Nanoparticles enhance brain delivery of blood-brain barrier-impermeable probes for in vivo optical and magnetic resonance imaging

Proceedings of the National Academy of Sciences of the United States of America

Volumn 108, Issue 46, 2011, Pages 18837-18842

  Koffie, Robert M ^a,b   Farrar, Christian T ^a   Saidi, Laiq Jan ^a   William, Christopher M ^a   Hyman, Bradley T ^a   Spires Jones, Tara L ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b HARVARD UNIVERSITY   (United States)

Author keywords

In vivo multiphoton imaging; Transgenic mice

Indexed keywords

AMYLOID BETA PROTEIN; APOLIPOPROTEIN E; CONTRAST MEDIUM; DEXTRAN; GADOBUTROL; GADOLINIUM; NANOCARRIER; NANOCOATING; NANOPARTICLE; POLY(N BUTYL CYANOACRYLATE) DEXTRAN; POLYMER; POLYSORBATE 80; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; AMYLOID PLAQUE; ANIMAL EXPERIMENT; ANTIBODY COMBINING SITE; ARTICLE; BASEMENT MEMBRANE; BIODEGRADABILITY; BLOOD BRAIN BARRIER; BRAIN MEMBRANE; CELL AGING; CONTRAST ENHANCEMENT; CONTROLLED STUDY; DIAGNOSTIC IMAGING; DRUG ABSORPTION; DRUG DELIVERY SYSTEM; DRUG HALF LIFE; ELECTRON MICROSCOPY; FLUORESCENCE ANALYSIS; IMMUNOHISTOCHEMISTRY; IN VIVO STUDY; MEMBRANE PERMEABILITY; MOLECULAR IMAGING; MOLECULAR PROBE; MOUSE; NEUROIMAGING; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PARTICLE SIZE; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; SYNAPSE; SYNTHESIS;

ALKALOIDS; ALZHEIMER DISEASE; ANIMALS; APOLIPOPROTEINS E; BLOOD-BRAIN BARRIER; BRAIN; CONTRAST MEDIA; GADOLINIUM; INDOLES; MAGNETIC RESONANCE IMAGING; MICE; NANOPARTICLES; OPTICS AND PHOTONICS; PHOTONS; QUINOLINES; TRYPAN BLUE;

MUS; MUS MUSCULUS;

EID: 81755172852     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1111405108     Document Type: Article

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