132612)
    • (1999) Lancet , vol.353 , Issue.9157 , pp. 981-982
    • Faucheux, B.A.1    Bonnet, A.-M.2    Agid, Y.3    Hirsch, E.C.4
  • 15
    • 0021287843 scopus 로고
    • 3 in the spinal cord and motor cortex of ALS patients
    • DOI 10.1016/0165-5728(84)90042-0
    • Donnenfeld H, Kascsak RJ, Bartfeld H,. Deposits of IgG and C3 in the spinal cord and motor cortex of ALS patients. J Neuroimmunol 1984; 6: 51-57. (Pubitemid 14132684)
    • (1984) Journal of Neuroimmunology , vol.6 , Issue.1 , pp. 51-57
    • Donnefeld, H.1    Kascsak, R.J.2    Bartfeld, H.3
  • 16
    • 0024994099 scopus 로고
    • IgG reactivity in the spinal cord and motor cortex in amyotrophic lateral sclerosis
    • Engelhardt JI, Appel SH,. IgG reactivity in the spinal cord and motor cortex in amyotrophic lateral sclerosis. Arch Neurol 1990; 47: 1210-1216. (Pubitemid 20381002)
    • (1990) Archives of Neurology , vol.47 , Issue.11 , pp. 1210-1216
    • Engelhardt, J.I.1    Appel, S.H.2
  • 17
    • 0021247422 scopus 로고
    • Cerebrospinal fluid (CSF) findings in amyotrophic lateral sclerosis
    • Leonardi A, Abbruzzese G, Arata L, et al. Cerebrospinal fluid (CSF) findings in amyotrophic lateral sclerosis. J Neurol 1984; 231: 75-78. (Pubitemid 14137306)
    • (1984) Journal of Neurology , vol.231 , Issue.2 , pp. 75-78
    • Leonardi, A.1    Abbruzzese, G.2    Arata, L.3
  • 18
    • 25444463573 scopus 로고    scopus 로고
    • Endothelial/pericyte interactions
    • DOI 10.1161/01.RES.0000182903.16652.d7
    • Armulik A, Abramsson A, Betsholtz C,. Endothelial/pericyte interactions. Circ Res 2005; 97: 512-523. (Pubitemid 41361741)
    • (2005) Circulation Research , vol.97 , Issue.6 , pp. 512-523
    • Armulik, A.1    Abramsson, A.2    Betsholtz, C.3
  • 19
    • 0037209457 scopus 로고    scopus 로고
    • Expression and adhesive properties of basement membrane proteins in cerebral capillary endothelial cell cultures
    • Tilling T, Engelbertz C, Decker S, et al. Expression and adhesive properties of basement membrane proteins in cerebral capillary endothelial cell cultures. Cell Tissue Res 2002; 310: 19-29.
    • (2002) Cell Tissue Res , vol.310 , pp. 19-29
    • Tilling, T.1    Engelbertz, C.2    Decker, S.3
  • 20
    • 77952423623 scopus 로고    scopus 로고
    • The contribution of astrocyte signalling to neurovascular coupling
    • Carmignoto G, Gomez-Gonzalo M,. The contribution of astrocyte signalling to neurovascular coupling. Brain Res Rev 2010; 63: 138-148.
    • (2010) Brain Res Rev , vol.63 , pp. 138-148
    • Carmignoto, G.1    Gomez-Gonzalo, M.2
  • 21
    • 77957021581 scopus 로고    scopus 로고
    • Astrocyte heterogeneity: An underappreciated topic in neurobiology
    • Zhang Y, Barres BA,. Astrocyte heterogeneity: An underappreciated topic in neurobiology. Curr Opin Neurobiol 2010; 20: 588-594.
    • (2010) Curr Opin Neurobiol , vol.20 , pp. 588-594
    • Zhang, Y.1    Barres, B.A.2
  • 22
    • 0035152834 scopus 로고    scopus 로고
    • Central nervous system perivascular cells are immunoregulatory cells that connect the CNS with the peripheral immune system
    • DOI 10.1002/glia.1105
    • Williams K, Alvarez X, Lackner AA,. Central nervous system perivascular cells are immunoregulatory cells that connect the CNS with the peripheral immune system. Glia 2001; 36: 156-164. (Pubitemid 33055904)
    • (2001) GLIA , vol.36 , Issue.2 , pp. 156-164
    • Williams, K.1    Alvarez, X.2    Lackner, A.A.3
  • 23
    • 0014481056 scopus 로고
    • Junctions between intimately apposed cell membranes in the vertebrate brain
    • Brightman MW, Reese TS,. Junctions between intimately apposed cell membranes in the vertebrate brain. J Cell Biol 1969; 40: 648-677.
    • (1969) J Cell Biol , vol.40 , pp. 648-677
    • Brightman, M.W.1    Reese, T.S.2
  • 24
    • 0014109002 scopus 로고
    • Fine structural localization of a blood-brain barrier to exogenous peroxidase
    • Reese TS, Karnovsky MJ,. Fine structural localization of a blood-brain barrier to exogenous peroxidase. J Cell Biol 1967; 34: 207-217.
    • (1967) J Cell Biol , vol.34 , pp. 207-217
    • Reese, T.S.1    Karnovsky, M.J.2
  • 25
    • 0015862443 scopus 로고
    • Transport of proteins across normal cerebral arterioles
    • Westergaard E, Brightman MW,. Transport of proteins across normal cerebral arterioles. J Comp Neurol 1973; 152: 17-44.
    • (1973) J Comp Neurol , vol.152 , pp. 17-44
    • Westergaard, E.1    Brightman, M.W.2
  • 26
    • 22744440362 scopus 로고    scopus 로고
    • Role of drug efflux transporters in the brain for drug disposition and treatment of brain diseases
    • DOI 10.1016/j.pneurobio.2005.04.006, PII S0301008205000444
    • Loscher W, Potschka H,. Role of drug efflux transporters in the brain for drug disposition and treatment of brain diseases. Prog Neurobiol 2005; 76: 22-76. (Pubitemid 41033402)
    • (2005) Progress in Neurobiology , vol.76 , Issue.1 , pp. 22-76
    • Loscher, W.1    Potschka, H.2
  • 27
    • 34547624611 scopus 로고    scopus 로고
    • Supply and demand in cerebral energy metabolism: The role of nutrient transporters
    • DOI 10.1038/sj.jcbfm.9600521, PII 9600521
    • Simpson IA, Carruthers A, Vannucci SJ,. Supply and demand in cerebral energy metabolism: The role of nutrient transporters. J Cereb Blood Flow Metab 2007; 27: 1766-1791. (Pubitemid 47624552)
    • (2007) Journal of Cerebral Blood Flow and Metabolism , vol.27 , Issue.11 , pp. 1766-1791
    • Simpson, I.A.1    Carruthers, A.2    Vannucci, S.J.3
  • 28
    • 70349339068 scopus 로고    scopus 로고
    • Nutrient transport systems in brain: 40 years of progress
    • Spector R,. Nutrient transport systems in brain: 40 years of progress. J Neurochem 2009; 111: 315-320.
    • (2009) J Neurochem , vol.111 , pp. 315-320
    • Spector, R.1
  • 29
    • 77950664220 scopus 로고    scopus 로고
    • Transporters in the brain endothelial barrier
    • Ueno M, Nakagawa T, Wu B, et al. Transporters in the brain endothelial barrier. Curr Med Chem 2010; 17: 1125-1138.
    • (2010) Curr Med Chem , vol.17 , pp. 1125-1138
    • Ueno, M.1    Nakagawa, T.2    Wu, B.3
  • 30
    • 34047198585 scopus 로고    scopus 로고
    • Endothelial Glycocalyx: Sweet Shield of Blood Vessels
    • DOI 10.1016/j.tcm.2007.02.002, PII S105017380700045X
    • Van Teeffelen JW, Brands J, Stroes ES, Vink H,. Endothelial glycocalyx: sweet shield of blood vessels. Trends Cardiovasc Med 2007; 17: 101-105. (Pubitemid 46533936)
    • (2007) Trends in Cardiovascular Medicine , vol.17 , Issue.3 , pp. 101-105
    • VanTeeffelen, J.W.1    Brands, J.2    Stroes, E.S.3    Vink, H.4
  • 31
    • 0029797605 scopus 로고    scopus 로고
    • Identification of distinct luminal domains for macromolecules, erythrocytes, and leukocytes within mammalian capillaries
    • Vink H, Duling BR,. Identification of distinct luminal domains for macromolecules, erythrocytes, and leukocytes within mammalian capillaries. Circ Res 1996; 79: 581-589. (Pubitemid 26276918)
    • (1996) Circulation Research , vol.79 , Issue.3 , pp. 581-589
    • Vink, H.1    Duling, B.R.2
  • 32
    • 0019798883 scopus 로고
    • Developing nervous tissue induces formation of blood-brain barrier characteristics in invading endothelial cells: A study using quail-chick transplantation chimeras
    • DOI 10.1016/0012-1606(81)90382-1
    • Stewart PA, Wiley MJ,. Developing nervous tissue induces formation of blood-brain barrier characteristics in invading endothelial cells: A study using quail-chick transplantation chimeras. Dev Biol 1981; 84: 183-192. (Pubitemid 11092411)
    • (1981) Developmental Biology , vol.84 , Issue.1 , pp. 183-192
    • Stewart, P.A.1    Wiley, M.J.2
  • 33
    • 78649467527 scopus 로고    scopus 로고
    • Pericytes regulate the blood-brain barrier
    • Armulik A, Genove G, Mae M, et al. Pericytes regulate the blood-brain barrier. Nature 2010; 468: 557-561.
    • (2010) Nature , vol.468 , pp. 557-561
    • Armulik, A.1    Genove, G.2    Mae, M.3
  • 34
    • 78649487239 scopus 로고    scopus 로고
    • Pericytes are required for blood-brain barrier integrity during embryogenesis
    • Daneman R, Zhou L, Kebede AA, Barres BA,. Pericytes are required for blood-brain barrier integrity during embryogenesis. Nature 2010; 468: 562-566.
    • (2010) Nature , vol.468 , pp. 562-566
    • Daneman, R.1    Zhou, L.2    Kebede, A.A.3    Barres, B.A.4
  • 35
    • 0023108382 scopus 로고
    • Astrocytes induce blood-brain barrier properties in endothelial cells
    • DOI 10.1038/325253a0
    • Janzer RC, Raff MC,. Astrocytes induce blood-brain barrier properties in endothelial cells. Nature 1987; 325: 253-257. (Pubitemid 17049884)
    • (1987) Nature , vol.325 , Issue.6101 , pp. 253-257
    • Janzer, R.C.1    Raff, M.C.2
  • 36
    • 79952525332 scopus 로고    scopus 로고
    • Endothelial Smad4 maintains cerebrovascular integrity by activating N-cadherin through cooperation with Notch
    • Li F, Lan Y, Wang Y, et al. Endothelial Smad4 maintains cerebrovascular integrity by activating N-cadherin through cooperation with Notch. Dev Cell 2011; 20: 291-302.
    • (2011) Dev Cell , vol.20 , pp. 291-302
    • Li, F.1    Lan, Y.2    Wang, Y.3
  • 37
    • 1842555340 scopus 로고    scopus 로고
    • Endothelial cell development, vasculogenesis, angiogenesis, and tumor neovascularization: An update
    • DOI 10.1055/s-2004-822975
    • Tang DG, Conti CJ,. Endothelial cell development, vasculogenesis, angiogenesis, and tumor neovascularization: An update. Semin Thromb Hemost 2004; 30: 109-117. (Pubitemid 38457305)
    • (2004) Seminars in Thrombosis and Hemostasis , vol.30 , Issue.1 , pp. 109-117
    • Tang, D.G.1    Conti, C.J.2
  • 38
    • 79961230399 scopus 로고    scopus 로고
    • Pericytes: Developmental, physiological, and pathological perspectives, problems, and promises
    • Armulik A, Genove G, Betsholtz C,. Pericytes: developmental, physiological, and pathological perspectives, problems, and promises. Dev Cell 2011; 21: 193-215.
    • (2011) Dev Cell , vol.21 , pp. 193-215
    • Armulik, A.1    Genove, G.2    Betsholtz, C.3
  • 39
    • 80055014830 scopus 로고    scopus 로고
    • Central nervous system pericytes in health and disease
    • Winkler EA, Bell RD, Zlokovic BV,. Central nervous system pericytes in health and disease. Nat Neurosci 2011; 14: 1398-1405.
    • (2011) Nat Neurosci , vol.14 , pp. 1398-1405
    • Winkler, E.A.1    Bell, R.D.2    Zlokovic, B.V.3
  • 40
    • 79960099283 scopus 로고    scopus 로고
    • A pericyte origin of spinal cord scar tissue
    • Goritz C, Dias DO, Tomilin N, et al. A pericyte origin of spinal cord scar tissue. Science 2011; 333: 238-242.
    • (2011) Science , vol.333 , pp. 238-242
    • Goritz, C.1    Dias, D.O.2    Tomilin, N.3
  • 42
    • 77957221743 scopus 로고    scopus 로고
    • The impact of the extracellular matrix on inflammation
    • Sorokin L,. The impact of the extracellular matrix on inflammation. Nat Rev Immunol 2010; 10: 712-723.
    • (2010) Nat Rev Immunol , vol.10 , pp. 712-723
    • Sorokin, L.1
  • 43
    • 33645869560 scopus 로고    scopus 로고
    • Dystroglycan is selectively cleaved at the parenchymal basement membrane at sites of leukocyte extravasation in experimental autoimmune encephalomyelitis
    • Agrawal S, Anderson P, Durbeej M, et al. Dystroglycan is selectively cleaved at the parenchymal basement membrane at sites of leukocyte extravasation in experimental autoimmune encephalomyelitis. J Exp Med 2006; 203: 1007-1019.
    • (2006) J Exp Med , vol.203 , pp. 1007-1019
    • Agrawal, S.1    Anderson, P.2    Durbeej, M.3
  • 44
    • 67349162632 scopus 로고    scopus 로고
    • Endothelial basement membrane laminin alpha5 selectively inhibits T lymphocyte extravasation into the brain
    • Wu C, Ivars F, Anderson P, et al. Endothelial basement membrane laminin alpha5 selectively inhibits T lymphocyte extravasation into the brain. Nat Med 2009; 15: 519-527.
    • (2009) Nat Med , vol.15 , pp. 519-527
    • Wu, C.1    Ivars, F.2    Anderson, P.3
  • 45
    • 78149425848 scopus 로고    scopus 로고
    • Glial and neuronal control of brain blood flow
    • Attwell D, Buchan AM, Charpak S, et al. Glial and neuronal control of brain blood flow. Nature 2010; 468: 232-243.
    • (2010) Nature , vol.468 , pp. 232-243
    • Attwell, D.1    Buchan, A.M.2    Charpak, S.3
  • 46
    • 80052419916 scopus 로고    scopus 로고
    • Role of astrocytes in neurovascular coupling
    • Petzold GC, Murthy VN,. Role of astrocytes in neurovascular coupling. Neuron 2011; 71: 782-797.
    • (2011) Neuron , vol.71 , pp. 782-797
    • Petzold, G.C.1    Murthy, V.N.2
  • 47
    • 84455205524 scopus 로고    scopus 로고
    • The Hedgehog pathway promotes blood-brain barrier integrity and CNS immune quiescence
    • Alvarez JI, Dodelet-Devillers A, Kebir H, et al. The Hedgehog pathway promotes blood-brain barrier integrity and CNS immune quiescence. Science 2011; 334: 1727-1731.
    • (2011) Science , vol.334 , pp. 1727-1731
    • Alvarez, J.I.1    Dodelet-Devillers, A.2    Kebir, H.3
  • 48
    • 0029775029 scopus 로고    scopus 로고
    • Signal transduction and glial cell modulation of cultured brain microvessel endothelial cell tight junctions
    • Raub TJ,. Signal transduction and glial cell modulation of cultured brain microvessel endothelial cell tight junctions. Am J Physiol 1996; 271: C495-C503.
    • (1996) Am J Physiol , vol.271
    • Raub, T.J.1
  • 49
    • 0030748912 scopus 로고    scopus 로고
    • F-actin cytoskeleton and sucrose permeability of immortalised rat brain microvascular endothelial cell monolayers: Effects of cyclic AMP and astrocytic factors
    • DOI 10.1016/S0006-8993(97)00586-6, PII S0006899397005866
    • Rist RJ, Romero IA, Chan MW, et al. F-actin cytoskeleton and sucrose permeability of immortalised rat brain microvascular endothelial cell monolayers: effects of cyclic AMP and astrocytic factors. Brain Res 1997; 768: 10-18. (Pubitemid 27433471)
    • (1997) Brain Research , vol.768 , Issue.1-2 , pp. 10-18
    • Rist, R.J.1    Romero, I.A.2    Chan, M.W.K.3    Couraud, P.-O.4    Roux, F.5    Abbott, N.J.6
  • 52
    • 80055082820 scopus 로고    scopus 로고
    • Glial-conditional deletion of aquaporin-4 (Aqp4) reduces blood-brain water uptake and confers barrier function on perivascular astrocyte endfeet
    • Haj-Yasein NN, Vindedal GF, Eilert-Olsen M, et al. Glial-conditional deletion of aquaporin-4 (Aqp4) reduces blood-brain water uptake and confers barrier function on perivascular astrocyte endfeet. Proc Natl Acad Sci U S A 2011; 108: 17815-17820.
