-
1
-
-
0020374726
-
Comparison of the actions of centrally and peripherally administered clonidine and guanfacine in the rabbit: Investigation of the differences
-
N.D. Barber, and J.L. Reid Comparison of the actions of centrally and peripherally administered clonidine and guanfacine in the rabbit: investigation of the differences Br. J. Pharmacol. 77 1982 641 647
-
(1982)
Br. J. Pharmacol.
, vol.77
, pp. 641-647
-
-
Barber, N.D.1
Reid, J.L.2
-
2
-
-
0036605677
-
Functional expression and localization of P-glycoprotein at the blood brain barrier
-
R. Bendayan, G. Lee, and M. Bendayan Functional expression and localization of P-glycoprotein at the blood brain barrier Microsc. Res. Tech. 57 2002 365 380
-
(2002)
Microsc. Res. Tech.
, vol.57
, pp. 365-380
-
-
Bendayan, R.1
Lee, G.2
Bendayan, M.3
-
4
-
-
0031892623
-
Distribution of bismuth in the rat after oral dosing with ranitidine bismuth citrate and bismuth subcitrate
-
J. Canena, J. Reis, A.S. Pinto, A.M. Santos, J. Leitao, T. Pinheiro, and M.G. Quina Distribution of bismuth in the rat after oral dosing with ranitidine bismuth citrate and bismuth subcitrate J. Pharm. Pharmacol. 50 1998 279 283
-
(1998)
J. Pharm. Pharmacol.
, vol.50
, pp. 279-283
-
-
Canena, J.1
Reis, J.2
Pinto, A.S.3
Santos, A.M.4
Leitao, J.5
Pinheiro, T.6
Quina, M.G.7
-
5
-
-
0026696199
-
Biodistribution of rhodamine-123 in nude mice heterotransplanted with human squamous cell carcinomas
-
D.J. Castro, S. Haghighat, R.E. Saxton, E. Reisler, N. Jongwaard, D.J. Castro, P.H. Ward, and R.B. Lufkin Biodistribution of rhodamine-123 in nude mice heterotransplanted with human squamous cell carcinomas Laryngoscope 102 1992 868 874
-
(1992)
Laryngoscope
, vol.102
, pp. 868-874
-
-
Castro, D.J.1
Haghighat, S.2
Saxton, R.E.3
Reisler, E.4
Jongwaard, N.5
Castro, D.J.6
Ward, P.H.7
Lufkin, R.B.8
-
6
-
-
0020081135
-
Electrical resistance of brain microvascular endothelium
-
C. Crone, and S.P. Olesen Electrical resistance of brain microvascular endothelium Brain Res. 241 1982 49 55
-
(1982)
Brain Res.
, vol.241
, pp. 49-55
-
-
Crone, C.1
Olesen, S.P.2
-
7
-
-
0031887288
-
P-glycoprotein: A new mechanism to control drug-induced nephrotoxicity
-
R.G. del Moral, A. Olmo, M. Aguilar, and F. O'Valle P-glycoprotein: a new mechanism to control drug-induced nephrotoxicity Exp. Nephrol. 6 1998 89 97
-
(1998)
Exp. Nephrol.
, vol.6
, pp. 89-97
-
-
Del Moral, R.G.1
Olmo, A.2
Aguilar, M.3
O'Valle, F.4
-
8
-
-
84962359573
-
High throughput artificial membrane permeability assay for blood-brain barrier
-
L. Di, E.H. Kerns, K. Fan, O.J. McConnell, and G.T. Carter High throughput artificial membrane permeability assay for blood-brain barrier Eur. J. Med. Chem. 38 2003 223 232
-
(2003)
Eur. J. Med. Chem.
