Iron, zinc, and copper in retinal physiology and disease

Survey of Ophthalmology

Volumn 58, Issue 6, 2013, Pages 585-609

  Ugarte, Marta ^a   Osborne, Neville N ^b,c   Brown, Laurence A ^c   Bishop, Paul N ^a  

^a MANCHESTER ROYAL EYE HOSPITAL   (United Kingdom)

^b Fundacion de Investigacion Oftalmologica   (Spain)

^c UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

Age related macular degeneration; Copper; Iron; Iron chelators; Metal homeostasis interactions; Retina; Trace metal deficiency and overload; Trace metal toxicity; Zinc; Zinc supplements

Indexed keywords

AGENTS ACTING ON THE EYE; ALPHA TOCOPHEROL; ASCORBIC ACID; BETA CAROTENE; COPPER; CUPRIC OXIDE; DEFERASIROX; DEFERIPRONE; DEFEROXAMINE; IRON; PLACEBO; UNCLASSIFIED DRUG; ZINC; ZINC MONOCYSTEINE COMPLEX; ZINC OXIDE; ZINC SULFATE;

ACERULOPLASMINEMIA; AUTOSOMAL RECESSIVE DISORDER; CELL METABOLISM; COPPER DEFICIENCY; COPPER METABOLISM; DISEASE ASSOCIATION; DOSE RESPONSE; DRUG EFFECT; DRUG MEGADOSE; DRUG SAFETY; EYE TOXICITY; FRIEDREICH ATAXIA; GENE MUTATION; HEMOCHROMATOSIS; HUMAN; IRON DEFICIENCY; IRON INDUCED RETINAL TOXICITY; IRON METABOLISM; IRON OVERLOAD; MENKES SYNDROME; MITOCHONDRIAL RESPIRATION; NEPHROTOXICITY; NONHUMAN; PHYSIOLOGICAL PROCESS; PRIORITY JOURNAL; RETINA DISEASE; RETINA MACULA AGE RELATED DEGENERATION; REVIEW; VISUAL DISORDER; VISUAL IMPAIRMENT; WILSON DISEASE; ZINC METABOLISM;

AGE-RELATED MACULAR DEGENERATION; COPPER; IRON; IRON CHELATORS; METAL HOMEOSTASIS INTERACTIONS; RETINA; TRACE METAL DEFICIENCY AND OVERLOAD; TRACE METAL TOXICITY; ZINC; ZINC SUPPLEMENTS;

COPPER; HUMANS; IRON COMPOUNDS; MACULAR DEGENERATION; RETINA; TRACE ELEMENTS; ZINC COMPOUNDS;

EID: 84886292033     PISSN: 00396257     EISSN: 18793304     Source Type: Journal    
DOI: 10.1016/j.survophthal.2012.12.002     Document Type: Review

References (410)

