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Volumn 98, Issue 10, 2009, Pages 3748-3760

On the mechanism and dynamics of uptake and permeation of polyether-copolyester dendrimers across an in vitro blood-brain barrier model

Author keywords

Blood brain barrier; Dendrimers; In vitro models; Nanotechnology; Permeability

Indexed keywords

4 DIMETHYLAMINOAZOBENZENE; ATENOLOL; CHLORPROMAZINE; CLATHRIN; CYTOCHALASIN B; DENDRIMER; ETHYLENEDIAMINE; POLYAMIDOAMINE; POLYESTER; POLYETHER; POLYETHER COPOLYESTER; RHODAMINE B; THEOPHYLLINE; UNCLASSIFIED DRUG; VERAPAMIL;

EID: 67649230473     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1002/jps.21669     Document Type: Article
Times cited : (39)

References (56)
  • 1
    • 0036463371 scopus 로고    scopus 로고
    • Drug and gene targeting to the brain with molecular Trojan horses
    • Pardridge WM. 2002. Drug and gene targeting to the brain with molecular Trojan horses. Nat Rev Drug Discov 1:131-139.
    • (2002) Nat Rev Drug Discov , vol.1 , pp. 131-139
    • Pardridge, W.M.1
  • 2
    • 0018847124 scopus 로고
    • The vascular system of the cerebral cortex
    • Bar T. 1980. The vascular system of the cerebral cortex. Adv Anat Embryol Cell Biol 59:1-62.
    • (1980) Adv Anat Embryol Cell Biol , vol.59 , pp. 1-62
    • Bar, T.1
  • 3
    • 0017689969 scopus 로고
    • Morphology of blood-brain interfaces
    • Brightman MW. 1977. Morphology of blood-brain interfaces. Exp Eye Res Suppl 25:1-25.
    • (1977) Exp Eye Res Suppl , vol.25 , pp. 1-25
    • Brightman, M.W.1
  • 4
    • 0033526179 scopus 로고    scopus 로고
    • Carrier-mediated or specialized transport of drugs across the blood-brain barrier
    • DOI 10.1016/S0169-409X(98)00084-2, PII S0169409X98000842
    • Tsuji A, Tamai I. 1999. Carrier-mediated or specialized transport of drugs across the blood-brain barrier. Adv Drug Deliv Rev 36:277-290. (Pubitemid 29121976)
    • (1999) Advanced Drug Delivery Reviews , vol.36 , Issue.2-3 , pp. 277-290
    • Tsuji, A.1    Tamai, I.2
  • 5
    • 0037079071 scopus 로고    scopus 로고
    • Drug and gene delivery to the brain: The vascular route
    • DOI 10.1016/S0896-6273(02)01054-1
    • Pardridge WM. 2002. Drug and gene delivery to the brain: The vascular route. Neuron 36:555-558. (Pubitemid 35346750)
    • (2002) Neuron , vol.36 , Issue.4 , pp. 555-558
    • Pardridge, W.M.1
  • 6
    • 0030993566 scopus 로고    scopus 로고
    • Delivery of loperamide across the blood-brain barrier with polysorbate 80-Coated polybutylcyanoacrylate nanoparticles
    • DOI 10.1023/A:1012098005098
    • Alyautidin RN, Petrov VE, Langer K, Berthold A, Kharkievich DA, Kreuter J. 1997. Delivery of loperamide across the blood-brain barrier with polysorbate 80-coated nanoparticles. Pharm Res 14:325-328. (Pubitemid 27160944)
    • (1997) Pharmaceutical Research , vol.14 , Issue.3 , pp. 325-328
    • Alyautdin, R.N.1    Petrov, V.E.2    Langer, K.3    Berthold, A.4    Kharkevich, D.A.5    Kreuter, J.6
  • 7
    • 0037935472 scopus 로고
    • Fate of adrenal cortical steroids following intrathecal injections
    • Fishman RA, Christy NP. 1965. Fate of adrenal cortical steroids following intrathecal injections. Neurology 15:1-6.
    • (1965) Neurology , vol.15 , pp. 1-6
    • Fishman, R.A.1    Christy, N.P.2
  • 8
    • 77952461038 scopus 로고    scopus 로고
    • Convection enhance delivery of IL13-PE38QQR for treatment of recurrent malignant glioma: Presentation of interim findings from ongoing phase 1 studies
    • Kunwar S. 2003. Convection enhance delivery of IL13-PE38QQR for treatment of recurrent malignant glioma: Presentation of interim findings from ongoing phase 1 studies. Acta Neurochir Suppl 88:105-111.
