Anthocyanidins inhibit cyclooxygenase-2 expression in LPS-evoked macrophages: Structure-activity relationship and molecular mechanisms involved

Biochemical Pharmacology

Volumn 70, Issue 3, 2005, Pages 417-425

  Hou, De Xing ^a   Yanagita, Takashi ^a   Uto, Takuhiro ^a   Masuzaki, Satoko ^a   Fujii, Makoto ^a  

^a KAGOSHIMA UNIVERSITY   (Japan)

Author keywords

Anthocyanidins; Cyclooxygenase 2; Delphinidin; Lipopolysaccharide; Mitogen activated protein kinase; Transcription factors

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; ANTHOCYANIN; ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; ANTIINFLAMMATORY AGENT; CCAAT ENHANCER BINDING PROTEIN DELTA; CYANIDIN; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; CYCLOOXYGENASE 2; DELPHINIDIN; I KAPPA B ALPHA; LIPOPOLYSACCHARIDE; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; MITOGEN ACTIVATED PROTEIN KINASE P38; PROTEIN; PROTEIN C JUN; STRESS ACTIVATED PROTEIN KINASE; SYNAPTOTAGMIN; TRANSCRIPTION FACTOR AP 1; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; DRUG MECHANISM; DRUG POTENCY; ENZYME ACTIVATION; ENZYME INHIBITION; MACROPHAGE; NONHUMAN; PHOSPHORYLATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; RODENT; STRUCTURE ACTIVITY RELATION; WESTERN BLOTTING;

ANIMALS; ANTHOCYANINS; CELL LINE; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITORS; CYCLOOXYGENASE INHIBITORS; GENE EXPRESSION REGULATION, ENZYMOLOGIC; LIPOPOLYSACCHARIDES; MACROPHAGES; MICE; MITOGEN-ACTIVATED PROTEIN KINASES; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; PROTEIN KINASE INHIBITORS; STRUCTURE-ACTIVITY RELATIONSHIP; TRANSCRIPTION, GENETIC;

EID: 21344453327     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcp.2005.05.003     Document Type: Article

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