A new dynamic in vitro model for the multidimensional study of astrocyte-endothelial cell interactions at the blood-brain barrier

Brain Research

Volumn 951, Issue 2, 2002, Pages 243-254

  Cucullo, Luca ^a   McAllister, Mark S ^a   Kight, Kelly ^a   Krizanac Bengez, Ljiljana ^a   Marroni, Matteo ^a   Mayberg, Marc R ^a   Stanness, Kathe A ^b   Janigro, Damir ^a  

^a LERNER RESEARCH INSTITUTE   (United States)

^b UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

Author keywords

Cerebral blood flow; Drug delivery; Gene therapy; Glia vascular interaction; Shear stress

Indexed keywords

ANIMAL CELL; ARTICLE; ASTROCYTE; BEHAVIOR; BIOLOGICAL MONITORING; BLOOD BRAIN BARRIER; CELL DIVISION; CELL INTERACTION; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; ENDOTHELIUM CELL; FENESTRATION; IN VITRO STUDY; LONGITUDINAL STUDY; MOLECULAR DYNAMICS; NONHUMAN; PINOCYTOSIS; PRIORITY JOURNAL;

ALGORITHMS; ANIMALS; AORTA; ASTROCYTES; BLOOD-BRAIN BARRIER; BRAIN NEOPLASMS; CAPILLARIES; CATTLE; CEREBROVASCULAR CIRCULATION; COCULTURE TECHNIQUES; CYTOLOGICAL TECHNIQUES; ENDOTHELIUM, VASCULAR; GLIOMA; GLUCOSE; LACTIC ACID; MINERAL FIBERS; MODELS, NEUROLOGICAL; NERVE FIBERS; PRESSURE; RATS; TUMOR CELLS, CULTURED;

EID: 0037019919     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(02)03167-0     Document Type: Article

References (42)