    • (2011) Proc Natl Acad Sci U S A , vol.108 , pp. 17815-17820
    • Haj-Yasein, N.N.1    Vindedal, G.F.2    Eilert-Olsen, M.3
  • 53
    • 0023949553 scopus 로고
    • Perivascular microglial cells of the CNS are bone marrow-derived and present antigen in vivo
    • Hickey WF, Kimura H,. Perivascular microglial cells of the CNS are bone marrow-derived and present antigen in vivo. Science 1988; 239: 290-292. (Pubitemid 18061496)
    • (1988) Science , vol.239 , Issue.4837 , pp. 290-292
    • Hickey, W.F.1    Kimura, H.2
  • 56
    • 0027431164 scopus 로고
    • Bone marrow-derived elements in the peripheral nervous system: An immunohistochemical and ultrastructural investigation in chimeric rats
    • Vass K, Hickey WF, Schmidt RE, Lassmann H,. Bone marrow-derived elements in the peripheral nervous system. An immunohistochemical and ultrastructural investigation in chimeric rats. Lab Invest 1993; 69: 275-282. (Pubitemid 23315711)
    • (1993) Laboratory Investigation , vol.69 , Issue.3 , pp. 275-282
    • Vass, K.1    Hickey, W.F.2    Schmidt, R.E.3    Lassmann, H.4
  • 57
    • 0018827790 scopus 로고
    • The mast cells of the mammalian central nervous system. VI. Uptake of tritiated thymidine by mast cells, neurolipomastocytoid cells and other elements of the central nervous system
    • Ibrahim MZ, Koshayan DS, Khreis YM,. The mast cells of the mammalian central nervous system. VI. Uptake of tritiated thymidine by mast cells, neurolipomastocytoid cells and other elements of the central nervous system. Acta Anat (Basel) 1980; 108: 102-114. (Pubitemid 10073469)
    • (1980) Acta Anatomica , vol.108 , Issue.11 , pp. 102-114
    • Ibrahim, M.Z.M.1    Koshayan, D.S.2    Khreis, Y.M.3
  • 58
    • 27844461127 scopus 로고    scopus 로고
    • Central nervous system neurons acquire mast cell products via transgranulation
    • DOI 10.1111/j.1460-9568.2005.04429.x
    • Wilhelm M, Silver R, Silverman AJ,. Central nervous system neurons acquire mast cell products via transgranulation. Eur J Neurosci 2005; 22: 2238-2248. (Pubitemid 41653537)
    • (2005) European Journal of Neuroscience , vol.22 , Issue.9 , pp. 2238-2248
    • Wilhelm, M.1    Silver, R.2    Silverman, A.-J.3
  • 59
    • 36448994709 scopus 로고    scopus 로고
    • Local self-renewal can sustain CNS microglia maintenance and function throughout adult life
    • DOI 10.1038/nn2014, PII NN2014
    • Ajami B, Bennett JL, Krieger C, et al. Local self-renewal can sustain CNS microglia maintenance and function throughout adult life. Nat Neurosci 2007; 10: 1538-1543. (Pubitemid 350175883)
    • (2007) Nature Neuroscience , vol.10 , Issue.12 , pp. 1538-1543
    • Ajami, B.1    Bennett, J.L.2    Krieger, C.3    Tetzlaff, W.4    Rossi, F.M.V.5
  • 61
    • 0032733230 scopus 로고    scopus 로고
    • Microglial and astrocyte chemokines regulate monocyte migration through the blood-brain barrier in human immunodeficiency virus-1 encephalitis
    • Persidsky Y, Ghorpade A, Rasmussen J, et al. Microglial and astrocyte chemokines regulate monocyte migration through the blood-brain barrier in human immunodeficiency virus-1 encephalitis. Am J Pathol 1999; 155: 1599-1611.
    • (1999) Am J Pathol , vol.155 , pp. 1599-1611
    • Persidsky, Y.1    Ghorpade, A.2    Rasmussen, J.3
  • 62
    • 26244449275 scopus 로고    scopus 로고
    • Astrocytes and microglia differentially regulate trafficking of lymphocyte subsets across brain endothelial cells
    • DOI 10.1016/j.brainres.2005.07.071, PII S0006899305011261
    • Hudson LC, Bragg DC, Tompkins MB, Meeker RB,. Astrocytes and microglia differentially regulate trafficking of lymphocyte subsets across brain endothelial cells. Brain Res 2005; 1058: 148-160. (Pubitemid 41416809)
    • (2005) Brain Research , vol.1058 , Issue.1-2 , pp. 148-160
    • Hudson, L.C.1    Bragg, D.C.2    Tompkins, M.B.3    Meeker, R.B.4
  • 63
    • 0000752197 scopus 로고
    • Junctional complexes in various epithelia
    • Farquhar MG, Palade GE,. Junctional complexes in various epithelia. J Cell Biol 1963; 17: 375-412.
    • (1963) J Cell Biol , vol.17 , pp. 375-412
    • Farquhar, M.G.1    Palade, G.E.2
  • 64
    • 0019631483 scopus 로고
    • Barrier function of epithelia
    • Powell DW,. Barrier function of epithelia. Am J Physiol 1981; 241: G275-G288.
    • (1981) Am J Physiol , vol.241
    • Powell, D.W.1
  • 65
    • 77952756845 scopus 로고    scopus 로고
    • Molecular basis of the core structure of tight junctions
    • Furuse M,. Molecular basis of the core structure of tight junctions. Cold Spring Harb Perspect Biol 2010; 2: A002907.
    • (2010) Cold Spring Harb Perspect Biol , vol.2
    • Furuse, M.1
  • 66
    • 77951745982 scopus 로고    scopus 로고
    • Claudins: Unlocking the code to tight junction function during embryogenesis and in disease
    • Gupta IR, Ryan AK,. Claudins: unlocking the code to tight junction function during embryogenesis and in disease. Clin Genet 2010; 77: 314-325.
    • (2010) Clin Genet , vol.77 , pp. 314-325
    • Gupta, I.R.1    Ryan, A.K.2
  • 68
    • 0030931449 scopus 로고    scopus 로고
    • Paracellular diffusion in Caco-2 cell monolayers: Effect of pertubation on the transport of hydrophilic compounds that vary in charge and size
    • DOI 10.1021/js9700309
    • Knipp GT, Ho NF, Barsuhn CL, Borchardt RT,. Paracellular diffusion in Caco-2 cell monolayers: effect of perturbation on the transport of hydrophilic compounds that vary in charge and size. J Pharm Sci 1997; 86: 1105-1110. (Pubitemid 27430913)
    • (1997) Journal of Pharmaceutical Sciences , vol.86 , Issue.10 , pp. 1105-1110
    • Knipp, G.T.1    Ho, N.F.H.2    Barsuhn, C.L.3    Borchardt, R.T.4
  • 70
    • 0034891627 scopus 로고    scopus 로고
    • Functional modeling of tight junctions in intestinal cell monolayers using polyethylene glycol oligomers
    • Watson CJ, Rowland M, Warhurst G,. Functional modeling of tight junctions in intestinal cell monolayers using polyethylene glycol oligomers. Am J Physiol Cell Physiol 2001; 281: C388-C397.
    • (2001) Am J Physiol Cell Physiol , vol.281
    • Watson, C.J.1    Rowland, M.2    Warhurst, G.3
  • 71
    • 0032577975 scopus 로고    scopus 로고
    • Claudin-1 and -2: Novel integral membrane proteins localizing at tight junctions with no sequence similarity to occludin
    • DOI 10.1083/jcb.141.7.1539
    • Furuse M, Fujita K, Hiiragi T, et al. Claudin-1 and -2: novel integral membrane proteins localizing at tight junctions with no sequence similarity to occludin. J Cell Biol 1998; 141: 1539-1550. (Pubitemid 28309169)
    • (1998) Journal of Cell Biology , vol.141 , Issue.7 , pp. 1539-1550
    • Furuse, M.1    Fujita, K.2    Hiiragi, T.3    Fujimoto, K.4    Tsukita, S.5
  • 72
    • 0032547833 scopus 로고    scopus 로고
    • A single gene product, claudin-1 or -2, reconstitutes tight junction strands and recruits occludin in fibroblasts
    • DOI 10.1083/jcb.143.2.391
    • Furuse M, Sasaki H, Fujimoto K, Tsukita S,. A single gene product, claudin-1 or -2, reconstitutes tight junction strands and recruits occludin in fibroblasts. J Cell Biol 1998; 143: 391-401. (Pubitemid 28487858)
    • (1998) Journal of Cell Biology , vol.143 , Issue.2 , pp. 391-401
    • Furuse, M.1    Sasaki, H.2    Fujimoto, K.3    Tsukita, S.4
  • 73
    • 0033598188 scopus 로고    scopus 로고
    • 2+-independent cell-adhesion activity of claudins, a family of integral membrane proteins localized at tight junctions
    • DOI 10.1016/S0960-9822(99)80452-7
    • Kubota K, Furuse M, Sasaki H, et al. Ca(2+)-independent cell-adhesion activity of claudins, a family of integral membrane proteins localized at tight junctions. Curr Biol 1999; 9: 1035-1038. (Pubitemid 29456172)
    • (1999) Current Biology , vol.9 , Issue.18 , pp. 1035-1038
    • Kubota, K.1    Furuse, M.2    Sasaki, H.3    Sonoda, N.4    Fujita, K.5    Nagafuchi, A.6    Tsukita, S.7
  • 74
    • 0035013499 scopus 로고    scopus 로고
    • Regulated expression of claudin-4 decreases paracellular conductance through a selective decrease in sodium permeability
    • Van Itallie C, Rahner C, Anderson JM,. Regulated expression of claudin-4 decreases paracellular conductance through a selective decrease in sodium permeability. J Clin Invest 2001; 107: 1319-1327. (Pubitemid 32494549)
    • (2001) Journal of Clinical Investigation , vol.107 , Issue.10 , pp. 1319-1327
    • Van Itallie, C.1    Rahner, C.2    Anderson, J.M.3
  • 75
    • 0035897412 scopus 로고    scopus 로고
    • Conversion of zonulae occludentes from tight to leaky strand type by introducing claudin-2 into Madin-Darby canine kidney I cells
    • DOI 10.1083/jcb.153.2.263
    • Furuse M, Furuse K, Sasaki H, Tsukita S,. Conversion of zonulae occludentes from tight to leaky strand type by introducing claudin-2 into Madin-Darby canine kidney I cells. J Cell Biol 2001; 153: 263-272. (Pubitemid 34280213)
    • (2001) Journal of Cell Biology , vol.153 , Issue.2 , pp. 263-272
    • Furuse, M.1    Furuse, K.2    Sasaki, H.3    Tsukita, S.4
  • 80
    • 0033571047 scopus 로고    scopus 로고
    • Manner of interaction of heterogeneous claudin species within and between tight junction strands
    • Furuse M, Sasaki H, Tsukita S,. Manner of interaction of heterogeneous claudin species within and between tight junction strands. J Cell Biol 1999; 147: 891-903.
    • (1999) J Cell Biol , vol.147 , pp. 891-903
    • Furuse, M.1    Sasaki, H.2    Tsukita, S.3
  • 81
    • 38049166110 scopus 로고    scopus 로고
    • Formation of tight junction: Determinants of homophilic interaction between classic claudins
    • Piontek J, Winkler L, Wolburg H, et al. Formation of tight junction: determinants of homophilic interaction between classic claudins. FASEB J 2008; 22: 146-158.
    • (2008) FASEB J , vol.22 , pp. 146-158
    • Piontek, J.1    Winkler, L.2    Wolburg, H.3
  • 82
    • 0038701734 scopus 로고    scopus 로고
    • Claudin extracellular domains determine paracellular charge selectivity and resistance but not tight junction fibril architecture
    • Colegio OR, Van Itallie C, Rahner C, Anderson JM,. Claudin extracellular domains determine paracellular charge selectivity and resistance but not tight junction fibril architecture. Am J Physiol Cell Physiol 2003; 284: C1346-C1354. (Pubitemid 36583375)
    • (2003) American Journal of Physiology - Cell Physiology , vol.284 , Issue.6
    • Colegio, O.R.1    Van Itallie, C.2    Rahner, C.3    Anderson, J.M.4
  • 86
    • 53549090146 scopus 로고    scopus 로고
    • Familial hypomagnesaemia with hypercalciuria and nephrocalcinosis (FHHNC): Compound heterozygous mutation in the claudin 16 (CLDN16) gene
    • Hampson G, Konrad MA, Scoble J,. Familial hypomagnesaemia with hypercalciuria and nephrocalcinosis (FHHNC): compound heterozygous mutation in the claudin 16 (CLDN16) gene. BMC Nephrol 2008; 9: 12.
    • (2008) BMC Nephrol , vol.9 , pp. 12
    • Hampson, G.1    Konrad, M.A.2    Scoble, J.3
  • 87
    • 0942290526 scopus 로고    scopus 로고
    • Inherited Hypercalciuric Syndromes: Dent's Disease (CLC-5) and Familial Hypomagnesemia with Hypercalciuria (Paracellin-1)
    • DOI 10.1053/j.semnephrol.2003.08.011
    • Knohl SJ, Scheinman SJ,. Inherited hypercalciuric syndromes: Dent's disease (CLC-5) and familial hypomagnesemia with hypercalciuria (paracellin-1). Semin Nephrol 2004; 24: 55-60. (Pubitemid 38141845)
    • (2004) Seminars in Nephrology , vol.24 , Issue.1 , pp. 55-60
    • Knohl, S.J.1    Scheinman, S.J.2
  • 90
    • 0033523758 scopus 로고    scopus 로고
    • Endothelial claudin: Claudin-5/TMVCF constitutes tight junction strands in endothelial cells
    • DOI 10.1083/jcb.147.1.185
    • Morita K, Sasaki H, Furuse M, Tsukita S,. Endothelial claudin: claudin-5/TMVCF constitutes tight junction strands in endothelial cells. J Cell Biol 1999; 147: 185-194. (Pubitemid 30211806)
    • (1999) Journal of Cell Biology , vol.147 , Issue.1 , pp. 185-194
    • Morita, K.1    Sasaki, H.2    Furuse, M.3    Tsukita, S.4
  • 91
    • 78149456928 scopus 로고    scopus 로고
    • The mouse blood-brain barrier transcriptome: A new resource for understanding the development and function of brain endothelial cells
    • Daneman R, Zhou L, Agalliu D, et al. The mouse blood-brain barrier transcriptome: A new resource for understanding the development and function of brain endothelial cells. PLoS One 2010; 5: e13741.
    • (2010) PLoS One , vol.5
    • Daneman, R.1    Zhou, L.2    Agalliu, D.3
  • 92
    • 56149124382 scopus 로고    scopus 로고
    • Wnt/beta-catenin signaling controls development of the blood-brain barrier
    • Liebner S, Corada M, Bangsow T, et al. Wnt/beta-catenin signaling controls development of the blood-brain barrier. J Cell Biol 2008; 183: 409-417.
    • (2008) J Cell Biol , vol.183 , pp. 409-417
    • Liebner, S.1    Corada, M.2    Bangsow, T.3
  • 93
    • 0029799520 scopus 로고    scopus 로고
    • Functional dissociation of paracellular permeability and transepithelial electrical resistance and disruption of the apical-basolateral intramembrane diffusion barrier by expression of a mutant tight junction membrane protein
    • Balda MS, Whitney JA, Flores C, et al. Functional dissociation of paracellular permeability and transepithelial electrical resistance and disruption of the apical-basolateral intramembrane diffusion barrier by expression of a mutant tight junction membrane protein. J Cell Biol 1996; 134: 1031-1049. (Pubitemid 26278226)
    • (1996) Journal of Cell Biology , vol.134 , Issue.4 , pp. 1031-1049
    • Balda, M.S.1    Whitney, J.A.2    Flores, C.3    Gonzalez, S.4    Cereijido, M.5    Matter, K.6
  • 95
    • 0031047483 scopus 로고    scopus 로고
    • Synthetic peptide corresponding to the extracellular domain of occludin perturbs the tight junction permeability barrier
    • DOI 10.1083/jcb.136.2.399
    • Wong V, Gumbiner BM,. A synthetic peptide corresponding to the extracellular domain of occludin perturbs the tight junction permeability barrier. J Cell Biol 1997; 136: 399-409. (Pubitemid 27063089)
    • (1997) Journal of Cell Biology , vol.136 , Issue.2 , pp. 399-409
    • Wong, V.1    Gumbiner, B.M.2
  • 96
    • 0033635344 scopus 로고    scopus 로고
    • Complex phenotype of mice lacking occludin, a component of tight junction strands
    • Saitou M, Furuse M, Sasaki H, et al. Complex phenotype of mice lacking occludin, a component of tight junction strands. Mol Biol Cell 2000; 11: 4131-4142.
    • (2000) Mol Biol Cell , vol.11 , pp. 4131-4142
    • Saitou, M.1    Furuse, M.2    Sasaki, H.3
  • 97
    • 79956202699 scopus 로고    scopus 로고
    • Occludin S408 phosphorylation regulates tight junction protein interactions and barrier function
    • Raleigh DR, Boe DM, Yu D, et al. Occludin S408 phosphorylation regulates tight junction protein interactions and barrier function. J Cell Biol 2011; 193: 565-582.
    • (2011) J Cell Biol , vol.193 , pp. 565-582
    • Raleigh, D.R.1    Boe, D.M.2    Yu, D.3
  • 98
    • 37549038994 scopus 로고    scopus 로고
    • JAM-A regulates permeability and inflammation in the intestine in vivo
    • Laukoetter MG, Nava P, Lee WY, et al. JAM-A regulates permeability and inflammation in the intestine in vivo. J Exp Med 2007; 204: 3067-3076.