1. Afridi H.I., Kazi T.G., Kazi N., et al. Evaluation of status of zinc, copper, and iron levels in biological samples of normal children and children with night blindness with age groups of 3-7 and 8-12 years. Biol Trace Elem Res 2011, 142:323-334.
2. Arandomized, placebo-controlled, clinical trial of high-dose supplementation with vitamins Cand E, beta carotene, and zinc for age-related macular degeneration and vision loss: AREDS report no. 8. Arch Ophthalmol 2001, 119:1417-1436. Age-Related Eye Disease Study Research Group.
3. Ahluwalia N., Gordon M.A., Handte G., et al. Iron status and stores decline with age in Lewis rats. JNutr 2000, 130:2378-2383.
4. Aisen P., Enns C., Wessling-Resnick M. Chemistry and biology of eukaryotic iron metabolism. Int J Biochem Cell Biol 2001, 33:940-959.
5. Aizenman E., Stout A.K., Hartnett K.A., et al. Induction of neuronal apoptosis by thiol oxidation: putative role of intracellular zinc release. JNeurochem 2000, 75:1878-1888.
6. Ajioka R.S., Phillips J.D., Kushner J.P. Biosynthesis of heme in mammals. Biochim Biophys Acta 2006, 1763:723-736.
7. Akagi T., Kaneda M., Ishii K., et al. Differential subcellular localization of zinc in the rat retina. JHistochem Cytochem 2001, 49:87-96.
8. Akeo K., Hiramitsu T., Yorifuji H., et al. Membranes of retinal pigment epithelial cells invitro are damaged in the phagocytotic process of the photoreceptor outer segment discs peroxidized by ferrous ions. Pigment Cell Res 2002, 15:341-347.
9. Algarín C., Peirano P., Garrido M., et al. Iron deficiency anemia in infancy: long-lasting effects on auditory and visual system functioning. Pediatr Res 2003, 53:217-223.
10. Alldredge C.D., Schlieve C.R., Miller N.R., et al. Pathophysiology of the optic neuropathy associated with Friedreich ataxia. Arch Ophthalmol 2003, 121:1582-1585.
11. Alvarado G., Murillo M. Multielemental fractionation in human peripheral blood mononuclear cells by size exclusion liquid chromatography coupled to UV andICP-MS detection. JChromatogr Sci 2010, 48:697-703.
12. Andreini C., Banci L., Bertini I., et al. Zinc through the three domains of life. JProteome Res 2006, 5:3173-3178.
13. Andrews N.C. Ferrit(in)ing out new mechanisms in iron homeostasis. Cell Metab 2010, 12:203-204.
14. Andrzejczyk J., Buszman E. Interaction of Fe3+, Cu2+ and Zn2+ with melanin and melanoproteins from bovine eyes. Acta Biochim Pol 1992, 39:85-88.
15. Arden G.B., Wonke B., Kennedy C., et al. Ocular changes in patients undergoing long-term desferrioxamine treatment. Br J Ophthalmol 1984, 68:873-877.
16. Armstrong C., Leong W., Lees G.J. Comparative effects of metal chelating agents on the neuronal cytotoxicity induced by copper (Cu+2), iron (Fe+3) and zinc in the hippocampus. Brain Res 2001, 892:51-62.
17. Arora A., Wren S., Gregory Evans K Desferrioxamine related maculopathy: a case report. Am J Hematol 2004, 76:386-388.
18. Arranz V., Dreuillet C., Crisanti P., et al. The zinc finger transcription factor, MOK2, negatively modulates expression of the interphotoreceptor retinoid-binding protein gene. IRBP J Biol Chem 2001, 276:11963-11969.
19. Badaracco M.E., Siri M.V., Pasquini J.M. Oligodendrogenesis: the role of iron. Biofactors 2010, 36:98-102.
20. Bal W., Christodoulou J., Sadler P.J., et al. Multi-metal binding site of serum albumin. JInorg Biochem 1998, 70:33-39.
21. Banci L., Bertini I., Ciofi-Baffoni S., et al. Mitochondrial copper(I) transfer from Cox17 to Sco1 is coupled to electron transfer. Proc Natl Acad Sci USA 2008, 105:6803-6808.
22. Bartlett H., Eperjesi F. Age-related macular degeneration and nutritional supplementation: a review of randomised controlled trials. Ophthalmic Physiol Opt 2003, 23:383-399.
23. Beard J.L., Murray-Kolb L.E., Rosales F.J., et al. Interpretation of serum ferritin concentrations as indicators of total-body iron stores in survey populations: the role of biomarkers for the acute phase response. Am J Clin Nutr 2006, 84:1498-1505.
24. Belbraouet S., Biaudet H., Tébi A., et al. Serum zinc and copper status in hospitalized vs. healthy elderly subjects. JAm Coll Nutr 2007, 26:650-654.
25. Bene C., Manzler A., Bene D., et al. Irreversible ocular toxicity from single "challenge" dose of deferoxamine. Clin Nephrol 1989, 31:45-48.
26. Bergstedt M., Johansson S., Muller R. Hereditary spastic ataxia with central retinal degeneration and vestibular impairment. A clinical report on a family. Neurology 1962, 12:124-132.
27. Bermejo F., García-López S. Aguide to diagnosis of iron deficiency and iron deficiency anemia in digestive diseases. World J Gastroenterol 2009, 15:4638-4643.
28. Bernard M., Voisin P. Photoreceptor-specific expression, light-dependent localization, and transcriptional targets of the zinc-finger protein Yin Yang 1 in the chicken retina. JNeurochem 2008, 105:595-604.
29. Bettger W.J. Zinc and selenium, site-specific versus general antioxidation. Can J Physiol Pharmacol 1993, 71:721-724.
30. Biesemeier A., Schraermeyer U., Eibl O. Chemical composition of melanosomes, lipofuscin and melanolipofuscin granules of human RPE tissues. Exp Eye Res 2011, 93:29-39.
31. Biesemeier A., Julien S., Kokkinou D., et al. Alow zinc diet leads to loss of Zn in melanosomes of the RPE but not in melanosomes of the choroidal melanocytes. Metallomics 2012, 4:323-332.
32. Bito L.Z., Baroody R.A. Ocular trace metal kinetics and toxicology. I. The distribution of intravitreally injected 67Cu++ within intraocular compartments and its loss from the globe. Invest Ophthalmol Vis Sci 1987, 28:101-105.
33. Bjork A., Lindblom U., Wadensten L. Retinal degeneration in hereditary ataxia. JNeurol Neurosurg Psychiatry 1956, 19:186-193.
34. Bonilha V.L., Rayborn M.E., Shadrach K., et al. Characterization of semenogelin proteins in the human retina. Exp Eye Res 2006, 83:120-127.
35. Bonilha V.L., Rayborn M.E., Shadrach K.G., et al. Semenogelins in the human retina: differences in distribution and content between AMD and normal donor tissues. Exp Eye Res 2008, 86:150-156.
36. Bowness J.M., Morton R.A., Shakir M.H., et al. Distribution of copper and zinc in mammalian eyes. Occurrence of metals in melanin fractions from eye tissues. Biochem J 1952, 51:521-530.
37. Bozym R.A., Chimienti F., Giblin L.J., et al. Free zinc ions outside a narrow concentration range are toxic to a variety of cells invitro. Exp Biol Med (Maywood) 2010, 235:741-750.
38. Bray T.M., Bettger W.J. The physiological role of zinc as an antioxidant. Free Radic Biol Med 1990, 8:281-291.
39. Brewer G.J., Hill G.M., Dick R.D., et al. Interactions of trace elements: clinical significance. JAm Coll Nutr 1985, 4:33-38.
40. Brittenham G.M., Danish E.H., Harris J.W. Assessment of bone marrow and body iron stores: old techniques and new technologies. Semin Hematol 1981, 18:194-221.
41. Brown A.M., Kristal B.S., Effron M.S., et al. Zn2+ inhibits alpha-ketoglutarate-stimulated mitochondrial respiration and the isolated alpha-ketoglutarate dehydrogenase complex. JBiol Chem 2000, 275:13441-13447.
42. Buettner G.R. Superoxide dismutase in redox biology: the roles of superoxide and hydrogen peroxide. Anticancer Agents Med Chem 2011, 11:341-346.
43. Burger P.C., Klintworth G.K. Experimental retinal degeneration in the rabbit produced by intraocular iron. Lab Invest 1974, 30:9-19.
44. Burri L., Vascotto K., Fredersdorf S., et al. Zim17, a novel zinc finger protein essential for protein import into mitochondria. JBiol Chem 2004, 279:50243-50249.
45. Cals M.J., Bories P.N., Devanlay M., et al. Extensive laboratory assessment of nutritional status in fit, health-conscious, elderly people living in the Paris area. Research Group on Aging. JAm Coll Nutr 1994, 13:646-657.
46. Cameron J.D., McClain C.J. Ocular histopathology of acrodermatitis enteropathica. Br J Ophthalmol 1986, 70:662-667.
47. Camina J.P., Campos J.F., Caminos J.E., et al. Obestatin-mediated proliferation of human retinal pigment epithelial cells: regulatory mechanisms. JCell Physiol 2007, 211:1-9.
48. Chappell R.L., Redenti S. Endogenous zinc as a neuromodulator in vertebrate retina: evidence from the retinal slice. Biol Bull 2001, 201:265-267.
49. Chen H., Liu B., Lukas T.J., et al. Changes in iron-regulatory proteins in the aged rodent neural retina. Neurobiol Aging 2009, 30:1865-1876.
50. Chen H., Lukas T.J., Du N., et al. Dysfunction of the retinal pigment epithelium with age: increased iron decreases phagocytosis and lysosomal activity. Invest Ophthalmol Vis Sci 2009, 50:1895-1902.
51. Chen L., Wu W., Dentchev T., et al. Increased metallothionein in light damaged mouse retinas. Exp Eye Res 2004, 79:287-293.
52. Chen L., Wu W., Dentchev T., et al. Light damage induced changes in mouse retinal gene expression. Exp Eye Res 2004, 79:239-247.
53. Chen W., Wang Z., Zhang Y. The effect of zinc on the apoptosis of cultured human retinal pigment epithelial cells. JHuazhong Univ Sci Technolog Med Sci 2003, 23:414-417.
54. Cho E., Stampfer M.J., Seddon J.M., et al. Prospective study of zinc intake and the risk of age-related macular degeneration. Ann Epidemiol 2001, 11:328-336.
55. Choi B.S., Zheng W. Copper transport to the brain by the blood-brain barrier and blood-CSF barrier. Brain Res 2009, 1248:14-21.
56. Choi J.S., Kim K.A., Yoon Y.J., et al. Inhibition of cyclooxygenase-2 expression by zinc-chelator in retinal ischemia. Vision Res 2006, 46:2721-2727.