    • (2003) Acta Neurochir Suppl , vol.88 , pp. 105-111
    • Kunwar, S.1
  • 9
    • 0033520487 scopus 로고    scopus 로고
    • In vivo protein transduction: Delivery of a biologically active protein into the mouse
    • Schwarze SR, Ho A, Vocero-Akbani A, Dowdy SF. 1999. In vivo protein transduction: Delivery of a biologically active protein into the mouse Science. 285:1569-1572.
    • (1999) Science , vol.285 , pp. 1569-1572
    • Schwarze, S.R.1    Ho, A.2    Vocero-Akbani, A.3    Dowdy, S.F.4
  • 10
    • 0034692118 scopus 로고    scopus 로고
    • Cell delivery to the central nervous system
    • DOI 10.1016/S0169-409X(00)00055-7, PII S0169409X00000557
    • Shoichet MS, Winn SR. 2000. Cell delivery to the central nervous system. Adv Drug Deliv Rev 42:81-102. (Pubitemid 30609636)
    • (2000) Advanced Drug Delivery Reviews , vol.42 , Issue.1-2 , pp. 81-102
    • Shoichet, M.S.1    Winn, S.R.2
  • 12
    • 33644787355 scopus 로고    scopus 로고
    • Gliadel wafer in initial surgery for malignant glioma: Long-term follow-up of a multicenter controlled trial
    • DOI 10.1007/s00701-005-0707-z
    • Westphal M, Ram Z, Riddle V, Hilt D, Bortey E. 2006. Gliadel wafer in initial surgery for malignant glioma: Long-term follow-up of a multicenter controlled trial. Acta Neurochir (Wien) 148:269-275. (Pubitemid 43341024)
    • (2006) Acta Neurochirurgica , vol.148 , Issue.3 , pp. 269-275
    • Westphal, M.1    Ram, Z.2    Riddle, V.3    Hilt, D.4    Bortey, E.5
  • 13
    • 0036665418 scopus 로고    scopus 로고
    • Antisense gene therapy of brain cancer with an artificial virus gene delivery system
    • DOI 10.1006/mthe.2002.0633
    • Zhang Y, Zhu C, Pardridge WM. 2002. Antisense gene therapy of brain cancer with an artificial virus gene delivery system. Mol Ther 6:67-72. (Pubitemid 36124272)
    • (2002) Molecular Therapy , vol.6 , Issue.1 , pp. 67-72
    • Zhang, Y.1    Zhu, C.2    Pardridge, W.M.3
  • 14
    • 0034454980 scopus 로고    scopus 로고
    • Endocytosis and transcytosis of an immunoliposome-based brain drug delivery system
    • Cerletti A, Drewe J, Fricker G, Eberle AN, Huwyler J. 2000. Endocytosis and transcytosis of an immunoliposome- based brain drug delivery system. J Drug Target 8:435-446. (Pubitemid 32366711)
    • (2000) Journal of Drug Targeting , vol.8 , Issue.6 , pp. 435-446
    • Cerletti, A.1    Drewe, J.2    Fricker, G.3    Eberle, A.N.4    Huwyler, J.5
  • 17
  • 19
    • 0035937595 scopus 로고    scopus 로고
    • Nanoparticulate systems for brain delivery of drugs
    • DOI 10.1016/S0169-409X(00)00122-8, PII S0169409X00001228
    • Kreuter J. 2001. Nanoparticulate systems for brain delivery of drugs. Adv Drug Del Rev 47:65-81. (Pubitemid 32209233)
    • (2001) Advanced Drug Delivery Reviews , vol.47 , Issue.1 , pp. 65-81
    • Kreuter, J.1
  • 20
    • 0036205158 scopus 로고    scopus 로고
    • Nanoparticle technology for drug delivery across the blood-brain barrier
    • Lockman PR, Mumper RJ, Kahn M, Allen DD. 2002. Nanoparticle technology for drug delivery across the blood-brain barrier. Drug Dev Ind Pharm 28:1-12.
    • (2002) Drug Dev Ind Pharm , vol.28 , pp. 1-12
    • Lockman, P.R.1    Mumper, R.J.2    Kahn, M.3    Allen, D.D.4
  • 21
    • 0035229874 scopus 로고    scopus 로고
    • Dendrimers: Properties and applications
    • Klajnert B, Bryszewska M. 2001. Dendrimers: Properties and applications. Acta Biochim Pol 48:199-208.