, vol.38
, pp. 223-232
-
-
Di, L.1
Kerns, E.H.2
Fan, K.3
McConnell, O.J.4
Carter, G.T.5
-
9
-
-
0035066252
-
Transporters involved in the elimination of drugs in the kidney: Organic anion transporters and organic cation transporters
-
M.J. Dresser, M.K. Leabman, and K.M. Giacomini Transporters involved in the elimination of drugs in the kidney: organic anion transporters and organic cation transporters J. Pharm. Sci. 90 2001 397 421
-
(2001)
J. Pharm. Sci.
, vol.90
, pp. 397-421
-
-
Dresser, M.J.1
Leabman, M.K.2
Giacomini, K.M.3
-
10
-
-
0042884316
-
Caco-2 permeability, P-glycoprotein transport ratios and brain penetration of heterocyclic drugs
-
F. Faassen, G. Vogel, H. Spanings, and H. Vromans Caco-2 permeability, P-glycoprotein transport ratios and brain penetration of heterocyclic drugs Int. J. Pharm. 263 2003 113 122
-
(2003)
Int. J. Pharm.
, vol.263
, pp. 113-122
-
-
Faassen, F.1
Vogel, G.2
Spanings, H.3
Vromans, H.4
-
11
-
-
0033949264
-
Primary cultures of brain microvessel endothelial cells: A valid and flexible model to study drug transport through the blood-brain barrier in vitro
-
H. Franke, H. Galla, and C.T. Beuckmann Primary cultures of brain microvessel endothelial cells: a valid and flexible model to study drug transport through the blood-brain barrier in vitro Brain Res. Prot. 5 2000 248 256
-
(2000)
Brain Res. Prot.
, vol.5
, pp. 248-256
-
-
Franke, H.1
Galla, H.2
Beuckmann, C.T.3
-
12
-
-
0035156232
-
Progress and limitations in the use of in vitro cell cultures to serve as a permeability screen for the blood-brain barrier
-
M. Gumbleton, and K.L. Audus Progress and limitations in the use of in vitro cell cultures to serve as a permeability screen for the blood-brain barrier J. Pharm. Sci. 90 2001 1681 1698
-
(2001)
J. Pharm. Sci.
, vol.90
, pp. 1681-1698
-
-
Gumbleton, M.1
Audus, K.L.2
-
13
-
-
0035524138
-
Assessing the absorption of new pharmaceuticals
-
I.J. Hidalgo Assessing the absorption of new pharmaceuticals Curr. Top. Med. Chem. 1 2001 385 401
-
(2001)
Curr. Top. Med. Chem.
, vol.1
, pp. 385-401
-
-
Hidalgo, I.J.1
-
14
-
-
0034003655
-
Modulating blood-brain barrier interactions of amino acid-based anticancer agents
-
D.M. Killian, L. Gharat, and P. Chikhale Modulating blood-brain barrier interactions of amino acid-based anticancer agents Drug Delivery 7 2000 21 25
-
(2000)
Drug Delivery
, vol.7
, pp. 21-25
-
-
Killian, D.M.1
Gharat, L.2
Chikhale, P.3
-
15
-
-
0022407769
-
The distribution of labeled antibiotics in normal and infected rat brain: An autoradiographic study
-
H. Kourtopoulos, S.E. Holm, and B. Winblad The distribution of labeled antibiotics in normal and infected rat brain: an autoradiographic study Scand. J. Infect. Dis. 17 1985 395 400
-
(1985)
Scand. J. Infect. Dis.
, vol.17
, pp. 395-400
-
-
Kourtopoulos, H.1
Holm, S.E.2
Winblad, B.3
-
17
-
-
1642579680
-
Development of a computational approach to predict blood-brain barrier permeability
-
X. Liu, M. Tu, R.S. Kelly, C. Chen, and B.J. Smith Development of a computational approach to predict blood-brain barrier permeability Drug Metab. Dispos. 32 2004 132 139
-
(2004)
Drug Metab. Dispos.