57. Chothe P.P., Gnana-Prakasam J.P., Ananth S., et al. Transport of hepcidin, an iron-regulatory peptide hormone, into retinal pigment epithelial cells via oligopeptide transporters and its relevance to iron homeostasis. Biochem Biophys Res Commun 2011, 405:244-249.
58. Chowers I., Wong R., Dentchev T., et al. The iron carrier transferrin is upregulated in retinas from patients with age-related macular degeneration. Invest Ophthalmol Vis Sci 2006, 47:2135-2140.
59. Chua A.C., Graham R.M., Trinder D., et al. The regulation of cellular iron metabolism. Crit Rev Clin Lab Sci 2007, 44:413-459.
60. Cibis P.A., Yamashita T., Rodriguez F. Clinical aspects of ocular siderosis and hemosiderosis. AMA Arch Ophthalmol 1959, 62:180-187.
61. Cipriani V., Leung H.T., Plagnol V., et al. Genome-wide association study of age-related macular degeneration identifies associated variants in the TNXB-FKBPL-NOTCH4 region of chromosome 6p21.3. Hum Mol Genet 2012, 21:4138-4150.
62. Clegg M.S., Hanna L.A., Niles B.J., et al. Zinc deficiency-induced cell death. IUBMB Life 2005, 57:661-669.
63. Cobine P.A., Ojeda L.D., Rigby K.M., et al. Yeast contain a non-proteinaceous pool of copper in the mitochondrial matrix. JBiol Chem 2004, 279:14447-14455.
64. Cobine P.A., Pierrel F., Winge D.R. Copper trafficking to the mitochondrion and assembly of copper metalloenzymes. Biochim Biophys Acta 2006, 1763:759-772.
65. Coleman J.E. Zinc proteins: enzymes, storage proteins, transcription factors, and replication proteins. Annu Rev Biochem 1992, 61:897-946.
66. Connor J.R., Menzies S.L., Burdo J.R., et al. Iron and iron management proteins in neurobiology. Pediatr Neurol 2001, 25:118-129.
67. Cook C.I., Yu B.P. Iron accumulation in aging: modulation by dietary restriction. Mech Ageing Dev 1998, 102:1-13.
68. Cousins R.J., Liuzzi J.P., Lichten L.A. Mammalian zinc transport, trafficking, and signals. JBiol Chem 2006, 281:24085-24089.
69. Coyne H.J., Ciofi-Baffoni S., Banci L., et al. The characterization and role of zinc binding in yeast Cox4. JBiol Chem 2007, 282:8926-8934.
70. Dake Y., Amemiya T. Electron microscopic study of the optic nerve in copper deficient rats. Exp Eye Res 1991, 52:277-281.
71. Dancis A., Yuan D.S., Haile D., et al. Molecular characterization of a copper transport protein in S. cerevisiae: an unexpected role for copper in iron transport. Cell 1994, 76:393-402.
72. Das S.K., Ray K. Wilson's disease: an update. Nat Clin Pract Neurol 2006, 2:482-493.
73. Davies K.M., Strauss M., Daum B., et al. Macromolecular organization of ATP synthase and complex I in whole mitochondria. Proc Natl Acad Sci USA 2011, 108:14121-14126.
74. Davies S.C., Marcus R.E., Hungerford J.L., et al. Ocular toxicity of high-dose intravenous desferrioxamine. Lancet 1983, 2:181-184.
75. Davis A.A., Hunt R.C. Transferrin is made and bound by photoreceptor cells. JCell Physiol 1993, 156:280-285.
76. D'Cruz P.M., Yasumura D., Weir J., et al. Mutation of the receptor tyrosine kinase gene Mertk in the retinal dystrophic RCS rat. Hum Mol Genet 2000, 9:645-651.
77. Declercq S.S., Meredith P.C., Rosenthal A.R. Experimental siderosis in the rabbit: correlation between electroretinography and histopathology. Arch Ophthalmol 1977, 95:1051-1058.
78. del Valle L.J., Ramon E., Canavate X., et al. Zinc-induced decrease of the thermal stability and regeneration of rhodopsin. JBiol Chem 2003, 278:4719-4724.
79. Deleon E., Lederman M., Berenstein E., et al. Alteration in iron metabolism during retinal degeneration in rd10 mouse. Invest Ophthalmol Vis Sci 2009, 50:1360-1365.
80. Dentchev T., Hahn P., Dunaief J.L. Strong labeling for iron and the iron-handling proteins ferritin and ferroportin in the photoreceptor layer in age-related macular degeneration. Arch Ophthalmol 2005, 123:1745-1746.
81. Deugnier Y. The iron driven pathway of hepcidin synthesis. Gastroenterol Clin Biol 2010, 34:351-354.
82. Dineley K.E. On the use of fluorescent probes to distinguish Ca2+ from Zn2+ in models of excitotoxicity. Cell Calcium 2007, 42:341-342.
83. Dineley K.E., Richards L.L., Votyakova T.V., et al. Zinc causes loss of membrane potential and elevates reactive oxygen species in rat brain mitochondria. Mitochondrion 2005, 5:55-65.
84. Dineley K.E., Votyakova T.V., Reynolds I.J. Zinc inhibition of cellular energy production: implications for mitochondria and neurodegeneration. JNeurochem 2003, 85:563-570.
85. Doherty K., Connor M., Cruickshank R. Zinc-containing denture adhesive: a potential source of excess zinc resulting in copper deficiency myelopathy. BrDent J 2011, 210:523-525.
86. Donovan A., Brownlie A., Zhou Y., et al. Positional cloning of zebrafish ferroportin1 identifies a conserved vertebrate iron exporter. Nature 2000, 403:776-781.
87. Dorea J.G., Olson J.A. The rate of rhodopsin regeneration in the bleached eyes of zinc-deficient rats in the dark. JNutr 1986, 116:121-127.
88. Dunaief J.L., Richa C., Franks E.P., et al. Macular degeneration in a patient with aceruloplasminemia, a disease associated with retinal iron overload. Ophthalmology 2005, 112:1062-1065.
89. Dunaief J.L. Iron induced oxidative damage as a potential factor in age-related macular degeneration: the Cogan Lecture. Invest Ophthalmol Vis Sci 2006, 47:4660-4664.
90. Ebadi M., Iversen P.L., Hao R., et al. Expression and regulation of brain metallothionein. Neurochem Int 1995, 27:1-22.
91. Eckhert C.D. Elemental concentrations in ocular tissues of various species. Exp Eye Res 1983, 37:639-647.
92. Erie J.C., Good J.A., Butz J.A., et al. Reduced zinc and copper in the retinal pigment epithelium and choroid in age-related macular degeneration. Am J Ophthalmol 2009, 147:276-282.
93. Evans G.W. Zinc and its deficiency diseases. Clin Physiol Biochem 1986, 4:94-98.
94. Fabe J.S., Grahn B.H., Paterson P.G. Zinc concentration of selected ocular tissues in zinc-deficient rats. Biol Trace Elem Res 2000, 75:43-52.
95. Fabiano A., Panfoli I., Calzia D., et al. Catalytic properties of the retinal rod outer segment disk ADP-ribosyl cyclase. Vis Neurosci 2011, 28:121-128.
96. Ferenci P. Pathophysiology and clinical features of Wilson disease. Metab Brain Dis 2004, 19:229-239.
97. Ferreira R.C., Heckenlively J.R., Menkes J.H., et al. Menkes disease. New ocular and electroretinographic findings. Ophthalmology 1998, 105:1076-1078.
98. Finney L.A., O'Halloran T.V. Transition metal speciation in the cell: insights from the chemistry of metal ion receptors. Science 2003, 300:931-936.
99. Forster H.S. Optic disc edema due to iron deficiency. Occurrence with normal cerebrospinal fluid pressure. Conn Med 1985, 49:290-292.
100. Fortuna F., Barboni P., Liguori R., et al. Visual system involvement in patients with Friedreich's ataxia. Brain 2009, 132:116-123.
101. Furuyama K., Kaneko K., Vargas P.D. Heme as a magnificent molecule with multiple emissions: heme determines its own fate and governs cellular homeostasis. Tohoku J Exp Med 2007, 213:1-16.
102. Ganz T. Hepcidin and iron regulation, 10 years later. Blood 2011, 117:4425-4433.
103. Gao H.L., Feng W.Y., Li X.L., et al. Golgi apparatus localization of ZNT7 in the mouse cerebellum. Histol Histopathol 2009, 24:567-572.
104. García-Castineiras S. Iron, the retina and the lens: a focused review. Exp Eye Res 2010, 90:664-678.
105. Garry P.J., Goodwin J.S., Hunt W.C. Iron status and anemia in the elderly: new findings and a review of previous studies. JAm Geriatr Soc 1983, 31:389-399.
106. Gartaganis S., Ismiridis K., Papageorgiou O., et al. Ocular abnormalities in patients with beta thalassemia. Am J Ophthalmol 1989, 108:699-703.
107. Gasch A.T., Caruso R.C., Kaler S.G., et al. Menkes' syndrome:ophthalmic findings. Ophthalmology 2002, 109:1477-1483.
108. Gehlbach P.L., Purple R.L., Hallaway P.E., et al. Polymer conjugation reduces deferoxamine induced retinopathy in an albino rat model. Invest Ophthalmol Vis Sci 1993, 34:2871-2877.
109. Giroux E., Schoun J. Copper and zinc ion binding by bovine, dog, and rat serum albumins. JInorg Biochem 1981, 14:359-362.
110. Gleim S., Stojanovic A., Arehart E., et al. Conserved rhodopsin intradiscal structural motifs mediate stabilization: effects of zinc. Biochemistry 2009, 48:1793-1800.
111. Gnana-Prakasam J.P., Martin P.M., Mysona B.A., et al. Hepcidin expression in mouse retina and its regulation via lipopolysaccharide/Toll-like receptor-4 pathway independent of Hfe. Biochem J 2008, 411:79-88.
112. Gnana-Prakasam J.P., Thangaraju M., Liu K., et al. Absence of iron-regulatory protein Hfe results in hyperproliferation of retinal pigment epithelium: role of cystine/glutamate exchanger. Biochem J 2009, 424:243-252.
113. Gnana-Prakasam J.P., Martin P.M., Smith S.B., et al. Expression and function of iron-regulatory proteins in retina. IUBMB Life 2010, 62:363-370.
114. Gnana-Prakasam J.P., Reddy S.K., Veeranan-Karmegam R., et al. Polarized distribution of heme transporters in retinal pigment epithelium and their regulation in the iron-overload disease hemochromatosis. Invest Ophthalmol Vis Sci 2011, 52:9279-9286.
115. Gnana-Prakasam J.P., Tawfik A., Romej M., et al. Iron-mediated retinal degeneration in haemojuvelin-knockout mice. Biochem J 2012, 441:599-608.
116. Good P.A., Claxson A., Morris C.J., et al. Amodel for desferrioxamine-induced retinopathy using the albino rat. Ophthalmologica 1990, 201:32-36.
117. Grahn B.H., Paterson P.G., Gottschall-Pass K.T., et al. Zinc and the eye. JAm Coll Nutr 2001, 20(2 Suppl):106-118.
118. Greenberg S.A., Briemberg H.R. Aneurological and hematological syndrome associated with zinc excess and copper deficiency. JNeurol 2004, 251:111-114.