    • (2007) J Exp Med , vol.204 , pp. 3067-3076
    • Laukoetter, M.G.1    Nava, P.2    Lee, W.Y.3
  • 100
    • 0034705379 scopus 로고    scopus 로고
    • Vascular endothelial junction-associated molecule, a novel member of the immunoglobulin superfamily, is localized to intercellular boundaries of endothelial cells
    • DOI 10.1074/jbc.M003189200
    • Palmeri D, van Zante A, Huang CC, et al. Vascular endothelial junction-associated molecule, a novel member of the immunoglobulin superfamily, is localized to intercellular boundaries of endothelial cells. J Biol Chem 2000; 275: 19139-19145. (Pubitemid 30422883)
    • (2000) Journal of Biological Chemistry , vol.275 , Issue.25 , pp. 19139-19145
    • Palmeri, D.1    Van Zante, A.2    Huang, C.-C.3    Hemmerich, S.4    Rosen, S.D.5
  • 101
    • 39849104321 scopus 로고    scopus 로고
    • Endothelial adherens and tight junctions in vascular homeostasis, inflammation and angiogenesis
    • DOI 10.1016/j.bbamem.2007.09.003, PII S000527360700346X
    • Wallez Y, Huber P,. Endothelial adherens and tight junctions in vascular homeostasis, inflammation and angiogenesis. Biochim Biophys Acta 2008; 1778: 794-809. (Pubitemid 351317803)
    • (2008) Biochimica et Biophysica Acta - Biomembranes , vol.1778 , Issue.3 , pp. 794-809
    • Wallez, Y.1    Huber, P.2
  • 102
    • 0033233421 scopus 로고    scopus 로고
    • Identification and characterization of human junctional adhesion molecule (JAM)
    • DOI 10.1016/S0161-5890(99)00122-4, PII S0161589099001224
    • Williams LA, Martin-Padura I, Dejana E, et al. Identification and characterisation of human junctional adhesion molecule (JAM). Mol Immunol 1999; 36: 1175-1188. (Pubitemid 30078900)
    • (1999) Molecular Immunology , vol.36 , Issue.17 , pp. 1175-1188
    • Williams, L.A.1    Martin-Padura, I.2    Dejana, E.3    Hogg, N.4    Simmons, D.L.5
  • 103
    • 0035895050 scopus 로고    scopus 로고
    • Heterogeneity of endothelial junctions is reflected by differential expression and specific subcellular localization of the three JAM family members
    • Aurrand-Lions M, Johnson-Leger C, Wong C, et al. Heterogeneity of endothelial junctions is reflected by differential expression and specific subcellular localization of the three JAM family members. Blood 2001; 98: 3699-3707.
    • (2001) Blood , vol.98 , pp. 3699-3707
    • Aurrand-Lions, M.1    Johnson-Leger, C.2    Wong, C.3
  • 105
    • 0036785376 scopus 로고    scopus 로고
    • Junctional adhesion molecule-2 (JAM-2) promotes lymphocyte transendothelial migration
    • Johnson-Leger CA, Aurrand-Lions M, Beltraminelli N, et al. Junctional adhesion molecule-2 (JAM-2) promotes lymphocyte transendothelial migration. Blood 2002; 100: 2479-2486.
    • (2002) Blood , vol.100 , pp. 2479-2486
    • Johnson-Leger, C.A.1    Aurrand-Lions, M.2    Beltraminelli, N.3
  • 106
    • 33644795491 scopus 로고    scopus 로고
    • Junctional adhesion molecules (JAM)-B and -C contribute to leukocyte extravasation to the skin and mediate cutaneous inflammation
    • Ludwig RJ, Zollner TM, Santoso S, et al. Junctional adhesion molecules (JAM)-B and -C contribute to leukocyte extravasation to the skin and mediate cutaneous inflammation. J Invest Dermatol 2005; 125: 969-976.
    • (2005) J Invest Dermatol , vol.125 , pp. 969-976
    • Ludwig, R.J.1    Zollner, T.M.2    Santoso, S.3
  • 108
    • 77955856027 scopus 로고    scopus 로고
    • Endothelial adherens junctions and the actin cytoskeleton: An 'infinity net'?
    • Lampugnani MG,. Endothelial adherens junctions and the actin cytoskeleton: An 'infinity net'? J Biol 2010; 9: 16.
    • (2010) J Biol , vol.9 , pp. 16
    • Lampugnani, M.G.1
  • 110
    • 77957233298 scopus 로고    scopus 로고
    • VE-cadherin: At the front, center, and sides of endothelial cell organization and function
    • Harris ES, Nelson WJ,. VE-cadherin: At the front, center, and sides of endothelial cell organization and function. Curr Opin Cell Biol 2010; 22: 651-658.
    • (2010) Curr Opin Cell Biol , vol.22 , pp. 651-658
    • Harris, E.S.1    Nelson, W.J.2
  • 111
    • 80054935637 scopus 로고    scopus 로고
    • Stabilizing the VE-cadherin-catenin complex blocks leukocyte extravasation and vascular permeability
    • Schulte D, Kuppers V, Dartsch N, et al. Stabilizing the VE-cadherin-catenin complex blocks leukocyte extravasation and vascular permeability. EMBO J 2011; 30: 4157-4170.
    • (2011) EMBO J , vol.30 , pp. 4157-4170
    • Schulte, D.1    Kuppers, V.2    Dartsch, N.3
  • 114
    • 2642522146 scopus 로고    scopus 로고
    • The temporospatial expression of peripheral myelin protein 22 at the developing blood-nerve and blood-brain barriers
    • DOI 10.1002/cne.20154
    • Roux KJ, Amici SA, Notterpek L,. The temporospatial expression of peripheral myelin protein 22 at the developing blood-nerve and blood-brain barriers. J Comp Neurol 2004; 474: 578-588. (Pubitemid 38720426)
    • (2004) Journal of Comparative Neurology , vol.474 , Issue.4 , pp. 578-588
    • Roux, K.J.1    Amici, S.A.2    Notterpek, L.3
  • 116
    • 79951830550 scopus 로고    scopus 로고
    • LSR defines cell corners for tricellular tight junction formation in epithelial cells
    • Masuda S, Oda Y, Sasaki H, et al. LSR defines cell corners for tricellular tight junction formation in epithelial cells. J Cell Sci 2011; 124 (pt 4): 548-555.
    • (2011) J Cell Sci , vol.124 , Issue.PART 4 , pp. 548-555
    • Masuda, S.1    Oda, Y.2    Sasaki, H.3
  • 119
    • 0018855966 scopus 로고
    • Polarity of the blood-brain barrier: Distribution of enzymes between the luminal and antiluminal membranes of brain capillary endothelial cells
    • DOI 10.1016/0006-8993(80)91004-5
    • Betz AL, Firth JA, Goldstein GW,. Polarity of the blood-brain barrier: distribution of enzymes between the luminal and antiluminal membranes of brain capillary endothelial cells. Brain Res 1980; 192: 17-28. (Pubitemid 10102183)
    • (1980) Brain Research , vol.192 , Issue.1 , pp. 17-28
    • Betz, A.L.1    Firth, J.A.2    Goldstein, G.W.3
  • 120
    • 0018080931 scopus 로고
    • Polarity of the blood-brain barrier: Neutral amino acid transport into isolated brain capillaries
    • Betz AL, Goldstein GW,. Polarity of the blood-brain barrier: neutral amino acid transport into isolated brain capillaries. Science 1978; 202: 225-227. (Pubitemid 9055121)
    • (1978) Science , vol.202 , Issue.4364 , pp. 225-227
    • Betz, A.L.1    Goldstein, G.W.2
  • 121
    • 0034624286 scopus 로고    scopus 로고
    • Structural alterations of tight junctions are associated with loss of polarity in stroke-prone spontaneously hypertensive rat blood-brain barrier endothelial cells
    • Lippoldt A, Kniesel U, Liebner S, et al. Structural alterations of tight junctions are associated with loss of polarity in stroke-prone spontaneously hypertensive rat blood-brain barrier endothelial cells. Brain Res 2000; 885: 251-261.
    • (2000) Brain Res , vol.885 , pp. 251-261
    • Lippoldt, A.1    Kniesel, U.2    Liebner, S.3
  • 122
    • 67650609849 scopus 로고    scopus 로고
    • Loss of astrocyte polarity marks blood-brain barrier impairment during experimental autoimmune encephalomyelitis
    • Wolburg-Buchholz K, Mack AF, Steiner E, et al. Loss of astrocyte polarity marks blood-brain barrier impairment during experimental autoimmune encephalomyelitis. Acta Neuropathol 2009; 118: 219-233.
    • (2009) Acta Neuropathol , vol.118 , pp. 219-233
    • Wolburg-Buchholz, K.1    MacK, A.F.2    Steiner, E.3
  • 124
    • 12344262373 scopus 로고    scopus 로고
    • Blood-brain barrier active efflux transporters: ATP-binding cassette gene family
    • DOI 10.1602/neurorx.2.1.86
    • Loscher W, Potschka H,. Blood-brain barrier active efflux transporters: ATP-binding cassette gene family. NeuroRx 2005; 2: 86-98. (Pubitemid 40128029)
    • (2005) NeuroRx , vol.2 , Issue.1 , pp. 86-98
    • Loscher, W.1    Potschka, H.2
  • 125
    • 0024576304 scopus 로고
    • Immunohistochemical localization in normal tissues of different epitopes in the multidrug transport protein P170: Evidence for localization in brain capillaries and crossreactivity of one antibody with a muscle protein
    • Thiebaut F, Tsuruo T, Hamada H, et al. Immunohistochemical localization in normal tissues of different epitopes in the multidrug transport protein P170: evidence for localization in brain capillaries and crossreactivity of one antibody with a muscle protein. J Histochem Cytochem 1989; 37: 159-164. (Pubitemid 19039163)
    • (1989) Journal of Histochemistry and Cytochemistry , vol.37 , Issue.2 , pp. 159-164
    • Thiebaut, F.1    Tsuruo, T.2    Hamada, H.3    Gottesman, M.M.4    Pastan, I.5    Willingham, M.C.6
  • 126
    • 35448949586 scopus 로고    scopus 로고
    • Mini review on molecular modeling of P-glycoprotein (Pgp)
    • DOI 10.2174/156802607782194806
    • Ha SN, Hochman J, Sheridan RP,. Mini review on molecular modeling of P-glycoprotein (Pgp). Curr Top Med Chem 2007; 7: 1525-1529. (Pubitemid 47618065)
    • (2007) Current Topics in Medicinal Chemistry , vol.7 , Issue.15 , pp. 1525-1529
    • Ha, S.N.1    Hochman, J.2    Sheridan, R.P.3
  • 127
    • 0025074116 scopus 로고
    • Specialized localization of P-glycoprotein recognized by MRK 16 monoclonal antibody in endothelial cells of the brain and the spinal cord
    • Sugawara I, Hamada H, Tsuruo T, Mori S,. Specialized localization of P-glycoprotein recognized by MRK 16 monoclonal antibody in endothelial cells of the brain and the spinal cord. Jpn J Cancer Res 1990; 81: 727-730. (Pubitemid 20246917)
    • (1990) Japanese Journal of Cancer Research , vol.81 , Issue.8 , pp. 727-730
    • Sugawara, I.1    Hamada, H.2    Tsuruo, T.3    Mori, S.4
  • 128
    • 0025165474 scopus 로고
    • Expression and functions of P-glycoprotein (mdr 1 gene product) in normal and malignant tissues
    • Sugawara I,. Expression and functions of P-glycoprotein (mdr1 gene product) in normal and malignant tissues. Acta Pathol Jpn 1990; 40: 545-553. (Pubitemid 20328971)
    • (1990) Acta Pathologica Japonica , vol.40 , Issue.8 , pp. 545-553
    • Sugawara, I.1
  • 131
    • 0028825399 scopus 로고
    • Absence of the mdr1a P-Glycoprotein in mice affects tissue distribution and pharmacokinetics of dexamethasone, digoxin, and cyclosporin A
    • Schinkel AH, Wagenaar E, van Deemter L, et al. Absence of the mdr1a P-Glycoprotein in mice affects tissue distribution and pharmacokinetics of dexamethasone, digoxin, and cyclosporin A. J Clin Invest 1995; 96: 1698-1705.
    • (1995) J Clin Invest , vol.96 , pp. 1698-1705
    • Schinkel, A.H.1    Wagenaar, E.2    Van Deemter, L.3
  • 132
    • 0036355398 scopus 로고    scopus 로고
    • Drug resistance in epilepsy: The role of the blood-brain barrier
    • Abbott NJ, Khan EU, Rollinson CM, et al. Drug resistance in epilepsy: The role of the blood-brain barrier. Novartis Found Symp 2002; 243: 38-47; discussion 47-53, 180-185.
    • (2002) Novartis Found Symp , vol.243 , pp. 38-47
    • Abbott, N.J.1    Khan, E.U.2    Rollinson, C.M.3
  • 133
    • 0035900333 scopus 로고    scopus 로고
    • P-glycoprotein and multidrug resistance-associated protein are involved in the regulation of extracellular levels of the major antiepileptic drug carbamazepine in the brain
    • Potschka H, Fedrowitz M, Loscher W,. P-glycoprotein and multidrug resistance-associated protein are involved in the regulation of extracellular levels of the major antiepileptic drug carbamazepine in the brain. Neuroreport 2001; 12: 3557-3560. (Pubitemid 33065498)
    • (2001) NeuroReport , vol.12 , Issue.16 , pp. 3557-3560
    • Potschka, H.1    Fedrowitz, M.2    Loscher, W.3
  • 134
    • 42449134059 scopus 로고    scopus 로고
    • P-glycoprotein - A clinical target in drug-refractory epilepsy?
    • DOI 10.1124/mol.108.046680
    • Robey RW, Lazarowski A, Bates SE,. P-glycoprotein-A clinical target in drug-refractory epilepsy? Mol Pharmacol 2008; 73: 1343-1346. (Pubitemid 351574823)
    • (2008) Molecular Pharmacology , vol.73 , Issue.5 , pp. 1343-1346
    • Robey, R.W.1    Lazarowski, A.2    Bates, S.E.3
  • 135
    • 0037113346 scopus 로고    scopus 로고
    • Localisation of breast cancer resistance protein in microvessel endothelium of human brain
    • DOI 10.1097/00001756-200211150-00014
    • Cooray HC, Blackmore CG, Maskell L, Barrand MA,. Localisation of breast cancer resistance protein in microvessel endothelium of human brain. Neuroreport 2002; 13: 2059-2063. (Pubitemid 36005925)
    • (2002) NeuroReport , vol.13 , Issue.16 , pp. 2059-2063
    • Cooray, H.C.1    Blackmore, C.G.2    Maskell, L.3    Barrand, M.A.4
  • 136
    • 3242682550 scopus 로고    scopus 로고
    • Contribution of glial cells and pericytes to the mRNA profiles of P-glycoprotein and multidrug resistance-associated proteins in an in vitro model of the blood-brain barrier
    • DOI 10.1016/j.brainres.2004.05.092, PII S0006899304007358
    • Berezowski V, Landry C, Dehouck MP, et al. Contribution of glial cells and pericytes to the mRNA profiles of P-glycoprotein and multidrug resistance-associated proteins in an in vitro model of the blood-brain barrier. Brain Res 2004; 1018: 1-9. (Pubitemid 38942854)
    • (2004) Brain Research , vol.1018 , Issue.1 , pp. 1-9
    • Berezowski, V.1    Landry, C.2    Dehouck, M.-P.3    Cecchelli, R.4    Fenart, L.5
  • 137
    • 6344265573 scopus 로고    scopus 로고
    • Expression and immunolocalization of the multidrug resistance proteins, MRP1-MRP6 (ABCC1-ABCC6), in human brain
    • DOI 10.1016/j.neuroscience.2004.07.051, PII S0306452204007171
    • Nies AT, Jedlitschky G, Konig J, et al. Expression and immunolocalization of the multidrug resistance proteins, MRP1-MRP6 (ABCC1-ABCC6), in human brain. Neuroscience 2004; 129: 349-360. (Pubitemid 39388854)
    • (2004) Neuroscience , vol.129 , Issue.2 , pp. 349-360
    • Nies, A.T.1    Jedlitschky, G.2    Konig, J.3    Herold-Mende, C.4    Steiner, H.H.5    Schmitt, H.-P.6    Keppler, D.7
  • 138
    • 0034623293 scopus 로고    scopus 로고
    • Expression of various multidrug resistance-associated protein (MRP) homologues in brain microvessel endothelial cells
    • Zhang Y, Han H, Elmquist WF, Miller DW,. Expression of various multidrug resistance-associated protein (MRP) homologues in brain microvessel endothelial cells. Brain Res 2000; 876: 148-153.
    • (2000) Brain Res , vol.876 , pp. 148-153
    • Zhang, Y.1    Han, H.2    Elmquist, W.F.3    Miller, D.W.4
  • 140
    • 0028127716 scopus 로고
    • The human brain GLUT1 glucose transporter: Ultrastructural localization to the blood-brain barrier endothelia
    • Cornford EM, Hyman S, Swartz BE,. The human brain GLUT1 glucose transporter: ultrastructural localization to the blood-brain barrier endothelia. J Cereb Blood Flow Metab 1994; 14: 106-112.
    • (1994) J Cereb Blood Flow Metab , vol.14 , pp. 106-112
    • Cornford, E.M.1    Hyman, S.2    Swartz, B.E.3
  • 141
    • 0021130764 scopus 로고
    • Transferrin receptor on endothelium of brain capillaries
    • DOI 10.1038/312162a0
    • Jefferies WA, Brandon MR, Hunt SV, et al. Transferrin receptor on endothelium of brain capillaries. Nature 1984; 312: 162-163. (Pubitemid 14000081)
    • (1984) Nature , vol.312 , Issue.5990 , pp. 162-163
    • Jefferies, W.A.1    Brandon, M.R.2    Hunt, S.V.3
  • 142
    • 0034053017 scopus 로고    scopus 로고
    • Functional clarification of MCT1-mediated transport of monocarboxylic acids at the blood-brain barrier using in vitro cultured cells and in vivo BUI studies
    • DOI 10.1023/A:1007518525161
    • Kido Y, Tamai I, Okamoto M, et al. Functional clarification of MCT1-mediated transport of monocarboxylic acids at the blood-brain barrier using in vitro cultured cells and in vivo BUI studies. Pharm Res 2000; 17: 55-62. (Pubitemid 30121100)
    • (2000) Pharmaceutical Research , vol.17 , Issue.1 , pp. 55-62
    • Kido, Y.1    Tamai, I.2    Okamoto, M.3    Suzuki, F.4    Tsuji, A.5
  • 144
    • 0028957713 scopus 로고
    • Cerebral microvascular endothelial cell Na-K-Cl cotransport: Regulation by astrocyte-conditioned medium
    • O'Donnell ME, Martinez A, Sun D,. Cerebral microvascular endothelial cell Na-K-Cl cotransport: regulation by astrocyte-conditioned medium. Am J Physiol 1995; 268: C747-C754.
