Induction of apoptosis in two human leukemia cell lines as well as differentiation in human promyelocytic cells by cyanidin-3-O-β- glucopyranoside

Biochemical Pharmacology

Volumn 67, Issue 11, 2004, Pages 2047-2056

  Fimognari, Carmela ^a   Berti, Fausto ^a   Nüsse, Michael ^b   Cantelli Forti, Giorgio ^a   Hrelia, Patrizia ^a  

^a UNIVERSITY OF BOLOGNA   (Italy)

^b INSTITUTE OF EPIDEMIOLOGY   (Germany)

Author keywords

1 (5 isoquinolinesulfonyl) 2 methylpiperazine; Cy g; cyanidin 3 O glucopyranoside; H 7; IC50; inhibitory concentration causing cell toxicity by 50 following one cell cycle exposure; NBT; nitroblue tetrazolium; PI3 K

Indexed keywords

1 (5 ISOQUINOLINESULFONYL) 2 METHYLPIPERAZINE; 2 MORPHOLINO 8 PHENYLCHROMONE; ANTHOCYANIN; CYANIDIN 3 O BETA GLUCOPYRANOSIDE; GLUCOPYRANOSIDE; MYC PROTEIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN BAX; PROTEIN BCL 2; PROTEIN KINASE C; PROTEIN P53; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CHEMOTHERAPY; CANCER PREVENTION; CELL DIFFERENTIATION; CELL STRAIN HL 60; CHEMOPROPHYLAXIS; CONTROLLED STUDY; CYTOLOGY; DRUG MECHANISM; DRUG SENSITIVITY; GRANULOCYTE; HUMAN; HUMAN CELL; IN VITRO STUDY; LEUKEMIA CELL LINE; LYMPHOBLASTOID CELL; MACROPHAGE; NECROSIS; PRIORITY JOURNAL; PROMYELOCYTE; PROTEIN EXPRESSION; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; T LYMPHOBLAST;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANTHOCYANINS; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; CELL DIFFERENTIATION; CELL SURVIVAL; DRUG INTERACTIONS; ENZYME INHIBITORS; GENE EXPRESSION; HL-60 CELLS; HUMANS; JURKAT CELLS; LEUKEMIA, PROMYELOCYTIC, ACUTE; PROTEIN KINASE C; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-BCL-2; PROTO-ONCOGENE PROTEINS C-MYC; TUMOR SUPPRESSOR PROTEIN P53;

EID: 2342464082     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcp.2004.02.021     Document Type: Article

References (42)