, vol.32
, pp. 132-139
-
-
Liu, X.1
Tu, M.2
Kelly, R.S.3
Chen, C.4
Smith, B.J.5
-
18
-
-
0033088690
-
Prediction of the brain-blood distribution of a large set of drugs from structurally derived descriptors using partial least-squares (PLS) modeling
-
J.M. Luco Prediction of the brain-blood distribution of a large set of drugs from structurally derived descriptors using partial least-squares (PLS) modeling J. Chem. Inf. Comput. Sci. 39 1999 396 404
-
(1999)
J. Chem. Inf. Comput. Sci.
, vol.39
, pp. 396-404
-
-
Luco, J.M.1
-
19
-
-
0035997330
-
Prediction of drug transport through the blood-brain barrier in vivo: A comparison between two in vitro cell models
-
S. Lundquist, M. Renftel, J. Brillault, L. Fenart, R. Cecchelli, and M.P. Dehouck Prediction of drug transport through the blood-brain barrier in vivo: a comparison between two in vitro cell models Pharm. Res. 19 2002 976 981
-
(2002)
Pharm. Res.
, vol.19
, pp. 976-981
-
-
Lundquist, S.1
Renftel, M.2
Brillault, J.3
Fenart, L.4
Cecchelli, R.5
Dehouck, M.P.6
-
20
-
-
0036896304
-
Passive permeability and P-glycoprotein-mediated efflux differentiate central nervous system (CNS) and non-CNS marketed drugs
-
K.M. Mahar Doan, J.E. Humphreys, L.O. Webster, S.A. Wring, L.J. Shampine, C.J. Serabjit-Singh, K.K. Adkison, and J.W. Polli Passive permeability and P-glycoprotein-mediated efflux differentiate central nervous system (CNS) and non-CNS marketed drugs J. Pharmacol. Exp. Ther. 303 2002 1029 1037
-
(2002)
J. Pharmacol. Exp. Ther.
, vol.303
, pp. 1029-1037
-
-
Mahar Doan, K.M.1
Humphreys, J.E.2
Webster, L.O.3
Wring, S.A.4
Shampine, L.J.5
Serabjit-Singh, C.J.6
Adkison, K.K.7
Polli, J.W.8
-
21
-
-
1842614887
-
18F]-l-m-tyrosine
-
18F]-l-m- tyrosine Synapse 52 2004 153 162
-
(2004)
Synapse
, vol.52
, pp. 153-162
-
-
Mamo, D.1
Remington, G.2
Nobrega, J.3
Hussey, D.4
Chirakal, R.5
Wilson, A.A.6
Baker, G.7
Houle, S.8
Kapur, S.9
-
22
-
-
0021324207
-
Clinical pharmacokinetics of labetalol
-
J.J. McNeil, and W.J. Louis Clinical pharmacokinetics of labetalol Clin. Pharmacokinet. 9 1984 157 167
-
(1984)
Clin. Pharmacokinet.
, vol.9
, pp. 157-167
-
-
McNeil, J.J.1
Louis, W.J.2
-
23
-
-
0042468096
-
Impact of drug transporter studies on drug discovery and development
-
N. Mizuno, T. Niwa, Y. Yotsumoto, and Y. Sugiyama Impact of drug transporter studies on drug discovery and development Pharmacol. Rev. 55 2003 425 461
-
(2003)
Pharmacol. Rev.
, vol.55
, pp. 425-461
-
-
Mizuno, N.1
Niwa, T.2
Yotsumoto, Y.3
Sugiyama, Y.4
-
24
-
-
0033827023
-
Comparison of blood-brain barrier permeability in mice and rats using in situ brain perfusion technique
-
H. Murakami, H. Takanaga, H. Matsuo, H. Ohtani, and Y. Sawada Comparison of blood-brain barrier permeability in mice and rats using in situ brain perfusion technique Am. J. Physiol. Heart Circ. Physiol. 279 2000 H1022 H1028
-
(2000)
Am. J. Physiol. Heart Circ. Physiol.