119. Guo B., Brown F.M., Phillips J.D., et al. Characterization and expression of iron regulatory protein 2 (IRP2). Presence of multiple IRP2 transcripts regulated by intracellular iron levels. JBiol Chem 1995, 270:16529-16535.
120. Haase H., Rink L. The immune system and the impact of zinc during aging. Immun Ageing 2009, 6:9.
121. Hadziahmetovic M., Dentchev T., Song Y., et al. Ceruloplasmin/hephaestin knockout mice model morphologic and molecular features of AMD. Invest Ophthalmol Vis Sci 2008, 49:2728-2736.
122. Hadziahmetovic M., Song Y., Wolkow N., et al. The oral iron chelator deferiprone protects against iron overload-induced retinal degeneration. Invest Ophthalmol Vis Sci 2011, 52:959-968.
123. Hadziahmetovic M., Song Y., Ponnuru P., et al. Age-dependent retinal iron accumulation and degeneration in hepcidin knockout mice. Invest Ophthalmol Vis Sci 2011, 52:109-118.
124. Hadziahmetovic M., Song Y., Wolkow N., et al. Bmp6 regulates retinal iron homeostasis and has altered expression in age-related macular degeneration. Am J Pathol 2011, 179:335-348.
125. Hahn P., Milam A.H., Dunaief J.L. Maculas affected by age-related macular degeneration contain increased chelatable iron in the retinal pigment epithelium and Bruch's membrane. Arch Ophthalmol 2003, 121:1099-1105.
126. Hahn P., Dentchev T., Qian Y., et al. Immunolocalization and regulation of iron handling proteins ferritin and ferroportin in the retina. Mol Vis 2004, 10:598-607.
127. Hahn P., Qian Y., Dentchev T., et al. Disruption of ceruloplasmin and hephaestin in mice causes retinal iron overload and retinal degeneration with features of age-related macular degeneration. Proc Natl Acad Sci USA 2004, 101:13850-13855.
128. Hahn P., Ying G.S., Beard J., et al. Iron levels in human retina: sex difference and increase with age. Neuroreport 2006, 17:1803-1806.
129. Hahn P., Song Y., Ying G.S., et al. Age-dependent and gender-specific changes in mouse tissue iron by strain. Exp Gerontol 2009, 44:594-600.
130. Haimovici R., D'Amico D.J., Gragoudas E.S., et al. Deferoxamine Retinopathy Study Group. The expanded clinical spectrum of deferoxamine retinopathy. Ophthalmology 2002, 109:164-171.
131. Hall A.C., Young B.W., Bremner I. Intestinal metallothionein and the mutual antagonism between copper and zinc in the rat. JInorg Biochem 1979, 11:57-66.
132. Hamza I., Gitlin J.D. Copper chaperones for cytochrome c oxidase and human disease. JBioenerg Biomembr 2002, 34:381-388.
133. Han Y., Wu S.M. Modulation of glycine receptors in retinal ganglion cells by zinc. Proc Natl Acad Sci USA 1999, 96:3234-3238.
134. Han M.H., Yang X.L. Zn2+ differentially modulates kinetics of GABA(C) vs GABA(A) receptors in carp retinal bipolar cells. Neuroreport 1999, 10:2593-2597.
135. Harvey L.J., Ashton K., Hooper L., et al. Methods of assessment of copper status in humans: a systematic review. Am J Clin Nutr 2009, 89:2009S-2024S.
136. He F., Seryshev A.B., Cowan C.W., et al. Multiple zinc binding sites in retinal rod cGMP phosphodiesterase, PDE6alpha beta. JBiol Chem 2000, 275:20572-20577.
137. He X., Hahn P., Iacovelli J., et al. Iron homeostasis and toxicity in retinal degeneration. Prog Retin Eye Res 2007, 26:649-673.
138. Hedera P., Fink J.K., Bockenstedt P.L., et al. Myelopolyneuropathy and pancytopenia due to copper deficiency and high zinc levels of unknown origin:further support for existence of a new zinc overload syndrome. Arch Neurol 2003, 60:1303-1306.
139. Henkin R.I. Metal-albumin-amino acid interactions: chemical and physiological interrelationships. Adv Exp Med Biol 1974, 48:299-328.
140. Hentze M.W., Kuhn L.C. Molecular control of vertebrate iron metabolism: mRNA-based regulatory circuits operated by iron, nitric oxide, and oxidative stress. Proc Natl Acad Sci USA 1996, 93:8175-8182.
141. Hirayama Y. Histochemical localization of zinc and copper in rat ocular tissues. Acta Histochem 1990, 89:107-111.
142. Hooper N.M. Families of zinc metalloproteases. FEBS Lett 1994, 354:1-6.
143. Huang M.L., Lane D.J., Richardson D.R. Mitochondrial mayhem: the mitochondrion as a modulator of iron metabolism and its role in disease. Antioxid Redox Signal 2011, 15:3003-3019.
144. Huber A.M., Gershoff S.N. Effects of zinc deficiency on the oxidation of retinol and ethanol in rats. JNutr 1975, 105:1486-1490.
145. Huibi X., Kaixun H., Qiuhua G., et al. Prevention of axial elongation in myopia by the trace element zinc. Biol Trace Elem Res 2001, 79:39-47.
146. Hunt R.C., Dewey A., Davis A.A. Transferrin receptors on the surfaces of retinal pigment epithelial cells are associated with the cytoskeleton. JCell Sci 1989, 92:655-666.
147. Hunt R.C., Davis A.A. Release of iron by human retinal pigment epithelial cells. JCell Physiol 1992, 152:102-110.
148. Hutchens T.W., Allen M.H. Differences in the conformational state of a zinc-finger DNA-binding protein domain occupied by zinc and copper revealed by electrospray ionization mass spectrometry. Rapid Commun Mass Spectrom 1992, 6:469-473.
149. Hyndman A.G., Hockberger P.E., Zeevalk G.D., Connor J.A. Transferrin can alter physiological properties of retinal neurons. Brain Res 1991, 561:318-323.
150. Hyun H.J., Sohn J., Ahn Y.H., et al. Depletion of intracellular zinc induces macromolecule synthesis- and caspase-dependent apoptosis of cultured retinal cells. Brain Res 2000, 869:39-48.
151. Hyun H.J., Sohn J.H., Ha D.W., et al. Depletion of intracellular zinc and copper with TPEN results in apoptosis of cultured human retinal pigment epithelial cells. Invest Ophthalmol Vis Sci 2001, 42:460-465.
152. Iacopetta B.J., Morgan E.H. The kinetics of transferrin endocytosis and iron uptake from transferrin in rabbit reticulocytes. JBiol Chem 1983, 258:9108-9115.
153. Ikkala E., Laitinen L. Papilloedema due to iron deficiency anaemia. Acta Haematol 1963, 29:368-370.
154. Irato P., Albergoni V. Interaction between copper and zinc in metal accumulation in rats with particular reference to the synthesis of induced-metallothionein. Chem Biol Interact 2005, 155:155-164.
155. Jacobson S.G., Meadows N.J., Keeling P.W., et al. Rod mediated retinal dysfunction in cats with zinc depletion: comparison with taurine depletion. Clin Sci (Lond) 1986, 71:559-564.
156. Jampol L.M. Antioxidants and zinc to prevent progression of age-related macular degeneration. JAMA 2001, 286:2466-2468.
157. Jethani J., Marwah K., Nikul, et al. Ocular abnormalities in patients with beta thalassemia on transfusion and chelation therapy: our experience. Indian J Ophthalmol 2010, 58:451-452.
158. Jiang D., Sullivan P.G., Sensi S.L., et al. Zn(2+) induces permeability transition pore opening and release of pro-apoptotic peptides from neuronal mitochondria. JBiol Chem 2001, 276:47524-47529.
159. Jomova K., Vondrakova D., Lawson M., et al. Metals, oxidative stress and neurodegenerative disorders. Mol Cell Biochem 2010, 345:91-104.
160. Jomova K., Valko M. Advances in metal-induced oxidative stress and human disease. Toxicology 2011, 283:65-87.
161. Jonas E.A. Molecular participants in mitochondrial cell death channel formation during neuronal ischemia. Exp Neurol 2009, 218:203-212.
162. Jonsson M., Linse S., Frohm B., et al. Semenogelins I and II bind zinc and regulate the activity of prostate-specific antigen. Biochem J 2005, 387:447-453.
163. Julien S., Biesemeier A., Kokkinou D., et al. Zinc deficiency leads to lipofuscin accumulation in the retinal pigment epithelium of pigmented rats. PLoS One 2011, 6:e29245.
164. Kacer B., Hattenbach L.O., Horle S., et al. Central retinal vein occlusion and nonarteritic ischemic optic neuropathy in 2 patients with mild iron deficiency anemia. Ophthalmologica 2001, 215:128-131.
165. Kadenbach B., Arnold S., Lee I., et al. The possible role of cytochrome c oxidase in stress-induced apoptosis and degenerative diseases. Biochim BiophysActa 2004, 1655:400-408.
166. Kagan H.M., Li W. Lysyl oxidase: properties, specificity, and biological roles inside and outside of the cell. JCell Biochem 2003, 88:660-672.
167. Kaneda M., Ishii K., Akagi T., et al. Endogenous zinc can be a modulator of glycinergic signaling pathway in the rat retina. JMol Histol 2005, 36:179-185.
168. Karcioglu Z.A., Stout R., Hahn H.J. Serum zinc levels in retinitis pigmentosa. Curr Eye Res 1984, 3:1043-1048.
169. Keeling P.W., O'Day J., Ruse W., et al. Zinc deficiency and photoreceptor dysfunction in chronic liver disease. Clin Sci (Lond) 1982, 62:109-111.
170. Keen C.L., Golub M.S., Gershwin M.E., et al. Studies of marginal zinc deprivation in rhesus monkeys. III. Use of liver biopsy in the assessment of zinc status. Am J Clin Nutr 1988, 47:1041-1045.
171. Kim S.Y., Kwak J.S., Shin J.P., et al. The protection of the retina from ischemic injury by the free radical scavenger EGb 761 and zinc in the cat retina. Ophthalmologica 1998, 212:268-274.
172. King J.C. Effect of reproduction on the bioavailability of calcium, zinc and selenium. JNutr 2001, 131:1355S-1358S.
173. King J.C. Zinc: an essential but elusive nutrient. Am J Clin Nutr 2011, 94:679S-684S.
174. Kirkham T.H., Wrigley P.F., Holt J.M. Central retinal vein occlusion complicating iron deficiency anaemia. Br J Ophthalmol 1971, 55:777-780.
175. Klein M.L., Francis P.J., Rosner B., et al. CFH and LOC387715/ARMS2 genotypes and treatment with antioxidants and zinc for age-related macular degeneration. Ophthalmology 2008, 115:1019-1025.
176. Klomp A.E., van de Sluis B., Klomp L.W., et al. The ubiquitously expressed MURR1 protein is absent in canine copper toxicosis. JHepatol 2003, 39:703-709.