1. Hong W.K., Sporn M.B. Recent advances in chemoprevention of cancer. Science. 278:1997;1073-1077
2. Suh N., Luyengi L., Fong H.H., Kinghorn A.D., Pezzuto J.M. Discovery of natural product chemopreventive agents utilizing HL-60 cell differentiation as a model. Anticancer Res. 15:1995;233-239
3. Cao G., Muccitelli H.U., Sanchez-Moreno C., Prior R.L. Anthocyanins are absorbed in glycated forms in elderly women: a pharmacokinetic study. Am. J. Clin. Nutr. 73:2001;920-926
4. Youdim K.A., Martin A., Joseph J.A. Incorporation of the elderberry anthocyanins by endothelial cells increases protection against oxidative stress. Free Radic. Biol. Med. 29:2000;51-60
5. Ghiselli A., Nardini M., Baldi A., Scaccini C. Antioxidant activity of different phenolic fractions separated from an Italian red wine. J. Agric. Food Chem. 46:1998;361-367
6. Bomser J., Madhavi D.L., Singletary K., Smith M.A. In vitro anticancer activity of fruit extracts from Vaccinium species. Planta Med. 62:1996;212-216
7. Lietti A., Cristoni A., Picci M. Studies on Vaccinium myrtillus anthocyanosides. I. Vasoprotective and antiinflammatory activity. Arzneimittelforschung. 26:1996;829-832
8. Wang H., Cao G., Prior R.L. Oxygen radical absorbing capacity of anthocyanins. J. Agric. Food Chem. 45:1997;304-309
9. Tsuda T., Shiga K., Ohshima K., Kawakishi S., Osawa T. Inhibition of lipid peroxidation and the active oxygen radical scavenging effect of anthocyanin pigments isolated from Phaseolus vulgaris L. Biochem. Pharmacol. 52:1996;1033-1039
10. Tsuda T., Horio F., Osawa T. Dietary cyanidin 3-O-beta-D-glucoside increases ex vivo oxidation resistance of serum in rats. Lipids. 33:1998;583-588
11. Tsuda T., Horio F., Kitoh J., Osawa T. Protective effects of dietary cyanidin 3-O-beta-D-glucoside on liver ischemia-reperfusion injury in rats. Arch. Biochem. Biophys. 368:1999;361-366
12. Amorini A.M., Fazzina G., Lazzarino G., Tavazzi B., Di Pierro D., Santucci R., et al. Activity and mechanism of the antioxidant properties of cyanidin-3-O-beta-glucopyranoside. Free Radic. Res. 35:2001;953-966
13. Iwamoto K.S., Mizuno T., Ito T., Tsuyama N., Kyoizumi S., Seyama T. Gain-of-function p53 mutations enhance alteration of the T-cell receptor following X-irradiation, independently of the cell cycle and cell survival. Cancer Res. 56:1996;3862-3865
14. Danova M., Giordano M., Mazzini G., Riccardi A. Expression of p53 protein during the cell cycle measured by flow cytometry in human leukemia. Leuk. Res. 14:1990;417-422
15. Martin S.J., Bradley J.G., Cotter T.G. HL-60 cells induced to differentiate towards neutrophils subsequently die via apoptosis. Clin. Exp. Immunol. 79:1990;448-453
16. Peña F.J., Johannisson A., Wallgren M., Rodríguez- Martínez H. Assessment of fresh and frozen-thawed boar semen using an Annexin-V assay: a new method of evaluating sperm membrane integrity. Theriogenology. 60:2003;677-689
17. Kim M.S., Lim W.K., Cha J.G., An N.H., Yoo S.J., Park J.H., et al. The activation of PI 3-K and PKC zeta in PMA-induced differentiation of HL-60 cells. Cancer Lett. 171:2001;79-85
18. Cafino J.J. Microtiter assay useful for screening of cell differentiation agents. J. Natl. Cancer Inst. 80:1988;962-966
19. Ahmed N., Williams J.F., Weidemann M. The human promyelocytic HL-60 cell line: a model of myeloid cell differentiation using dimethylsulphoxide, phorbol ester and butyrate. Biochem. Int. 23:1991;591-602
20. Zhou J.Y., Norman A.W., Lubbert M., Collins E.D., Uskokovic M.R., Koeffler H.P. Novel vitamin D analogs that modulate leukemic cell growth and differentiation with little effect on either intestinal calcium absorption or bone mobilization. Blood. 74:1989;82-93
21. Liu X., Zhu X.Z. Roles of p53, c-Myc, Bcl-2, Bax and caspases in glutamate-induced neuronal apoptosis and the possible neuroprotective mechanism of basic fibroblast growth factor. Mol. Brain Res. 71:1999;210-216
