Contribution of berry anthocyanins to their chemopreventive properties

Berries and Cancer Prevention

Volumn , Issue , 2011, Pages 3-40

  Jing, Pu ^a   Giusti, M Monica ^a,b  

^a SHANGHAI JIAO TONG UNIVERSITY   (China)

^b OHIO STATE UNIVERSITY   (United States)

Author keywords

Anthocyanin; Berry; Bioavailability; Chemoprevention; Concentration; Interaction effect; Structure; Structure bioactivity relationship

Indexed keywords

EID: 84900981769     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1007/978-1-4419-7554-6_1     Document Type: Chapter

References (159)

1. Afaq F, Syed DN, Malik A et al (2006) Delphinidin, an anthocyanidin in pigmented fruits and vegetables, protects human hacat keratinocytes and mouse skin against UVB-mediated oxidative stress and apoptosis. J Invest Dermatol 127:222-232
2. Andersen ØM (1985) Chromatographic separation of anthocyanins in cowberry (lingonberry) Vaccinium vites-idaea L. J Food Sci 50:1230-1232
3. Andersen ØM (1987) Anthocyanins in fruits of Vaccinium uliginosum L. (bog whortleberry). J Food Sci 52:665-666, 680
4. Andersen ØM (1989) Anthocyanins in fruits of Vaccinium oxycoccus L. (small cranberry). J Food Sci 54:383-384, 387
5. Andersen ØM, Fossen T, Torskangerpoll K et al (2004) Anthocyanin from strawberry (Fragaria x ananassa) with the novel aglycone, 5-carboxypyranopelargonidin. Phytochemistry 65:405-410
6. Andersen ØM, Jordheim M (2005) The anthocyanins. In: Andersen ØM, Markham KR (eds) Flavonoids: chemistry, biochemistry and applications, 1st edn. CRC press, Boca Raton, FL
7. Angel P, Karin M (1991) The role of Jun, fos and the AP-1 complex in cell-proliferation and transformation. Biochim Biophys Acta 1072:129-157
8. Aziz RM, Nines R, Rodrigo K et al (2002) The effect of freeze-dried blueberries on N-nitrosomethylbenzylamine tumorigenesis in the rat esophagus. Pharm Biol 40(Suppl):43-49
9. Bakowska-Barczak AM, Kolodziejczyk P (2008) Evaluation of Saskatoon berry (Amelanchier alnifolia Nutt.) cultivars for their polyphenol content, antioxidant properties, and storage stability. J Agric Food Chem 56:9933-9940
10. Balkwill F, Mantovani A (2001) Inflammation and cancer: back to Virchow? Lancet 357:539-545
11. Benvenuti S, Pellati F, Melegari M et al (2004) Polyphenols, anthocyanins, ascorbic acid, and radical scavenging activity of Rubus, Ribes, and Aronia. J Food Sci 69:FCT164-FCT169
12. Boateng J, Verghese M, Shackelford L et al (2007) Selected fruits reduce azoxymethane (AOM)-induced aberrant crypt foci (ACF) in Fisher 344 male rats. Food Chem Toxicol 45:725-732
13. Bomser J, Madhavi DL, Singletary K et al (1996) In vitro anticancer activity of fruit extracts from Vaccinium species. Planta Med 62:212-216
14. Bovin D, Blanchette M, Barrette S et al (2007) Inhibition of cancer cell proliferation and suppression of TNF-induced activation of NFκB by edible berry juice. Anticancer Res 27:937-948
15. Bub A, Watzl B, Heeb D et al (2001) Malvidin-3-glucoside bioavailability in humans after ingestion of red wine, dealcoholized red wine and red grape juice. Eur J Nutr 40:113-120
16. Burrows C, Moore PP (2002) Genotype x environment effects on raspberry fruit quality. Acta Hortic 585:467-473
17. Cao G, Muccitelli HU, Sanchez-Moreno C et al (2001) Anthocyanins are absorbed in glycated forms in elderly women: a pharmacokinetic study. Am J Clin Nutr 73:920-926
18. Carlton PS, Kresty LA, Siglin JC et al (2001) Inhibition of N-nitrosomethylbenzylamine-induced tumorigenesis in the rat esophagus by dietary freeze-dried strawberries. Carcinogenesis 22:441-446
