Black raspberry extracts inhibit benzo(a)pyrene diol-epoxide-induced activator protein 1 activation and VEGF transcription by targeting the phosphotidylinositol 3-kinase/Akt pathway

Cancer Research

Volumn 66, Issue 1, 2006, Pages 581-587

  Huang, Chuanshu ^a   Li, Jingxia ^a   Song, Lun ^a   Zhang, Dongyun ^a   Tong, Qiangsong ^a   Ding, Min ^b   Bowman, Linda ^b   Aziz, Robeena ^c   Stoner, Gary D ^c  

^a NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b NATIONAL INSTITUTE FOR OCCUPATIONAL SAFETY AND HEALTH   (United States)

^c OHIO STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BLACK RASPBERRY EXTRACT; DIHYDROXYBENZO[A]PYRENE OXIDE; INDUCIBLE NITRIC OXIDE SYNTHASE; MUTANT PROTEIN; PHOSPHATIDYLINOSITOL 3 KINASE; PLANT EXTRACT; PROTEIN KINASE B; PROTEIN P85; S6 KINASE; TRANSCRIPTION FACTOR AP 1; UNCLASSIFIED DRUG; VASCULOTROPIN;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG PROTEIN BINDING; DRUG TARGETING; EMBRYO CELL; ENZYME INHIBITION; GENE EXPRESSION; GENE OVEREXPRESSION; GENE TARGETING; MOUSE; NONHUMAN; PRIORITY JOURNAL; SYRIAN HAMSTER; TRANSCRIPTION INITIATION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; 7,8-DIHYDRO-7,8-DIHYDROXYBENZO(A)PYRENE 9,10-OXIDE; ANIMALS; CARCINOGENS; CRICETINAE; ENZYME INDUCTION; FRUIT; MICE; NITRIC OXIDE SYNTHASE TYPE II; PLANT EXTRACTS; PROTO-ONCOGENE PROTEINS C-AKT; RIBOSOMAL PROTEIN S6 KINASES, 70-KDA; ROSACEA; TRANSCRIPTION FACTOR AP-1; TRANSCRIPTION, GENETIC; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 31544436674     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-05-1951     Document Type: Article

References (34)