177. Klomp L.W., Gitlin J.D. Expression of the ceruloplasmin gene in the human retina and brain: implications for a pathogenic model in aceruloplasminemia. Hum Mol Genet 1996, 5:1989-1996.
178. Knizley H., Noyes W.D. Iron deficiency anemia, papilledema, thrombocytosis, and transient hemiparesis. Arch Intern Med 1972, 129:483-486.
179. Koeppen A.H. Friedreich's ataxia: pathology, pathogenesis, and molecular genetics. JNeurol Sci 2011, 303:1-12.
180. Kokkinou D., Kasper H.U., Schwarz T., et al. Zinc uptake and storage: the role of fundus pigmentation. Graefes Arch Clin Exp Ophthalmol 2005, 243:1050-1055.
181. Kozlowski H., Janicka-Klos A., Brasun J., et al. Copper, iron and zinc ions homeostasis and their role in neurodegenerative disorders. Coordination Chem Rev 2009, 253:2665.
182. Kraft S.P., Parker J.A., Matuk Y., et al. The rat electroretinogram in combined zinc and vitamin A deficiency. Invest Ophthalmol Vis Sci 1987, 28:975-984.
183. Krajacic P., Qian Y., Hahn P., et al. Retinal localization and copper-dependent relocalization of the Wilson and Menkes disease proteins. Invest Ophthalmol Vis Sci 2006, 47:3129-3134.
184. Kumar A., Singh B.K., Ahmad I., et al. Involvement of NADPH oxidase and glutathione in zinc-induced dopaminergic neurodegeneration in rats: Similarity with paraquat neurotoxicity. Brain Res 2012, 1438:48-64.
185. Kumar N., Ahlskog J.E., Gross J.B. Acquired hypocupremia after gastric surgery. Clin Gastroenterol Hepatol 2004, 2:1074-1079.
186. Kuo Y.M., Gybina A.A., Pyatskowit J.W., et al. Copper transport protein (Ctr1) levels in mice are tissue specific and dependent on copper status. JNutr 2006, 136:21-26.
187. La Fontaine S., Ackland M.L., Mercer J.F. Mammalian copper-transporting P-type ATPases, ATP7A and ATP7B: emerging roles. Int J Biochem Cell Biol 2010, 42:206-209.
188. Labbe, Dewanji A. Iron assessment tests: transferrin receptor vs zinc protoporphyrin. Clin Biochem 2004, 37:165-174.
189. Lakhanpal V., Schocket S.S., Jiji R. Deferoxamine (Desferal)-induced toxic retinal pigmentary degeneration and presumed optic neuropathy. Ophthalmology 1984, 91:443-451.
190. Le T.H., Blair D., McManus D.P. Aleucine zipper protein of mitochondrial origin. Biochim Biophys Acta 2001, 1546. 435-3.
191. Lederman M., Obolensky A., Grunin M., et al. Retinal function and structure in the hypotransferrinemic mouse. Invest Ophthalmol Vis Sci 2012, 53:605-612.
192. Lee A.Y., Brantley M.A. CFH and LOC387715/ARMS2 genotypes and antioxidants and zinc therapy for age-related macular degeneration. Pharmacogenomics 2008, 9:1547-1550.
193. Lengyel D., Török B. [Acquired temporary night blindness in vitamin A and zinc deficiency in anorexia nervosa nine years after kidney transplantation]. Klin Monbl Augenheilkd 2006, 223:453-455.
194. Lengyel I., Flinn J.M., Peto T., et al. High concentration of zinc in sub-retinal pigment epithelial deposits. Exp Eye Res 2007, 84:772-780.
195. Lesuisse E., Santos R., Matzanke B.F., et al. Iron use for haeme synthesis is under control of the yeast frataxin homologue (Yfh1). Hum Mol Genet 2003, 12:879-889.
196. Leung K.W., Liu M., Xu X., et al. Expression of ZnT and ZIP zinc transporters in the human RPE and their regulation by neurotrophic factors. Invest Ophthalmol Vis Sci 2008, 49:1221-1231.
197. Leung K.W., Gvritishvili A., Liu Y., et al. ZIP2 and ZIP4 mediate age-related zinc fluxes across the retinal pigment epithelium. JMol Neurosci 2012, 46:122-137.
198. Leure-du Pree A.E., McClain C.J. The effect of severe zinc deficiency on the morphology of the rat retinal pigment epithelium. Invest Ophthalmol Vis Sci 1982, 23:425-434.
199. Levin L.A., Geszvain K.M. Expression of ceruloplasmin in the retina: induction after optic nerve crush. Invest Ophthalmol Vis Sci 1998, 39:157-163.
200. Li H., Wang H., Wang F., et al. Snail involves in the transforming growth factor β1-mediated epithelial-mesenchymal transition of retinal pigment epithelial cells. PLoS One 2011, 6:e23322.
201. Linder M.C., Lomeli N.A., Donley S., et al. Copper transport in mammals. Adv Exp Med Biol 1999, 448:1-16.
202. Link T.A., von Jagow G. Zinc ions inhibit the QP center of bovine heart mitochondrial bc1 complex by blocking a protonatable group. JBiol Chem 1995, 270:25001-25006.
203. Lowe N.M., Fekete K., Decsi T. Methods of assessment of zinc status in humans: a systematic review. Am J Clin Nutr 2009, 89:2040S-2051S.
204. Lu J., Stewart A.J., Sadler P.J., et al. Albumin as a zinc carrier: properties of its high-affinity zinc-binding site. Biochem Soc Trans 2008, 36:1317-1321.
205. Lubeck M.J. Papilledema caused by iron-deficiency anemia. Trans Am Acad Ophthalmol Otolaryngol 1959, 63:306-310.
206. Luo D.G., Yang X.L. Zn2+ differentially modulates signals from red- and short wavelength-sensitive cones to horizontal cells in carp retina. Brain Res 2001, 900:95-102.
207. Lutsenko S., Tsivkovskii R., Walker J.M. Functional properties of the human copper-transporting ATPase ATP7B (the Wilson's disease protein) and regulation by metallochaperone Atox1. Ann NY Acad Sci 2003, 986:204-211.
208. Lutsenko S., Bhattacharjee A., Hubbard A.L. Copper handling machinery of the brain. Metallomics 2010, 2:596-608.
209. Lynch S. Case studies: iron. Am J Clin Nutr 2011, 94:637S-678S.
210. Lovstad R.A. Akinetic study on the distribution of Cu(II)-ions between albumin and transferrin. Biometals 2004, 17:111-113.
211. Mackenzie B., Takanaga H., Hubert N., et al. Functional properties of multiple isoforms of human divalent metal-ion transporter 1 (DMT1). Biochem J 2007, 403:59-69.
212. MacPherson I.S., Murphy M.E. Type-2 copper-containing enzymes. Cell Mol Life Sci 2007, 64:2887-2899.
213. Mainous A.G., Diaz V.A., Everett C.J., et al. IRon Overload screeNing tool (IRON): development of a tool to guide screening in primary care. Am J Hematol 2011, 86:733-737.
214. Maret W. Metals on the move: zinc ions in cellular regulation and in the coordination dynamics of zinc proteins. Biometals 2011, 24:411-418.
215. Maret W. Molecular aspects of human cellular zinc homeostasis: redox control of zinc potentials and zinc signals. Biometals 2009, 22:149-157.
216. Marmolino D., Manto M. Pregabalin antagonizes copper-induced toxicity in the brain: invitro and invivo studies. Neurosignals 2010, 18:210-222.
217. Martin P.M., Gnana-Prakasam J.P., Roon P., et al. Expression and polarized localization of the hemochromatosis gene product HFE in retinal pigment epithelium. Invest Ophthalmol Vis Sci 2006, 47:4238-4244.
218. Masciulli L., Anderson D.R., Charles S. Experimental ocular siderosis in the squirrel monkey. Am J Ophthalmol 1972, 74:638-661.
219. Massie H.R., Aiello V.R., Banziger V. Iron accumulation and lipid peroxidation in aging C57BL/6J mice. Exp Gerontol 1983, 18:277-285.
220. Masuoka J., Saltman P. Zinc(II) and copper(II) binding to serum albumin. A comparative study of dog, bovine, and human albumin. JBiol Chem 1994, 269:25557-25561.
221. Materia S., Cater M.A., Klomp L.W., et al. Clusterin and COMMD1 independently regulate degradation of the mammalian copper-ATPases ATP7Aand ATP7B. JBiol Chem 2011, 287:2485-2499.
222. Mathie A., Sutton G.L., Clarke C.E., et al. Zinc and copper: pharmacological probes and endogenous modulators of neuronal excitability. Pharmacol Ther 2006, 111:567-583.
223. Matoba Y., Bando N., Oda K., et al. molecular mechanism for copper transportation to tyrosinase that is assisted by a metallochaperone, caddie protein. JBiol Chem 2011, 286:30219-30231.
224. Matsuoka Y., Hayasaka S., Yamada K. Incomplete occlusion of central retinal artery in a girl with iron deficiency anemia. Ophthalmologica 1996, 210:358-360.
225. McCormick L.D. Bound trace element content of bovine retinal disk membranes as determined by particle-induced x-ray emission. Biophys J 1985, 47:381-385.
226. Medvedeva Y.V., Lin B., Shuttleworth C.W., et al. Intracellular Zn2+accumulation contributes to synaptic failure, mitochondrial depolarization, and cell death in an acute slice oxygen-glucose deprivation model of ischemia. JNeurosci 2009, 29:1105-1114.
227. Miceli M.V., Tate D.J., Alcock N.W., et al. Zinc deficiency and oxidative stress in the retina of pigmented rats. Invest Ophthalmol Vis Sci 1999, 40:1238-1244.
228. Milman N., Schultz-Larsen K. Iron stores in 70-year-old Danish men and women. Evaluation in 469 individuals by serum ferritin and hemoglobin. Aging (Milano) 1994, 6:97-103.
229. Mishima K., Dake Y., Amemiya T., et al. Electron microscopic study of optic nerves of macular mice. Exp Eye Res 1996, 63:85-90.
230. Mishima K., Amemiya T., Takano K. X-ray microanalysis of melanin granules of retinal pigment epithelium and choroid in hereditary copper deficient mice (macular mice). Exp Eye Res 1999, 68:59-65.
231. Mochizuki K., Murase H., Imose M., et al. Improvement of scotopic electroretinograms and night blindness with recovery of serum zinc levels. Jpn J Ophthalmol 2006, 50:532-536.
232. Moiseyev G., Chen Y., Takahashi Y., et al. RPE65 is the isomerohydrolase in the retinoid visual cycle. Proc Natl Acad Sci USA 2005, 102:12413-12418.
233. Monga M., Walia V., Gandhi A., et al. Effect of iron deficiency anemia on visual evoked potential of growing children. Brain Dev 2010, 32:213-216.
234. Moos T., Bernth N., Courtois Y., et al. Developmental iron uptake and axonal transport in the retina of the rat. Mol Cell Neurosci 2011, 46:607-613.