19. Casto BC, Kresty LA, Kraly CL et al (2002) Chemoprevention of oral cancer by black raspberries. Anticancer Res 22:4005-4015
20. Chen PN, Chu SC, Chiou HL et al (2005) Cyanidin 3-glucoside and peonidin 3-glucoside inhibit tumor cell growth and induce apoptosis in vitro and suppress tumor growth in vivo. Nutr Cancer 53:232-243
21. Chen PN, Chu SC, Chiou HL et al (2006a) Mulberry anthocyanins, cyanidin 3-rutinoside and cyanidin 3-glucoside, exhibited an inhibitory effect on the migration and invasion of a human lung cancer cell line. Cancer Lett 235:248-259
22. Chen PN, Kuo WH, Chiang CL et al (2006b) Black rice anthocyanins inhibit cancer cells invasion via repressions of MMPs and u-PA expression. Chem Biol Interact 163:218-229
23. Cho MJ, Howard LR, Prior RL et al (2004) Flavonoid glycosides and antioxidant capacity of various blackberry, blueberry and red grape genotypes determined by high-performance liquid chromatography/mass spectrometry. J Sci Food Agric 84:1771-1782
24. Chou TC, Talalay P (1984) Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitors. Adv Enzyme Regul 22:27-55
25. Clark JR, Howard L, Talcott S (2002) Antioxidant activity of blackberry genotypes. Acta Hortic 585:475-480
26. Clifford MN (2000) Anthocyanins-nature, occurrence and dietary burden. J Sci Food Agric 80:1063-1072
27. Coates E, Popa G, Gill C et al (2007) Colon-available raspberry polyphenols exhibit anti-cancer effects on in vitro models of colon cancer. J Carcinog 6:4
28. Connor AM, Luby JJ, Hancock JF et al (2002) Changes in fruit antioxidant activity among blueberry cultivars during cold-temperature storage. J Agric Food Chem 50:893-898
29. Min mouse model of intestinal carcinogenesis-relationship with tissue anthocyanin levels. Int J Cancer 119: 2213-2220
30. Cordenunsi BR, Oliveira do Nascimento JR, Genovese MI et al (2002) Influence of cultivar on quality parameters and chemical composition of strawberry fruits grown in Brazil. J Agric Food Chem 50:2581-2586
31. Dai J, Gupte A, Gates L et al (2009) A comprehensive study of anthocyanin-containing extracts from selected blackberry cultivars: extraction methods, stability, anticancer properties and mechanisms. Food Chem Toxicol 47:837-847
32. Deighton N, Brennan R, Finn C et al (2000) Antioxidant properties of domesticated and wild Rubus species. J Sci Food Agric 80:1307-1313
33. Ding M, Feng R, Wang SY et al (2006) Cyanidin-3-glucoside, a natural product derived from blackberry, exhibits chemopreventive and chemotherapeutic activity. J Biol Chem 281: 17359-17368
34. Doris M, Nicole P, Zeina T et al (2004) The substitution pattern of anthocyanidins affects different cellular signaling cascades regulating cell proliferation. Mol Nutr Food Res 48:318-325
35. Dreiseitel A, Oosterhuis B, Vukman KV, et al (2009) Berry anthocyanins and anthocyanidins exhibit distinct affinities for the efflux transporters BCRP and MDR1. Br J Clin Pharmacol 158:1942-1950
36. Dreiseitel A, Schreier P, Oehme A et al (2008) Inhibition of proteasome activity by anthocyanins and anthocyanidins. Biochem Biophys Res Commun 372:57-61
37. Dugo P, Mondello L, Errante G et al (2001) Identification of anthocyanins in berries by narrow-bore high-performance liquid chromatography with electrospray ionization detection. J Agric Food Chem 49:3987-3992
38. Elisia I, Hu C, Popovich DG et al (2007) Antioxidant assessment of an anthocyanin-enriched blackberry extract. Food Chem 101:1052-1058