1. Wogen GN, Hecht SS, Felton JS, Conney AH, Loeb LA. Environmental and chemical carcinogenesis. Semin Cancer Biol 2004;14:473-86.
2. Baird WM, Hooven LA, Mahadevan B. Carcinogenic polycyclic aromatic hydrocarbon-DNA adducts and mechanism of action. Environ Mol Mutagen 2005;45: 106-14.
3. Skupinska K, Misiewicz I, Kasprzycka-Guttman T. Polycyclic aromatic hydrocarbons: physicochemical properties, environmental appearance and impact on living organisms. Acta Pol Pharm 2004;61:233-40.
4. Bostrom CE, Gerde P, Hanberg A, et al. Cancer risk assessment, indicators, and guidelines for polycyclic aromatic hydrocarbons in the ambient air. Environ Health Perspect 2002;110:451-88.
5. Farmer PB, Singh R, Kaur B, et al. Molecular epidemiology studies of carcinogenic environmental pollutants. Effects of polycyclic aromatic hydrocarbons (PAHs) in environmental pollution on exogenous and oxidative DNA damage. Mutat Res 2003;544:397-402.
6. Hanelt S, Helbig R, Hartmann A, Lang M, Seidel A, Speit G. A comparative investigation of DNA adducts, DNA strand breaks and gene mutations induced by benzo(a)pyrene and (+/-)-anti-benzo(a)pyrene-7,8-diol 9,10-oxide in cultured human cells. Mutat Res 1997;390: 179-88.
7. Potter JD, Steinmetz K. Vegetables, fruit and phytoestrogens as preventive agents. In: Steward BW, MacGregor D, Kleihues P, editors. Principles of chemoprevention. Vol. 139. Lyon: IARC Scientific Publications; 1996. p. 61-90.
8. Kim YL. Vegetables, fruits, and colorectal cancer risk what should we believe? Nutr Rev 2001;59:394-8.
9. Kresty LA, Morse MA, Morgan C, et al. Chemoprevention of esophageal tumorigenesis by dietary administration of lyophilized black raspberries. Cancer Res 2001;61:6112-9.
10. Cao G, Prior RL. Anthocyanins are detected in human plasma after oral administration of an elderberry extract. Clin Chem 1999;45:574-6.
11. Stoner GD, Kresty LA, Carlton PS, Siglin JC, Morse MA. Isothiocyanates and freeze-dried strawberries as inhibitors of esophageal cancer. Toxicol Sci 1999;52:95-100.
12. Carlton PS, Kresty LA, Siglin JC, et al. Inhibition of N-nitrosomethylbenzylamine-induced tumorigenesis in the rat esophagus by freeze-dried strawberries. Carcinogenesis 2001;22:441-6.
13. Harris GK, Gupta A, Nines RG, et al. Effects of lyophilized black raspberries on azoxymethane-induced colon cancer and 8-hydroxy-2′- deoxyguanosine levels in the Fischer 344 rat. Nutr Cancer 2001;40:125-33.
14. Meyers KJ, Watkins CB, Pritts MP, Liu RH. Antioxidant and antiproliferative activities of strawberries. J Agric Food Chem 2003;51:6887-92.
15. Xue H, Aziz RM, Sun N, et al. Inhibition of cellular transformation by berry extracts. Carcinogenesis 2001; 22:351-6.
16. Huang C, Huang Y, Li J, et al. Inhibition of benzo(a)pyrene diol-epoxide-induced transactivation of activated protein 1 and nuclear factor-κB by black raspberry extracts. Cancer Res 2002;62:6857-63.
17. Li J, Tang MS, Liu B, Shi X Huang C. A critical role of PI-3K/Akt/JNKs pathway in benzo(a)pyrene diol-epoxide [B(a)PDE]-induced AP-1 transactivation in mouse epidermal Cl 41 cells. Oncogene 2004;23:3932-44.
18. Li J, Davidson G, Huang Y, et al. Nickel compounds act through phosphatidylinositol-3-kinase/Akt-dependent, p70(S6k)-independent pathway to induce hypoxia inducible factor transactivation and Cap43 expression in mouse epidermal Cl 41 cells. Cancer Res 2004;64:94-101.
19. Huang C, Li J, Ding M, et al. UV induces phosphorylation of protein kinase B (Akt) at Ser-473 and Thr-308 in mouse epidermal Cl 41 cells through hydrogen peroxide. J Biol Chem 2001;276:40234-40.
20. Li J, Chen H, Tang MS, et al. PI-3K and Akt are mediators of AP-1 induction by 5-MCDE in mouse epidermal Cl 41 cells. J Cell Biol 2004;165:77-86.
21. Ferrara N. VEGF and the quest for tumour angiogenesis factors. Nat Rev Cancer 2002;2:795-803.
22. Watanabe K, Kawamori T, Nakatsugi S, Wakabayashi K. COX-2 and iNOS, good targets for chemoprevention of colon cancer. Biofactors 2000;12:129-33.
23. Josko J, Mazurek M. Transcription factors having impact on vascular endothelial growth factor (VEGF) gene expression in angiogenesis. Med Sci Monit 2004;10: RA89-98.
24. Miyoshi C, Ohshima N. Vascular endothelial growth factor (VEGF) expression regulates angiogenesis accompanying tumor growth in a peritoneal disseminated tumor model. In Vivo 2001;15:233-8.
25. Tran J, Master Z, Yu JL, Rak J, Dumont DJ, Kerbel RS. A role for survivin in chemoresistance of endothelial cells mediated by VEGF. Proc Natl Acad Sci U S A 2002; 99:4349-54.
26. Mesri M, Morales-Ruiz M, Ackermann EJ, et al. Suppression of vascular endothelial growth factor-mediated endothelial cell protection by survivin targeting. Am J Pathol 2001;158:1757-65.
27. Finch JS, Albino HE, Bowden GT. Quantitation of early clonal expansion of two mutant 61st codon c-Ha-ras alleles in DMBA/TPA treated mouse skin by nested PCR/RFLP. Carcinogenesis 1996;17:2551-7.
28. Detmar M, Brown LF, Schon MP, et al. Increased microvascular density and enhanced leukocyte rolling and adhesion in the skin of VEGF transgenic mice. J Invest Dermatol 1998;111:1-6.
29. Park NH, Gujuluva CN, Baek JH, Cherrick HM, Shin KH, Min BM. Combined oral carcinogenicity of HPV-16 and benzo(a)pyrene: an in vitro multistep carcinogenesis model. Oncogene 1995;10:2145-53.
30. Milanini J, Vinals F, Pouyssegur' J, Pages' G. p42/p44 MAP kinase module plays a key role in the transcriptional regulation of the vascular endothelial growth factor gene in fibroblasts. J Biol Chem 1998;273:18165-72.
31. Rak J, Mitsuhashi Y, Sheehan C, et al. Oncogenes and tumor angiogenesis: differential modes of vascular endothelial growth factor up-regulation in ras-transformed epithelial cells and fibroblasts. Cancer Res 2000; 60:490-8.
32. Abid MR, Guo S, Minami T, et al. Vascular endothelial growth factor activates PI3K/Akt/forkhead signaling in endothelial cells. Arterioscler Thromb Vasc Biol 2004;24: 294-300.
33. Jiang BH, Zheng JZ, Aoki M, Vogt PK. Phosphatidylinositol 3-kinase signaling mediates angiogenesis and expression of vascular endothelial growth factor in endothelial cells. Proc Natl Acad Sci U S A 2000;97: 1749-53.
34. Kasapinovic S, MaCallum GP, Viley MJ, Wells PG. The peroxynitrite pathway in development: phenytoin and benzo(a)pyrene embryopathies in inducible nitric oxide synthase knockout mice. Free Radic Biol Med 2004;37: 1703-11.