235. Moriya M., Ho Y.H., Grana A., et al. Copper is taken up efficiently from albumin and alpha2-macroglobulin by cultured human cells by more than one mechanism. Am J Physiol Cell Physiol 2008, 295:C708-C721.
236. Morrison S.A., Russell R.M., Carney E.A., et al. Zinc deficiency: a cause of abnormal dark adaptation in cirrhotics. Am J Clin Nutr 1978, 31:276-281.
237. Moustafa S.A. Zinc might protect oxidative changes in the retina and pancreas at the early stage of diabetic rats. Toxicol Appl Pharmacol 2004, 201:149-155.
238. Muller P.A., Klomp L.W. ATOX1: a novel copper-responsive transcription factor in mammals?. Int J Biochem Cell Biol 2009, 41:1233-1236.
239. Murdanoto A.P., Sakai Y., Konishi T., et al. Purification and properties of methyl formate synthase, a mitochondrial alcohol dehydrogenase, participating in formaldehyde oxidation in methylotrophic yeasts. Appl Environ Microbiol 1997, 63:1715-1720.
240. Musallam K.M., Taher A.T. Iron chelation therapy for transfusional iron overload: a swift evolution. Hemoglobin 2011, 35:565-573.
241. Munoz M., García-Erce J.A., Remacha A.F. Disorders of iron metabolism. Part II: iron deficiency and iron overload. JClin Pathol 2011, 64:287-296.
242. Nagy B., Lehrer S.S. Circular dichroism of iron, copper, and zinc complexes of transferrin. Arch Biochem Biophys 1972, 148:27-36.
243. Naismith R.T., Shepherd J.B., Weihl C.C., et al. Acute and bilateral blindness due to optic neuropathy associated with copper deficiency. Arch Neurol 2009, 66:1025-1027.
244. Nakamichi N., Chidlow G., Osborne N.N. Effects of intraocular injection of a low concentration of zinc on the rat retina. Neuropharmacology 2003, 45:637-648.
245. Nam H., Knutson M.D. Effect of dietary iron deficiency and overload on the expression of ZIP metal-ion transporters in rat liver. Biometals 2012, 25:115-124.
246. Nan R., Gor J., Lengyel I., et al. Uncontrolled zinc- and copper-induced oligomerisation of the human complement regulator factor H and its possible implications for function and disease. JMol Biol 2008, 384:1341-1352.
247. Nandal A., Ruiz J.C., Subramanian P., et al. Activation of the HIF prolyl hydroxylase by the iron chaperones PCBP1 and PCBP2. Cell Metab 2011, 14:647-657.
248. Newsome D.A., Swartz M., Leone N.C., et al. Oral zinc in macular degeneration. Arch Ophthalmol 1988, 106:192-198.
249. Newsome D.A., Oliver P.D., Deupree D.M., et al. Zinc uptake by primate retinal pigment epithelium and choroid. Curr Eye Res 1992, 11:213-217.
250. Newsome D.A. Arandomized, prospective, placebo-controlled clinical trial of a novel zinc-monocysteine compound in age-related macular degeneration. Curr Eye Res 2008, 33:591-598.
251. Niciu M.J., Ma X.M., El Meskini R., et al. Altered ATP7A expression and other compensatory responses in a murine model of Menkes disease. Neurobiol Dis 2007, 27:278-291.
252. Nicolas M.G., Fujiki K., Murayama K., et al. Studies on the mechanism of early onset macular degeneration in cynomolgus monkeys. II. Suppression of metallothionein synthesis in the retina in oxidative stress. Exp Eye Res 1996, 62:399-408.
253. Niles B.J., Clegg M.S., Hanna L.A., et al. Zinc deficiency-induced iron accumulation, a consequence of alterations in iron regulatory protein-binding activity, iron transporters, and iron storage proteins. JBiol Chem 2008, 283:5168-5177.
254. Noh K.M., Koh J.Y. Induction and activation by zinc of NADPH oxidase in cultured cortical neurons and astrocytes. JNeurosci 2000, 20:RC111.
255. Noh K.M., Kim Y.H., Koh J.Y. Mediation by membrane protein kinase C of zinc-induced oxidative neuronal injury in mouse cortical cultures. JNeurochem 1999, 72:1609-1616.
256. Nose Y., Wood L.K., Kim B.E., et al. Ctr1 is an apical copper transporter in mammalian intestinal epithelial cells invivo that is controlled at the level of protein stability. JBiol Chem 2010, 285:32385-32392.
257. O'Dell B.L. Mineral interactions relevant to nutrient requirements. JNutr 1989, 119(12 Suppl):1832-1838.
258. O'Halloran T.V., Culotta V.C. Metallochaperones, an intracellular shuttle service for metal ions. JBiol Chem 2000, 275:25057-25060.
259. O'Neil-Cutting M.A., Bomford A., Munro H.N. Effect of excess dietary zinc on tissue storage of iron in rats. JNutr 1981, 111:1969-1979.
260. O'Shea J.G. Age-related macular degeneration: a leading cause of blindness. Med J Aust 1996, 165:561-564.
261. Obolensky A., Berenshtein E., Lederman M., et al. Zinc-desferrioxamine attenuates retinal degeneration in the rd10 mouse model of retinitis pigmentosa. Free Radic BiolMed 2011, 51:1482-1491.
262. Okawa H., Sampath A.P., Laughlin S.B., et al. ATP consumption by mammalian rod photoreceptors in darkness and in light. Curr Biol 2008, 18:1917-1921.
263. Organisciak D., Wong P., Rapp C., et al. Light-induced retinal degeneration is prevented by zinc, a component in the age-related eye disease study formulation. Photochem Photobiol 2012, 88:1396-1407.
264. Osaki S. Kinetic studies of ferrous ion oxidation with crystalline human ferroxidase (ceruloplasmin). JBiol Chem 1966, 241:5053-5059.
265. Osborne N.N., Wood J.P. The beta-adrenergic receptor antagonist metipranolol blunts zinc-induced photoreceptor and RPE apoptosis. Invest Ophthalmol Vis Sci 2006, 47:3178-3186.
266. Otteson D.C., Liu Y., Lai H., et al. Kruppel-like factor 15, a zinc-finger transcriptional regulator, represses the rhodopsin and interphotoreceptor retinoid-binding protein promoters. Invest Ophthalmol Vis Sci 2004, 45:2522-2530.
267. Palacios O., Atrian S., Capdevila M. Zn- and Cu-thioneins: a functional classification for metallothioneins?. JBiol Inorg Chem 2011, 16:991-1009.
268. Pandolfo M. Friedreich ataxia. Handb Clin Neurol 2012, 103:275-294.
269. Paradkar P.N., Zumbrennen K.B., Paw B.H., et al. Regulation of mitochondrial iron import through differential turnover of mitoferrin 1 and mitoferrin 2. Mol Cell Biol 2009, 29:1007-1016.
270. Park P.S., Sapra K.T., Kolinski M., et al. Stabilizing effect of Zn2+ in native bovine rhodopsin. JBiol Chem 2007, 282:11377-11385.
271. Patel B.N., David S. Anovel glycosylphosphatidylinositol-anchored form of ceruloplasmin is expressed by mammalian astrocytes. JBiol Chem 1997, 272:20185-20190.
272. Patterson A.J., Brown W.J., Powers J.R., et al. Iron deficiency, general health and fatigue: results from the Australian Longitudinal Study on Women's Health. Qual Life Res 2000, 9:491-497.
273. Pedraza-Chaverrí J., Torres-Rodríguez G.A., Cruz C., et al. Copper and zinc metabolism in aminonucleoside-induced nephrotic syndrome. Nephron 1994, 66:87-92.
274. Permyakov S.E., Cherskaya A.M., Wasserman L.A., et al. Recoverin is a zinc-binding protein. JProteome Res 2003, 2:51-57.
275. Petrak J., Vyoral D. Hephaestin-a ferroxidase of cellular iron export. Int J Biochem Cell Biol 2005, 37:1173-1178.
276. Picard E., Fontaine I., Jonet L., et al. The protective role of transferrin in Muller glial cells after iron-induced toxicity. Mol Vis 2008, 14:928-941.
277. Picard E., Jonet L., Sergeant C., et al. Overexpressed or intraperitoneally injected human transferrin prevents photoreceptor degeneration in rd10 mice. Mol Vis 2010, 16:2612-2625.
278. Picard E., Ranchon-Cole I., Jonet L., et al. Light-induced retinal degeneration correlates with changes in iron metabolism gene expression, ferritin level, and aging. Invest Ophthalmol Vis Sci 2011, 52:1261-1274.
279. Pineles S.L., Wilson C.A., Balcer L.J., et al. Combined optic neuropathy and myelopathy secondary to copper deficiency. Surv Ophthalmol 2010, 55:386-392.
280. Prasad A.S. Impact of the discovery of human zinc deficiency on health. JAm Coll Nutr 2009, 28:257-265.
281. Predki P.F., Sarkar B. Effect of replacement of "zinc finger" zinc on estrogen receptor DNA interactions. JBiol Chem 1992, 267:5842-5846.
282. Prodan C.I., Holland N.R., Wisdom P.J., et al. CNS demyelination associated with copper deficiency and hyperzincemia. Neurology 2002, 59:1453-1456.
283. Prohaska J.R., Bailey W.R. Regional specificity in alterations of rat brain copper and catecholamines following perinatal copper deficiency. JNeurochem 1994, 63:1551-1557.
284. Prohaska J.R., Gybina A.A. Intracellular copper transport in mammals. JNutr 2004, 134:1003-1006.
285. Punnonen K., Irjala K., Rajamaki A. Serum transferrin receptor and its ratio to serum ferritin in the diagnosis of iron deficiency. Blood 1997, 89:1052-1057.
286. Qian H., Li L., Chappell R.L., et al. GABA receptors of bipolar cells from the skate retina: actions of zinc on GABA-mediated membrane currents. JNeurophysiol 1997, 78:2402-2412.
287. Rahi A.H., Hungerford J.L., Ahmed A.I. Ocular toxicity of desferrioxamine: light microscopic histochemical and ultrastructural findings. Br J Ophthalmol 1986, 70:373-381.
288. Ramey G., Deschemin J.C., Vaulont S. Cross-talk between the mitogen activated protein kinase and bone morphogenetic protein/hemojuvelin pathways is required for the induction of hepcidin by holotransferrin in primary mouse hepatocytes. Haematologica 2009, 94:765-772.
289. Redenti S., Chappell R.L. Localization of zinc transporter-3 (ZnT-3) in mouse retina. Vision Res 2004, 44:3317-3321.
290. Redenti S., Chappell R.L. Neuroimaging of zinc released by depolarization of rat retinal cells. Vision Res 2005, 45:3520-3525.
291. Redenti S., Chappell R.L. Muller cell zinc transporter-3 labeling suggests a role in outer retina zinc homeostasis. Mol Med 2007, 13:376-379.
292. Redenti S., Ripps H., Chappell R.L. Zinc release at the synaptic terminals of rod photoreceptors. Exp Eye Res 2007, 85:580-584.