39. Escribano-Bailón MT, Alcalde-Eon C, Muñoz O et al (2006) Anthocyanins in berries of Maqui (Aristotelia chilensis (Mol.) Stuntz). Phytochem Anal 17:8-14
40. Evan GI, Vousden KH (2001) Proliferation, cell cycle and apoptosis in cancer. Nature 411:342-348
41. Felgines C, Talavera S, Gonthier MP et al (2003) Strawberry anthocyanins are recovered in urine as glucuro-and sulfoconjugates in humans. J Nutr 133:1296-1301
42. Felgines C, Talavera S, Texier O et al (2005) Blackberry anthocyanins are mainly recovered from urine as methylated and gucuronidated conjugates in humans. J Agric Food Chem 53: 7721-7727
43. Felgines C, Texier O, Garcin P et al (2009) Tissue distribution of anthocyanins in rats fed a blackberry anthocyanin-enriched diet. Mol Nutr Food Res 53:1098
44. Feng R, Ni H-M, Wang SY et al (2007) Cyanidin-3-rutinoside, a natural polyphenol antiox-idant, selectively kills leukemic cells by induction of oxidative stress. J Biol Chem 282: 13468-13476
45. Fimognari C, Berti F, Nüsse M et al (2004) Induction of apoptosis in two human leukemia cell lines as well as differentiation in human promyelocytic cells by cyanidin-3-O-[beta]-glucopyranoside. Biochem Pharmacol 67:2047-2056
46. Fiorini M (1995) Preparative high-performance liquid chromatography for the purification of natural anthocyanins. J Chromatogr A 692:213-219
47. Fleschhut J, Kratzer F, Rechkemmer G et al (2006) Stability and biotransformation of various dietary anthocyanins in vitro. Eur J Nutr 45:7-18
48. Fox SB (2006) Quantitative angiogenesis in breast cancer. Methods Mol Med 120:161-187
49. Garzón GA, Riedl KM, Schwartz SJ (2009) Determination of anthocyanins, total phenolic content, and antioxidant activity in Andes berry (Rubus glaucus Benth). J Food Sci 74:C227-C232
50. Giusti MM, Jing P (2007) Natural pigments of berry fruits: functionality and application. In: Zhao Y (ed) Berry fruit: value-added products for health promotion, 1st edn. Taylor & Francis, Boca Raton
51. FL Giusti MM, Wrolstad RE (2003) Acylated anthocyanins from edible sources and their applications in food systems. Biochem Eng J 14:217-225
52. Goiffon JP, Brun M, Bourrier MJ (1991) High-performance liquid chromatography of red fruit anthocyanins. J Chromatogr 537:101-121
53. Hafeez BB, Siddiqui IA, Asim M, Malik A et al (2008) A dietary anthocyanidin delphinidin induces apoptosis of human prostate cancer PC3 cells in vitro and in vivo: involvement of nuclear factor-{kappa}B signaling. Cancer Res 68:8564-8572
54. Haffner K, Rosenfeld HJ, Skrede G et al (2002) Quality of red raspberry Rubus idaeus L cultivars after storage in controlled and normal atmospheres. Postharvest Biol Technol 24:279-289
55. Hakimuddin F, Paliyath G, Meckling K (2004) Selective cytotoxicity of a red grape wine flavonoid fraction against MCF-7 cells. Breast Cancer Res Treat 85:65-79
56. Han C, Ding H, Casto B et al (2005) Inhibition of the growth of premalignant and malignant human oral cell lines by extracts and components of black raspberries. Nutr Cancer 51:207-217
57. Harborne JB (1979) Correlations between flavonoid chemistry, anatomy and geography in the restionaceae from Australasia and South Africa. Phytochemistry 18:1323-1327
58. Harris GK, Gupta A, Nines RG et al (2001) Effects of lyophilized black raspberries on azoxymethane-induced colon cancer and 8-hydroxy-2'-deoxyguanosine levels in the Fischer 344 rat. Nutr Cancer 40:125-133
59. Hassimotto NMA, Genovese MI, Lajolo FM (2008) Absorption and metabolism of cyanidin-3-glucoside and cyanidin-3-rutinoside extracted from wild mulberry (Morus nigra L.) in rats. Nutr Res 28:198-207