    • (1995) Am J Physiol , vol.268
    • O'Donnell, M.E.1    Martinez, A.2    Sun, D.3
  • 145
    • 0037000620 scopus 로고    scopus 로고
    • Glucose transporter 1 deficiency syndrome and other glycolytic defects
    • discussion 3S24-3S25
    • De Vivo DC, Leary L, Wang D,. Glucose transporter 1 deficiency syndrome and other glycolytic defects. J Child Neurol 2002; 17 (suppl 3): 3S15-3S23; discussion 3S24-3S25.
    • (2002) J Child Neurol , vol.17 , Issue.SUPPL. 3
    • De Vivo, D.C.1    Leary, L.2    Wang, D.3
  • 146
    • 0025819954 scopus 로고
    • Defective glucose transport across the blood-brain barrier as a cause of persistent hypoglycorrhachia, seizures, and developmental delay
    • De Vivo DC, Trifiletti RR, Jacobson RI, et al. Defective glucose transport across the blood-brain barrier as a cause of persistent hypoglycorrhachia, seizures, and developmental delay. N Engl J Med 1991; 325: 703-709.
    • (1991) N Engl J Med , vol.325 , pp. 703-709
    • De Vivo, D.C.1    Trifiletti, R.R.2    Jacobson, R.I.3
  • 147
    • 0018812822 scopus 로고
    • The ketogenic diet: Mechanism of anticonvulsant action
    • Withrow CD,. The ketogenic diet: mechanism of anticonvulsant action. Adv Neurol 1980; 27: 635-642.
    • (1980) Adv Neurol , vol.27 , pp. 635-642
    • Withrow, C.D.1
  • 148
    • 33747781747 scopus 로고    scopus 로고
    • Inflammation in stroke and focal cerebral ischemia
    • DOI 10.1016/j.surneu.2005.12.028, PII S0090301906001017
    • Huang J, Upadhyay UM, Tamargo RJ,. Inflammation in stroke and focal cerebral ischemia. Surg Neurol 2006; 66: 232-245. (Pubitemid 44279808)
    • (2006) Surgical Neurology , vol.66 , Issue.3 , pp. 232-245
    • Huang, J.1    Upadhyay, U.M.2    Tamargo, R.J.3
  • 150
    • 53049110581 scopus 로고    scopus 로고
    • Immune cell entry into the central nervous system: Involvement of adhesion molecules and chemokines
    • Engelhardt B,. Immune cell entry into the central nervous system: involvement of adhesion molecules and chemokines. J Neurol Sci 2008; 274: 23-26.
    • (2008) J Neurol Sci , vol.274 , pp. 23-26
    • Engelhardt, B.1
  • 152
    • 67651108919 scopus 로고    scopus 로고
    • The prototype endothelial marker PAL-E is a leukocyte trafficking molecule
    • Keuschnigg J, Henttinen T, Auvinen K, et al. The prototype endothelial marker PAL-E is a leukocyte trafficking molecule. Blood 2009; 114: 478-484.
    • (2009) Blood , vol.114 , pp. 478-484
    • Keuschnigg, J.1    Henttinen, T.2    Auvinen, K.3
  • 153
    • 41049099175 scopus 로고    scopus 로고
    • Plasmalemmal vesicle associated protein-1 (PV-1) is a marker of blood-brain barrier disruption in rodent models
    • Shue EH, Carson-Walter EB, Liu Y, et al. Plasmalemmal vesicle associated protein-1 (PV-1) is a marker of blood-brain barrier disruption in rodent models. BMC Neurosci 2008; 9: 29.
    • (2008) BMC Neurosci , vol.9 , pp. 29
    • Shue, E.H.1    Carson-Walter, E.B.2    Liu, Y.3
  • 154
    • 29244463365 scopus 로고    scopus 로고
    • Astrocyte-endothelial interactions at the blood-brain barrier
    • DOI 10.1038/nrn1824
    • Abbott NJ, Ronnback L, Hansson E,. Astrocyte-endothelial interactions at the blood-brain barrier. Nat Rev Neurosci 2006; 7: 41-53. (Pubitemid 41828930)
    • (2006) Nature Reviews Neuroscience , vol.7 , Issue.1 , pp. 41-53
    • Abbott, N.J.1    Ronnback, L.2    Hansson, E.3
  • 157
    • 79961022877 scopus 로고    scopus 로고
    • The effect of astrocytes on the induction of barrier properties in aortic endothelial cells
    • 2011 Apr 20. doi: 10.1002/btpr.620
    • Shayan G, Shuler ML, Lee KH,. The effect of astrocytes on the induction of barrier properties in aortic endothelial cells. Biotechnol Prog 2011 Apr 20. doi: 10.1002/btpr.620.
    • Biotechnol Prog
    • Shayan, G.1    Shuler, M.L.2    Lee, K.H.3
  • 158
    • 0027362473 scopus 로고
    • Neovascularization and the appearance of morphological characteristics of the blood-brain barrier in the embryonic mouse central nervous system
    • DOI 10.1016/0165-3806(93)90031-5
    • Bauer HC, Bauer H, Lametschwandtner A, et al. Neovascularization and the appearance of morphological characteristics of the blood-brain barrier in the embryonic mouse central nervous system. Brain Res Dev Brain Res 1993; 75: 269-278. (Pubitemid 23293577)
    • (1993) Developmental Brain Research , vol.75 , Issue.2 , pp. 269-278
    • Bauer, H.C.1    Bauer, H.2    Lametschwandter, A.3    Amberger, A.4    Ruiz, P.5    Steiner, M.6
  • 159
    • 0026437932 scopus 로고
    • Embryonic development of the CNS microvasculature in the mouse: New insights into the structural mechanisms of early angiogenesis
    • Bauer HC, Steiner M, Bauer H,. Embryonic development of the CNS microvasculature in the mouse: new insights into the structural mechanisms of early angiogenesis. EXS 1992; 61: 64-68.
    • (1992) EXS , vol.61 , pp. 64-68
    • Bauer, H.C.1    Steiner, M.2    Bauer, H.3
  • 160
    • 33645460483 scopus 로고    scopus 로고
    • Functional effectiveness of the blood-brain barrier to small water-soluble molecules in developing and adult opossum (Monodelphis domestica)
    • Ek CJ, Dziegielewska KM, Stolp H, Saunders NR,. Functional effectiveness of the blood-brain barrier to small water-soluble molecules in developing and adult opossum (Monodelphis domestica). J Comp Neurol 2006; 496: 13-26.
    • (2006) J Comp Neurol , vol.496 , pp. 13-26
    • Ek, C.J.1    Dziegielewska, K.M.2    Stolp, H.3    Saunders, N.R.4
  • 161
    • 58849119932 scopus 로고    scopus 로고
    • Wnt/beta-catenin signaling is required for CNS, but not non-CNS, angiogenesis
    • Daneman R, Agalliu D, Zhou L, et al. Wnt/beta-catenin signaling is required for CNS, but not non-CNS, angiogenesis. Proc Natl Acad Sci U S A 2009; 106: 641-646.
    • (2009) Proc Natl Acad Sci U S A , vol.106 , pp. 641-646
    • Daneman, R.1    Agalliu, D.2    Zhou, L.3
  • 162
    • 56749104928 scopus 로고    scopus 로고
    • Canonical Wnt signaling regulates organ-specific assembly and differentiation of CNS vasculature
    • Stenman JM, Rajagopal J, Carroll TJ, et al. Canonical Wnt signaling regulates organ-specific assembly and differentiation of CNS vasculature. Science 2008; 322: 1247-1250.
    • (2008) Science , vol.322 , pp. 1247-1250
    • Stenman, J.M.1    Rajagopal, J.2    Carroll, T.J.3
  • 163
    • 78049279739 scopus 로고    scopus 로고
    • Pericytes control key neurovascular functions and neuronal phenotype in the adult brain and during brain aging
    • Bell RD, Winkler EA, Sagare AP, et al. Pericytes control key neurovascular functions and neuronal phenotype in the adult brain and during brain aging. Neuron 2010; 68: 409-427.
    • (2010) Neuron , vol.68 , pp. 409-427
    • Bell, R.D.1    Winkler, E.A.2    Sagare, A.P.3
  • 164
    • 20044387390 scopus 로고    scopus 로고
    • Brain pericytes contribute to the induction and up-regulation of blood-brain barrier functions through transforming growth factor-β production
    • DOI 10.1016/j.brainres.2005.01.027
    • Dohgu S, Takata F, Yamauchi A, et al. Brain pericytes contribute to the induction and up-regulation of blood-brain barrier functions through transforming growth factor-beta production. Brain Res 2005; 1038: 208-215. (Pubitemid 40332685)
    • (2005) Brain Research , vol.1038 , Issue.2 , pp. 208-215
    • Dohgu, S.1    Takata, F.2    Yamauchi, A.3    Nakagawa, S.4    Egawa, T.5    Naito, M.6    Tsuruo, T.7    Sawada, Y.8    Niwa, M.9    Kataoka, Y.10
  • 165
    • 1942455227 scopus 로고    scopus 로고
    • A pericyte-derived angiopoietin-1 multimeric complex induces occludin gene expression in brain capillary endothelial cells through Tie-2 activation in vitro
    • DOI 10.1111/j.1471-4159.2004.02343.x
    • Hori S, Ohtsuki S, Hosoya K, et al. A pericyte-derived angiopoietin-1 multimeric complex induces occludin gene expression in brain capillary endothelial cells through Tie-2 activation in vitro. J Neurochem 2004; 89: 503-513. (Pubitemid 38495998)
    • (2004) Journal of Neurochemistry , vol.89 , Issue.2 , pp. 503-513
    • Hori, S.1    Ohtsuki, S.2    Hosoya, K.-I.3    Nakashima, E.4    Terasaki, T.5
  • 166
    • 77952035085 scopus 로고    scopus 로고
    • Endothelial cell heterogeneity of blood-brain barrier gene expression along the cerebral microvasculature
    • Macdonald JA, Murugesan N, Pachter JS,. Endothelial cell heterogeneity of blood-brain barrier gene expression along the cerebral microvasculature. J Neurosci Res 2010; 88: 1457-1474.
    • (2010) J Neurosci Res , vol.88 , pp. 1457-1474
    • MacDonald, J.A.1    Murugesan, N.2    Pachter, J.S.3
  • 167
    • 0017276160 scopus 로고
    • Entry of peroxidase into neurons of the central and peripheral nervous systems from extracerebral and cerebral blood
    • Broadwell RD, Brightman MW,. Entry of peroxidase into neurons of the central and peripheral nervous systems from extracerebral and cerebral blood. J Comp Neurol 1976; 166: 257-283.
    • (1976) J Comp Neurol , vol.166 , pp. 257-283
    • Broadwell, R.D.1    Brightman, M.W.2
  • 168
    • 0026722452 scopus 로고
    • Circumventricular organ capillaries
    • Gross PM,. Circumventricular organ capillaries. Prog Brain Res 1992; 91: 219-233.
    • (1992) Prog Brain Res , vol.91 , pp. 219-233
    • Gross, P.M.1
  • 169
    • 77649192491 scopus 로고    scopus 로고
    • Choroid plexus: Biology and pathology
    • Wolburg H, Paulus W,. Choroid plexus: biology and pathology. Acta Neuropathol 2010; 119: 75-88.
    • (2010) Acta Neuropathol , vol.119 , pp. 75-88
    • Wolburg, H.1    Paulus, W.2
  • 170
    • 80051551970 scopus 로고    scopus 로고
    • The blood-spinal cord barrier: Morphology and clinical implications
    • Bartanusz V, Jezova D, Alajajian B, Digicaylioglu M,. The blood-spinal cord barrier: morphology and clinical implications. Ann Neurol 2011; 70: 194-206.
    • (2011) Ann Neurol , vol.70 , pp. 194-206
    • Bartanusz, V.1    Jezova, D.2    Alajajian, B.3    Digicaylioglu, M.4
  • 171
    • 17844378527 scopus 로고    scopus 로고
    • Pathophysiology of blood-spinal cord barrier in traumatic injury and repair
    • DOI 10.2174/1381612053507837
    • Sharma HS,. Pathophysiology of blood-spinal cord barrier in traumatic injury and repair. Curr Pharm Des 2005; 11: 1353-1389. (Pubitemid 40598002)
    • (2005) Current Pharmaceutical Design , vol.11 , Issue.11 , pp. 1353-1389
    • Sharma, H.S.1
  • 172
    • 0027319870 scopus 로고
    • Pericyte physiology
    • Shepro D, Morel NM,. Pericyte physiology. FASEB J 1993; 7: 1031-1038. (Pubitemid 23243445)
    • (1993) FASEB Journal , vol.7 , Issue.11 , pp. 1031-1038
    • Shepro, D.1    Morel, N.M.L.2
  • 173
    • 0023233845 scopus 로고
    • Pericyte coverage is greater in the retinal than in the cerebral capillaries of the rat
    • Frank RN, Dutta S, Mancini MA,. Pericyte coverage is greater in the retinal than in the cerebral capillaries of the rat. Invest Ophthalmol Vis Sci 1987; 28: 1086-1091. (Pubitemid 17089946)
    • (1987) Investigative Ophthalmology and Visual Science , vol.28 , Issue.7 , pp. 1086-1091
    • Frank, R.N.1    Dutta, S.2    Mancini, M.A.3
  • 176
    • 79952596356 scopus 로고    scopus 로고
    • Angiogenic sprouting into neural tissue requires Gpr124, an orphan G protein-coupled receptor
    • Anderson KD, Pan L, Yang XM, et al. Angiogenic sprouting into neural tissue requires Gpr124, an orphan G protein-coupled receptor. Proc Natl Acad Sci U S A 2011; 108: 2807-2812.
    • (2011) Proc Natl Acad Sci U S A , vol.108 , pp. 2807-2812
    • Anderson, K.D.1    Pan, L.2    Yang, X.M.3
  • 177
    • 79955029851 scopus 로고    scopus 로고
    • GPR124, an orphan G protein-coupled receptor, is required for CNS-specific vascularization and establishment of the blood-brain barrier
    • Cullen M, Elzarrad MK, Seaman S, et al. GPR124, an orphan G protein-coupled receptor, is required for CNS-specific vascularization and establishment of the blood-brain barrier. Proc Natl Acad Sci U S A 2011; 108: 5759-5764.
    • (2011) Proc Natl Acad Sci U S A , vol.108 , pp. 5759-5764
    • Cullen, M.1    Elzarrad, M.K.2    Seaman, S.3
  • 178
    • 78149399666 scopus 로고    scopus 로고
    • Essential regulation of CNS angiogenesis by the orphan G protein-coupled receptor GPR124
    • Kuhnert F, Mancuso MR, Shamloo A, et al. Essential regulation of CNS angiogenesis by the orphan G protein-coupled receptor GPR124. Science 2010; 330: 985-989.
    • (2010) Science , vol.330 , pp. 985-989
    • Kuhnert, F.1    Mancuso, M.R.2    Shamloo, A.3
  • 179
    • 67650602106 scopus 로고    scopus 로고
    • Pathology and new players in the pathogenesis of brain edema
    • Nag S, Manias JL, Stewart DJ,. Pathology and new players in the pathogenesis of brain edema. Acta Neuropathol 2009; 118: 197-217.
    • (2009) Acta Neuropathol , vol.118 , pp. 197-217
    • Nag, S.1    Manias, J.L.2    Stewart, D.J.3
  • 180
    • 85052608985 scopus 로고    scopus 로고
    • Inflammation and brain edema: New insights into the role of chemokines and their receptors
    • Stamatovic SM, Dimitrijevic OB, Keep RF, Andjelkovic AV,. Inflammation and brain edema: new insights into the role of chemokines and their receptors. Acta Neurochir Suppl 2006; 96: 444-450.
    • (2006) Acta Neurochir Suppl , vol.96 , pp. 444-450
    • Stamatovic, S.M.1    Dimitrijevic, O.B.2    Keep, R.F.3    Andjelkovic, A.V.4
  • 181
    • 9344264016 scopus 로고    scopus 로고
    • Edema and brain trauma
    • DOI 10.1016/j.neuroscience.2004.06.046, PII S0306452204005433, Brain Water Homeostasis
    • Unterberg AW, Stover J, Kress B, Kiening KL,. Edema and brain trauma. Neuroscience 2004; 129: 1021-1029. (Pubitemid 39556253)
    • (2004) Neuroscience , vol.129 , Issue.4 , pp. 1021-1029
    • Unterberg, A.W.1    Stover, J.2    Kress, B.3    Kiening, K.L.4
  • 182
    • 34250315324 scopus 로고    scopus 로고
    • The blood-brain-barrier in multiple sclerosis: Functional roles and therapeutic targeting
    • Correale J, Villa A,. The blood-brain-barrier in multiple sclerosis: functional roles and therapeutic targeting. Autoimmunity 2007; 40: 148-160.
