Patented in vitro blood-brain barrier models in CNS drug discovery

Recent Patents on CNS Drug Discovery

Volumn 6, Issue 2, 2011, Pages 107-118

  Tóth, Andrea ^a   Veszelka, Szilvia ^a   Nakagawa, Shinsuke ^b,c   Niwa, Masami ^b,c   Deli, Mária A ^a,b  

^a INSTITUTE OF BIOCHEMISTRY   (Hungary)

^b PharmaCo Cell Co Ltd   (Japan)

^c NAGASAKI UNIVERSITY GRADUATE SCHOOL OF BIOMEDICAL SCIENCES   (Japan)

Author keywords

Blood brain barrier; Brain endothelial cell; Co culture; In vitro blood brain barrier model; Model for CNS drug testing; Prediction model for CNS permeability

Indexed keywords

4 (3 BUTOXY 4 METHOXYBENZYL) 2 IMIDAZOLIDINONE; 8 (4 CHLOROPHENYLTHIO) CYCLIC AMP; BETA CATENIN; CENTRAL NERVOUS SYSTEM AGENTS; CLAUDIN 5; CYCLIC AMP; FORSKOLIN; ISOBUTYLMETHYLXANTHINE; ISOPRENALINE; LITHIUM; OCCLUDIN; PROTEIN ZO1; ROLIPRAM; THEOPHYLLINE; WNT PROTEIN;

ASTROCYTE; BLOOD BRAIN BARRIER; CELL CULTURE; CELL LINE; CELL TYPE; COCULTURE; CYTOARCHITECTURE; DRUG CLEARANCE; DRUG DISPOSITION; DRUG DISTRIBUTION; DRUG PENETRATION; DRUG SCREENING; DRUG TRANSPORT; ENDOTHELIUM CELL; HUMAN; MEMBRANE MODEL; MEMBRANE PERMEABILITY; NEURAL STEM CELL; NONHUMAN; PATENT; PERICYTE; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; REVIEW; SHEAR STRESS; SIGNAL TRANSDUCTION; TIGHT JUNCTION;

ANIMALS; BLOOD-BRAIN BARRIER; CELL LINE; CENTRAL NERVOUS SYSTEM AGENTS; COCULTURE TECHNIQUES; CYCLIC AMP; DRUG DISCOVERY; HUMANS; PATENTS AS TOPIC; SHEAR STRENGTH; SIGNAL TRANSDUCTION; WNT PROTEINS;

EID: 79959337016     PISSN: 15748898     EISSN: 15748898     Source Type: Journal    
DOI: 10.2174/157488911795933910     Document Type: Review

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