    • (2001) Acta Biochim Pol , vol.48 , pp. 199-208
    • Klajnert, B.1    Bryszewska, M.2
  • 22
    • 0043063880 scopus 로고    scopus 로고
    • Dendrimers: A new class of nanoscopic containers and delivery devices
    • Aulenta F, Hayes W, Rannard S. 2003. Dendrimers: A new class of nanoscopic containers and delivery devices. Eur Poly J 39:1741-1771.
    • (2003) Eur Poly J , vol.39 , pp. 1741-1771
    • Aulenta, F.1    Hayes, W.2    Rannard, S.3
  • 23
    • 0036899037 scopus 로고    scopus 로고
    • Biological applications of dendrimers
    • Cloninger M. 2002. Biological applications of dendrimers. Curr Opin Chem Bio 6:742-748.
    • (2002) Curr Opin Chem Bio , vol.6 , pp. 742-748
    • Cloninger, M.1
  • 24
    • 0035342007 scopus 로고    scopus 로고
    • Poly(amidoamine) (PAMAM) dendrimers: From biomimicry to drug delivery and biomedical applications
    • DOI 10.1016/S1359-6446(01)01757-3, PII S1359644601017573
    • Esfand R, Tomalia DA. 2001. Poly(amidoamine) (PAMAM) dendrimers: From biomimicry to drug delivery and biomedical applications. Drug Discov Today 6:427-436. (Pubitemid 32328297)
    • (2001) Drug Discovery Today , vol.6 , Issue.8 , pp. 427-436
    • Esfand, R.1    Tomalia, D.A.2
  • 25
  • 27
    • 28744443398 scopus 로고    scopus 로고
    • Dendrimers in biomedical applications-Reflections on the field
    • Svenson S, Tomalia DA. 2005. Dendrimers in biomedical applications-Reflections on the field. Adv Drug Deliv Rev 57:2106-2129.
    • (2005) Adv Drug Deliv Rev , vol.57 , pp. 2106-2129
    • Svenson, S.1    Tomalia, D.A.2
  • 28
    • 0042899083 scopus 로고    scopus 로고
    • Blood-brain barrier drug targeting: The future of brain drug development
    • Pardridge WM. 2003. Blood-brain barrier drug targeting: The future of brain drug development. Mol Intervent 3:90-105.
    • (2003) Mol Intervent , vol.3 , pp. 90-105
    • Pardridge, W.M.1
  • 29
    • 33745263735 scopus 로고    scopus 로고
    • Endocytosis at the blood-brain barrier: From basic understanding to drug delivery strategies
    • DOI 10.1080/10611860600650086, PII G638036323217271
    • Smith MW, Gumbleton M. 2006. Endocytosis at the blood-brain barrier: From basic understanding to drug delivery strategies. J Drug Target 14:191-214. (Pubitemid 43922061)
    • (2006) Journal of Drug Targeting , vol.14 , Issue.4 , pp. 191-214
    • Smith, M.W.1    Gumbleton, M.2
  • 30
    • 31544443297 scopus 로고    scopus 로고
    • Synthesis and evaluation of novel dendrimers with a hydrophilic interior as nanocarriers for drug delivery
    • DOI 10.1021/bc050184c
    • Dhanikula RS, Hildgen P. 2006. Synthesis and evaluation of novel dendrimers with a hydrophilic interior as nanocarriers for drug delivery. Bioconjug Chem 17:29-41. (Pubitemid 43157582)
    • (2006) Bioconjugate Chemistry , vol.17 , Issue.1 , pp. 29-41
    • Dhanikula, R.S.1    Hildgen, P.2
  • 31
    • 0027162899 scopus 로고
    • Prolongation of the circulation time of doxorubicin encapsulated in liposomes containing a polyethylene glycol-derivatized phospholipid: Pharmacokinetic studies in rodents and dogs
    • DOI 10.1023/A:1018907715905
    • Gabizon AA, Barenholz Y, Bialer M. 1993. Prolongation of the circulation time of doxorubicin encapsulated in liposomes containing a polyethylene glycol-derivatized phospholipid: Pharmacokinetic studies in rodents and dogs. Pharm Res 10:703-708. (Pubitemid 23152316)
    • (1993) Pharmaceutical Research , vol.10 , Issue.5 , pp. 703-708
    • Gabizon, A.A.1    Barenholz, Y.2    Bialer, M.3
  • 32
    • 0025341615 scopus 로고
