A co-culture-based model of human blood-brain barrier: Application to active transport of indinavir and in vivo-in vitro correlation

Brain Research

Volumn 927, Issue 2, 2002, Pages 153-167

  Megard, Isabelle ^a   Garrigues, Alexia ^b   Orlowski, Stéphane ^b   Jorajuria, Sylvie ^c   Clayette, Pascal ^c,d   Ezan, Eric ^a   Mabondzo, Alose ^a  

^a Institut National de la Recherche Agronomique   (France)

^b DIF   (France)

^c INSTITUT DE RADIOPROTECTION ET DE SÛRETÉ NUCLÉAIRE   (France)

^d SPI Bio   (France)

Author keywords

Blood brain barrier; Central nervous system; Drug transport; Indinavir; P Glycoprotein

Indexed keywords

GLYCOPROTEIN P; INDINAVIR; OCTANOL; PROTEINASE INHIBITOR; QUINIDINE; WATER;

ACTIVE TRANSPORT; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; ASTROCYTE; BINDING SITE; BIOLOGICAL MODEL; BLOOD BRAIN BARRIER; BRAIN REGION; CELL CULTURE; CENTRAL NERVOUS SYSTEM; COCULTURE; CONTROLLED STUDY; CORRELATION ANALYSIS; DRUG ACCUMULATION; DRUG BLOOD LEVEL; DRUG BRAIN LEVEL; DRUG INHIBITION; DRUG PENETRATION; DRUG PROTEIN BINDING; DRUG SCREENING; DRUG TRANSPORT; ENDOTHELIUM CELL; ENZYME ACTIVATION; HUMAN; HUMAN CELL; IN VIVO STUDY; KNOCKOUT MOUSE; MALE; MOLECULAR WEIGHT; MOUSE; NONHUMAN; PARTITION COEFFICIENT; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION;

ADENOSINE TRIPHOSPHATASES; ADULT; ANIMALS; ASTROCYTES; ATP-BINDING CASSETTE TRANSPORTERS; BIOLOGICAL TRANSPORT, ACTIVE; BLOOD-BRAIN BARRIER; CAPILLARY PERMEABILITY; CELL LINE; COCULTURE TECHNIQUES; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOTHELIUM, VASCULAR; HIV PROTEASE INHIBITORS; HUMANS; INDINAVIR; MALE; MICE; MICE, KNOCKOUT; P-GLYCOPROTEINS;

EID: 0037081556     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(01)03337-6     Document Type: Article

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