, vol.279
-
-
Murakami, H.1
Takanaga, H.2
Matsuo, H.3
Ohtani, H.4
Sawada, Y.5
-
25
-
-
0027281128
-
Analysis and distribution of etoposide in rat brain tumor model: Intracarotid versus intracarotid with angiotensin II-induced hypertension
-
H. Ogasawara, T. Uozumi, K. Kiya, K. Kurisu, T. Mikami, T. Hotta, and K. Sugiyama Analysis and distribution of etoposide in rat brain tumor model: intracarotid versus intracarotid with angiotensin II-induced hypertension Cancer Invest. 11 1993 299 305
-
(1993)
Cancer Invest.
, vol.11
, pp. 299-305
-
-
Ogasawara, H.1
Uozumi, T.2
Kiya, K.3
Kurisu, K.4
Mikami, T.5
Hotta, T.6
Sugiyama, K.7
-
26
-
-
0034896546
-
Evaluation of the BBMEC model for screening the CNS permeability of drugs
-
K.W. Otis, M.L. Avery, S.M. Broward-Partin, D.K. Hansen, H.W. Behlow Jr., D.O. Scott, and T.N. Thompson Evaluation of the BBMEC model for screening the CNS permeability of drugs J. Pharmacol. Toxicol. Methods 45 2001 71 77
-
(2001)
J. Pharmacol. Toxicol. Methods
, vol.45
, pp. 71-77
-
-
Otis, K.W.1
Avery, M.L.2
Broward-Partin, S.M.3
Hansen, D.K.4
Behlow Jr., H.W.5
Scott, D.O.6
Thompson, T.N.7
-
27
-
-
0026638367
-
Permeability of bovine brain microvessel endothelial cells in vitro: Barrier tightening by a factor released from astroglioma cells
-
T.J. Raub, S.L. Kuentzel, and G.A. Sawada Permeability of bovine brain microvessel endothelial cells in vitro: barrier tightening by a factor released from astroglioma cells Exp. Cell Res. 199 1992 330 340
-
(1992)
Exp. Cell Res.
, vol.199
, pp. 330-340
-
-
Raub, T.J.1
Kuentzel, S.L.2
Sawada, G.A.3
-
28
-
-
0030748912
-
F-actin cytoskeleton and sucrose permeability of immortalised rat brain microvascular endothelial cell monolayers: Effects of cyclic AMP and astrocytic factors
-
R.J. Rist, I.A. Romero, M.W. Chan, P.O. Couraud, F. Roux, and N.J. Abbott F-actin cytoskeleton and sucrose permeability of immortalised rat brain microvascular endothelial cell monolayers: effects of cyclic AMP and astrocytic factors Brain Res. 768 1997 10 18
-
(1997)
Brain Res.
, vol.768
, pp. 10-18
-
-
Rist, R.J.1
Romero, I.A.2
Chan, M.W.3
Couraud, P.O.4
Roux, F.5
Abbott, N.J.6
-
29
-
-
0028146558
-
Measurement of carbamazepine and carbamazepine epoxide in the human brain using in vivo microdialysis
-
R.D. Scheyer, M.J. During, D.D. Spencer, J.A. Cramer, and R.H. Mattson Measurement of carbamazepine and carbamazepine epoxide in the human brain using in vivo microdialysis Neurology 44 1994 1469 1472
-
(1994)
Neurology
, vol.44
, pp. 1469-1472
-
-
Scheyer, R.D.1
During, M.J.2
Spencer, D.D.3
Cramer, J.A.4
Mattson, R.H.5
-
30
-
-
0029892497
-
P-glycoprotein in the blood-brain barrier of mice influences the brain penetration and pharmacological activity of many drugs
-
A.H. Schinkel, E. Wagenaar, C.A. Mol, and L. van Deemter P-glycoprotein in the blood-brain barrier of mice influences the brain penetration and pharmacological activity of many drugs J. Clin. Invest. 97 1996 2517 2524
-
(1996)