    • Amphipathic polyethyleneglycols effectively prolong the circulation time of liposomes
    • DOI 10.1016/0014-5793(90)81016-H
    • Klibanov AL, Maruyama K, Torchilin VP, Huang L. 1990. Amphipathic polyethyleneglycols effectively prolong the circulation time of liposomes. FEBS Lett 268:235-237. (Pubitemid 20233874)
    • (1990) FEBS Letters , vol.268 , Issue.1 , pp. 235-237
    • Klibanov, A.L.1    Maruyama, K.2    Torchilin, V.P.3    Huang, L.4
  • 33
    • 34247473017 scopus 로고    scopus 로고
    • Influence of molecular architecture of polyether-co-polyester dendrimers on the encapsulation and release of methotrexate
    • DOI 10.1016/j.biomaterials.2007.03.012, PII S014296120700230X
    • Dhanikula RS, Hildgen P. 2007. Influence of molecular architecture of polyether-co-polyester dendrimers on the encapsulation and release of methotrexate. Biomaterials 28:3140-3152. (Pubitemid 46656188)
    • (2007) Biomaterials , vol.28 , Issue.20 , pp. 3140-3152
    • Dhanikula, R.S.1    Hildgen, P.2
  • 34
    • 0026459641 scopus 로고
    • In vitro phagocytosis assay of nano- And microparticles by chemiluminescence. I. Effect of analytical parameters, particle size and particle concentration
    • Rudt S, Muller RH. 1992. In vitro phagocytosis assay of nano- and microparticles by chemiluminescence. I. Effect of analytical parameters, particle size and particle concentration. J Control Release 22:263-272.
    • (1992) J Control Release , vol.22 , pp. 263-272
    • Rudt, S.1    Muller, R.H.2
  • 35
    • 0027318126 scopus 로고
    • In vitro phagocytosis assay of nano- And microparticles by chemiluminescence. II. Effect of surface modification by coating of particles with poloxamer on the phagocytic uptake
    • Rudt S, Muller RH. 1993. In vitro phagocytosis assay of nano- and microparticles by chemiluminescence. II. Effect of surface modification by coating of particles with poloxamer on the phagocytic uptake. J Control Release 25:51-59.
    • (1993) J Control Release , vol.25 , pp. 51-59
    • Rudt, S.1    Muller, R.H.2
  • 36
    • 0141894132 scopus 로고    scopus 로고
    • Evaluation of the immortalised mouse brain capillary endothelial cell line, b.End3, as an in vitro blood-brain barrier model for drug uptake and transport studies
    • DOI 10.1016/S0006-8993(03)03443-7
    • Omidi Y, Campbell L, Barar J, Connell D, Akhtar S, Gumbleton M. 2003. Evaluation of the immortalised mouse brain capillary endothelial cell line, b.End3, as an in vitro blood-brain barrier model for drug uptake and transport studies. Brain Res 990:95-112. (Pubitemid 37247600)
    • (2003) Brain Research , vol.990 , Issue.1-2 , pp. 95-112
    • Omidi, Y.1    Campbell, L.2    Barar, J.3    Connell, D.4    Akhtar, S.5    Gumbleton, M.6
  • 37
    • 1542272431 scopus 로고    scopus 로고
    • HPLC with programmed wavelength fluorescence detection for the simultaneous determination of marker compounds of integrity and P-gp functionality in the Caco-2 intestinal absorption model
    • DOI 10.1016/j.jpba.2003.11.016, PII S0731708503006964
    • Augustijns P, Mols R. 2004. HPLC with programmed wavelength fluorescence detection for simultaneous determination of marker compounds of integrity and P-gp functionality in Caco-2 intestinal absorption model. J Pharm Biomed Anal 34:971-978. (Pubitemid 38296400)
    • (2004) Journal of Pharmaceutical and Biomedical Analysis , vol.34 , Issue.5 , pp. 971-978
    • Augustijns, P.1    Mols, R.2
  • 38
    • 0033973754 scopus 로고    scopus 로고
    • Caco-2 versus Caco-2/HT29-MTX co-cultured cell lines: Permeabilities via diffusion, inside- And outside-directed carrier-mediated transport
