Characterization of cellular uptake and toxicity of aminosilane-coated iron oxide nanoparticles with different charges in central nervous system-relevant cell culture models

International Journal of Nanomedicine

Volumn 8, Issue , 2013, Pages 961-970

  Sun, Zhizhi ^a   Yathindranath, Vinith ^a   Worden, Matthew ^b   Thliveris, James A ^a   Chu, Stephanie ^a   Parkinson, Fiona E ^a   Hegmann, Torsten ^a,b   Miller, Donald W ^a  

^a UNIVERSITY OF MANITOBA   (Canada)

^b KENT STATE UNIVERSITY   (United States)

Author keywords

Biocompatibility; Brain; Cellular accumulation; Drug delivery; Magnetic field; Magnetic nanoparticles

Indexed keywords

AMINOSILANE; CHEMICAL COMPOUND; IRON OXIDE NANOPARTICLE; NANOPARTICLE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; ASTROCYTE; BIOACCUMULATION; CELL TRANSPORT; CELL VIABILITY; CENTRAL NERVOUS SYSTEM; CHEMICAL COMPOSITION; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CYTOTOXICITY TEST; MAGNETIC FIELD; MATERIAL COATING; MOUSE; NANOANALYSIS; NANOENCAPSULATION; NEUROTOXICITY; NONHUMAN; PARTICLE SIZE; PHYSICAL CHEMISTRY; SURFACE CHARGE; SURFACE PROPERTY; TEMPERATURE SENSITIVITY;

BIOCOMPATIBILITY; BRAIN; CELLULAR ACCUMULATION; DRUG DELIVERY; MAGNETIC FIELD; MAGNETIC NANOPARTICLES;

ANALYSIS OF VARIANCE; ANIMALS; ASTROCYTES; CELL LINE; CELL SURVIVAL; DRUG CARRIERS; MAGNETITE NANOPARTICLES; MICE; NEURONS; SILANES;

EID: 84875043885     PISSN: 11769114     EISSN: 11782013     Source Type: Journal    
DOI: 10.2147/IJN.S39048     Document Type: Article

References (38)

