A new blood-brain barrier model using primary rat brain endothelial cells, pericytes and astrocytes

Neurochemistry International

Volumn 54, Issue 3-4, 2009, Pages 253-263

  Nakagawa, Shinsuke ^a,c   Deli, Mária A ^b,c   Kawaguchi, Hiroko ^d   Shimizudani, Takeshi ^d   Shimono, Takanori ^c   Kittel, Ágnes ^e   Tanaka, Kunihiko ^a   Niwa, Masami ^a,c  

^a NAGASAKI UNIVERSITY GRADUATE SCHOOL OF BIOMEDICAL SCIENCES   (Japan)

^b INSTITUTE OF BIOCHEMISTRY   (Hungary)

^c PharmaCo Cell Co Ltd   (Japan)

^d DAINIPPON SUMITOMO PHARMA CO LTD   (Japan)

^e INSTITUTE OF EXPERIMENTAL MEDICINE   (Hungary)

Author keywords

Astrocytes; Blood brain barrier; Brain endothelial cells; Co culture; Drug permeability; In vitro BBB model (rat); P Glycoprotein; Pericytes; Tight junction; Transendothelial electrical resistance

Indexed keywords

ATENOLOL; CAFFEINE; CARBAMAZEPINE; CIMETIDINE; CLAUDIN 5; DIGOXIN; EPINASTINE; GLUCOSE TRANSPORTER 1; GLYCOPROTEIN P; HYDROCORTISONE; HYDROXYZINE; MULTIDRUG RESISTANCE PROTEIN 1; OCCLUDIN; PHENAZONE; PHENYTOIN; PRAZOSIN; PROPRANOLOL DERIVATIVE; PROTEIN ZO1; QUINIDINE; SULPIRIDE; TRAZODONE; VERAPAMIL; VINBLASTINE; VINCRISTINE; ZOLPIDEM;

ANIMAL CELL; ANIMAL CELL CULTURE; ANIMAL TISSUE; ARTICLE; ASTROCYTE; BLOOD BRAIN BARRIER; BRAIN BLOOD VESSEL; CELL STRUCTURE; CELL TYPE; COCULTURE; CONTROLLED STUDY; ELECTRIC RESISTANCE; ELECTRON MICROSCOPY; ENDOTHELIUM CELL; EXPERIMENTAL MODEL; MEMBRANE PERMEABILITY; MICROVASCULATURE; MONOLAYER CULTURE; NONHUMAN; PERICYTE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; RAT; TIGHT JUNCTION;

ANIMALS; ASTROCYTES; BLOOD-BRAIN BARRIER; CAPILLARIES; CARRIER PROTEINS; CELL MEMBRANE PERMEABILITY; CELLS, CULTURED; CEREBRAL ARTERIES; ENDOTHELIAL CELLS; MEMBRANE POTENTIALS; MEMBRANE PROTEINS; MICROCIRCULATION; MICROSCOPY, ELECTRON, TRANSMISSION; MODELS, BIOLOGICAL; P-GLYCOPROTEIN; P-GLYCOPROTEINS; PERICYTES; PHOSPHOPROTEINS; RATS; RHODAMINE 123; TIGHT JUNCTIONS;

RATTUS;

EID: 60949110463     PISSN: 01970186     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuint.2008.12.002     Document Type: Article

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