Applicability of a blood-brain barrier specific artificial membrane permeability assay at the early stage of natural product-based CNS drug discovery

Journal of Natural Products

Volumn 76, Issue 4, 2013, Pages 655-663

  Könczöl, Árpád ^a   Müller, Judit ^a,b   Földes, Emília ^b   Béni, Zoltán ^a   Végh, Krisztina ^c   Kéry, Ágnes ^c   Balogh, György T ^a  

^a GEDEON RICHTER LTD   (Hungary)

^b BUDAPEST UNIVERSITY OF TECHNOLOGY AND ECONOMICS   (Hungary)

^c SEMMELWEIS UNIVERSITY   (Hungary)

Author keywords

[No Author keywords available]

Indexed keywords

ALKALOID; BROMOCRIPTINE; CARBOXYLIC ACID; CENTRAL NERVOUS SYSTEM AGENTS; CORYDALIS CAVA EXTRACT; COUMARIN; DEXTROMETHORPHAN; ESTRADIOL; ETOPOSIDE; FLAVONOID; GLYCOSIDE; HYDROCORTISONE; MANNITOL; NARINGENIN; NATURAL PRODUCT; PERGOLIDE; PHYSOSTIGMINE; PLANT EXTRACT; PREDNISONE; QUERCETIN; SALVIA OFFICINALIS EXTRACT; SELEGILINE; TANACETUM PARTHENIUM EXTRACT; TOPIRAMATE; UNCLASSIFIED DRUG; UNINDEXED DRUG; VERAPAMIL; VINBLASTINE; VINCA MAJOR EXTRACT; VINCAMINE; VINCRISTINE;

ARTICLE; ARTIFICIAL MEMBRANE; BLOOD BRAIN BARRIER; CONTROLLED STUDY; CORYDALIS CAVA; DRUG DETERMINATION; DRUG ISOLATION; DRUG PENETRATION; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; FILTER; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; MEMBRANE PERMEABILITY; MOLECULAR LIBRARY; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PARALLEL ARTIFICIAL MEMBRANE PERMEABILITY ASSAY FOR THE BLOOD BRAIN BARRIER ASSAY; PERFORMANCE; PHYSICAL CHEMISTRY; PHYTOCHEMISTRY; SALVIA OFFICINALIS; TANACETUM PARTHENIUM; VALIDATION PROCESS; VINCA MAJOR;

BIOLOGICAL AGENTS; BIOLOGICAL TRANSPORT; BLOOD-BRAIN BARRIER; BRAIN; CELL MEMBRANE PERMEABILITY; CENTRAL NERVOUS SYSTEM AGENTS; CORYDALIS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DISCOVERY; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PLANT EXTRACTS; SALVIA OFFICINALIS; TANACETUM PARTHENIUM; VINCA;

CORYDALIS CAVA; SALVIA OFFICINALIS; TANACETUM PARTHENIUM; VINCA MAJOR;

EID: 84876942766     PISSN: 01633864     EISSN: 15206025     Source Type: Journal    
DOI: 10.1021/np300882f     Document Type: Article

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