293. Richardson D.R., Lane D.J., Becker E.M., et al. Mitochondrial iron trafficking and the integration of iron metabolism between the mitochondrion and cytosol. Proc Natl Acad Sci USA 2010, 107:10775-10782.
294. Rinaldi M., Della Corte M., Ruocco V., et al. Ocular involvement correlated with age in patients affected by major and intermedia beta-thalassemia treated or not with desferrioxamine. Metab Pediatr Syst Ophthalmol 1993, 16:23-25.
295. Rink L., Gabriel P. Zinc and the immune system. Proc Nutr Soc 2000, 59:541-552.
296. Robinson N.J., Winge D.R. Copper metallochaperones. Annu Rev Biochem 2010, 79:537-562.
297. Rogers B.S., Symons R.C., Komeima K., et al. Differential sensitivity of cones to iron-mediated oxidative damage. Invest Ophthalmol Vis Sci 2007, 48:438-445.
298. Rogers J.M., Keen C.L., Hurley L.S. Zinc deficiency in pregnant Long-Evans hooded rats: teratogenicity and tissue trace elements. Teratology 1985, 31:89-100.
299. Roth A.M., Foos R.Y. Ocular pathologic changes in primary hemochromatosis. Arch Ophthalmol 1972, 87:507-514.
300. Rouault T.A., Tong W.H. Iron-sulphur cluster biogenesis and mitochondrial iron homeostasis. Nat Rev Mol Cell Biol 2005, 6:345-351.
301. Rowin J., Lewis S.L. Copper deficiency myeloneuropathy and pancytopenia secondary to overuse of zinc supplementation. JNeurol Neurosurg Psychiatry 2005, 76:750-751.
302. Saghizadeh M., Akhmedov N.B., Yamashita C.K., et al. ZBED4, a BED-type zinc-finger protein in the cones of the human retina. Invest Ophthalmol Vis Sci 2009, 50:3580-3588.
303. Saleh T., Green W. Bilateral reversible optic disc oedema associated with iron deficiency anaemia. Eye (Lond) 2000, 14:672-673.
304. Salmi M., Jalkanen S. VAP-1: an adhesin and an enzyme. Trends Immunol 2001, 22:211-216.
305. Samuelson D.A., Smith P., Ulshafer R.J., et al. X-ray microanalysis of ocular melanin in pigs maintained on normal and low zinc diets. Exp Eye Res 1993, 56:63-70.
306. Sarici S.U., Okutan V., Dundaroz M.R., et al. The effect of iron supplementation on visual-evoked potentials in infants with iron-deficiency anemia. JTrop Pediatr 2001, 47:132-135.
307. Sarkar B., Roberts E.A. The puzzle posed by COMMD1, a newly discovered protein binding Cu(II). Metallomics 2011, 3:20-27.
308. Satishchandra P., Ravishankar Naik K. Visual pathway abnormalities Wilson's disease: an electrophysiological study using electroretinography and visual evoked potentials. JNeurol Sci 2000, 176:13-20.
309. Schippert R., Burkhardt E., Feldkaemper M., et al. Relative axial myopia in Egr-1 (ZENK) knockout mice. Invest Ophthalmol Vis Sci 2007, 48:11-17.
310. Schlief M.L., Craig A.M., Gitlin J.D. NMDA receptor activation mediates copper homeostasis in hippocampal neurons. JNeurosci 2005, 25:239-246.
311. Schlief M.L., Gitlin J.D. Copper homeostasis in the CNS: a novel link between the NMDA receptor and copper homeostasis in the hippocampus. Mol Neurobiol 2006, 33:81-90.
312. Schmitt S., Kury S., Giraud M., et al. An update on mutations of the SLC39A4 gene in acrodermatitis enteropathica. Hum Mutat 2009, 30:926-933.
313. Sebastiani G., Pantopoulos K. Disorders associated with systemic or local iron overload: from pathophysiology to clinical practice. Metallomics 2011, 3:971-986.
314. Sensi S.L., Yin H.Z., Carriedo S.G., et al. Preferential Zn2+ influx through Ca2+-permeable AMPA/kainate channels triggers prolonged mitochondrial superoxide production. Proc Natl Acad Sci USA 1999, 96:2414-2419.
315. Sensi S.L., Jeng J.M. Rethinking the excitotoxic ionic milieu: the emerging role of Zn(2+) in ischemic neuronal injury. Curr Mol Med 2004, 4:87-111.
316. Sensi S.L., Paoletti P., Koh J.Y., et al. The neurophysiology and pathology of brain zinc. JNeurosci 2011, 31:16076-16085.
317. Sergeant C., Gouget B., Llabador Y., et al. Iron in hereditary retinal degeneration: PIXE microanalysis. Nuclear Instruments and Methods in Physics. Research 1999, 158:344-348.
318. Sergeant C., Vesvres M.S., Pravikoff M.S., et al. Trace metals in human retina during aging period. Metals Ions in Biology and Medicine 2004, vol. 8:491-495. John Libbey Eurotext, Paris.
319. Setty S.R., Tenza D., Sviderskaya E.V., et al. Cell-specific ATP7A transport sustains copper-dependent tyrosinase activity in melanosomes. Nature 2008, 454:1142-1146.
320. Shakespeare P.G. Studies on the serum levels of iron, copper and zinc and the urinary excretion of zinc after burn injury. Burns Incl Therm Inj 1982, 8:358-364.
321. Shang H.F., Jiang X.F., Burgunder J.M., et al. Novel mutation in the ceruloplasmin gene causing a cognitive and movement disorder with diabetes mellitus. Mov Disord 2006, 21:2217-2220.
322. Sharma S., Dimasi D., Higginson K., et al. RZF, a zinc-finger protein in the photoreceptors of human retina. Gene 2004, 342:219-229.
323. Shaw G.C., Cope J.J., Li L., Corson K., et al. Mitoferrin is essential for erythroid iron assimilation. Nature 2006, 440:96-100.
324. Sheikh S.P., Zvyaga T.A., Lichtarge O., et al. Rhodopsin activation blocked by metal-ion-binding sites linking transmembrane helices C andF. Nature 1996, 383:347-350.
325. Sheline C.T., Choi D.W. Cu2+ toxicity inhibition of mitochondrial dehydrogenases invitro and invivo. Ann Neurol 2004, 55:645-653.
326. Sheline C.T., Zhou Y., Bai S. Light-induced photoreceptor and RPE degeneration involve zinc toxicity and are attenuated by pyruvate, nicotinamide, or cyclic light. Mol Vis 2010, 16:2639-2652.
327. Shi H., Bencze K.Z., Stemmler T.L., et al. Acytosolic iron chaperone that delivers iron to ferritin. Science 2008, 320:1207-1210.
328. Shichi H. Microsomal electron transfer system of bovine retinal pigment epithelium. Exp Eye Res 1969, 8:60-68.
329. Shuster T.A., Nagy A.K., Conly D.C., et al. Direct zinc binding to purified rhodopsin and disc membranes. Biochem J 1992, 282:123-128.
330. Shuster T.A., Martin F., Nagy A.K. Zinc causes an apparent increase in rhodopsin phosphorylation. Curr Eye Res 1996, 15:1019-1024.
331. Siapich S.A., Wrubel H., Albanna W., et al. Effect of ZnCl2 and chelation of zinc ions by N, N-diethyldithiocarbamate (DEDTC) on the ERG b-wave amplitude from the isolated superfused vertebrate retina. Curr Eye Res 2010, 35:322-334.
332. Silverstone B.Z. Effects of zinc and copper metabolism in highly myopic patients. Ciba Found Symp 1990, 155:210-221.
333. Smidt K., Rungby J. ZnT3: a zinc transporter active in several organs. Biometals 2012, 25:1-8.
334. Sohal R.S., Wennberg-Kirch E., Jaiswal K., et al. Effect of age and caloric restriction on bleomycin-chelatable and nonheme iron in different tissues of C57BL/6 mice. Free Radic Biol Med 1999, 27:287-293.
335. Solomons N.W. Biochemical, metabolic, and clinical role of copper in human nutrition. JAm Coll Nutr 1985, 4:83-105.
336. Sooriyaarachchi M., Gailer J. Removal of Fe3+ and Zn2+ from plasma metalloproteins by iron chelating therapeutics depicted with SEC-ICP-AES. Dalton Trans 2010, 39:7466-7473.
337. Sorcinelli R., Sitzia A., Figus A., et al. Ocular findings in beta-thalassemia. Metab Pediatr Syst Ophthalmol 1990, 13:23-25.
338. Stoebner R., Kiser R., Alperin J.B. Iron deficiency anemia and papilledema. Rapid resolution with oral iron therapy. Am J Dig Dis 1970, 15:919-922.
339. Stojanovic A., Stitham J., Hwa J. Critical role of transmembrane segment zinc binding in the structure and function of rhodopsin. JBiol Chem 2004, 279:35932-35941.
340. Stur M., Tittl M., Reitner A., et al. Oral zinc and the second eye in age-related macular degeneration. Invest Ophthalmol Vis Sci 1996, 37:1225-1235.
341. Subramanian P., Rodrigues A.V., Ghimire-Rijal S., et al. Iron chaperones for mitochondrial Fe-S cluster biosynthesis and ferritin iron storage. Curr Opin Chem Biol 2011, 15:312-318.
342. Sun Y., Zhang Y.T., Gong H.Q., et al. The mechanisms of Zn2+ effects onCa2+-permeable AMPA receptors on carp retinal horizontal cells. Brain Res 2010, 1345:103-109.
343. Sun Z., Zhang D.Q., McMahon D.G. Zinc modulation of hemi-gap-junction channel currents in retinal horizontal cells. JNeurophysiol 2009, 101:1774-1780.
344. Suzuki K.T., Someya A., Komada Y., et al. Roles of metallothionein in copper homeostasis: responses to Cu-deficient diets in mice. JInorg Biochem 2002, 88:173-182.
345. Takeda T., Kimura M., Yokoi K., et al. Effect of age and dietary protein level on tissue mineral levels in female rats. Biol Trace Elem Res 1996, 54:55-74.
346. Tam S.W., Wilber K.E., Wagner F.W. Light sensitive zinc content of protein fractions from bovine rod outer segments. Biochem Biophys Res Commun 1976, 72:302-309.
347. Tamada Y., Walkup R.D., Shearer T.R., et al. Contribution of calpain to cellular damage in human retinal pigment epithelial cells cultured with zinc chelator. Curr Eye Res 2007, 32:565-573.
348. Taneja R., Malik P., Sharma M., et al. Multiple transfused thalassemia major: ocular manifestations in a hospital-based population. Indian J Ophthalmol 2010, 58:125-130.
349. Tate D.J., Newsome D.A., Oliver P.D. Metallothionein shows an age-related decrease in human macular retinal pigment epithelium. Invest Ophthalmol Vis Sci 1993, 34:2348-2351.
350. Tate D.J., Miceli M.V., Newsome D.A. Zinc protects against oxidative damage in cultured human retinal pigment epithelial cells. Free Radic Biol Med 1999, 26:704-713.
351. Tate D.J., Miceli M.V., Newsome D.A., et al. Influence of zinc on selected cellular functions of cultured human retinal pigment epithelium. Curr Eye Res 1995, 14:897-903.
352. Tate D.J., Miceli M.V., Newsome D.A. Expression of metallothionein isoforms in human chorioretinal complex. Curr Eye Res 2002, 24:12-25.