1. Moraes L, Vasconcelos-Dos-Santos A, Santana FC, et al. Neuroprotective effects and magnetic resonance imaging of mesenchymal stem cells labeled with SPION in a rat model of Huntington's disease. Stem cell Res. 2012;9(2):143-155.
2. Maier-Hauff K, Ulrich F, Nestler D, et al. Efficacy and safety of intratumoral thermotherapy using magnetic iron-oxide nanoparticles combined with external beam radiotherapy on patients with recurrent glioblastoma multiforme. J Neurooncol. 2011;103(2):317-324.
3. Kenzaoui BH, Bernasconi CC, Hofmann H, Juillerat-Jeanneret L. Evaluation of uptake and transport of ultrasmall superparamagnetic iron oxide nanoparticles by human brain-derived endothelial cells. Nanomedicine (Lond). 2012;7(1):39-53.
4. Bae JE, Huh MI, Ryu BK, et al. The effect of static magnetic fields on the aggregation and cytotoxicity of magnetic nanoparticles. Biomaterials. 2011;32(35):9401-9414.
5. Prohaska R, Sibon OC, Rudnicki DD, et al. Brain, blood, and iron: perspectives on the roles of erythrocytes and iron in neurodegeneration. Neurobiol Dis. 2012;46(3):607-624.
6. Zheng W, Monnot AD. Regulation of brain iron and copper homeostasis by brain barrier systems: implication in neurodegenerative diseases. Pharmacol Ther. 2012;133(2):177-188.
7. Batista-Nascimento L, Pimentel C, Menezes RA, Rodrigues-Pousada C. Iron and neurodegeneration: from cellular homeostasis to disease. Oxid Med Cell Longev. 2012;2012:128647.
8. Kubinova S, Sykova E. Nanotechnology for treatment of stroke and spinal cord injury. Nanomedicine (Lond). 2010;5(1):99-108.
9. Stoll G, Bendszus M. Imaging of inflammation in the peripheral and central nervous system by magnetic resonance imaging. Neuroscience. 2009;158(3):1151-1160.
10. Voinov MA, Sosa Pagan JO, Morrison E, Smirnova TI, Smirnov AI. Surface-mediated production of hydroxyl radicals as a mechanism of iron oxide nanoparticle biotoxicity. J Am Chem Soc. 2011;133(1):35-41.
11. Hanini A, Schmitt A, Kacem K, Chau F, Ammar S, Gavard J. Evaluation of iron oxide nanoparticle biocompatibility. Int J Nanomedicine. 2011;6:787-794.
12. Ma P, Luo Q, Chen J, et al. Intraperitoneal injection of magnetic Fe(3)O(4)-nanoparticle induces hepatic and renal tissue injury via oxidative stress in mice. Int J Nanomedicine. 2012;7:4809-4818.
13. Naqvi S, Samim M, Abdin M, et al. Concentration-dependent toxicity of iron oxide nanoparticles mediated by increased oxidative stress. Int J Nanomedicine. 2010;5:983-989.
14. Rivet CJ, Yuan Y, Borca-Tasciuc DA, Gilbert RJ. Altering iron oxide nanoparticle surface properties induce cortical neuron cytotoxicity. Chem Res Toxicol. 2012;25(1):153-161.
15. Bernardi A, Frozza RL, Meneghetti A, et al. Indomethacin-loaded lipid-core nanocapsules reduce the damage triggered by Abeta1-42 in Alzheimer's disease models. Int J Nanomedicine. 2012;7:4927-4942.
16. Hong SC, Lee JH, Lee J, et al. Subtle cytotoxicity and genotoxicity differences in superparamagnetic iron oxide nanoparticles coated with various functional groups. Int J Nanomedicine. 2011;6:3219-3231.
17. Galeotti F, Bertini F, Scavia G, Bolognesi A. A controlled approach to iron oxide nanoparticles functionalization for magnetic polymer brushes. J Colloid Interface. 2011;360(2):540-547.
18. Yathindranath V, Rebbouh L, Moore DF, Miller DW, van Lierop J, Hegmann T. A versatile method for the reductive, one-pot synthesis of bare, hydrophilic and hydrophobic magnetite nanoparticles. Adv Funct Mater. 2011;21(8):1457-1464.
19. Zamzow CR, Xiong W, Parkinson FE. Adenosine produced by neurons is metabolized to hypoxanthine by astrocytes. J Neurosci Res. 2008;86(15):3447-3455.
20. Luft JH. Improvements in epoxy resin embedding methods. J Biophys Biochem Cytol. 1961;9:409-414.
21. Wohlfart S, Gelperina S, Kreuter J. Transport of drugs across the blood-brain barrier by nanoparticles. J Control Release. 2012;161(2): 264-273.
22. Celia C, Cosco D, Paolino D, Fresta M. Nanoparticulate devices for brain drug delivery. Med Res Rev. 2010;31:716-756.
23. Wagner S, Zensi A, Wien SL, et al. Uptake mechanism of ApoE-modified nanoparticles on brain capillary endothelial cells as a blood-brain barrier model. PloS one. 2012;7(3):e32568.
24. Wankhede M, Bouras A, Kaluzova M, Hadjipanayis CG. Magnetic nanoparticles: an emerging technology for malignant brain tumor imaging and therapy. Expert Rev Clin Pharmacol. 2012;5(2):173-186.
25. Liu HL, Hua MY, Yang HW, et al. Magnetic resonance monitoring of focused ultrasound/magnetic nanoparticle targeting delivery of therapeutic agents to the brain. Proc Natl Acad Sci U S A. 2010;107(34):15205-15210.
26. Hutter E, Boridy S, Labrecque S, et al. Microglial response to gold nanoparticles. ACS nano. 2010;4(5):2595-2606.
27. Zhao J, Xu L, Zhang T, Ren G, Yang Z. Influences of nanoparticle zinc oxide on acutely isolated rat hippocampal CA3 pyramidal neurons. Neurotoxicology. 2009;30(2):220-230.
28. Wang J, Chen C, Liu Y, et al. Potential neurological lesion after nasal instillation of TiO(2) nanoparticles in the anatase and rutile crystal phases. Toxicol Lett. 2008;183(1-3):72-80.
29. Chertok B, David AE, Yang VC. Polyethyleneimine-modified iron oxide nanoparticles for brain tumor drug delivery using magnetic targeting and intra-carotid administration. Biomaterials. 2010;31(24):6317-6324.
30. Boridy S, Takahashi H, Akiyoshi K, Maysinger D. The binding of pullulan modified cholesteryl nanogels to Abeta oligomers and their suppression of cytotoxicity. Biomaterials. 2009;30(29):5583-5591.
31. Feeney CJ, Frantseva MV, Carlen PL, et al. Vulnerability of glial cells to hydrogen peroxide in cultured hippocampal slices. Brain Res. 2008;1198:1-15.
32. Haase A, Rott S, Mantion A, et al. Effects of silver nanoparticles on primary mixed neural cell cultures: uptake, oxidative stress and acute calcium responses. Toxicol Sci. 2012;126(2):457-468.
33. Mahmoudi M, Laurent S, Shokrgozar MA, Hosseinkhani M. Toxicity evaluations of superparamagnetic iron oxide nanoparticles: cell "vision" versus physicochemical properties of nanoparticles. ACS Nano. 2011;5(9):7263-7276.
34. Zhu XM, Wang YX, Leung KC, et al. Enhanced cellular uptake of aminosilane-coated superparamagnetic iron oxide nanoparticles in mammalian cell lines. Int J Nanomedicine. 2012;7:953-964.
35. Kang YS, Pardridge WM. Brain delivery of biotin bound to a conjugate of neutral avidin and cationized human albumin. Pharm Res. 1994;11(9):1257-1264.
36. Safi M, Courtois J, Seigneuret M, Conjeaud H, Berret JF. The effects of aggregation and protein corona on the cellular internalization of iron oxide nanoparticles. Biomaterials. 2011;32(35):9353-9363.
37. Lamkowsky MC, Geppert M, Schmidt MM, Dringen R. Magnetic field-induced acceleration of the accumulation of magnetic iron oxide nanoparticles by cultured brain astrocytes. J Biomed Mater Res A. 2012;100A:323-334.
38. Tresilwised N, Pithayanukul P, Mykhaylyk O, et al. Boosting oncolytic adenovirus potency with magnetic nanoparticles and magnetic force. Mol Pharm. 2010;7(4):1069-1089.