J. Clin. Invest.
, vol.97
, pp. 2517-2524
-
-
Schinkel, A.H.1
Wagenaar, E.2
Mol, C.A.3
Van Deemter, L.4
-
31
-
-
0021915660
-
Muscarinic receptor heterogeneity revealed by interaction with bretylium tosylate. Different ligand-receptor conformations versus different receptor subclasses
-
G. Schreiber, and M. Sokolovsky Muscarinic receptor heterogeneity revealed by interaction with bretylium tosylate. Different ligand-receptor conformations versus different receptor subclasses Mol. Pharmacol. 27 1985 27 31
-
(1985)
Mol. Pharmacol.
, vol.27
, pp. 27-31
-
-
Schreiber, G.1
Sokolovsky, M.2
-
32
-
-
0031842597
-
The effect of antioxidative combination therapy on post hypoxic-ischemic perfusion, metabolism, and electrical activity of the newborn brain
-
M. Shadid, R. Moison, P. Steendijk, L. Hiltermann, H.M. Berger, and F. van Bel The effect of antioxidative combination therapy on post hypoxic-ischemic perfusion, metabolism, and electrical activity of the newborn brain Pediatr. Res. 44 1998 119 124
-
(1998)
Pediatr. Res.
, vol.44
, pp. 119-124
-
-
Shadid, M.1
Moison, R.2
Steendijk, P.3
Hiltermann, L.4
Berger, H.M.5
Van Bel, F.6
-
33
-
-
0141749108
-
Distinct effects of protein kinase C on the barrier function at different developmental stages
-
A. Sjo, K.E. Magnusson, and K.H. Peterson Distinct effects of protein kinase C on the barrier function at different developmental stages Biosci. Rep. 23 2003 87 102
-
(2003)
Biosci. Rep.
, vol.23
, pp. 87-102
-
-
Sjo, A.1
Magnusson, K.E.2
Peterson, K.H.3
-
34
-
-
0021920344
-
Regional cerebrovascular transport of leucine as measured by the in situ brain perfusion technique
-
Q.R. Smith, Y. Takasato, D.J. Sweeney, and S.I. Rapoport Regional cerebrovascular transport of leucine as measured by the in situ brain perfusion technique J. Cereb. Blood Flow Metab. 5 1985 300 311
-
(1985)
J. Cereb. Blood Flow Metab.
, vol.5
, pp. 300-311
-
-
Smith, Q.R.1
Takasato, Y.2
Sweeney, D.J.3
Rapoport, S.I.4
-
35
-
-
0029689906
-
Brain perfusion systems for studies of drug uptake and metabolism in the central nervous system
-
R.T. Borchardt Plenum Press New York*et al.
-
Q.R. Smith Brain perfusion systems for studies of drug uptake and metabolism in the central nervous system R.T. Borchardt Models for Assessing Drug Absorption and Metabolism 1996 Plenum Press New York pp. 285-307
-
(1996)
Models for Assessing Drug Absorption and Metabolism
-
-
Smith, Q.R.1
-
36
-
-
0018350646
-
Tissue levels of several radiolabelled beta-adrenoceptor antagonists after intravenous administration in rats
-
J.A. Street, B.A. Hemsworth, A.G. Roach, and M.D. Day Tissue levels of several radiolabelled beta-adrenoceptor antagonists after intravenous administration in rats Arch. Int. Pharmacodyn. Ther. 237 1979 180 190
-
(1979)
Arch. Int. Pharmacodyn. Ther.
, vol.237
, pp. 180-190
-
-
Street, J.A.1
Hemsworth, B.A.2
Roach, A.G.3
Day, M.D.4
-
37
-
-
11144278004
-
Strategic use of preclinical pharmacokinetics studies and in vitro ADME models in optimizing ADME properties
-
Parsippany, NJ.