353. Theil E.C. Iron homeostasis and nutritional iron deficiency. JNutr 2011, 141:724S-728S.
354. Toledo D., Cordomi, Proietti M.G., et al. Structural characterization of a zinc high-affinity binding site in rhodopsin. Photochem Photobiol 2009, 85:479-484.
355. Trujillo M.H., Desenne J.J., Pinto H.B. Reversible papilledema in iron deficiency anemia. Two cases with normal spinal fluid pressure. Ann Ophthalmol 1972, 4:378-380.
356. Uehara F., Matthes M.T., Yasumura D., et al. Light-evoked changes in the interphotoreceptor matrix. Science 1990, 248:1633-1636.
357. Ugarte M., Osborne N.N. The localization of endogenous zinc and the invitro effect of exogenous zinc on the GABA immunoreactivity and formation of reactive oxygen species in the retina. Gen Pharmacol 1998, 30:297-303.
358. Ugarte M., Osborne N.N. The localization of free zinc varies in rat photoreceptors during light and dark adaptation. Exp Eye Res 1999, 69:459-461.
359. Ugarte M., Osborne N.N. Zinc in the retina. Prog Neurobiol 2001, 64:219-249.
360. Ugarte M., Nicol D.A., Jones N.P., et al. Chronic intraocular copper foreign body and candida: a unique combination. Ocul Immunol Inflamm 2009, 17:356-360.
361. Ugarte M., Grime G.W., Lord G., et al. Concentration of various trace elements in the rat retina and their distribution in different structures. Metallomics 2012, 4:1245-1254.
362. Vallee B.L., Falchuk K.H. The biochemical basis of zinc physiology. Physiol Rev 1993, 73:79-118.
363. VandenLangenberg G.M., Mares-Perlman J.A., Klein R., et al. Associations between antioxidant and zinc intake and the 5-year incidence of early age-related maculopathy in the Beaver Dam Eye Study. Am J Epidemiol 1998, 148:204-214.
364. Veldhuis N.A., Valova V.A., Gaeth A.P., et al. Phosphorylation regulates copper-responsive trafficking of the Menkes copper transporting P-type ATPase. Int J Biochem Cell Biol 2009, 41:2403-2412.
365. Vergara O., Ogden T., Ryan S. Posterior penetrating injury in the rabbit eye: effect of blood and ferrous ions. Exp Eye Res 1989, 49:1115-1126.
366. Vilardaga J.P., Frank M., Krasel C., et al. Differential conformational requirements for activation of G proteins and the regulatory proteins arrestin and G protein-coupled receptor kinase in the G protein-coupled receptor for parathyroid hormone (PTH)/PTH-related protein. JBiol Chem 2001, 276:33435-33443.
367. Vollrath D., Feng W., Duncan J.L., et al. Correction of the retinal dystrophy phenotype of the RCS rat by viral gene transfer of Mertk. Proc Natl Acad Sci USA 2001, 98:12584-12589.
368. Vulpe C.D., Kuo Y.M., Murphy T.L., et al. Hephaestin, a ceruloplasmin homologue implicated in intestinal iron transport, is defective in the sla mouse. Nat Genet 1999, 21:195-199.
369. Vulpe C., Levinson B., Whitney S., et al. Isolation of a candidate gene for Menkes disease and evidence that it encodes a copper-transporting ATPase. Nat Genet 1993, 3:7-13. Erratum in: Nat Genet 1993;3:273.
370. Walters G.O., Miller F.M., Worwood M. Serum ferritin concentration and iron stores in normal subjects. JClin Pathol 1973, 26:770-772.
371. Wang W., Knovich M.A., Coffman L.G., et al. Serum ferritin: past, present and future. Biochim Biophys Acta 2010, 1800:760-769.
372. Wang X., Wang Z.Y., Gao H.L., et al. Localization of ZnT7 and zinc ions in mouse retina-immunohistochemistry and selenium autometallography. Brain Res Bull 2006, 71:91-96.
373. Wang Z.J., Lam K.W., Lam T.T., et al. Iron-induced apoptosis in the photoreceptor cells of rats. Invest Ophthalmol Vis Sci 1998, 39:631-633.
374. Wastney M.E., Aamodt R.L., Rumble W.F., et al. Kinetic analysis of zinc metabolism and its regulation in normal humans. Am J Physiol 1986, 251:R398-R408.
375. Watabe Y., Baba Y., Nakauchi H., et al. The role of Zic family zinc finger transcription factors in the proliferation and differentiation of retinal progenitor cells. Biochem Biophys Res Commun 2011, 415:42-47.
376. Webb M., Cain K. Functions of metallothionein. Biochem Pharmacol 1982, 31:137-142.
377. Wills M.S., Monaghan S.A., Miller M.L., et al. Zinc-induced copper deficiency: a report of three cases initially recognized on bone marrow examination. Am J Clin Pathol 2005, 123:125-131.
378. Wills N.K., Ramanujam V.M., Kalariya N., et al. Copper and zinc distribution in the human retina: relationship to cadmium accumulation, age, and gender. Exp Eye Res 2008, 87:80-88.
379. Wills N.K., Kalariya N., Sadagopa Ramanujam V.M., et al. Human retinal cadmium accumulation as a factor in the etiology of age-related macular degeneration. Exp Eye Res 2009, 89:79-87.
380. Wish J.B. Assessing iron status: beyond serum ferritin and transferrin saturation. Clin J Am Soc Nephrol 2006, 1(Suppl 1)):S4-S8.
381. Wolkow N., Song Y., Wu T.D., et al. Aceruloplasminemia: retinal histopathologic manifestations and iron-mediated melanosome degradation. Arch Ophthalmol 2011, 129:1466-1474.
382. Wolkow N., Song D., Song Y., et al. Ferroxidase hephaestin's cell-autonomous role in the retinal pigment epithelium. Am J Pathol 2012, 180:1614-1624.
383. Wong R.W., Richa D.C., Hahn P., et al. Iron toxicity as a potential factor in AMD. Retina 2007, 27:997-1003.
384. Wray S.H., Kuwabara T., Sanderson P. Menkes' kinky hair disease: a light and electron microscopic study of the eye. Invest Ophthalmol 1976, 15:128-138.
385. Wu L., Cao X.Y., Chen Y., et al. Metabolic disturbance in age-related macular degeneration. Metab Pediatr Syst Ophthalmol 1994, 17:38-40.
386. Wu Y.H., Frey A.G., Eide D.J. Transcriptional regulation of the Zrg17 zinc transporter of the yeast secretory pathway. Biochem J 2011, 435:259-266.
387. Wunderlich K.A., Leveillard T., Penkowa M., et al. Altered expression of metallothionein-I and -II and their receptor megalin in inherited photoreceptor degeneration. Invest Ophthalmol Vis Sci 2010, 51:4809-4820.
388. Wysokinski D., Danisz K., Blasiak J., et al. An association of transferrin gene polymorphism and serum transferrin levels with age-related macular degeneration. Exp Eye Res 2013, 106:14-23.
389. Wysokinski D., Zaras M., Dorecka M., et al. An association between environmental factors and the IVS4+44C>A polymorphism of the DMT1 gene in age-related macular degeneration. Graefes Arch Clin Exp Ophthalmol 2012, 250:1057-1065.
390. Xu X., Pin S., Gathinji M., et al. Aceruloplasminemia: an inherited neurodegenerative disease with impairment of iron homeostasis. Ann NY Acad Sci 2004, 1012:299-305.
391. Yamaguchi K., Takahashi S., Kawanami T., et al. Retinal degeneration in hereditary ceruloplasmin deficiency. Ophthalmologica 1998, 212:11-14.
392. Yamasaki S., Sakata-Sogawa K., Hasegawa A., et al. Zinc is a novel intracellular second messenger. JCell Biol 2007, 177:637-645.
393. Yau K.W., Baylor D.A. Cyclic GMP-activated conductance of retinal photoreceptor cells. Annu Rev Neurosci 1989, 12:289-327.
394. Ye H., Rouault T.A. Human iron-sulfur cluster assembly, cellular iron homeostasis, and disease. Biochemistry 2010, 49:4945-4956.
395. Yefimova M.G., Jeanny J.C., Guillonneau X., et al. Iron, ferritin, transferrin, and transferrin receptor in the adult rat retina. Invest Ophthalmol Vis Sci 2000, 41:2343-2351.
396. Yefimova M.G., Jeanny J.C., Keller N., et al. Impaired retinal iron homeostasis associated with defective phagocytosis in Royal College of Surgeons rats. Invest Ophthalmol Vis Sci 2002, 43:537-545.
397. Yim M.B., Chock P.B., Stadtman E.R. Enzyme function of copper, zinc superoxide dismutase as a free radical generator. JBiol Chem 1993, 268:4099-4105.
398. Yin S.J., Chou C.F., Lai C.L., et al. Human class IV alcohol dehydrogenase: kinetic mechanism, functional roles and medical relevance. Chem Biol Interact 2003, 143-144:219-227.
399. Yoo M.H., Lee J.Y., Lee S.E., et al. Protection by pyruvate of rat retinal cells against zinc toxicity invitro, and pressure-induced ischemia invivo. Invest Ophthalmol Vis Sci 2004, 45:1523-1530.
400. Yoshikawa S., Muramoto K., Shinzawa-Itoh K. Proton-pumping mechanism of cytochrome C oxidase. Annu Rev Biophys 2011, 40:205-223.
401. Yoshikumi Y., Mashima H., Ueda N., et al. Roles of CTPL/Sfxn3 and Sfxn family members in pancreatic islet. JCell Biochem 2005, 95:1157-1168.
402. Yu D.Y., Cringle S.J. Retinal degeneration and local oxygen metabolism. Exp Eye Res 2005, 80:745-751.
403. Yu T.Y., Acosta M.L., Ready S., et al. Light exposure causes functional changes in the retina: increased photoreceptor cation channel permeability, photoreceptor apoptosis, and altered retinal metabolic function. JNeurochem 2007, 103:714-724.
404. Zatta P., Frank A. Copper deficiency and neurological disorders in man and animals. Brain Res Rev 2007, 54:19-33.
405. Zauber N.P., Zauber A.G. Hematologic data of healthy very old people. JAMA 1987, 257:2181-2184.
406. Zhang D.Q., Sun Z., McMahon D.G. Modulation of A-type potassium currents in retinal horizontal cells by extracellular calcium and zinc. Vis Neurosci 2006, 23:825-832.
407. Zhang J., Jin Z., Bao Z.Z. Disruption of gradient expression of Zic3 resulted in abnormal intra-retinal axon projection. Development 2004, 131:1553-1562.
408. Zhang Q., Mashima Y., Noda S., et al. Characterization of AOC2 gene encoding a copper-binding amine oxidase expressed specifically in retina. Gene 2003, 318:45-53.
409. Zimmermann M.B., Hurrell R.F. Nutritional iron deficiency. Lancet 2007, 370:511-520.
410. Zimmermann M.B. Methods to assess iron and iodine status. Br J Nutr 2008, 99(Suppl 3):S2-S9.