Potential synergy of phytochemicals in cancer prevention: Mechanism of action

Journal of Nutrition

Volumn 134, Issue 12 SUPPL., 2004, Pages

  Liu, Rui Hai ^a  

^a Department of Obstetrics Gynecology   (United States)

Author keywords

Antioxidant; Cancer prevention; Diet and cancer; Fruits; Phytochemicals; Vegetables

Indexed keywords

4 HYDROXYBENZOIC ACID; APIGENIN; BENZOIC ACID DERIVATIVE; CAFFEIC ACID; CATECHIN; CINNAMIC ACID DERIVATIVE; EPICATECHIN; EPIGALLOCATECHIN; EPIGALLOCATECHIN GALLATE; FERULIC ACID; FLAVANOL DERIVATIVE; FLAVANONE DERIVATIVE; FLAVONE DERIVATIVE; FLAVONOID; FLAVONOL; GALLIC ACID; GENISTEIN; ISOFLAVAN DERIVATIVE; ISOFLAVONOID; KAEMPFEROL; LUTEOLIN; MYRICETIN; NARINGENIN; PARA COUMARIC ACID; PROTOCATECHUIC ACID; QUERCETIN; SINAPIC ACID; SYRINGIC ACID; UNINDEXED DRUG; VANILLIC ACID;

ANTINEOPLASTIC ACTIVITY; ANTIOXIDANT ACTIVITY; CANCER PREVENTION; CARDIOVASCULAR DISEASE; CHRONIC DISEASE; CONFERENCE PAPER; DRUG MECHANISM; FOOD INTAKE; FRUIT; HUMAN; NUTRITIONAL REQUIREMENT; VEGETABLE;

ANTIOXIDANTS; CAROTENOIDS; CHEMOPREVENTION; DIET; DRUG SYNERGISM; FLAVONOIDS; FRUIT; HEALTH PROMOTION; HUMANS; HYDROXYBENZOIC ACIDS; NEOPLASMS; PHENOLS; PLANT EXTRACTS; VEGETABLES;

EID: 9744222928     PISSN: 00223166     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper

References (40)