60. He J, Magnuson BA, Giusti MM (2005) Analysis of anthocyanins in rat intestinal contents-impact of anthocyanin chemical structure on fecal excretion. J Agric Food Chem 53:2859-2866
61. Hogan S, Chung H, Zhang L et al (2010) Antiproliferative and antioxidant properties of anthocyanin-rich extract from açai. Food Chem 118:208-214
62. Hosseinian FS, Beta T (2007) Saskatoon and wild blueberries have higher anthocyanin contents than other Manitoba berries. J Agric Food Chem 55:10832-10838
63. Hou DX, Fujii M, Terahara N et al (2004a) Molecular mechanisms behind the chemopreventive effects of anthocyanidins. J Biomed Biotechnol 5:321-325
64. Hou DX, Kai K, Li JJ et al (2004b) Anthocyanidins inhibit activator protein 1 activity and cell transformation: structure-activity relationship and molecular mechanisms. Carcinogenesis 25:29-36
65. Hou DX, Ose T, Lin S et al (2003) Anthocyanidins induce apoptosis in human promyelo-cytic leukemia cells: structure-activity relationship and mechanisms involved. Int J Oncol 23: 705-712
66. Hou DX, Tong X, Terahara N et al (2005a) Delphinidin 3-sambubioside, a Hibiscus anthocyanin, induces apoptosis in human leukemia cells through reactive oxygen species-mediated mitochondrial pathway. Arch Biochem Biophys 440:101-109
67. Hou DX, Yanagita T, Uto T et al (2005b) Anthocyanidins inhibit cyclooxygenase-2 expression in LPS-evoked macrophages: structure-activity relationship and molecular mechanisms involved. Biochem Pharmacol 70:417-425
68. Huang C, Huang Y, Li J et al (2002) Inhibition of Benzo(a)Pyrene diol-epoxide-induced trans-activation of activated protein 1 and nuclear factor B by black raspberry extracts. Cancer Res 62:6857-6863
69. Huang C, Li J, Song L et al (2006) Black raspberry extracts inhibit Benzo(a)Pyrene diol-epoxide-induced activator protein 1 activation and VEGF transcription by targeting the phosphotidylinositol 3-kinase/Akt pathway. Cancer Res 66:581-587
70. Huopalahti R, Järvenpää E, Katina K (2000) A novel solid-phase extraction-HPLC method for the analysis of anthocyanin and organic acid composition of Finnish cranberry. J Liq Chromatogr Relat Technol 23:2695-2701
71. Ichiyanagi T, Rahman MM, Hatano Y et al (2007) Protocatechuic acid is not the major metabolite in rat blood plasma after oral administration of cyanidin 3-O-fi-d-glucopyranoside. Food Chem 105:1032-1039
72. Ichiyanagi T, Rahman MM, Kashiwada Y et al (2004) Absorption and metabolism of delphinidin 3-O-fi-d-glucopyranoside in rats. Free Radic Biol Med 36:930-937
73. Inami O, Tamura I, Kikuzaki H et al (1996) Stability of anthocyanins of Sambucus canadensis and Sambucus nigra. J Agric Food Chem 44:3090-3096
74. Jing P, Bomser JA, Schwartz SJ et al (2008) Structure-function relationships of anthocyanins from various anthocyanin-rich extracts on the inhibition of colon cancer cell growth. J Agric Food Chem 56:9391-9398
75. Jung KJ, Wallig MA, Singletary KW (2006) Purple grape juice inhibits 7, 12-dimethylbenz[a]anthracene (DMBA)-induced rat mammary tumorigenesis and in vivo DMBA-DNA adduct formation. Cancer Lett 233:279-288
76. Kaack K, Kuhn BF (1992) Black chokeberry (Aronia melanocarpa) for manufacture of a food colorant. Tidsskrift Planteavl 96:183-196
77. Kähkönen MP, Heinamaki J, Ollilainen V et al (2003) Berry anthocyanins: isolation, identification and antioxidant properties. J Sci Food Agric 83:1403-1411