    • (2007) Autoimmunity , vol.40 , pp. 148-160
    • Correale, J.1    Villa, A.2
  • 183
    • 33750924816 scopus 로고    scopus 로고
    • The blood-brain barrier and epilepsy
    • DOI 10.1111/j.1528-1167.2006.00817.x
    • Oby E, Janigro D,. The blood-brain barrier and epilepsy. Epilepsia 2006; 47: 1761-1774. (Pubitemid 44730046)
    • (2006) Epilepsia , vol.47 , Issue.11 , pp. 1761-1774
    • Oby, E.1    Janigro, D.2
  • 185
    • 0030580410 scopus 로고    scopus 로고
    • Quantitative evaluation of blood-brain barrier permeability following middle cerebral artery occlusion in rats
    • DOI 10.1016/S0006-8993(96)00815-3, PII S0006899396008153
    • Belayev L, Busto R, Zhao W, Ginsberg MD,. Quantitative evaluation of blood-brain barrier permeability following middle cerebral artery occlusion in rats. Brain Res 1996; 739: 88-96. (Pubitemid 26387366)
    • (1996) Brain Research , vol.739 , Issue.1-2 , pp. 88-96
    • Belayev, L.1    Busto, R.2    Zhao, W.3    Ginsberg, M.D.4
  • 187
    • 79955922988 scopus 로고    scopus 로고
    • Specific role of tight junction proteins claudin-5, occludin, and ZO-1 of the blood-brain barrier in a focal cerebral ischemic insult
    • Jiao H, Wang Z, Liu Y, et al. Specific role of tight junction proteins claudin-5, occludin, and ZO-1 of the blood-brain barrier in a focal cerebral ischemic insult. J Mol Neurosci 2011; 44: 130-139.
    • (2011) J Mol Neurosci , vol.44 , pp. 130-139
    • Jiao, H.1    Wang, Z.2    Liu, Y.3
  • 188
    • 0022410974 scopus 로고
    • The biphasic opening of the blood-brain barrier to proteins following temporary middle cerebral artery occlusion
    • DOI 10.1007/BF00688633
    • Kuroiwa T, Ting P, Martinez H, Klatzo I,. The biphasic opening of the blood-brain barrier to proteins following temporary middle cerebral artery occlusion. Acta Neuropathol 1985; 68: 122-129. (Pubitemid 16242137)
    • (1985) Acta Neuropathologica , vol.68 , Issue.2 , pp. 122-129
    • Kuroiwa, T.1    Ting, P.2    Martinez, H.3    Klatzo, I.4
  • 189
    • 23844506444 scopus 로고    scopus 로고
    • Multiple sclerosis pathology: Evolution of pathogenetic concepts
    • Lassmann H,. Multiple sclerosis pathology: evolution of pathogenetic concepts. Brain Pathol 2005; 15: 217-222. (Pubitemid 41161177)
    • (2005) Brain Pathology , vol.15 , Issue.3 , pp. 217-222
    • Lassmann, H.1
  • 190
    • 0035096330 scopus 로고    scopus 로고
    • Heterogeneity of multiple sclerosis pathogenesis: Implications for diagnosis and therapy
    • DOI 10.1016/S1471-4914(00)01909-2, PII S1471491400019092
    • Lassmann H, Bruck W, Lucchinetti C,. Heterogeneity of multiple sclerosis pathogenesis: implications for diagnosis and therapy. Trends Mol Med 2001; 7: 115-121. (Pubitemid 32201673)
    • (2001) Trends in Molecular Medicine , vol.7 , Issue.3 , pp. 115-121
    • Lassmann, H.1    Bruck, W.2    Lucchinetti, C.3
  • 192
    • 0037465364 scopus 로고    scopus 로고
    • MRI contrast uptake in new lesions in relapsing-remitting MS followed at weekly intervals
    • Cotton F, Weiner HL, Jolesz FA, Guttmann CR,. MRI contrast uptake in new lesions in relapsing-remitting MS followed at weekly intervals. Neurology 2003; 60: 640-646. (Pubitemid 36246083)
    • (2003) Neurology , vol.60 , Issue.4 , pp. 640-646
    • Cotton, F.1    Weiner, H.L.2    Jolesz, F.A.3    Guttmann, C.R.G.4
  • 193
    • 0025854083 scopus 로고
    • Serial gadolinium-enhanced magnetic resonance imaging scans in patients with early, relapsing-remitting multiple sclerosis: Implications for clinical trials and natural history
    • Harris JO, Frank JA, Patronas N, et al. Serial gadolinium-enhanced magnetic resonance imaging scans in patients with early, relapsing-remitting multiple sclerosis: implications for clinical trials and natural history. Ann Neurol 1991; 29: 548-555.
    • (1991) Ann Neurol , vol.29 , pp. 548-555
    • Harris, J.O.1    Frank, J.A.2    Patronas, N.3
  • 194
    • 0027503708 scopus 로고
    • Correlation between magnetic resonance imaging findings and lesion development in chronic, active multiple sclerosis
    • DOI 10.1002/ana.410340507
    • Katz D, Taubenberger JK, Cannella B, et al. Correlation between magnetic resonance imaging findings and lesion development in chronic, active multiple sclerosis. Ann Neurol 1993; 34: 661-669. (Pubitemid 23333237)
    • (1993) Annals of Neurology , vol.34 , Issue.5 , pp. 661-669
    • Katz, D.1    Taubenberger, J.K.2    Cannella, B.3    McFarlin, D.E.4    Raine, C.S.5    McFarland, H.F.6
  • 196
    • 34248643430 scopus 로고    scopus 로고
    • Neuroimaging in multiple sclerosis
    • Zivadinov R, Cox JL,. Neuroimaging in multiple sclerosis. Int Rev Neurobiol 2007; 79: 449-474.
    • (2007) Int Rev Neurobiol , vol.79 , pp. 449-474
    • Zivadinov, R.1    Cox, J.L.2
  • 197
    • 73449124392 scopus 로고    scopus 로고
    • Progressive multiple sclerosis
    • Bradl M, Lassmann H,. Progressive multiple sclerosis. Semin Immunopathol 2009; 31: 455-465.
    • (2009) Semin Immunopathol , vol.31 , pp. 455-465
    • Bradl, M.1    Lassmann, H.2
  • 198
    • 33846515216 scopus 로고    scopus 로고
    • Differences in expression of junctional adhesion molecule-A and β-catenin in multiple sclerosis brain tissue: Increasing evidence for the role of tight junction pathology
    • DOI 10.1007/s00401-006-0145-x
    • Padden M, Leech S, Craig B, et al. Differences in expression of junctional adhesion molecule-A and beta-catenin in multiple sclerosis brain tissue: increasing evidence for the role of tight junction pathology. Acta Neuropathol 2007; 113: 177-186. (Pubitemid 46158150)
    • (2007) Acta Neuropathologica , vol.113 , Issue.2 , pp. 177-186
    • Padden, M.1    Leech, S.2    Craig, B.3    Kirk, J.4    Brankin, B.5    McQuaid, S.6
  • 199
    • 0141926694 scopus 로고    scopus 로고
    • Tight junctional abnormality in multiple sclerosis white matter affects all calibres of vessel and is associated with blood-brain barrier leakage and active demyelination
    • DOI 10.1002/path.1434
    • Kirk J, Plumb J, Mirakhur M, McQuaid S,. Tight junctional abnormality in multiple sclerosis white matter affects all calibres of vessel and is associated with blood-brain barrier leakage and active demyelination. J Pathol 2003; 201: 319-327. (Pubitemid 37258943)
    • (2003) Journal of Pathology , vol.201 , Issue.2 , pp. 319-327
    • Kirk, J.1    Plumb, J.2    Mirakhur, M.3    McQuaid, S.4
  • 200
    • 33846134731 scopus 로고    scopus 로고
    • Persistent endothelial abnormalities and blood-brain barrier leak in primary and secondary progressive multiple sclerosis
    • DOI 10.1111/j.1365-2990.2006.00781.x
    • Leech S, Kirk J, Plumb J, McQuaid S,. Persistent endothelial abnormalities and blood-brain barrier leak in primary and secondary progressive multiple sclerosis. Neuropathol Appl Neurobiol 2007; 33: 86-98. (Pubitemid 46090313)
    • (2007) Neuropathology and Applied Neurobiology , vol.33 , Issue.1 , pp. 86-98
    • Leech, S.1    Kirk, J.2    Plumb, J.3    McQuaid, S.4
  • 201
    • 0036211141 scopus 로고    scopus 로고
    • Abnormal endothelial tight junctions in active lesions and normal-appearing white matter in multiple sclerosis
    • Plumb J, McQuaid S, Mirakhur M, Kirk J,. Abnormal endothelial tight junctions in active lesions and normal-appearing white matter in multiple sclerosis. Brain Pathol 2002; 12: 154-169. (Pubitemid 34259917)
    • (2002) Brain Pathology , vol.12 , Issue.2 , pp. 154-169
    • Plumb, J.1    McQuaid, S.2    Mirakhur, M.3    Kirk, J.4
  • 202
    • 0021744512 scopus 로고
    • Immunohistochemical localization of extravasated serum albumin in the hippocampus of human subjects with partial and generalized epilepsies and epileptiform convulsions
    • DOI 10.1007/BF00689824
    • Mihaly A, Bozoky B,. Immunohistochemical localization of extravasated serum albumin in the hippocampus of human subjects with partial and generalized epilepsies and epileptiform convulsions. Acta Neuropathol 1984; 65: 25-34. (Pubitemid 15191144)
    • (1984) Acta Neuropathologica , vol.65 , Issue.1 , pp. 25-34
    • Mihaly, A.1    Bozoky, B.2
  • 203
    • 33846629927 scopus 로고    scopus 로고
    • Blood-brain barrier leakage may lead to progression of temporal lobe epilepsy
    • DOI 10.1093/brain/awl318
    • van Vliet EA, da Costa Araujo S, Redeker S, et al. Blood-brain barrier leakage may lead to progression of temporal lobe epilepsy. Brain 2007; 130: 521-534. (Pubitemid 46181105)
    • (2007) Brain , vol.130 , Issue.2 , pp. 521-534
    • Van Vliet, E.A.1    Araujo, S.D.C.2    Redeker, S.3    Van Schaik, R.4    Aronica, E.5    Gorter, J.A.6
  • 204
    • 0020512477 scopus 로고
    • Osmotic blood-brain barrier modification: Clinical documentation by enhanced CT scanning and/or radionuclide brain scanning
    • Neuwelt EA, Specht HD, Howieson J, et al. Osmotic blood-brain barrier modification: clinical documentation by enhanced CT scanning and/or radionuclide brain scanning. AJR Am J Roentgenol 1983; 141: 829-835. (Pubitemid 13006715)
    • (1983) American Journal of Roentgenology , vol.141 , Issue.4 , pp. 829-835
    • Neuwelt, E.A.1    Specht, H.D.2    Howieson, J.3
  • 207
    • 13844299003 scopus 로고    scopus 로고
    • Significance of MDR1 and multiple drug resistance in refractory human epileptic brain
    • Marchi N, Hallene KL, Kight KM, et al. Significance of MDR1 and multiple drug resistance in refractory human epileptic brain. BMC Med 2004; 2: 37.
    • (2004) BMC Med , vol.2 , pp. 37
    • Marchi, N.1    Hallene, K.L.2    Kight, K.M.3
  • 208
    • 0028895740 scopus 로고
    • MDR1 gene expression in brain of patients with medically intractable epilepsy
    • Tishler DM, Weinberg KI, Hinton DR, et al. MDR1 gene expression in brain of patients with medically intractable epilepsy. Epilepsia 1995; 36: 1-6.
    • (1995) Epilepsia , vol.36 , pp. 1-6
    • Tishler, D.M.1    Weinberg, K.I.2    Hinton, D.R.3
  • 209
    • 13544268809 scopus 로고    scopus 로고
    • Neurovascular mechanisms of Alzheimer's neurodegeneration
    • DOI 10.1016/j.tins.2005.02.001
    • Zlokovic BV,. Neurovascular mechanisms of Alzheimer's neurodegeneration. Trends Neurosci 2005; 28: 202-208. (Pubitemid 40445527)
    • (2005) Trends in Neurosciences , vol.28 , Issue.4 , pp. 202-208
    • Zlokovic, B.V.1
  • 210
    • 72849106266 scopus 로고    scopus 로고
    • A leaky blood-brain barrier, fibrinogen infiltration and microglial reactivity in inflamed Alzheimer's disease brain
    • Ryu JK, McLarnon JG,. A leaky blood-brain barrier, fibrinogen infiltration and microglial reactivity in inflamed Alzheimer's disease brain. J Cell Mol Med 2009; 13: 2911-2925.
    • (2009) J Cell Mol Med , vol.13 , pp. 2911-2925
    • Ryu, J.K.1    McLarnon, J.G.2
  • 211
    • 33748931285 scopus 로고    scopus 로고
    • Is the ischemic blood-brain barrier insufficiency responsible for full-blown Alzheimer's disease?
    • DOI 10.1179/016164106X130399
    • Pluta R,. Is the ischemic blood-brain barrier insufficiency responsible for full-blown Alzheimer's disease? Neurol Res 2006; 28: 665-671. (Pubitemid 44433327)
    • (2006) Neurological Research , vol.28 , Issue.6 , pp. 665-671
    • Pluta, R.1
  • 214
    • 0027473452 scopus 로고
    • Lymphocytic infiltrates in the spinal cord in amyotrophic lateral sclerosis
    • Engelhardt JI, Tajti J, Appel SH,. Lymphocytic infiltrates in the spinal cord in amyotrophic lateral sclerosis. Arch Neurol 1993; 50: 30-36. (Pubitemid 23019197)
    • (1993) Archives of Neurology , vol.50 , Issue.1 , pp. 30-36
    • Engelhardt, J.I.1    Tajti, J.2    Appel, S.H.3
  • 215
    • 34250658083 scopus 로고    scopus 로고
    • Ultrastructure of blood-brain barrier and blood-spinal cord barrier in SOD1 mice modeling ALS
    • DOI 10.1016/j.brainres.2007.04.044, PII S0006899307009729
    • Garbuzova-Davis S, Haller E, Saporta S, et al. Ultrastructure of blood-brain barrier and blood-spinal cord barrier in SOD1 mice modeling ALS. Brain Res 2007; 1157: 126-137. (Pubitemid 46935078)
    • (2007) Brain Research , vol.1157 , Issue.1 , pp. 126-137
    • Garbuzova-Davis, S.1    Haller, E.2    Saporta, S.3    Kolomey, I.4    Nicosia, S.V.5    Sanberg, P.R.6
  • 216
    • 49849094080 scopus 로고    scopus 로고
    • Evidence of compromised blood-spinal cord barrier in early and late symptomatic SOD1 mice modeling ALS
    • Garbuzova-Davis S, Saporta S, Haller E, et al. Evidence of compromised blood-spinal cord barrier in early and late symptomatic SOD1 mice modeling ALS. PLoS One 2007; 2: e1205.
    • (2007) PLoS One , vol.2
    • Garbuzova-Davis, S.1    Saporta, S.2    Haller, E.3
  • 217
    • 71849084133 scopus 로고    scopus 로고
    • Impaired blood-brain and blood-spinal cord barriers in mutant SOD1-linked ALS rat
    • Nicaise C, Mitrecic D, Demetter P, et al. Impaired blood-brain and blood-spinal cord barriers in mutant SOD1-linked ALS rat. Brain Res 2009; 1301: 152-162.
    • (2009) Brain Res , vol.1301 , pp. 152-162
    • Nicaise, C.1    Mitrecic, D.2    Demetter, P.3
  • 219
    • 0038241171 scopus 로고    scopus 로고
    • Polymorphism in the P-glycoprotein drug transporter MDR1 gene: A possible link between environmental and genetic factors in Parkinson's disease
    • DOI 10.1097/00008571-200305000-00004
    • Drozdzik M, Bialecka M, Mysliwiec K, et al. Polymorphism in the P-glycoprotein drug transporter MDR1 gene: A possible link between environmental and genetic factors in Parkinson's disease. Pharmacogenetics 2003; 13: 259-263. (Pubitemid 36583992)
    • (2003) Pharmacogenetics , vol.13 , Issue.5 , pp. 259-263
    • Drozdzik, M.1    Bialecka, M.2    Mysliwiec, K.3    Honczarenko, K.4    Stankiewicz, J.5    Sych, Z.6
  • 220
    • 49649128693 scopus 로고    scopus 로고
    • Blood-brain barrier P-glycoprotein function is not impaired in early Parkinson's disease
    • Bartels AL, van Berckel BN, Lubberink M, et al. Blood-brain barrier P-glycoprotein function is not impaired in early Parkinson's disease. Parkinsonism Relat Disord 2008; 14: 505-508.
    • (2008) Parkinsonism Relat Disord , vol.14 , pp. 505-508
    • Bartels, A.L.1    Van Berckel, B.N.2    Lubberink, M.3
  • 221
    • 46649085260 scopus 로고    scopus 로고
    • Decreased blood-brain barrier P-glycoprotein function in the progression of Parkinson's disease, PSP and MSA
    • Bartels AL, Willemsen AT, Kortekaas R, et al. Decreased blood-brain barrier P-glycoprotein function in the progression of Parkinson's disease, PSP and MSA. J Neural Transm 2008; 115: 1001-1009.
    • (2008) J Neural Transm , vol.115 , pp. 1001-1009
    • Bartels, A.L.1    Willemsen, A.T.2    Kortekaas, R.3
  • 222
    • 84857624257 scopus 로고    scopus 로고
    • Evidence for angiogenesis in Parkinson's disease, incidental Lewy body disease, and progressive supranuclear palsy
    • Desai Bradaric B, Patel A, Schneider JA, et al. Evidence for angiogenesis in Parkinson's disease, incidental Lewy body disease, and progressive supranuclear palsy. J Neural Transm 2012; 119: 59-71.