1. Temple, N. J. (2000) Antioxidants and disease: more questions than answers. Nutr. Res. 20: 449-459.
2. Willett, W. C. (1994) Diet and health: what should we eat. Science 254: 532-537.
3. Willett, W. C. (2002) Balancing life-style and genomics research for disease prevention. Science 296: 695-698.
4. Doll, R. & Peto, R. (1981) Avoidable risks of cancer in the United States. J. Natl. Cancer Inst. 66: 1197-1265.
5. Willett, W. C. (1995) Diet, nutrition, and avoidable cancer. Environ. Health Perspect. 103: 165-170.
6. National Academy of Sciences, National Research Council (1982) Diet, Nutrition, and Cancer. National Academy Press, Washington, DC.
7. National Academy of Sciences, Committee on Diet and Health, National Research Council (1989) Diet and Health: Implications for Reducing Chronic Disease Risk. National Academy Press, Washington, DC.
8. Liu, R. H. (2003) Health benefits of fruits and vegetables are from additive and synergistic combination of phytochemicals. Am. J. Clin. Nutr. 78: 517S-520S.
9. Ames, B. N. & Gold, L. S. (1991) Endogenous mutagens and the causes of aging and cancer. Mutat. Res. 250: 3-16.
10. Sun, J., Chu, Y.-F., Wu, X. & Liu, R. H. (2002) Antioxidant and antiproliferative activities of fruits. J. Agric. Food Chem. 50: 7449-7454.
11. Chu, Y.-F., Sun, J., Wu, X. & Liu, R. H. (2002) Antioxidant and antiproliferative activities of vegetables. J. Agric. Food Chem. 50: 6910-6916.
12. Hollman, P.C.H. & Arts, I.C.W. (2000) (2000) Flavonols, flavones and flavanols - nature, occurrence and dietary burden. J. Sci. Food Agric. 80: 1081-1093.
13. Hollman, P.C.H. & Katan, M. B. (1999) Dietary flavonoids: intake, health effects and bioavailability. Food Chem. Toxicol. 37: 937-942.
14. Kuhnau, J. (1976) The flavonoids. A class of semi-essential food components: their role in human nutrition. World Rev. Nutr. Diet. 24: 117-191.
15. Hertog, M.G.L., Hollman, P.C.H., Katan, M. B. & Kromhout, D. (1993) Intake of potentially anticarcinogenic flavonoids and their determinants in adults in The Netherlands. Nutr. Cancer 20: 21-29.
16. Adom, K. K. & Liu, R. H. (2002) Antioxidant activity of grains. J. Agric. Food Chem. 50: 6182-6187.
17. Dewanto, V., Wu, X. & Liu, R. H. (2002) Processed sweet corn has higher antioxidant activity. J. Agric. Food Chem. 50: 4959-4964.
18. Britton, G. (1995) Structure and properties of carotenoids in relation to function. FASEB J. 9: 1551-1558.
19. Liu, R. H. & Hotchkiss, J. H. (1995) Potential genotoxicity of chronically elevated nitric oxide: A review. Mutat. Res. 339: 73-89.
20. Ames, B. N., Shigenaga, M. K. & Gold, L. S. (1993) DNA lesions, inducible DNA repair, and cell division: the three key factors in mutagenesis and carcinogenesis. Environ. Health Perspect. 101 (suppl. 5): 35-44.
21. Wang, H., Cao, G. H. & Prior R. L. (1996) Total antioxidant capacity of fruits. J. Agric. Food Chem. 44: 701-705.
22. Vinson, J. A., Hao, Y., Su, X., Zubik, L. & Bose, P. (2001) Phenol antioxidant quantity and quality in foods: fruits. J. Agric. Food Chem. 49: 5315-5321.
23. Adom, K. K., Sorrells, M. E. & Liu, R. H. (2003) Phytochemicals and antioxidant activity of wheat varieties. J. Agric. Food Chem. 51: 7825-7834.
24. Block, G., Patterson, B. & Subar, A. (1992) Fruit, vegetables, and cancer prevention: a review of the epidemiological evidence. Nutr. Cancer 18: 1-29.
25. Knekt, P., Jarvinen, R., Seppanen, R., Hellovaara, M., Teppo, L., Pukkala, E. & Aromaa, A. (1997) Dietary flavonoids and the risk of lung cancer and other malignant neoplasms. Am. J. Epidemiol. 146: 223-230.
26. Le Marchand, L., Murphy, S. P., Hankin, J. H., Wilkens, L. R. & Kolonel, L. N. (2000) Intake of flavonoids and lung cancer. J. Natl. Cancer Inst. 92: 154-160.
27. Boyle, S. P., Dobson, V. L., Duthie, S. J., Kyle, J.A.M. & Collins, A. R. (2000) Absorption and DNA protective effects of flavonoid glycosides from an onion meal. Eur. J. Nutr. 39: 213-223.
28. Dragsted, L. O., Strube, M. & Larsen, J. C. (1993) Cancer-protective factors in fruits and vegetables: biochemical and biological background. Pharmacol. Toxicol. 72: 116-135.
29. Waladkhani, A. R. & Clemens, M. R. (1998) Effect of dietary phytochemicals on cancer development. Int. J. Mol. Med. 1: 747-753.
30. Ommen, G. S., Goodman, G. E., Thomquist, M. D., Barnes, J. & Cullen, M. R. (1996) Effects of a combination of β-carotene and vitamin A on lung cancer and cardiovascular disease. N. Engl. J. Med. 334: 1150-1155.
31. Stephens, N. G., Parsons, A., Schofield, P. M., Kelly, F., Cheeseman, K. & Mitchinson, M. J. (1996) Randomized controlled trial of vitamin E in patients with coronary disease: Cambridge Heart Antioxidant Study (CHAOS). Lancet 347: 781-786.
32. Yusuf, S., Dagenais, G., Pogue, J., Bosch, J. & Sleight, P. (2000) Vitamin E supplementation and cardiovascular events in high-risk patients. The Heart Outcomes Prevention Evaluation Study Investigators. N. Engl. J. Med. 342: 154-160.
33. Hennekens, C. H., Buring, J. E., Manson, J. E., Stampfer, M. & Rosner, B. (1996) Lack of effect of long-term supplementation with β-carotene on the incidence of malignant neoplasms and cardiovascular disease. N. Engl. J. Med. 334: 1145-1149.
34. Greenberg, E. R., Baron, J. A., Stuckel, T. A., Stevens, M. M. & Mandel, J. S. (1990) A clinical trial of β-carotene to prevent basal cell and squamous cell cancers of the skin. N. Engl. J. Med. 323: 789-795.
35. The Alpha-Tocopherol, Beta Carotene Cancer Prevention Study Group (1994) The effect of vitamin E and β-carotene on the incidence of lung cancer and other cancers in male smokers. N. Engl. J. Med. 330: 1029-1035.
36. GISSI-Prevenzione Investigators (1999) Dietary supplementation with n-3 polyunsaturated fatty acids and vitamin E after myocardial infarction: results of the GISSI-Prevenzione trial. Lancet 354: 447-455.
37. Blot, W. J., Li, J. Y., Taylor, P. R., Guo, W., Dawsey, S., Wang, G. Q., Yang, C. S., Zheng, S. F., Gail, M., et al. (1993) Nutrition intervention trials in Linxian, China: supplementation with specific vitamin/mineral combinations, cancer incidence, and disease-specific mortality in the general population. J. Natl. Cancer Inst. 85: 1483-1492.
38. Salonen, J. T., Nyyssonen, K., Salonen, R., Lakka, H. M., Kaikkonen, J., Porkkala-Sarataho, E., Voutilainen, S., Lakka, T. A., Rissanen, T., et al. (2000) Antioxidant supplementation in artherosclerosis prevention (ASAP) study: a randomized trial of the effect of vitamins E and C on 3-year progression of carotid atherosclerosis. J. Intern. Med. 248: 377-386.
39. Eberhardt, M. V., Lee, C. Y. & Liu, R. H. (2000) Antioxidant activity of fresh apples. Nature 405: 903-904.
40. Temple, N. J. & Gladwin, K. K. (2003) Fruits, vegetables, and the prevention of cancer: research challenges. Nutrition 19: 467-470.