Benzothiazepine CGP37157 and its isosteric 2′-ethyl analogue provide neuroprotection and block cell calcium entry

ACS Chemical Neuroscience

Volumn 3, Issue 7, 2012, Pages 519-529

  González Lafuente, Laura ^a,b   Egea, Javier ^a,b   León, Rafael ^a,b   Martínez Sanz, Francisco J ^b   Monjas, Leticia ^c   Perez, Concepción ^c   Merino, Cristina ^b   García De Diego, Antonio M ^b   Rodríguez Franco, María I ^c   García, Antonio G ^a,b   Villarroya, Mercedes ^b   López, Manuela G ^b,d   De Los Ríos, Cristóbal ^a,b  

^a HOSPITAL UNIVERSITARIO DE LA PRINCESA   (Spain)

^b INSTITUTO TEÓFILO HERNANDO   (Spain)

^c INSTITUTO DE QUÍMICA MÉDICA   (Spain)

^d HOSPITAL UNIVERSITARIO LA PAZ IDIPAZ   (Spain)

Author keywords

Alzheimers disease; cell calcium; CGP37157; mitochondrial sodium calcium exchanger; neuroprotection; oxidative stress

Indexed keywords

7 CHLORO 5 (2 CHLOROPHENYL) 1,5 DIHYDRO 4,1 BENZOTHIAZEPIN 2(3H) ONE; 7 CHLORO 5 2 TOLYL 1,2,3,5 TETRAHYDRO 4,1 BENZOTHIABENZOTHIAZEPIIN 2 ONE; CALCIUM CHANNEL; CALCIUM ION; GLUCOSE; GLUTAMIC ACID; ITH 12505; NEUROPROTECTIVE AGENT; OLIGOMYCIN; OXYGEN; ROTENONE; SODIUM ION; UNCLASSIFIED DRUG; VERATRIDINE;

ARTICLE; BLOOD BRAIN BARRIER; CALCIUM CELL LEVEL; CALCIUM TRANSPORT; CHROMAFFIN CELL; DRUG SYNTHESIS; HIPPOCAMPUS; HUMAN; HUMAN CELL; MITOCHONDRION; NEUROPROTECTION; PRIORITY JOURNAL;

ANIMALS; CALCIUM; CALCIUM CHANNEL BLOCKERS; CATTLE; CELL LINE, TUMOR; CELL SURVIVAL; CLONAZEPAM; HIPPOCAMPUS; HUMANS; NEUROPROTECTIVE AGENTS; ORGAN CULTURE TECHNIQUES; RATS; RATS, SPRAGUE-DAWLEY; STEREOISOMERISM; THIAZEPINES;

EID: 84863904535     PISSN: None     EISSN: 19487193     Source Type: Journal    
DOI: 10.1021/cn300009e     Document Type: Article

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