    • (2012) J Neural Transm , vol.119 , pp. 59-71
    • Desai Bradaric, B.1    Patel, A.2    Schneider, J.A.3
  • 223
    • 0031459856 scopus 로고    scopus 로고
    • Increased gelatinase A (MMP-2) and gelatinase B (MMP-9) activities in human brain after focal ischemia
    • DOI 10.1016/S0304-3940(97)00859-8, PII S0304394097008598
    • Clark AW, Krekoski CA, Bou SS, et al. Increased gelatinase A (MMP-2) and gelatinase B (MMP-9) activities in human brain after focal ischemia. Neurosci Lett 1997; 238: 53-56. (Pubitemid 28015782)
    • (1997) Neuroscience Letters , vol.238 , Issue.1-2 , pp. 53-56
    • Clark, A.W.1    Krekoski, C.A.2    Bou, S.-S.3    Chapman, K.R.4    Edwards, D.R.5
  • 228
    • 0033638508 scopus 로고    scopus 로고
    • Role for matrix metalloproteinase 9 after focal cerebral ischemia: Effects of gene knockout and enzyme inhibition with BB-94
    • Asahi M, Asahi K, Jung JC, et al. Role for matrix metalloproteinase 9 after focal cerebral ischemia: effects of gene knockout and enzyme inhibition with BB-94. J Cereb Blood Flow Metab 2000; 20: 1681-1689.
    • (2000) J Cereb Blood Flow Metab , vol.20 , pp. 1681-1689
    • Asahi, M.1    Asahi, K.2    Jung, J.C.3
  • 229
    • 0031959973 scopus 로고    scopus 로고
    • Matrix metalloproteinase expression increases after cerebral focal ischemia in rats: Inhibition of matrix metalloproteinase-9 reduces infarct size
    • Romanic AM, White RF, Arleth AJ, et al. Matrix metalloproteinase expression increases after cerebral focal ischemia in rats: inhibition of matrix metalloproteinase-9 reduces infarct size. Stroke 1998; 29: 1020-1030. (Pubitemid 28228167)
    • (1998) Stroke , vol.29 , Issue.5 , pp. 1020-1030
    • Romanic, A.M.1    White, R.F.2    Arleth, A.J.3    Ohlstein, E.H.4    Barone, F.C.5
  • 230
    • 77950516409 scopus 로고    scopus 로고
    • Matrix metalloproteinase-9 mediates hypoxia-induced vascular leakage in the brain via tight junction rearrangement
    • Bauer AT, Burgers HF, Rabie T, Marti HH,. Matrix metalloproteinase-9 mediates hypoxia-induced vascular leakage in the brain via tight junction rearrangement. J Cereb Blood Flow Metab 2010; 30: 837-848.
    • (2010) J Cereb Blood Flow Metab , vol.30 , pp. 837-848
    • Bauer, A.T.1    Burgers, H.F.2    Rabie, T.3    Marti, H.H.4
  • 231
    • 33947493391 scopus 로고    scopus 로고
    • Matrix metalloproteinase-mediated disruption of tight junction proteins in cerebral vessels is reversed by synthetic matrix metalloproteinase inhibitor in focal ischemia in rat
    • DOI 10.1038/sj.jcbfm.9600375, PII 9600375
    • Yang Y, Estrada EY, Thompson JF, et al. Matrix metalloproteinase-mediated disruption of tight junction proteins in cerebral vessels is reversed by synthetic matrix metalloproteinase inhibitor in focal ischemia in rat. J Cereb Blood Flow Metab 2007; 27: 697-709. (Pubitemid 46474608)
    • (2007) Journal of Cerebral Blood Flow and Metabolism , vol.27 , Issue.4 , pp. 697-709
    • Yang, Y.1    Estrada, E.Y.2    Thompson, J.F.3    Liu, W.4    Rosenberg, G.A.5
  • 234
    • 77952547253 scopus 로고    scopus 로고
    • Molecular insights and therapeutic targets for blood-brain barrier disruption in ischemic stroke: Critical role of matrix metalloproteinases and tissue-type plasminogen activator
    • Jin R, Yang G, Li G,. Molecular insights and therapeutic targets for blood-brain barrier disruption in ischemic stroke: critical role of matrix metalloproteinases and tissue-type plasminogen activator. Neurobiol Dis 2010; 38: 376-385.
    • (2010) Neurobiol Dis , vol.38 , pp. 376-385
    • Jin, R.1    Yang, G.2    Li, G.3
  • 235
    • 0030865278 scopus 로고    scopus 로고
    • Vascular endothelial growth factor increases microvascular permeability via a Ca(2+)-dependent pathway
    • Bates DO, Curry FE,. Vascular endothelial growth factor increases microvascular permeability via a Ca(2+)-dependent pathway. Am J Physiol 1997; 273: H687-H694.
    • (1997) Am J Physiol , vol.273
    • Bates, D.O.1    Curry, F.E.2
  • 236
    • 0030693379 scopus 로고    scopus 로고
    • Rapid induction of vascular endothelial growth factor gene expression after transient middle cerebral artery occlusion in rats
    • Hayashi T, Abe K, Suzuki H, Itoyama Y,. Rapid induction of vascular endothelial growth factor gene expression after transient middle cerebral artery occlusion in rats. Stroke 1997; 28: 2039-2044. (Pubitemid 27459016)
    • (1997) Stroke , vol.28 , Issue.10 , pp. 2039-2044
    • Hayashi, T.1    Abe, K.2    Suzuki, H.3    Itoyama, Y.4
  • 237
    • 0033797255 scopus 로고    scopus 로고
    • VEGF enhances angiogenesis and promotes blood-brain barrier leakage in the ischemic brain
    • Zhang ZG, Zhang L, Jiang Q, et al. VEGF enhances angiogenesis and promotes blood-brain barrier leakage in the ischemic brain. J Clin Invest 2000; 106: 829-838.
    • (2000) J Clin Invest , vol.106 , pp. 829-838
    • Zhang, Z.G.1    Zhang, L.2    Jiang, Q.3
  • 238
    • 33645092394 scopus 로고    scopus 로고
    • Upregulation of vascular growth factors in multiple sclerosis: Correlation with MRI findings
    • Su JJ, Osoegawa M, Matsuoka T, et al. Upregulation of vascular growth factors in multiple sclerosis: correlation with MRI findings. J Neurol Sci 2006; 243: 21-30.
    • (2006) J Neurol Sci , vol.243 , pp. 21-30
    • Su, J.J.1    Osoegawa, M.2    Matsuoka, T.3
  • 239
    • 60649108674 scopus 로고    scopus 로고
    • VEGF-mediated disruption of endothelial CLN-5 promotes blood-brain barrier breakdown
    • Argaw AT, Gurfein BT, Zhang Y, et al. VEGF-mediated disruption of endothelial CLN-5 promotes blood-brain barrier breakdown. Proc Natl Acad Sci U S A 2009; 106: 1977-1982.
    • (2009) Proc Natl Acad Sci U S A , vol.106 , pp. 1977-1982
    • Argaw, A.T.1    Gurfein, B.T.2    Zhang, Y.3
  • 240
    • 77956621126 scopus 로고    scopus 로고
    • The novel VEGF receptor antagonist, VGA1155, reduces edema, decreases infarct and improves neurological function after stroke in rats
    • Koyama J, Miyake S, Sasayama T, et al. The novel VEGF receptor antagonist, VGA1155, reduces edema, decreases infarct and improves neurological function after stroke in rats. Kobe J Med Sci 2010; 56: E1-E11.
    • (2010) Kobe J Med Sci , vol.56
    • Koyama, J.1    Miyake, S.2    Sasayama, T.3
  • 242
    • 67650153191 scopus 로고    scopus 로고
    • Involvement of ROS in BBB dysfunction
    • Pun PB, Lu J, Moochhala S,. Involvement of ROS in BBB dysfunction. Free Radic Res 2009; 43: 348-364.
    • (2009) Free Radic Res , vol.43 , pp. 348-364
    • Pun, P.B.1    Lu, J.2    Moochhala, S.3
  • 243
    • 0023127649 scopus 로고
    • Free oxygen radicals decrease electrical resistance of microvascular endothelium in brain
    • Olesen SP,. Free oxygen radicals decrease electrical resistance of microvascular endothelium in brain. Acta Physiol Scand 1987; 129: 181-187.
    • (1987) Acta Physiol Scand , vol.129 , pp. 181-187
    • Olesen, S.P.1
  • 244
    • 0032752658 scopus 로고    scopus 로고
    • Potential role of cerebral glutathione in the maintenance of blood-brain barrier integrity in rat
    • Agarwal R, Shukla GS,. Potential role of cerebral glutathione in the maintenance of blood-brain barrier integrity in rat. Neurochem Res 1999; 24: 1507-1514.
    • (1999) Neurochem Res , vol.24 , pp. 1507-1514
    • Agarwal, R.1    Shukla, G.S.2
  • 245
    • 33744815599 scopus 로고    scopus 로고
    • Evaluating therapeutic targets for reperfusion-related brain hemorrhage
    • DOI 10.1002/ana.20850
    • Maier CM, Hsieh L, Crandall T, et al. Evaluating therapeutic targets for reperfusion-related brain hemorrhage. Ann Neurol 2006; 59: 929-938. (Pubitemid 43830925)
    • (2006) Annals of Neurology , vol.59 , Issue.6 , pp. 929-938
    • Maier, C.M.1    Hsieh, L.2    Crandall, T.3    Narasimhan, P.4    Chan, P.H.5
  • 247
    • 0033623569 scopus 로고    scopus 로고
    • Kinin B1 receptor expression and function on human brain endothelial cells
    • Prat A, Biernacki K, Pouly S, et al. Kinin B1 receptor expression and function on human brain endothelial cells. J Neuropathol Exp Neurol 2000; 59: 896-906.
    • (2000) J Neuropathol Exp Neurol , vol.59 , pp. 896-906
    • Prat, A.1    Biernacki, K.2    Pouly, S.3
  • 248
    • 0030878204 scopus 로고    scopus 로고
    • 2 receptor antagonist, inhibits brain injury in a rat model of reversible middle cerebral artery occlusion
    • Relton JK, Beckey VE, Hanson WL, Whalley ET,. CP-0597, a selective bradykinin B2 receptor antagonist, inhibits brain injury in a rat model of reversible middle cerebral artery occlusion. Stroke 1997; 28: 1430-1436. (Pubitemid 27300683)
    • (1997) Stroke , vol.28 , Issue.7 , pp. 1430-1436
    • Relton, J.K.1    Beckey, V.E.2    Hanson, W.L.3    Whalley, E.T.4
  • 249
    • 79951960264 scopus 로고    scopus 로고
    • Blockade of the kinin receptor B1 protects from autoimmune CNS disease by reducing leukocyte trafficking
    • Gobel K, Pankratz S, Schneider-Hohendorf T, et al. Blockade of the kinin receptor B1 protects from autoimmune CNS disease by reducing leukocyte trafficking. J Autoimmun 2011; 36: 106-114.
    • (2011) J Autoimmun , vol.36 , pp. 106-114
    • Gobel, K.1    Pankratz, S.2    Schneider-Hohendorf, T.3
  • 250
    • 0027409052 scopus 로고
    • Increased levels of circulating ICAM-1 in serum and cerebrospinal fluid of patients with active multiple sclerosis. Correlation with TNF-α and blood-brain barrier damage
    • Sharief MK, Noori MA, Ciardi M, et al. Increased levels of circulating ICAM-1 in serum and cerebrospinal fluid of patients with active multiple sclerosis. Correlation with TNF-alpha and blood-brain barrier damage. J Neuroimmunol 1993; 43: 15-21. (Pubitemid 23103635)
    • (1993) Journal of Neuroimmunology , vol.43 , Issue.1-2 , pp. 15-21
    • Sharief, M.K.1    Noori, M.A.2    Ciardi, M.3    Cirelli, A.4    Thompson, E.J.5
  • 251
    • 0026596353 scopus 로고
    • In vivo relationship of tumor necrosis factor-alpha to blood-brain barrier damage in patients with active multiple sclerosis
    • Sharief MK, Thompson EJ,. In vivo relationship of tumor necrosis factor-alpha to blood-brain barrier damage in patients with active multiple sclerosis. J Neuroimmunol 1992; 38: 27-33.
    • (1992) J Neuroimmunol , vol.38 , pp. 27-33
    • Sharief, M.K.1    Thompson, E.J.2
  • 252
    • 0025856580 scopus 로고
    • Tumor necrosis factor and interleukin-1 in the CSF and sera of patients with multiple sclerosis
    • Tsukada N, Miyagi K, Matsuda M, et al. Tumor necrosis factor and interleukin-1 in the CSF and sera of patients with multiple sclerosis. J Neurol Sci 1991; 104: 230-234.
    • (1991) J Neurol Sci , vol.104 , pp. 230-234
    • Tsukada, N.1    Miyagi, K.2    Matsuda, M.3
  • 254
    • 0027049701 scopus 로고
    • Modulation of blood-brain barrier permeability by tumor necrosis factor and antibody to tumor necrosis factor in the rat
    • Kim KS, Wass CA, Cross AS, Opal SM,. Modulation of blood-brain barrier permeability by tumor necrosis factor and antibody to tumor necrosis factor in the rat. Lymphokine Cytokine Res 1992; 11: 293-298. (Pubitemid 23014635)
    • (1992) Lymphokine and Cytokine Research , vol.11 , Issue.6 , pp. 293-298
    • Kwang Sik Kim1    Wass, C.A.2    Cross, A.S.3    Opal, S.M.4
  • 255
    • 0028147754 scopus 로고
    • Blood-brain barrier changes following intracerebral injection of human recombinant tumor necrosis factor-α in the rat
    • Wright JL, Merchant RE,. Blood-brain barrier changes following intracerebral injection of human recombinant tumor necrosis factor-alpha in the rat. J Neurooncol 1994; 20: 17-25. (Pubitemid 24299471)
    • (1994) Journal of Neuro-Oncology , vol.20 , Issue.1 , pp. 17-25
    • Wright, J.L.1    Merchant, R.E.2
  • 256
    • 0033565947 scopus 로고    scopus 로고
    • Cutting edge: Combined treatment of TNF-α and IFN-γ causes redistribution of junctional adhesion molecule in human endothelial cells
    • Ozaki H, Ishii K, Horiuchi H, et al. Cutting edge: combined treatment of TNF-alpha and IFN-gamma causes redistribution of junctional adhesion molecule in human endothelial cells. J Immunol 1999; 163: 553-557. (Pubitemid 29328054)
    • (1999) Journal of Immunology , vol.163 , Issue.2 , pp. 553-557
    • Ozaki, H.1    Ishii, K.2    Horiuchi, H.3    Arai, H.4    Kawamoto, T.5    Okawa, K.6    Iwamatsu, A.7    Kita, T.8
  • 257
    • 2642615752 scopus 로고    scopus 로고
    • Regulation of TNF-α-induced reorganization of the actin cytoskeleton and cell-cell junctions by Rho, Rac, and Cdc42 in human endothelial cells
    • DOI 10.1002/(SICI)1097-4652(199807)176:1 <150::AID-JCP17>3.0.CO;2-B
    • Wojciak-Stothard B, Entwistle A, Garg R, Ridley AJ,. Regulation of TNF-alpha-induced reorganization of the actin cytoskeleton and cell-cell junctions by Rho, Rac, and Cdc42 in human endothelial cells. J Cell Physiol 1998; 176: 150-165. (Pubitemid 28277205)
    • (1998) Journal of Cellular Physiology , vol.176 , Issue.1 , pp. 150-165
    • Wojciak-Stothard, B.1    Entwistle, A.2    Garg, R.3    Ridley, A.J.4
  • 258
    • 0026656192 scopus 로고
    • Interleukin-1 receptor antagonist inhibits ischaemic and excitotoxic neuronal damage in the rat
    • Relton JK, Rothwell NJ,. Interleukin-1 receptor antagonist inhibits ischaemic and excitotoxic neuronal damage in the rat. Brain Res Bull 1992; 29: 243-246.
    • (1992) Brain Res Bull , vol.29 , pp. 243-246
    • Relton, J.K.1    Rothwell, N.J.2
  • 259
    • 0027660930 scopus 로고
    • Involvement of interleukin-1 and lipocortin-1 in ischaemic brain damage
    • Rothwell NJ, Relton JK,. Involvement of interleukin-1 and lipocortin-1 in ischaemic brain damage. Cerebrovasc Brain Metab Rev 1993; 5: 178-198.
    • (1993) Cerebrovasc Brain Metab Rev , vol.5 , pp. 178-198
    • Rothwell, N.J.1    Relton, J.K.2
  • 260
    • 67650064909 scopus 로고    scopus 로고
    • Role of interleukin-1beta in early brain injury after subarachnoid hemorrhage in mice
    • Sozen T, Tsuchiyama R, Hasegawa Y, et al. Role of interleukin-1beta in early brain injury after subarachnoid hemorrhage in mice. Stroke 2009; 40: 2519-2525.
    • (2009) Stroke , vol.40 , pp. 2519-2525
    • Sozen, T.1    Tsuchiyama, R.2    Hasegawa, Y.3
  • 261
    • 0029865092 scopus 로고    scopus 로고
    • Peripheral administration of interleukin-1 receptor antagonist inhibits brain damage after focal cerebral ischemia in the rat
    • DOI 10.1006/exnr.1996.0059
    • Relton JK, Martin D, Thompson RC, Russell DA,. Peripheral administration of interleukin-1 receptor antagonist inhibits brain damage after focal cerebral ischemia in the rat. Exp Neurol 1996; 138: 206-213. (Pubitemid 26135199)
    • (1996) Experimental Neurology , vol.138 , Issue.2 , pp. 206-213
    • Relton, J.K.1    Martin, D.2    Thompson, R.C.3    Russell, D.A.4
  • 262
    • 58149357031 scopus 로고    scopus 로고
    • Systemic inflammation alters the kinetics of cerebrovascular tight junction disruption after experimental stroke in mice
    • McColl BW, Rothwell NJ, Allan SM,. Systemic inflammation alters the kinetics of cerebrovascular tight junction disruption after experimental stroke in mice. J Neurosci 2008; 28: 9451-9462.