78. Kalt W, Forney CF, Martin A et al (1999) Antioxidant capacity, vitamin C, phenolics, and anthocyanins after fresh storage of small fruits. J Agric Food Chem 47:4638-4644
79. Kamei H, Hashimoto Y, Koide T et al (1998) Antitumor effect of methanol extracts from red and white wines. Cancer Biother Radiopharm 13:447-452
80. Kampuse S, Kampuss K, Pizika L (2002) Stability of anthocyanins and ascorbic acid in raspberry and blackcurrant cultivars during frozen storage. Acta Hortic 585:507-510
81. Katsube N, Iwashita K, Tsushida T et al (2003) Induction of apoptosis in cancer cells by bilberry (Vaccinium myrtillus) and the anthocyanins. J Agric Food Chem 51:68-75
82. Kay CD, Mazza G, Holub BJ et al (2004) Anthocyanin metabolites in human urine and serum. Br J Nutr 91:933-942
83. Klopotek Y, Otto K, Bohm V (2005) Processing strawberries to different products alters contents of vitamin C, total phenolics, total anthocyanins, and antioxidant capacity. J Agric Food Chem 53:5640-5646
84. Koide T, Hashimoto Y, Kamei H et al (1997) Antitumor effect of anthocyanin fractions extracted from red soybeans and red beans in vitro and in vivo. Cancer Biother Radiopharm 12:277-280
85. Kong JM, Chia LS, Goh NK et al (2003) Analysis and biological activities of anthocyanins. Phytochemistry 64:923-933
86. Kresty LA, Frankel WL, Hammond CD et al (2006) Transitioning from preclinical to clinical chemopreventive assessments of lyophilized black raspberries: interim results show berries modulate markers of oxidative stress in Barrett's esophagus patients. Nutr Cancer 54(1):148-156
87. Kresty LA, Morse MA, Morgan C et al (2001) Chemoprevention of esophageal tumorigenesis by dietary administration of lyophilized black raspberries. Cancer Res 61:6112-6119
88. Kuskoski EM, Vega JM, Rios JJ et al (2003) Characterization of anthocyanins from the fruits of baguaçu (Eugenia umbelliflora Berg). J Agric Food Chem 51:5450-5454
89. Lala G, Malik M, Zhao C et al (2006) Anthocyanin-rich extracts inhibit multiple biomarkers of colonic cancer in rats. Nutr Cancer 54:84-93
90. Lazze MC, Savio M, Pizzala R et al (2004) Anthocyanins induce cell cycle perturbations and apoptosis in different human cell lines. Carcinogenesis 25:1427-1433
91. Lee J, Finn CE, Wrolstad RE (2004) Comparison of anthocyanin pigment and other phenolic compounds of Vaccinium membranaceum and Vaccinium ovatum native to the Pacific Northwest of North America. J Agric Food Chem 52:7039-7044
92. Lister CE, Wilson PE, Sutton KH et al (2002) Understanding the health benefits of blackcurrants. Acta Hortic 585:443-449
93. Liu RH (2004) Potential synergy of phytochemicals in cancer prevention: mechanism of action. J Nutr 134:3479S-3485S
94. Liu M, Li XQ, Weber C et al (2002) Antioxidant and antiproliferative activities of raspberries. J Agric Food Chem 50:2926-2930
95. Longo L, Vasapollo G (2005) Anthocyanins from Bay (Laurus nobilis L.) berries. J Agric Food Chem 53:8063-8067
96. Longo L, Vasapollo G, Rescio L (2005) Identification of anthocyanins in Rhamnus alaternus L. Berries. J Agric Food Chem 53:1723-1727
97. Lopes-da-Silva F, de Pascual-Teresa S, Rivas-Gonzalo J et al (2002) Identification of anthocyanin pigments in strawberry (cv Camarosa) by LC using DAD and ESI-MS detection. Eur Food Res Technol 214:248-253
98. Maatta KR, Kamal-Eldin A, Torronen AR (2003) High-performance liquid chromatography (HPLC) analysis of phenolic compounds in berries with diode array and electrospray ionization mass spectrometric (MS) detection: ribes species. J Agric Food Chem 51:6736-6744