1. Abbott N.J., Revest P.A. Control of brain endothelial permeability. Cerebrovasc. Brain Metab. Rev. 3:1991;39-69.
2. Abbott N.J., Romero I.A. Transporting therapeutics across the blood-brain barrier. Mol. Neurobiol. 2:1994;106-113.
3. Abbott N.J., Revest P.A., Romero I.A. Astrocyte-endothelial interaction: physiology and pathology. Neuropathol. Appl. Neurobiol. 18:1992;424-433.
4. Abbott N.J., Roux F., Couraud P.O., Begley D.J. Studies on an immortalized brain endothelial cell line: differentiation, permeability and transport. Greenwood J., Begley D.J., Segal M.B., Current Concepts of a Blood-Brain Barrier. 1995;239-249 Plenum, New York.
5. Abbott N.J., Hughes C.C., Revest P.A., Greenwood J. Development and characterisation of a rat brain capillary endothelial culture: towards an in vitro blood-brain barrier. J. Cell Sci. 103:1992;23-37.
6. Sdil/Cip1/Waf1. Circ. Res. 86:2000;185-190.
7. Ballermann B.J., Dardik A., Eng E., Liu A. Shear stress and the endothelium. Kidney Int. Suppl. 67:1998;S100-S108.
8. Bao X., Lu C., Frangos J.A. Temporal gradient in shear but not steady shear stress induces PDGF-A and MCP-1 expression in endothelial cells: role of NO, NF kappa B, and egr-1. Arterioscler. Thromb. Vasc. Biol. 19:1999;996-1003.
9. Bao X., Clark C.B., Frangos J.A. Temporal gradient in shear-induced signaling pathway: involvement of MAP kinase, c-fos, and connexin43. Am. J. Physiol. Heart Circ. Physiol. 278:2000;H1598-H1605.
10. Begley D.J., Lechardeur D., Chen Z.D., Rollinson C., Bardoul M., Roux F., Scherman D., Abbott N.J. Functional expression of P-glycoprotein in an immortalised cell line of rat brain endothelial cells, RBE4. J. Neurochem. 67:1996;988-995.
11. L. Bengez, M. Kapural, F.E. Parkinson, M. Hossein, A. Barth, D. Janigro, The role of flow cessation on endothelial-glia communication at the blood-brain barrier. Soc. Neurosci. Abstr., 27 (2001).
12. Betz A.L. Transport of ions across the blood-brain barrier. Fed. Proc. 45:1986;2050-2054.
13. L. Cucullo, M. Marroni, G.A. Grant, M. Kinter, S. Desai, M.R. Mayberg, K. Signorelli, D. Janigro, Genomics and proteomics of the human blood-brain barrier. Soc. Neurosci. Abstr., 27 (2001).
14. De Bault L.E., Cancilla P.A. Gammaglutamyl transpeptidase in isolated brain endothelial cells: induction by glial cells in vitro. Science. 207:1980;653-655.
15. Desai S., Mayberg M.R., Bengez L., Janigro D. The DIV-BBB: A powerful tool to study gene expression changes in endothelial cells. Endothelium. 7:2001;201.
16. Desai S., Marroni M., Cucullo L., Bengez L., Hossein M., Mayberg M.R., Grant G.A., Janigro D. Mechanisms of endothelial survival under shear stress. Endothelium. 9:2002;89-102.
17. Desai S., McAllister M.S., Mayberg M.R., Janigro D. Mechanisms of endothelial survival under shear stress. Kobiler D., Lustig H.S., Shapira S., Blood-Brain Barrier Delivery and Brain Pathology. 2001;63-70 Kluwer, Dordrecht.
18. Grant G.A., Abbott N.J., Janigro D. Understanding the physiology of the blood-brain barrier: in vitro models. News Physiol. Sci. 13:1998;287-293.
19. Haidekker M.A., L'Heureux N., Frangos J.A. Fluid shear stress increases membrane fluidity in endothelial cells: a study with DCVJ fluorescence. Am. J. Physiol. Heart Circ. Physiol. 278:2000;H1401-H1406.
20. Hochleitner B.W., Hochleitner E.O., Obrist P., Eberl T., Amberger A., Xu Q., Margreiter R., Wick G. Fluid shear stress induces heat shock protein 60 expression in endothelial cells in vitro and in vivo. Arterioscler. Thromb. Vasc. Biol. 20:2000;617-623.
21. D. Janigro, K.A. Stanness, C. Soderland, A.G. Grant, Development of an in vitro blood-brain barrier. In: Biochemical and Molecular Neurotoxicology, Wiley, New York, 2000, pp. 12.2.1-12.2.10.
22. Janigro D., Leaman S.M., Stanness K.A. Dynamic modeling of the blood-brain barrier: a novel tool for studies of drug delivery to the brain. Pharm. Sci. Technol. Today. 2:1999;7-12.
23. Janigro D., Stanness K.A., Nguyen T.-S., Tinklepaugh D.L., Winn H.R. Possible role of glia in the induction of CNS-like properties in aortic endothelial cells: ATP-activated channels. Bellardinelli L., Pelleg A., Adenosine and Adenine Nucleotides. 1996;85-96 Nijhoff, Boston.
24. Kim S., Scheerer S., Geyer M.A., Howell S.B. Direct cerebrospinal fluid delivery of an antiretroviral agent using multivesicular liposomes. J. Infect. Dis. 162:1990;750-752.
25. McAllister M.S., Krizanac-Bengez L., Macchia F., Naftalin R.J., Pedley K.C., Mayberg M.R., Marroni M., Leaman S., Stanness K.A., Janigro D. Mechanisms of glucose transport at the blood-brain barrier: an in vitro study. Brain Res. 904:2001;20-30.
26. Nagel T., Resnick N., Atkinson W.J., Dewey C.F., Gimbrone M.A. Shear stress selectively upregulates intercellular adhesion molecule-1 expression in cultured human vascular endothelial cells. J. Clin. Invest. 94:1994;885-891.
27. Ott M.J., Olson J.L., Ballermann B.J. Chronic in vitro flow promotes ultrastructural differentiation of endothelial cells. Endothelium. 3:1995;21-30.
28. Pardridge W.M. Why is the global CNS pharmaceutical market so under-penetrated? Drug Discov. Today. 7:2002;5-7.
29. Parkinson F.E., Paterson A.R.P., Young J.D., Cass C.E. Inhibitory effects of propentofylline on adenosine influx. Biochem. Pharmacol. 46:1993;891-896.
30. Pekny M., Stanness K.A., Eliasson C., Betsholtz C., Janigro D. Impaired induction of blood-brain barrier properties in aortic endothelial cells by astrocytes from GFAP-deficient mice. Glia. 22:1998;390-400.
31. Pohlman T.H., Harlan J.M. Adaptive responses of the endothelium to stress. J. Surg. Res. 89:2000;85-119.
32. Risau W., Esser S., Engelhardt B. Differentiation of blood-brain barrier endothelial cells. Pathol. Biol. Paris. 46:1998;171-175.
33. Rubin L.L., Staddon J.M. The cell biology of the blood-brain barrier. Annu. Rev. Neurosci. 22:1999;11-28.
34. Salvetti F., Ceci F., Janigro D., Lucacchini A., Benzi L., Martini C. Insulin permeability across an in vitro model of the endothelium. Pharm. Res. 19:2002;445-450.
35. Schinkel A.H. P-Glycoprotein, a gatekeeper in the blood-brain barrier. Adv. Drug Deliv. Rev. 36:1999;179-194.
36. Sinclair C.J., Krizanac-Bengez L., Stanness K.A., Janigro D., Parkinson F.E. Adenosine permeation of a dynamic in vitro blood-brain barrier inhibited by dipyridamole. Brain Res. 898:2001;122-125.
37. Stanness K.A., Guatteo E., Janigro D. A dynamic model of the blood-brain barrier 'in vitro'. Neurotoxicology. 17:1996;481-496.
38. Stanness K.A., Westrum L.E., Fornaciari E., Mascagni P., Nelson J.A., Stenglein S.G., Myers T., Janigro D. Morphological and functional characterization of an in vitro blood-brain barrier model. Brain Res. 771:1997;329-342.
39. Stanness K.A., Neumaier J.F., Sexton T.J., Grant G.A., Emmi A., Maris D.O., Janigro D. A new model of the blood-brain barrier: co-culture of neuronal, endothelial and glial cells under dynamic conditions. Neuroreport. 10:1999;3725-3731.
40. Strelow L., Janigro D., Nelson J.A. The blood-brain barrier and AIDS. Adv. Virus Res. 56:2001;355-388.
41. Tsukamoto H., Hamada Y., Wu D., Boado R.J., Pardridge W.M. GLUT1 glucose transporter: differential gene transcription and mRNA binding to cytosolic and polysome proteins in brain and peripheral tissues. Brain Res. Mol. Brain Res. 58:1998;170-177.
42. Zhao S., Suciu A., Ziegler T., Moore J.E. Jr., Burki E., Meister J.J., Brunner H.R. Synergistic effects of fluid shear stress and cyclic circumferential stretch on vascular endothelial cell morphology and cytoskeleton. Arterioscler. Thromb. Vasc. Biol. 15:1995;1781-1786.