    • (2008) J Neurosci , vol.28 , pp. 9451-9462
    • McColl, B.W.1    Rothwell, N.J.2    Allan, S.M.3
  • 263
    • 0035795039 scopus 로고    scopus 로고
    • T lymphocytes conditioned with Interferon β induce membrane and soluble VCAM on human brain endothelial cells
    • DOI 10.1016/S0165-5728(01)00253-3, PII S0165572801002533
    • Calabresi PA, Prat A, Biernacki K, et al. T lymphocytes conditioned with interferon beta induce membrane and soluble VCAM on human brain endothelial cells. J Neuroimmunol 2001; 115: 161-167. (Pubitemid 32245664)
    • (2001) Journal of Neuroimmunology , vol.115 , Issue.1-2 , pp. 161-167
    • Calabresi, P.A.1    Prat, A.2    Biernacki, K.3    Rollins, J.4    Antel, J.P.5
  • 265
    • 3843101531 scopus 로고    scopus 로고
    • Interferon-β stabilizes barrier characteristics of brain endothelial cells in vitro
    • DOI 10.1002/ana.20161
    • Kraus J, Ling AK, Hamm S, et al. Interferon-beta stabilizes barrier characteristics of brain endothelial cells in vitro. Ann Neurol 2004; 56: 192-205. (Pubitemid 39037915)
    • (2004) Annals of Neurology , vol.56 , Issue.2 , pp. 192-205
    • Kraus, J.1    Ling, A.K.2    Hamm, S.3    Voigt, K.4    Oschmann, P.5    Engelhardt, B.6
  • 266
    • 48349131669 scopus 로고    scopus 로고
    • Interferon-beta stabilizes barrier characteristics of the blood-brain barrier in four different species in vitro
    • Kraus J, Voigt K, Schuller AM, et al. Interferon-beta stabilizes barrier characteristics of the blood-brain barrier in four different species in vitro. Mult Scler 2008; 14: 843-852.
    • (2008) Mult Scler , vol.14 , pp. 843-852
    • Kraus, J.1    Voigt, K.2    Schuller, A.M.3
  • 267
    • 70450233404 scopus 로고    scopus 로고
    • Interleukin-25 expressed by brain capillary endothelial cells maintains blood-brain barrier function in a protein kinase Cepsilon-dependent manner
    • Sonobe Y, Takeuchi H, Kataoka K, et al. Interleukin-25 expressed by brain capillary endothelial cells maintains blood-brain barrier function in a protein kinase Cepsilon-dependent manner. J Biol Chem 2009; 284: 31834-31842.
    • (2009) J Biol Chem , vol.284 , pp. 31834-31842
    • Sonobe, Y.1    Takeuchi, H.2    Kataoka, K.3
  • 268
    • 70449106029 scopus 로고    scopus 로고
    • Effector T cell interactions with meningeal vascular structures in nascent autoimmune CNS lesions
    • Bartholomaus I, Kawakami N, Odoardi F, et al. Effector T cell interactions with meningeal vascular structures in nascent autoimmune CNS lesions. Nature 2009; 462: 94-98.
    • (2009) Nature , vol.462 , pp. 94-98
    • Bartholomaus, I.1    Kawakami, N.2    Odoardi, F.3
  • 269
    • 65649096159 scopus 로고    scopus 로고
    • Localizing central nervous system immune surveillance: Meningeal antigen-presenting cells activate T cells during experimental autoimmune encephalomyelitis
    • Kivisakk P, Imitola J, Rasmussen S, et al. Localizing central nervous system immune surveillance: meningeal antigen-presenting cells activate T cells during experimental autoimmune encephalomyelitis. Ann Neurol 2009; 65: 457-469.
    • (2009) Ann Neurol , vol.65 , pp. 457-469
    • Kivisakk, P.1    Imitola, J.2    Rasmussen, S.3
  • 270
    • 0035728356 scopus 로고    scopus 로고
    • Expression of P-selectin and intercellular adhesion molecule-1 in human brain after focal infarction or cardiac arrest
    • DOI 10.1046/j.1365-2990.2001.00356.x
    • Love S, Barber R,. Expression of P-selectin and intercellular adhesion molecule-1 in human brain after focal infarction or cardiac arrest. Neuropathol Appl Neurobiol 2001; 27: 465-473. (Pubitemid 34264262)
    • (2001) Neuropathology and Applied Neurobiology , vol.27 , Issue.6 , pp. 465-473
    • Love, S.1    Barber, R.2
  • 271
    • 0028147428 scopus 로고
    • P-selectin and intercellular adhesion molecule-1 expression after focal brain ischemia and reperfusion
    • Okada Y, Copeland BR, Mori E, et al. P-selectin and intercellular adhesion molecule-1 expression after focal brain ischemia and reperfusion. Stroke 1994; 25: 202-211.
    • (1994) Stroke , vol.25 , pp. 202-211
    • Okada, Y.1    Copeland, B.R.2    Mori, E.3
  • 272
    • 0027200051 scopus 로고
    • Monoclonal antibody to the ICAM-1 adhesion site reduces neurological damage in a rabbit cerebral embolism stroke model
    • DOI 10.1006/exnr.1993.1023
    • Bowes MP, Zivin JA, Rothlein R,. Monoclonal antibody to the ICAM-1 adhesion site reduces neurological damage in a rabbit cerebral embolism stroke model. Exp Neurol 1993; 119: 215-219. (Pubitemid 23132018)
    • (1993) Experimental Neurology , vol.119 , Issue.2 , pp. 215-219
    • Bowes, M.P.1    Zivin, J.A.2    Rothlein, R.3
  • 274
    • 0027209421 scopus 로고
    • Leukocyte rolling and extravasation are severely compromised in P selectin-deficient mice
    • Mayadas TN, Johnson RC, Rayburn H, et al. Leukocyte rolling and extravasation are severely compromised in P selectin-deficient mice. Cell 1993; 74: 541-554. (Pubitemid 23244619)
    • (1993) Cell , vol.74 , Issue.3 , pp. 541-554
    • Mayadas, T.N.1    Johnson, R.C.2    Rayburn, H.3    Hynes, R.O.4    Wagner, D.D.5
  • 275
    • 40049095589 scopus 로고    scopus 로고
    • E- and P-selectin are not required for the development of experimental autoimmune encephalomyelitis in C57BL/6 and SJL mice
    • Doring A, Wild M, Vestweber D, et al. E- and P-selectin are not required for the development of experimental autoimmune encephalomyelitis in C57BL/6 and SJL mice. J Immunol 2007; 179: 8470-8479.
    • (2007) J Immunol , vol.179 , pp. 8470-8479
    • Doring, A.1    Wild, M.2    Vestweber, D.3
  • 276
  • 277
    • 33644584352 scopus 로고    scopus 로고
    • A randomized, placebo-controlled trial of natalizumab for relapsing multiple sclerosis
    • Polman CH, O'Connor PW, Havrdova E, et al. A randomized, placebo-controlled trial of natalizumab for relapsing multiple sclerosis. N Engl J Med 2006; 354: 899-910.
    • (2006) N Engl J Med , vol.354 , pp. 899-910
    • Polman, C.H.1    O'Connor, P.W.2    Havrdova, E.3
  • 278
    • 0026506799 scopus 로고
    • Prevention of experimental autoimmune encephalomyelitis by antibodies against alpha 4 beta 1 integrin
    • Yednock TA, Cannon C, Fritz LC, et al. Prevention of experimental autoimmune encephalomyelitis by antibodies against alpha 4 beta 1 integrin. Nature 1992; 356: 63-66.
    • (1992) Nature , vol.356 , pp. 63-66
    • Yednock, T.A.1    Cannon, C.2    Fritz, L.C.3
  • 280
    • 0036895062 scopus 로고    scopus 로고
    • Progressive multifocal leukoencephalopathy and apoptosis of infected oligodendrocytes in the central nervous system of patients with and without AIDS
    • DOI 10.1001/archneur.59.12.1930
    • Richardson-Burns SM, Kleinschmidt-DeMasters BK, DeBiasi RL, Tyler KL,. Progressive multifocal leukoencephalopathy and apoptosis of infected oligodendrocytes in the central nervous system of patients with and without AIDS. Arch Neurol 2002; 59: 1930-1936. (Pubitemid 35424652)
    • (2002) Archives of Neurology , vol.59 , Issue.12 , pp. 1930-1936
    • Richardson-Burns, S.M.1    Kleinschmidt-DeMasters, B.K.2    DeBiasi, R.L.3    Tyler, K.L.4
  • 281
    • 38349176343 scopus 로고    scopus 로고
    • Activated leukocyte cell adhesion molecule promotes leukocyte trafficking into the central nervous system
    • Cayrol R, Wosik K, Berard JL, et al. Activated leukocyte cell adhesion molecule promotes leukocyte trafficking into the central nervous system. Nat Immunol 2008; 9: 137-145.
    • (2008) Nat Immunol , vol.9 , pp. 137-145
    • Cayrol, R.1    Wosik, K.2    Berard, J.L.3
  • 282
    • 83255181785 scopus 로고    scopus 로고
    • Role of Ninjurin-1 in the migration of myeloid cells to central nervous system inflammatory lesions
    • Ifergan I, Kebir H, Terouz S, et al. Role of Ninjurin-1 in the migration of myeloid cells to central nervous system inflammatory lesions. Ann Neurol 2011; 70: 751-763.
    • (2011) Ann Neurol , vol.70 , pp. 751-763
    • Ifergan, I.1    Kebir, H.2    Terouz, S.3
  • 283
    • 84863012054 scopus 로고    scopus 로고
    • Regional neural activation defines a gateway for autoreactive T cells to cross the blood-brain barrier
    • Arima Y, Harada M, Kamimura D, et al. Regional neural activation defines a gateway for autoreactive T cells to cross the blood-brain barrier. Cell 2012; 148: 447-457.
    • (2012) Cell , vol.148 , pp. 447-457
    • Arima, Y.1    Harada, M.2    Kamimura, D.3
  • 284
    • 9244250315 scopus 로고    scopus 로고
    • Mini review: Transendothelial migration of leukocytes: Through the front door or around the side of the house?
    • DOI 10.1002/eji.200425327
    • Engelhardt B, Wolburg H,. Mini-review: Transendothelial migration of leukocytes: Through the front door or around the side of the house? Eur J Immunol 2004; 34: 2955-2963. (Pubitemid 39549374)
    • (2004) European Journal of Immunology , vol.34 , Issue.11 , pp. 2955-2963
    • Engelhardt, B.1    Wolburg, H.2
  • 285
    • 34948910651 scopus 로고    scopus 로고
    • Increased caveolin-1 expression precedes decreased expression of occludin and claudin-5 during blood-brain barrier breakdown
    • DOI 10.1007/s00401-007-0274-x
    • Nag S, Venugopalan R, Stewart DJ,. Increased caveolin-1 expression precedes decreased expression of occludin and claudin-5 during blood-brain barrier breakdown. Acta Neuropathol 2007; 114: 459-469. (Pubitemid 47521502)
    • (2007) Acta Neuropathologica , vol.114 , Issue.5 , pp. 459-469
    • Nag, S.1    Venugopalan, R.2    Stewart, D.J.3
  • 288
    • 34547791784 scopus 로고    scopus 로고
    • Fibrin deposition accelerates neurovascular damage and neuroinflammation in mouse models of Alzheimer's disease
    • DOI 10.1084/jem.20070304
    • Paul J, Strickland S, Melchor JP,. Fibrin deposition accelerates neurovascular damage and neuroinflammation in mouse models of Alzheimer's disease. J Exp Med 2007; 204: 1999-2008. (Pubitemid 47236333)
    • (2007) Journal of Experimental Medicine , vol.204 , Issue.8 , pp. 1999-2008
    • Paul, J.1    Strickland, S.2    Melchor, J.P.3
  • 289
    • 0033921540 scopus 로고    scopus 로고
    • Complement components of the innate immune system in health and disease in the CNS
    • PII S0162310900002186
    • Gasque P, Dean YD, McGreal EP, et al. Complement components of the innate immune system in health and disease in the CNS. Immunopharmacology 2000; 49: 171-186. (Pubitemid 30445228)
    • (2000) Immunopharmacology , vol.49 , Issue.1-2 , pp. 171-186
    • Gasque, P.1    Dean, Y.D.2    McGreal, E.P.3    Vanbeek, J.4    Morgan, B.P.5
  • 291
    • 79954467045 scopus 로고    scopus 로고
    • Current approaches for drug delivery to central nervous system
    • Hossain S, Akaike T, Chowdhury EH,. Current approaches for drug delivery to central nervous system. Curr Drug Deliv 2010; 7: 389-397.
    • (2010) Curr Drug Deliv , vol.7 , pp. 389-397
    • Hossain, S.1    Akaike, T.2    Chowdhury, E.H.3
  • 292
    • 77954334041 scopus 로고    scopus 로고
    • Potential approaches for drug delivery to the brain: Past, present, and future
    • Soni V, Jain A, Khare P, et al. Potential approaches for drug delivery to the brain: past, present, and future. Crit Rev Ther Drug Carrier Syst 2010; 27: 187-236.
    • (2010) Crit Rev Ther Drug Carrier Syst , vol.27 , pp. 187-236
    • Soni, V.1    Jain, A.2    Khare, P.3
  • 293
    • 3242759188 scopus 로고    scopus 로고
    • Osmotic blood-brain barrier modification for the treatment of malignant brain tumors
    • Haluska M, Anthony ML,. Osmotic blood-brain barrier modification for the treatment of malignant brain tumors. Clin J Oncol Nurs 2004; 8: 263-267.
    • (2004) Clin J Oncol Nurs , vol.8 , pp. 263-267
    • Haluska, M.1    Anthony, M.L.2
  • 296
    • 17344392837 scopus 로고    scopus 로고
    • The 4F2hc/LAT1 complex transports L-DOPA across the blood-brain barrier
    • Kageyama T, Nakamura M, Matsuo A, et al. The 4F2hc/LAT1 complex transports L-DOPA across the blood-brain barrier. Brain Res 2000; 879: 115-121.
    • (2000) Brain Res , vol.879 , pp. 115-121
    • Kageyama, T.1    Nakamura, M.2    Matsuo, A.3
  • 297
    • 0034815482 scopus 로고    scopus 로고
    • Receptor-mediated gene targeting to tissues in vivo following intravenous administration of pegylated immunoliposomes
    • DOI 10.1023/A:1010910523202
    • Shi N, Boado RJ, Pardridge WM,. Receptor-mediated gene targeting to tissues in vivo following intravenous administration of pegylated immunoliposomes. Pharm Res 2001; 18: 1091-1095. (Pubitemid 32900392)
    • (2001) Pharmaceutical Research , vol.18 , Issue.8 , pp. 1091-1095
    • Shi, N.1    Boado, R.J.2    Pardridge, W.M.3
  • 298
    • 0035910336 scopus 로고    scopus 로고
    • Conjugation of brain-derived neurotrophic factor to a blood-brain barrier drug targeting system enables neuroprotection in regional brain ischemia following intravenous injection of the neurotrophin
    • DOI 10.1016/S0006-8993(00)03108-5, PII S0006899300031085
    • Zhang Y, Pardridge WM,. Conjugation of brain-derived neurotrophic factor to a blood-brain barrier drug targeting system enables neuroprotection in regional brain ischemia following intravenous injection of the neurotrophin. Brain Res 2001; 889: 49-56. (Pubitemid 32146264)
    • (2001) Brain Research , vol.889 , Issue.1-2 , pp. 49-56
    • Zhang, Y.1    Pardridge, W.M.2
  • 299
    • 33846897981 scopus 로고    scopus 로고
    • Humanization of anti-human insulin receptor antibody for drug targeting across the human blood-brain barrier
    • DOI 10.1002/bit.21120
    • Boado RJ, Zhang Y, Pardridge WM,. Humanization of anti-human insulin receptor antibody for drug targeting across the human blood-brain barrier. Biotechnol Bioeng 2007; 96: 381-391. (Pubitemid 46232272)
    • (2007) Biotechnology and Bioengineering , vol.96 , Issue.2 , pp. 381-391
    • Boado, R.J.1    Zhang, Y.2    Zhang, Y.3    Pardridge, W.M.4
  • 300
    • 78651415887 scopus 로고    scopus 로고
    • The potential of combinations of drug-loaded nanoparticle systems and adult stem cells for glioma therapy
    • Roger M, Clavreul A, Venier-Julienne MC, et al. The potential of combinations of drug-loaded nanoparticle systems and adult stem cells for glioma therapy. Biomaterials 2011; 32: 2106-2116.
    • (2011) Biomaterials , vol.32 , pp. 2106-2116
    • Roger, M.1    Clavreul, A.2    Venier-Julienne, M.C.3
  • 301
    • 77955466238 scopus 로고    scopus 로고
    • Nanoparticle-mediated brain-specific drug delivery, imaging, and diagnosis
    • Yang H,. Nanoparticle-mediated brain-specific drug delivery, imaging, and diagnosis. Pharm Res 2010; 27: 1759-1771.
    • (2010) Pharm Res , vol.27 , pp. 1759-1771
    • Yang, H.1
  • 302
    • 79957439772 scopus 로고    scopus 로고
    • Boosting brain uptake of a therapeutic antibody by reducing its affinity for a transcytosis target
    • Yu YJ, Zhang Y, Kenrick M, et al. Boosting brain uptake of a therapeutic antibody by reducing its affinity for a transcytosis target. Sci Transl Med 2011; 3: 84ra44.