22. Viallard J.F., Lacombe F., Dupouy M., Ferry H., Belloc F., Reiffers J. Flow cytometry study of human cyclin B1 and cyclin E expression in leukemic cell lines: cell cycle kinetics and cell localization. Exp. Cell Res. 247:1999;208-219
23. 3 on cell cycle progression and cyclins D1 and B1 expression in two glioblastoma cell lines differing in p53 status. Int. J. Oncol. 21:2002;49-55
24. Pan Q., Granger J., O'Connell T.D., Somerman M.J., Simpson R.U. Promotion of HL-60 cell differentiation by 1, 25-dihydroxyvitamin D3 regulation of protein kinase C levels and activity. Biochem. Pharmacol. 54:1997;909-915
25. Bertagnolo V., Neri L.M., Marchisio M., Mischiati C., Capitani S. Phosphoinositide 3-kinase activity is essential for all-trans-retinoic acid-induced granulocytic differentiation of HL-60 cells. Cancer Res. 59:1999;542-546
26. Raff M. Social control on cell survival and cell death. Nature. 356:1993;397-400
27. Foekens J.A., Sieuwerts A.M., Stuurman-Smeets E.M., Dorssers L.C., Berns E.M., Klijn J.G. Pleiotropic actions of suramin on the proliferation of human breast-cancer cells in vitro. Int. J. Cancer. 51:1992;439-444
28. Fong C.J., Sutkowski D.M., Braun E.J., Bauer K.D., Sherwood E.R., Lee C., et al. Effect of retinoic acid on the proliferation and secretory activity of androgen-responsive prostatic carcinoma cells. J. Urol. 149:1993;1190-1194
29. Abe T., Gotoh S., Higashi K. Attenuation by glutathione of hsp72 gene expression induced by cadmium in cisplatin-resistant human ovarian cancer cells. Biochem. Pharmacol. 58:1999;69-76
30. Hsu J.T., Jean T.C., Chan M.A., Ying C. Differential display screening for specific gene expression induced by dietary nonsteroidal estrogen. Mol. Reprod. Dev. 52:1999;141-148
31. Yam L.T., Li C.Y., Crosby W.H. Cytochemical identification of monocytes and granulocytes. Am. J. Clin. Pathol. 55:1971;283-290
32. Pae H.O., Seo W.G., Kim N.Y., Oh G.S., Kim G.E., Kim Y.H., et al. Induction of granulocytic differentiation in acute promyelocytic leukemia cells (HL-60) by water-soluble chitosan oligomer. Leuk. Res. 25:2001;339-346
33. Ruvolo P.P., Deng X., Carr B.K., May W.S. A functional role for mitochondrial protein kinase Calpha in Bcl2 phosphorylation and suppression of apoptosis. J. Biol. Chem. 273:1998;25436-25442
34. Amorini A.M., Lazzarino G., Galvano F., Fazzina G., Tavazzi B., Galvano G. Cyanidin-3-O-beta-glucopyranoside protects myocardium and erythrocytes from oxygen radical-mediated damages. Free Radic. Res. 37:2003;453-460
35. Ramirez-Tortosa C., Andersen O.M., Gardner P.T., Morrice P.C., Wood S.G., Duthie S.J., et al. Anthocyanin-rich extract decreases indices of lipid peroxidation and DNA damage in vitamin E-depleted rats. Free Radic. Biol. Med. 31:2001;1033-1037
36. Kim M.Y., Iwai K., Onodera A., Matsue H. Identification and antiradical properties of anthocyanins in fruits of Viburnum dilatatum thunb. J. Agric. Food Chem. 51:2003;6173-6177
37. Loo G. Redox-sensitive mechanisms of phytochemical-mediated inhibition of cancer cell proliferation (review). J. Nutr. Biochem. 14:2003;64-73
38. Toyokuni S., Okamoto K., Yodoi J., Hiai H. Persistent oxidative stress in cancer. FEBS Lett. 358:1995;1-3
39. Kong G., Lee S.J., Kim H.J., Surh Y.J., Kim N.D. Induction of granulocytic differentiation in acute promyelocytic leukemia cells (HL-60) by 2-(allylthio) pyrazine. Cancer Lett. 144:1999;1-8
40. Frank T., Netzel M., Strass G., Bitsch R., Bitsch I. Bioavailability of anthocyanidin-3-glucosides following consumption of red wine and red grape juice. Can. J. Physiol. Pharmacol. 81:2003;423-435
41. Netzel M., Strass G., Janssen M., Bitsch I., Bitsch R. Bioactive anthocyanins detected in human urine after ingestion of blackcurrant juice. J. Environ. Pathol. Toxicol. Oncol. 20:2001;89-95
42. Brackman D., Lund-Johansen F., Aarskog D. Expression of cell surface antigens during the differentiation of HL-60 cells induced by 1, 25-dihydroxyvitamin D3, retinoic acid and DMSO. Leuk. Res. 19:1995;57-64