    • DOI 10.1002/(SICI)1520-6017(200001)89:1<63::AID-JPS7>3.0.CO;2-6
    • Hilgendorf C, Spahn-Langguth H, Regardh CG, Lipka E, Amidon GL, Langguth P. 2000. Caco-2 versus Caco-2/HT29-MTX co-cultured cell lines: Permeabilities via diffusion, inside- and outside-directed carrier-mediated transport. J Pharm Sci 89:63-75. (Pubitemid 30080155)
    • (2000) Journal of Pharmaceutical Sciences , vol.89 , Issue.1 , pp. 63-75
    • Hilgendorf, C.1    Spahn-Langguth, H.2    Regardh, C.G.3    Lipka, E.4    Amidon, G.L.5    Langguth, P.6
  • 39
    • 14644432278 scopus 로고    scopus 로고
    • Comparison of in vitro models for the prediction of compound absorption across the human intestinal mucosa
    • DOI 10.1177/1087057104267162
    • Miret S, Abrahamse L, Groene EMd. 2004. Comparison of in vitro models for the prediction of compound absorption across the human intestinal mucosa. J Biomol Screen 9:598. (Pubitemid 40503517)
    • (2004) Journal of Biomolecular Screening , vol.9 , Issue.7 , pp. 598-606
    • Miret, S.1    Abrahamse, L.2    De Groene, E.M.3
  • 40
    • 0346634895 scopus 로고    scopus 로고
    • In vitro cytotoxicity testing of polycations: Influence of polymer structure on cell viability and hemolysis
    • Fischer D, Li YX, Ahlemeyer B, Krieglstein J, Kissel T. 2003. In vitro cytotoxicity testing of polycations: Influence of polymer structure on cell viability and hemolysis. Biomaterials 24:1121-1131.
    • (2003) Biomaterials , vol.24 , pp. 1121-1131
    • Fischer, D.1    Li, Y.X.2    Ahlemeyer, B.3    Krieglstein, J.4    Kissel, T.5
  • 43
    • 0035869373 scopus 로고    scopus 로고
    • Regulation of phagocytosis and endo-phagosomal trafficking pathways in Dictyostelium discoideum
    • DOI 10.1016/S0304-4165(01)00106-4, PII S0304416501001064
    • Rupper A, Cardelli J. 2001. Regulation of phagocytosis and endosomal trafficking pathways in Dictyostelium discoideum. Biochim Biophys Acta 1525:205-216. (Pubitemid 32226417)
    • (2001) Biochimica et Biophysica Acta - General Subjects , vol.1525 , Issue.3 , pp. 205-216
    • Rupper, A.1    Cardelli, J.2
  • 45
    • 0016298145 scopus 로고
    • Inhibition of phagocytosis and plasma membrane motility of the cultivated macrophage by cytochalasin B
    • Axline SG, Reaven EP. 1974. Inhibition of phagocytosis and plasma membrane motility of the cultivated macrophage by cytochalasin B. J Cell Biol 62:647-659.
    • (1974) J Cell Biol , vol.62 , pp. 647-659
    • Axline, S.G.1    Reaven, E.P.2
  • 46
    • 0027564616 scopus 로고
    • A quantitative assessment of non-specific pinocytosis by human endothelial cells surviving in vitro
    • Catizone A, Albani ALM, Reola F, Alescio T. 1993. A quantitative assessment of non-specific pinocytosis by human endothelial cells surviving in vitro. Cell Mol Biol 39:155-169.
    • (1993) Cell Mol Biol , vol.39 , pp. 155-169
    • Catizone, A.1    Albani, A.L.M.2    Reola, F.3    Alescio, T.4
  • 47
    • 0024595608 scopus 로고
    • Hypertonic media inhibits receptor mediated endocytosis by blocking clathrin-coated pit formation
    • Heuser JE, Anderson RGW. 1989. Hypertonic media inhibits receptor mediated endocytosis by blocking clathrin-coated pit formation. J Cell Biol 108:389-400.
    • (1989) J Cell Biol , vol.108 , pp. 389-400
    • Heuser, J.E.1    Anderson, R.G.W.2
  • 48
    • 0023464728 scopus 로고
    • Two threshold values of low pH block endocytosis at different stages
    • Davoust J, Gruenberg J, Howell KE. 1988. Two threshold values of low pH block endocytosis at different stages. Eur Mol Biol Organ J 6:3601-3609.
