Strong labeling for iron and the iron-handling proteins ferritin and ferroportin in the photoreceptor layer in age-related macular degeneration

Archives of Ophthalmology

Volumn 123, Issue 12, 2005, Pages 1745-1746

  Dentchev, Tzvete ^b   Hahn, Paul ^b   Dunaief, Joshua L ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

FERRITIN; FERROPORTIN 1;

AGED; ARTICLE; AUTOPSY; CASE REPORT; CELL LABELING; EVIDENCE BASED MEDICINE; HUMAN; MALE; OXIDATIVE STRESS; PHOTORECEPTOR; PRIORITY JOURNAL; RETINA MACULA AGE RELATED DEGENERATION;

AGED; ATROPHY; CATION TRANSPORT PROTEINS; FERRITINS; HUMANS; IMMUNOENZYME TECHNIQUES; MACULAR DEGENERATION; MALE; PHOTORECEPTORS, VERTEBRATE;

EID: 28944437164     PISSN: 00039950     EISSN: 00039950     Source Type: Journal    
DOI: 10.1001/archopht.123.12.1745     Document Type: Article

References (8)

1. Klein R, Wang Q, Klein BE, Moss SE, Meuer SM. The relationship of age-related maculopathy, cataract, and glaucoma to visual acuity. Invest Ophthalmol Vis Sci. 1995;36:182-191.
2. Age-Related Eye Disease Study Research Group. A randomized, placebo-controlled, clinical trial of high-dose supplementation with vitamins C and E, beta carotene, and zinc for age-related macular degeneration and vision loss: AREDS report No. 8. Arch Ophthalmol. 2001;119:1417-1436.
3. Dunaief JL, Richa C, Franks EP, et al. Macular degeneration in a patient with aceruloplasminemia, a disease associated with retinal iron overload. Ophthalmology. 2005;112:1062-1065.
4. Yefimova MG, Jeanny JC, Keller N, et al. Impaired retinal iron homeostasis associated with defective phagocytosis in Royal College of Surgeons rats. Invest Ophthalmol Vis Sci. 2002;43:537-545.
5. Dunaief JL, Dentchev T, Ying G-S, Milam AH. The role of apoptosis in age-related macular degeneration. Arch Ophthalmol. 2002;120:1435-1442.
6. Rouault TA. Iron on the brain. Nat Genet. 2001;28:299-300.
7. Hahn P, Qian Y, Dentchev T, et al. Disruption of ceruloplasmin and hephaestin in mice causes retinal iron overload and retinal degeneration with features of age-related macular degeneration. Proc Natl Acad Sci U S A. 2004;101:13 850-13 855.
8. Hahn P, Dentchev T, Qian Y, Rouault T, Harris ZL, Dunaief JL. Immunolocalization and regulation of iron handling proteins ferritin and ferroportin in the retina. Mol Vis. 2004;10:598-607.