    • (2011) Sci Transl Med , vol.3
    • Yu, Y.J.1    Zhang, Y.2    Kenrick, M.3
  • 303
    • 44149105668 scopus 로고    scopus 로고
    • The tight junction protein complex undergoes rapid and continuous molecular remodeling at steady state
    • DOI 10.1083/jcb.200711165
    • Shen L, Weber CR, Turner JR,. The tight junction protein complex undergoes rapid and continuous molecular remodeling at steady state. J Cell Biol 2008; 181: 683-695. (Pubitemid 351717514)
    • (2008) Journal of Cell Biology , vol.181 , Issue.4 , pp. 683-695
    • Shen, L.1    Weber, C.R.2    Turner, J.R.3
  • 304
    • 65649105035 scopus 로고    scopus 로고
    • Clearance of amyloid-beta peptide across the blood-brain barrier: Implication for therapies in Alzheimer's disease
    • Deane R, Bell RD, Sagare A, Zlokovic BV,. Clearance of amyloid-beta peptide across the blood-brain barrier: implication for therapies in Alzheimer's disease. CNS Neurol Disord Drug Targets 2009; 8: 16-30.
    • (2009) CNS Neurol Disord Drug Targets , vol.8 , pp. 16-30
    • Deane, R.1    Bell, R.D.2    Sagare, A.3    Zlokovic, B.V.4
  • 305
    • 57449084208 scopus 로고    scopus 로고
    • ApoE isoform-specific disruption of amyloid beta peptide clearance from mouse brain
    • Deane R, Sagare A, Hamm K, et al. apoE isoform-specific disruption of amyloid beta peptide clearance from mouse brain. J Clin Invest 2008; 118: 4002-4013.
    • (2008) J Clin Invest , vol.118 , pp. 4002-4013
    • Deane, R.1    Sagare, A.2    Hamm, K.3
  • 307
    • 2642563866 scopus 로고    scopus 로고
    • Molecular anatomy of interendothelial junctions in human blood-brain barrier microvessels
    • Vorbrodt AW, Dobrogowska DH,. Molecular anatomy of interendothelial junctions in human blood-brain barrier microvessels. Folia Histochem Cytobiol 2004; 42: 67-75. (Pubitemid 38714693)
    • (2004) Folia Histochemica et Cytobiologica , vol.42 , Issue.2 , pp. 67-75
    • Vorbrodt, A.W.1    Dobrogowska, D.H.2
  • 308
    • 43649106042 scopus 로고    scopus 로고
    • Decreased junctional adhesion molecule-A expression during blood-brain barrier breakdown
    • Yeung D, Manias JL, Stewart DJ, Nag S,. Decreased junctional adhesion molecule-A expression during blood-brain barrier breakdown. Acta Neuropathol 2008; 115: 635-642.
    • (2008) Acta Neuropathol , vol.115 , pp. 635-642
    • Yeung, D.1    Manias, J.L.2    Stewart, D.J.3    Nag, S.4
  • 309
    • 78650622142 scopus 로고    scopus 로고
    • Monocarboxylate transporter 1 is deficient on microvessels in the human epileptogenic hippocampus
    • Lauritzen F, de Lanerolle NC, Lee TS, et al. Monocarboxylate transporter 1 is deficient on microvessels in the human epileptogenic hippocampus. Neurobiol Dis 2011; 41: 577-584.
    • (2011) Neurobiol Dis , vol.41 , pp. 577-584
    • Lauritzen, F.1    De Lanerolle, N.C.2    Lee, T.S.3
  • 311
    • 49349102757 scopus 로고    scopus 로고
    • Subcellular localization of transporters along the rat blood-brain barrier and blood-cerebral-spinal fluid barrier by in vivo biotinylation
    • Roberts LM, Black DS, Raman C, et al. Subcellular localization of transporters along the rat blood-brain barrier and blood-cerebral-spinal fluid barrier by in vivo biotinylation. Neuroscience 2008; 155: 423-438.
    • (2008) Neuroscience , vol.155 , pp. 423-438
    • Roberts, L.M.1    Black, D.S.2    Raman, C.3
  • 312
    • 69549126157 scopus 로고    scopus 로고
    • Culture-induced changes in blood-brain barrier transcriptome: Implications for amino-acid transporters in vivo
    • Lyck R, Ruderisch N, Moll AG, et al. Culture-induced changes in blood-brain barrier transcriptome: implications for amino-acid transporters in vivo. J Cereb Blood Flow Metab 2009; 29: 1491-1502.
    • (2009) J Cereb Blood Flow Metab , vol.29 , pp. 1491-1502
    • Lyck, R.1    Ruderisch, N.2    Moll, A.G.3
  • 313
    • 1642529749 scopus 로고    scopus 로고
    • Developmental Regulation of the Rabbit Blood-Brain Barrier LAT1 Large Neutral Amino Acid Transporter mRNA and Protein
    • DOI 10.1203/01.PDR.0000113461.07950.72
    • Boado RJ, Li JY, Pardridge WM,. Developmental regulation of the rabbit blood-brain barrier LAT1 large neutral amino acid transporter mRNA and protein. Pediatr Res 2004; 55: 557-560. (Pubitemid 38405839)
    • (2004) Pediatric Research , vol.55 , Issue.4 , pp. 557-560
    • Boado, R.J.1    Li, J.Y.2    Pardridge, W.M.3
  • 314
    • 0039967156 scopus 로고    scopus 로고
    • Na(+)-dependent glutamate transporters (EAAT1, EAAT2, and EAAT3) of the blood-brain barrier. A mechanism for glutamate removal
    • O'Kane RL, Martinez-Lopez I, DeJoseph MR, et al. Na(+)-dependent glutamate transporters (EAAT1, EAAT2, and EAAT3) of the blood-brain barrier. A mechanism for glutamate removal. J Biol Chem 1999; 274: 31891-31895.
    • (1999) J Biol Chem , vol.274 , pp. 31891-31895
    • O'Kane, R.L.1    Martinez-Lopez, I.2    Dejoseph, M.R.3
  • 315
    • 79961096875 scopus 로고    scopus 로고
    • Transcriptomic and quantitative proteomic analysis of transporters and drug metabolizing enzymes in freshly isolated human brain microvessels
    • Shawahna R, Uchida Y, Decleves X, et al. Transcriptomic and quantitative proteomic analysis of transporters and drug metabolizing enzymes in freshly isolated human brain microvessels. Mol Pharm 2011; 8: 1332-1341.
    • (2011) Mol Pharm , vol.8 , pp. 1332-1341
    • Shawahna, R.1    Uchida, Y.2    Decleves, X.3
  • 316
    • 79959819792 scopus 로고    scopus 로고
    • Differential axial localization along the mouse brain vascular tree of luminal sodium-dependent glutamine transporters Snat1 and Snat3
    • Ruderisch N, Virgintino D, Makrides V, Verrey F,. Differential axial localization along the mouse brain vascular tree of luminal sodium-dependent glutamine transporters Snat1 and Snat3. J Cereb Blood Flow Metab 2011; 31: 1637-1647.
    • (2011) J Cereb Blood Flow Metab , vol.31 , pp. 1637-1647
    • Ruderisch, N.1    Virgintino, D.2    Makrides, V.3    Verrey, F.4
  • 317
    • 68849124098 scopus 로고    scopus 로고
    • Cerebral microvascular endothelial cell Na/H exchange: Evidence for the presence of NHE1 and NHE2 isoforms and regulation by arginine vasopressin
    • Lam TI, Wise PM, O'Donnell ME,. Cerebral microvascular endothelial cell Na/H exchange: evidence for the presence of NHE1 and NHE2 isoforms and regulation by arginine vasopressin. Am J Physiol Cell Physiol 2009; 297: C278-C289.
    • (2009) Am J Physiol Cell Physiol , vol.297
    • Lam, T.I.1    Wise, P.M.2    O'Donnell, M.E.3
  • 321
    • 79952001112 scopus 로고    scopus 로고
    • Inflammatory pain signals an increase in functional expression of organic anion transporting polypeptide 1a4 at the blood-brain barrier
    • Ronaldson PT, Finch JD, Demarco KM, et al. Inflammatory pain signals an increase in functional expression of organic anion transporting polypeptide 1a4 at the blood-brain barrier. J Pharmacol Exp Ther 2011; 336: 827-839.
    • (2011) J Pharmacol Exp Ther , vol.336 , pp. 827-839
    • Ronaldson, P.T.1    Finch, J.D.2    Demarco, K.M.3
  • 324
    • 0036788234 scopus 로고    scopus 로고
    • Role of blood-brain barrier organic anion transporter 3 (OAT3) in the efflux of indoxyl sulfate, a uremic toxin: Its involvement in neurotransmitter metabolite clearance from the brain
    • Ohtsuki S, Asaba H, Takanaga H, et al. Role of blood-brain barrier organic anion transporter 3 (OAT3) in the efflux of indoxyl sulfate, a uremic toxin: its involvement in neurotransmitter metabolite clearance from the brain. J Neurochem 2002; 83: 57-66.
    • (2002) J Neurochem , vol.83 , pp. 57-66
    • Ohtsuki, S.1    Asaba, H.2    Takanaga, H.3
  • 325
    • 83755190692 scopus 로고    scopus 로고
    • Caveolin-1 regulates nitric oxide-mediated matrix metalloproteinases activity and blood-brain barrier permeability in focal cerebral ischemia and reperfusion injury
    • Gu Y, Zheng G, Xu M, et al. Caveolin-1 regulates nitric oxide-mediated matrix metalloproteinases activity and blood-brain barrier permeability in focal cerebral ischemia and reperfusion injury. J Neurochem 2012; 120: 147-156.
    • (2012) J Neurochem , vol.120 , pp. 147-156
    • Gu, Y.1    Zheng, G.2    Xu, M.3
  • 326
    • 77956058742 scopus 로고    scopus 로고
    • Bradykinin increases the permeability of the blood-tumor barrier by the caveolae-mediated transcellular pathway
    • Liu LB, Xue YX, Liu YH,. Bradykinin increases the permeability of the blood-tumor barrier by the caveolae-mediated transcellular pathway. J Neurooncol 2010; 99: 187-194.
    • (2010) J Neurooncol , vol.99 , pp. 187-194
    • Liu, L.B.1    Xue, Y.X.2    Liu, Y.H.3
  • 327
    • 79955915694 scopus 로고    scopus 로고
    • Vascular endothelial growth factor increases permeability of the blood-tumor barrier via caveolae-mediated transcellular pathway
    • Zhao LN, Yang ZH, Liu YH, et al. Vascular endothelial growth factor increases permeability of the blood-tumor barrier via caveolae-mediated transcellular pathway. J Mol Neurosci 2011; 44: 122-129.
    • (2011) J Mol Neurosci , vol.44 , pp. 122-129
    • Zhao, L.N.1    Yang, Z.H.2    Liu, Y.H.3
  • 328
    • 0033662074 scopus 로고    scopus 로고
    • Postischemic cerebrovascular E-selectin expression mediates tissue injury in murine stroke
    • Huang J, Choudhri TF, Winfree CJ, et al. Postischemic cerebrovascular E-selectin expression mediates tissue injury in murine stroke. Stroke 2000; 31: 3047-3053.
    • (2000) Stroke , vol.31 , pp. 3047-3053
    • Huang, J.1    Choudhri, T.F.2    Winfree, C.J.3
  • 329
    • 77649097668 scopus 로고    scopus 로고
    • Reduced blood brain barrier breakdown in P-selectin deficient mice following transient ischemic stroke: A future therapeutic target for treatment of stroke
    • Jin AY, Tuor UI, Rushforth D, et al. Reduced blood brain barrier breakdown in P-selectin deficient mice following transient ischemic stroke: A future therapeutic target for treatment of stroke. BMC Neurosci 2010; 11: 12.
    • (2010) BMC Neurosci , vol.11 , pp. 12
    • Jin, A.Y.1    Tuor, U.I.2    Rushforth, D.3
  • 330
    • 0242494863 scopus 로고    scopus 로고
    • T-cell interaction with ICAM-1/ICAM-2 double-deficient brain endothelium in vitro: The cytoplasmic tail of endothelial ICAM-1 is necessary for transendothelial migration of T cells
    • DOI 10.1182/blood-2003-02-0358
    • Lyck R, Reiss Y, Gerwin N, et al. T-cell interaction with ICAM-1/ICAM-2 double-deficient brain endothelium in vitro: The cytoplasmic tail of endothelial ICAM-1 is necessary for transendothelial migration of T cells. Blood 2003; 102: 3675-3683. (Pubitemid 37409388)
    • (2003) Blood , vol.102 , Issue.10 , pp. 3675-3683
    • Lyck, R.1    Reiss, Y.2    Gerwin, N.3    Greenwood, J.4    Adamson, P.5    Engelhardt, B.6
  • 331
    • 73949109168 scopus 로고    scopus 로고
    • Identification and expression profiling of blood-brain barrier membrane proteins
    • Agarwal N, Lippmann ES, Shusta EV,. Identification and expression profiling of blood-brain barrier membrane proteins. J Neurochem 2010; 112: 625-635.
    • (2010) J Neurochem , vol.112 , pp. 625-635
    • Agarwal, N.1    Lippmann, E.S.2    Shusta, E.V.3
  • 332
    • 0026650593 scopus 로고
    • Carbonic anhydrase IV on brain capillary endothelial cells: A marker associated with the blood-brain barrier
    • Ghandour MS, Langley OK, Zhu XL, et al. Carbonic anhydrase IV on brain capillary endothelial cells: A marker associated with the blood-brain barrier. Proc Natl Acad Sci U S A 1992; 89: 6823-6827.
    • (1992) Proc Natl Acad Sci U S A , vol.89 , pp. 6823-6827
    • Ghandour, M.S.1    Langley, O.K.2    Zhu, X.L.3
  • 334
    • 0038346312 scopus 로고    scopus 로고
    • Correlation of emmprin expression in vascular endothelial cells with blood-brain-barrier function: A study using magnetic resonance imaging enhanced by Gd-DTPA and immunohistochemistry in brain tumors
    • Sameshima T, Nabeshima K, Toole BP, et al. Correlation of emmprin expression in vascular endothelial cells with blood-brain-barrier function: A study using magnetic resonance imaging enhanced by Gd-DTPA and immunohistochemistry in brain tumors. Virchows Arch 2003; 442: 577-584. (Pubitemid 36819252)
    • (2003) Virchows Archiv , vol.442 , Issue.6 , pp. 577-584
    • Sameshima, T.1    Nabeshima, K.2    Toole, B.P.3    Inoue, T.4    Yokogami, K.5    Nakano, S.6    Ohi, T.7    Wakisaka, S.8
  • 335
    • 1842479164 scopus 로고    scopus 로고
    • Mice lacking insulin or insulin-like growth factor 1 receptors in vascular endothelial cells maintain normal blood-brain barrier
    • DOI 10.1016/j.bbrc.2004.03.043, PII S0006291X04005054
    • Kondo T, Hafezi-Moghadam A, Thomas K, et al. Mice lacking insulin or insulin-like growth factor 1 receptors in vascular endothelial cells maintain normal blood-brain barrier. Biochem Biophys Res Commun 2004; 317: 315-320. (Pubitemid 38452484)
    • (2004) Biochemical and Biophysical Research Communications , vol.317 , Issue.2 , pp. 315-320
    • Kondo, T.1    Hafezi-Moghadam, A.2    Thomas, K.3    Wagner, D.D.4    Kahn, C.R.5
  • 336
    • 0021841594 scopus 로고
    • Human blood-brain barrier insulin receptor
    • DOI 10.1111/j.1471-4159.1985.tb07167.x
    • Pardridge WM, Eisenberg J, Yang J,. Human blood-brain barrier insulin receptor. J Neurochem 1985; 44: 1771-1778. (Pubitemid 15000282)
    • (1985) Journal of Neurochemistry , vol.44 , Issue.6 , pp. 1771-1778
    • Pardridge, W.M.1    Eisenberg, J.2    Yang, J.3
  • 337
    • 0016375397 scopus 로고
    • Gamma-glutamyl transpeptidase in brain capillaries: Possible site of a blood-brain barrier for amino acids
    • Orlowski M, Sessa G, Green JP,. Gamma-glutamyl transpeptidase in brain capillaries: possible site of a blood-brain barrier for amino acids. Science 1974; 184: 66-68.
    • (1974) Science , vol.184 , pp. 66-68
    • Orlowski, M.1    Sessa, G.2    Green, J.P.3
  • 338
    • 44449160095 scopus 로고    scopus 로고
    • Clinical review: Imaging in ischaemic stroke - Implications for acute management
    • Moustafa RR, Baron JC,. Clinical review: Imaging in ischaemic stroke-implications for acute management. Crit Care 2007; 11: 227.
    • (2007) Crit Care , vol.11 , pp. 227
    • Moustafa, R.R.1    Baron, J.C.2
  • 339
    • 0035975584 scopus 로고    scopus 로고
    • CT and MRI in the diagnosis of acute stroke and their role in thrombolysis
    • Rother J,. CT and MRI in the diagnosis of acute stroke and their role in thrombolysis. Thromb Res 2001; 103 (suppl 1): S125-S133.
    • (2001) Thromb Res , vol.103 , Issue.SUPPL. 1
    • Rother, J.1
  • 340
    • 0029780302 scopus 로고    scopus 로고
    • Dynamics of polymorphonuclear leukocyte accumulation in acute cerebral infarction and their correlation with brain tissue damage
    • Akopov SE, Simonian NA, Grigorian GS,. Dynamics of polymorphonuclear leukocyte accumulation in acute cerebral infarction and their correlation with brain tissue damage. Stroke 1996; 27: 1739-1743. (Pubitemid 26332496)
    • (1996) Stroke , vol.27 , Issue.10 , pp. 1739-1743
    • Akopov, S.E.1    Simonian, N.A.2    Grigorian, G.S.3
  • 341
    • 0026667919 scopus 로고
    • Polymorphonuclear leukocytes and monocytes/macrophages in the pathogenesis of cerebral ischemia and stroke
    • Kochanek PM, Hallenbeck JM,. Polymorphonuclear leukocytes and monocytes/macrophages in the pathogenesis of cerebral ischemia and stroke. Stroke 1992; 23: 1367-1379.
    • (1992) Stroke , vol.23 , pp. 1367-1379
    • Kochanek, P.M.1    Hallenbeck, J.M.2


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