99. Maatta-Riihinen KR, Kamal-Eldin A, Mattila PH et al (2004) Distribution and contents of phenolic compounds in eighteen Scandinavian berry species. J Agric Food Chem 52:4477-4486
100. Malik M, Zhao C, Schoene N et al (2003) Anthocyanin-rich extract from Aronia meloncarpa E induces a cell cycle block in colon cancer but not normal colonic cells. Nutr Cancer 46:186-196
101. Mallery SR, Stoner GD, Larsen PE et al (2007) Formulation and in-vitro and in-vivo evaluation of a mucoadhesive gel containing freeze dried black raspberries: implications for oral cancer chemoprevention. Pharm Res 24:728
102. Martin S, Favot L, Matz R et al (2003) Delphinidin inhibits endothelial cell proliferation and cell cycle progression through a transient activation of ERK-1/-2. Biochem Pharmacol 65:669-675
103. Matsumoto H, Nakamura Y, Iida H et al (2006) Comparative assessment of distribution of blackcurrant anthocyanins in rabbit and rat ocular tissues. Exp Eye Res 83:348-356
104. McGhie TK, Ainge GD, Barnett LE et al (2003) Anthocyanin glycosides from berry fruit are absorbed and excreted unmetabolized by both humans and rats. J Agric Food Chem 51: 4539-4548
105. McGhie TK, Hall HK, Ainge GD et al (2002) Breeding Rubus cultivars for high anthocyanin content and high antioxidant capacity. Acta Hortic 585:495-500
106. Meiers S, Kemeny M, Weyand U et al (2001) The anthocyanidins cyanidin and delphinidin are potent inhibitors of the epidermal growth-factor receptor. J Agric Food Chem 49:958-962
107. Meyers KJ, Watkins CB, Pritts MP et al (2003) Antioxidant and antiproliferative activities of strawberries. J Agric Food Chem 51:6887-6892
108. Moyer RA, Hummer KE, Finn CE et al (2002) Anthocyanins, phenolics, and antioxidant capacity in diverse small fruits: Vaccinium, Rubus, and Ribes. J Agric Food Chem 50:519-525
109. Mullen W, Lean ME, Crozier A (2002) Rapid characterization of anthocyanins in red raspberry fruit by high-performance liquid chromatography coupled to single quadrupole mass spectrometry. J Chromatogr A 966:63-70
110. Nemeth K, Plumb GW, Berrin JG et al (2003) Deglycosylation by small intestinal epithelial cell beta-glucosidases is a critical step in the absorption and metabolism of dietary flavonoid glycosides in humans. Eur J Nutr 42:29-42
111. Nickavar B, Amin G (2004) Anthocyanins from Vaccinium arctostaphylos berries. Pharm Biol 42:289-291
112. Nielsen IL, Dragsted LO, Ravn-Haren G et al (2003) Absorption and excretion of black currant anthocyanins in humans and watanabe heritable hyperlipidemic rabbits. J Agric Food Chem 51:2813-2820
113. Olsson ME, Gustavsson KE, Andersson S et al (2004) Inhibition of cancer cell proliferation in vitro by fruit and berry extracts and correlations with antioxidant levels. J Agric Food Chem 52:7264-7271
114. Oszmianski J, Sapis JC (1988) Anthocyanins in fruits of Aronia melanocarpa (chokeberry). J Food Sci 53:1241-1242
115. Padhani AR, Harvey CJ, Cosgrove DO (2005) Angiogenesis imaging in the management of prostate cancer. Nat Clin Pract Urol 2:596-607
116. Perkins-Veazie P, Kalt W (2002) Postharvest storage of blackberry fruit does not increase antioxidant levels. Acta Hortic 585:521-524
117. Poulsen HE, Prieme H, Loft S (1998) Role of oxidative DNA damage in cancer initiation and promotion. Eur J Cancer Prev 7:9-16
118. Prior RL, Cao G, Martin A et al (1998) Antioxidant capacity as influenced by total phenolic and anthocyanin content, maturity, and variety of Vaccinium species. J Agric Food Chem 46: 2686-2693