-
Thakker, D.R., 2004. Strategic use of preclinical pharmacokinetics studies and in vitro ADME models in optimizing ADME properties. AAPS Workshop in Optimization of Drug-like Properties during Lead Optimization. Parsippany, NJ.
-
(2004)
AAPS Workshop in Optimization of Drug-like Properties during Lead Optimization
-
-
Thakker, D.R.1
-
38
-
-
0026584396
-
Cyclosporins as drug resistance modifiers
-
P.R. Twentyman Cyclosporins as drug resistance modifiers Biochem. Pharmacol. 43 1992 109 117
-
(1992)
Biochem. Pharmacol.
, vol.43
, pp. 109-117
-
-
Twentyman, P.R.1
-
39
-
-
0033952456
-
Penetration of amitriptyline, but not of fluoxetine, into brain is enhanced in mice with blood-brain barrier deficiency due to mdr1a P-glycoprotein gene disruption
-
M. Uhr, T. Steckler, A. Yassouridis, and F. Holsboer Penetration of amitriptyline, but not of fluoxetine, into brain is enhanced in mice with blood-brain barrier deficiency due to mdr1a P-glycoprotein gene disruption Neuropsychopharmacology 22 2000 380 387
-
(2000)
Neuropsychopharmacology
, vol.22
, pp. 380-387
-
-
Uhr, M.1
Steckler, T.2
Yassouridis, A.3
Holsboer, F.4
-
40
-
-
0025333781
-
Reversal of drug-resistant falciparum malaria by calcium antagonists: Potential for host cell toxicity
-
G. Watt, G.W. Long, M. Grogl, and S.K. Martin Reversal of drug-resistant falciparum malaria by calcium antagonists: potential for host cell toxicity Trans. R. Soc. Trop. Med. Hyg. 84 1990 187 190
-
(1990)
Trans. R. Soc. Trop. Med. Hyg.
, vol.84
, pp. 187-190
-
-
Watt, G.1
Long, G.W.2
Grogl, M.3
Martin, S.K.4
-
41
-
-
11144344639
-
Cultured epithelial cell assays used to estimate intestinal absorption potential
-
R.T. Borchardt E.H. Kerns C.A. Lipinski D.R. Thakker B. Wang AAPS Press Arlington, VA
-
K. Weinstein, P. Kardos, R. Strab, and I.J. Hildaog Cultured epithelial cell assays used to estimate intestinal absorption potential R.T. Borchardt E.H. Kerns C.A. Lipinski D.R. Thakker B. Wang Pharmaceutical Profiling in Drug Discovery and Lead Selection 2004 AAPS Press Arlington, VA pp. 217-234
-
(2004)
Pharmaceutical Profiling in Drug Discovery and Lead Selection
-
-
Weinstein, K.1
Kardos, P.2
Strab, R.3
Hildaog, I.J.4
-
42
-
-
0033996280
-
Distinct effects of Vibrio cholerae haemagglutinin/protease on the structure and localization of the tight junction-associated proteins occludin and ZO-1
-
Z. Wu, P. Nybom, and K.E. Magnusson Distinct effects of Vibrio cholerae haemagglutinin/protease on the structure and localization of the tight junction-associated proteins occludin and ZO-1 Cell Microbiol. 2 2000 11 17
-
(2000)
Cell Microbiol.
, vol.2
, pp. 11-17
-
-
Wu, Z.1
Nybom, P.2
Magnusson, K.E.3
-
43
-
-
0041736008
-
Developmental aspects of blood-brain barrier (BBB) and rat brain endothelial (RBE4) cells as in vitro model for studies on chlorpyrifos transport
-
J. Yang, and M. Aschner Developmental aspects of blood-brain barrier (BBB) and rat brain endothelial (RBE4) cells as in vitro model for studies on chlorpyrifos transport Neurotoxicology 24 2003 741 745
-
(2003)
Neurotoxicology
, vol.24
, pp. 741-745
-
-
Yang, J.1
Aschner, M.2
|