    • (1988) Eur Mol Biol Organ J , vol.6 , pp. 3601-3609
    • Davoust, J.1    Gruenberg, J.2    Howell, K.E.3
  • 49
    • 0023582912 scopus 로고
    • Acidification of the cytosol inhibits endocytosis from coated pits
    • Sandvig SK, Olsnes S, Peterson OW, Deurs Bv. 1987. Acidification of the cytosol inhibits endocytosis from coated pits. J Cell Biol 105:679-689. (Pubitemid 18043831)
    • (1987) Journal of Cell Biology , vol.105 , Issue.2 , pp. 679-689
    • Sandvig, K.1    Olsnes, S.2    Petersen, O.W.3    Van Deurs, B.4
  • 50
    • 0020626609 scopus 로고
    • Depletion of intracellular potassium arrests coated pit function and receptor mediated endocytosis in fibroblasts
    • Larkin JM, Brown MS, Goldstein JL, Anderson RGW. 1983. Depletion of intracellular potassium arrests coated pit function and receptor mediated endocytosis in fibroblasts. Cell 33:273-285.
    • (1983) Cell , vol.33 , pp. 273-285
    • Larkin, J.M.1    Brown, M.S.2    Goldstein, J.L.3    Anderson, R.G.W.4
  • 51
    • 0022401444 scopus 로고
    • Modulation of intracellular potassium and ATP: Effects on coated pit function in fibroblasts and hepatocytes
    • Larkin JM, Donzell WC, Goldstein JL, Anderson RGW. 1985. Modulation of intracellular potassium and ATP: Effects on coated pit function in fibroblasts and hepatocytes. J Cell Physiol 124:372-378.
    • (1985) J Cell Physiol , vol.124 , pp. 372-378
    • Larkin, J.M.1    Donzell, W.C.2    Goldstein, J.L.3    Anderson, R.G.W.4
  • 52
  • 53
    • 0027520440 scopus 로고
    • Mis-assembly of clathrin lattices on endosomes reveals a regulatory switch for coated pit formation
    • DOI 10.1083/jcb.123.5.1107
    • Wang LH, Rothberg KG, Anderson RG. 1993. Misassembly of clathrin lattices on endosomes reveals a regulatory switch for coated pit formation. J Cell Biol 123:1107-1117. (Pubitemid 23352421)
    • (1993) Journal of Cell Biology , vol.123 , Issue.5 , pp. 1107-1117
    • Wang, L.-H.1    Rothberg, K.G.2    Anderson, R.G.W.3
  • 54
    • 0032516835 scopus 로고    scopus 로고
    • Cholesterol depletion of caveolae causes hyperactivation of extracellular signal-related kinase (ERK)
    • DOI 10.1074/jbc.273.33.21099
    • Furuchi T, Anderson GW. 1998. Cholestrol depletion of caveolae causes hyperactivation of extracellular signal-related kinase. J Biol Chem 273:21099-21104. (Pubitemid 28385396)
    • (1998) Journal of Biological Chemistry , vol.273 , Issue.33 , pp. 21099-21104
    • Furuchi, T.1    Anderson, R.G.W.2
  • 55
    • 1042288482 scopus 로고    scopus 로고
    • Culture of murine brain microvascular endothelial cells that maintain expression and cytoskeletal association of tight junction-associated proteins
    • DOI 10.1290/1543-706X(2003)039<0313:COMBME>2.0.CO;2
    • Song L, Pachter JS. 2003. Culture of murine brain microvascular endothelial cells that maintain expression and cytoskeletal association of tight junction-associated proteins. In Vitro Cell Dev Biol Anim 39:313-320. (Pubitemid 38200254)
    • (2003) In Vitro Cellular and Developmental Biology - Animal , vol.39 , Issue.7 , pp. 313-320
    • Song, L.1    Pachter, J.S.2
  • 56
    • 0031665981 scopus 로고    scopus 로고
    • Effects of pluronic P85 unimers and micelles on drug permeability in polarized BBMEC and Caco-2 cells
    • Batrakova EV, Han HY, Miller DW, Kabanov AV. 1998. Effects of pluronic P85 unimers and micelles on drug permeability in polarized BBMEC and Caco-2 cells. Pharm Res 15:1525-1532.
    • (1998) Pharm Res , vol.15 , pp. 1525-1532
    • Batrakova, E.V.1    Han, H.Y.2    Miller, D.W.3    Kabanov, A.V.4


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