119. Prior RL, Lazarus SA, Cao G et al (2001) Identification of procyanidins and anthocyanins in blueberries and cranberries (Vaccinium Spp.) Using high-performance liquid chromatography/mass spectrometry. J Agric Food Chem 49:1270-1276
120. Rechner AR, Kuhnle G, Hu H et al (2002) The metabolism of dietary polyphenols and the relevance to circulating levels of conjugated metabolites. Free Radic Res 36:1229-1241
121. Reddy MK, Alexander-Lindo RL, Nair MG (2005) Relative inhibition of lipid peroxidation, cyclooxygenase enzymes, and human tumor cell proliferation by natural food colors. J Agric Food Chem 53:9268-9273
122. Renis M, Calandra L, Scifo C et al (2008) Response of cell cycle/stress-related protein expression and DNA damage upon treatment of CaCo2 cells with anthocyanins. Br J Nutr 100: 27-35
123. Rodrigo KA, Rawal Y, Renner RJ et al (2006) Suppression of the tumorigenic phenotype in human oral squamous cell carcinoma cells by an ethanol extract derived from freeze-dried black raspberries. Nutr Cancer 54:58-68
124. Roy S, Khanna S, Alessio HM et al (2002) Anti-angiogenic property of edible berries. Free Radic Res 36:1023-1031
125. Saario M (2000) Fresh lingonberry quality as affected by storage conditions and packaging. J Food Qual 23:453-463
126. Sandler AB (2005) Targeting angiogenesis in lung cancer. Semin Oncol 32:S16-S22
127. Sarma AD, Sharma R (1999) Anthocyanin-DNA copigmentation complex: mutual protection against oxidative damage. Phytochemistry 52:1313-1318
128. Seeram NP, Adams LS, Hardy ML et al (2004) Total cranberry extract versus its phytochemical constituents: antiproliferative and synergistic effects against human tumor cell lines. J Agric Food Chem 52:2512-2517
129. Seeram NP, Adams LS, Zhang Y et al (2006) Blackberry, black raspberry, blueberry, cranberry, red raspberry, and strawberry extracts inhibit growth and stimulate apoptosis of human cancer cells in vitro. J Agric Food Chem 54:9329-9339
130. Seeram NP, Momin RA, Nair MG et al (2001) Cyclooxygenase inhibitory and antioxidant cyanidin glycosides in cherries and berries. Phytomedicine 8:362-369
131. Shih PH, Yeh CT, Yen GC (2005) Effects of anthocyanidin on the inhibition of proliferation and induction of apoptosis in human gastric adenocarcinoma cells. Food Chem Toxicol 43: 1557-1566
132. Shih P-H, Yeh C-T, Yen G-C (2007) Anthocyanins induce the activation of phase II enzymes through the antioxidant response element pathway against oxidative stress-induced apoptosis. J Agric Food Chem 55:9427
133. Singletary KW, Jung KJ, Giusti MM (2007) Anthocyanin-rich grape extract blocks breast cell DNA damage. J Med Food 10:244-251
134. Slimestad R, Torskangerpoll K, Nateland HS et al (2005) Flavonoids from black chokeberries, Aronia melanocarpa. J Food Compost Anal 18:61-68
135. Stoner GD, Wang L-S, Casto BC (2008) Laboratory and clinical studies of cancer chemoprevention by antioxidants in berries. Carcinogenesis 29:1665-1674
136. Stoner GD, Wang L-S, Zikri N et al (2007) Cancer prevention with freeze-dried berries and berry components. Semin Cancer Biol 17:403-410
137. Strigl AW, Leitner E, Pfannhauser W (1995) Chokeberries as natural food colorant source. Dtsch Lebensmitt Rundsch 91:177-180
138. Strik BC (2007) Berry crops: worldwide area and production systems. In: Zhao Y (ed) Berry fruit: value-added products for health promotion, 1st edn. Taylor & Francis, Boca Raton, FL
139. Strik BC, Finn C, Wrolstad R (2003) Performance of chokeberry (Aronia melanocarpa) in Oregon, USA. Paper presented at the Berry Crop Breeding, Production and Utilization for a New Century (ISHS), 626, pp 439-443
140. Sun J, Chu YF, Wu X et al (2002) Antioxidant and antiproliferative activities of common fruits. J Agric Food Chem 50:7449-7454
141. Thomasset S, Berry DP, Cai H et al (2009) Pilot study of oral anthocyanins for colorectal cancer chemoprevention. Cancer Prev Res 2:625-633
142. Tian Q, Giusti MM, Stoner GD et al (2006) Characterization of a new anthocyanin in black raspberries (Rubus occidentalis) by liquid chromatography electrospray ionization tandem mass spectrometry. Food Chem 94:465-468
143. Wada L, Ou B (2002) Antioxidant activity and phenolic content of oregon caneberries. J Agric Food Chem 50:3495-3500
144. Wang SY, Feng R, Bowman L et al (2005) Antioxidant activity in lingonberries (Vaccinium vitis-idaea L.) And its inhibitory effect on activator protein-1, nuclear factor-kappab, and mitogen-activated protein kinases activation. J Agric Food Chem 53:3156-3166
145. Wang SY, Lin HS (2000) Antioxidant activity in fruits and leaves of blackberry, raspberry, and strawberry varies with cultivar and developmental stage. J Agric Food Chem 48:140-146
146. Wang LS, Stoner GD (2008) Anthocyanins and their role in cancer prevention. Cancer Lett 269:281-290
147. Wang SY, Stretch AW (2001) Antioxidant capacity in cranberry is influenced by cultivar and storage temperature. J Agric Food Chem 49:969-974
148. Weisel T, Baum M, Eisenbrand G et al (2006) An anthocyanin/polyphenolic- rich fruit juice reduces oxidative DNA damage and increases glutathione level in healthy probands. Biotechnol J 1:388-397
149. Wu X, Gu L, Prior RL et al (2004) Characterization of anthocyanins and proanthocyanidins in some cultivars of Ribes, Aronia, and Sambucus and their antioxidant capacity. J Agric Food Chem 52:7846-7856
150. Wu X, Pittman HE, McKay S et al (2005) Aglycones and sugar moieties alter antho-cyanin absorption and metabolism after berry consumption in weanling pigs. J Nutr 135: 2417-2424
151. Wu X, Prior RL (2005) Systematic identification and characterization of anthocyanins by HPLC-ESI-MS/MS in common foods in the United States: fruits and berries. J Agric Food Chem 53:2589-2599
152. Yance DR Jr, Sagar SM (2006) Targeting angiogenesis with integrative cancer therapies. Integr Cancer Ther 5:9-29
153. Yi W, Akoh CC, Fischer J et al (2006) Effects of phenolic compounds in blueberries and muscadine grapes on HepG2 cell viability and apoptosis. Food Res Int 39:628-638
154. Yi W, Fischer J, Krewer G et al (2005) Phenolic compounds from blueberries can inhibit colon cancer cell proliferation and induce apoptosis. J Agric Food Chem 53:7320-7329
155. Yoshimoto M, Okuno S, Yamaguchi M et al (2001) Antimutagenicity of deacylated anthocyanins in purple-fleshed sweetpotato. Biosci Biotechnol Biochem 65:1652-1655
156. Youdim KA, Martin A, Joseph JA (2000) Incorporation of the elderberry anthocyanins by endothelial cells increases protection against oxidative stress. Free Radic Biol Med 29:51-60
157. Zhang Y, Vareed SK, Nair MG (2005) Human tumor cell growth inhibition by nontoxic antho-cyanidins, the pigments in fruits and vegetables. Life Sci 76:1465-1472
158. Zhao C, Giusti MM, Malik M et al (2004) Effects of commercial anthocyanin-rich extracts on colonic cancer and nontumorigenic colonic cell growth. J Agric Food Chem 52:6122-6128
159. Zheng W, Wang SY (2003) Oxygen radical absorbing capacity of phenolics in blueberries, cranberries, chokeberries, and lingonberries. J Agric Food Chem 51:502-509