Ferroxidase hephaestin's cell-autonomous role in the retinal pigment epithelium

American Journal of Pathology

Volumn 180, Issue 4, 2012, Pages 1614-1624

  Wolkow, Natalie ^a   Song, Delu ^a   Song, Ying ^a   Chu, Sally ^a   Hadziahmetovic, Majda ^a   Lee, Jennifer C ^a   Iacovelli, Jared ^a   Grieco, Steven ^a   Dunaief, Joshua L ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID PRECURSOR PROTEIN; CERULOPLASMIN; HEPHAESTIN; IRON; PROTEIN; UNCLASSIFIED DRUG; ZYKLOPEN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL LEVEL; GENE SILENCING; IRON TRANSPORT; KNOCKOUT MOUSE; MOUSE; MUELLER CELL; NONHUMAN; PHOTORECEPTOR CELL; PIGMENT EPITHELIUM; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; RETINA PIGMENT DEGENERATION; TISSUE LEVEL;

ANIMALS; CELLS, CULTURED; CERULOPLASMIN; DISEASE MODELS, ANIMAL; IRON; MACULAR DEGENERATION; MEMBRANE PROTEINS; MICE; MICE, KNOCKOUT; MUTATION; PHOTORECEPTOR CELLS, VERTEBRATE; PROTO-ONCOGENE PROTEINS PP60(C-SRC); RETINAL NEURONS; RETINAL PIGMENT EPITHELIUM;

EID: 84859085424     PISSN: 00029440     EISSN: 15252191     Source Type: Journal    
DOI: 10.1016/j.ajpath.2011.12.041     Document Type: Article

References (39)

1. B.A. Syed, N.J. Beaumont, A. Patel, C.E. Naylor, H.K. Bayele, C.L. Joannou, P.S. Rowe, R.W. Evans, S.K. Srai Analysis of the human hephaestin gene and protein: comparative modelling of the N-terminus ecto-domain based upon ceruloplasmin Protein Eng 15 2002 205 214
2. C.D. Vulpe, Y.M. Kuo, T.L. Murphy, L. Cowley, C. Askwith, N. Libina, J. Gitschier, G.J. Anderson Hephaestin, a ceruloplasmin homologue implicated in intestinal iron transport, is defective in the sla mouse Nat Genet 21 1999 195 199
3. I. De Domenico, D.M. Ward, M.C. di Patti, S.Y. Jeong, S. David, G. Musci, J. Kaplan Ferroxidase activity is required for the stability of cell surface ferroportin in cells expressing GPI-ceruloplasmin EMBO J 26 2007 2823 2831
4. P. Hahn, Y. Qian, T. Dentchev, L. Chen, J. Beard, Z.L. Harris, J.L. Dunaief Disruption of ceruloplasmin and hephaestin in mice causes retinal iron overload and retinal degeneration with features of age-related macular degeneration Proc Natl Acad Sci U S A 101 2004 13850 13855
5. G. Moiseyev, Y. Takahashi, Y. Chen, S. Gentleman, T.M. Redmond, R.K. Crouch, J.X. Ma RPE65 is an iron(II)-dependent isomerohydrolase in the retinoid visual cycle J Biol Chem 281 2006 2835 2840
6. N. Wolkow, Y. Song, T. Wu, J. Qian, J. Guerquin-Kern, J.L. Dunaief Aceruloplasminemia: retinal histopathologic manifestations and iron-mediated melanosome degradation Arch Ophthalmol 129 2011 1466 1474
7. P. Hahn, A.H. Milam, J.L. Dunaief Maculas affected by age-related macular degeneration contain increased chelatable iron in the retinal pigment epithelium and Bruch's membrane Arch Ophthalmol 121 2003 1099 1105
8. R.W. Young The renewal of photoreceptor cell outer segments J Cell Biol 33 1967 61 72
9. J.K. McBee, K. Palczewski, W. Baehr, D.R. Pepperberg Confronting complexity: the interlink of phototransduction and retinoid metabolism in the vertebrate retina Prog Retin Eye Res 20 2001 469 529
10. A. Gal, Y. Li, D.A. Thompson, J. Weir, U. Orth, S.G. Jacobson, E. Apfelstedt-Sylla, D. Vollrath Mutations in MERTK, the human orthologue of the RCS rat retinal dystrophy gene, cause retinitis pigmentosa Nat Genet 26 2000 270 271
11. S.M. Gu, D.A. Thompson, C.R. Srikumari, B. Lorenz, U. Finckh, A. Nicoletti, K.R. Murthy, M. Rathmann, G. Kumaramanickavel, M.J. Denton, A. Gal Mutations in RPE65 cause autosomal recessive childhood-onset severe retinal dystrophy Nat Genet 17 1997 194 197
12. L. Chen, T. Dentchev, R. Wong, P. Hahn, R. Wen, J. Bennett, J.L. Dunaief Increased expression of ceruloplasmin in the retina following photic injury Mol Vis 9 2003 151 158
13. B.N. Patel, R.J. Dunn, S.Y. Jeong, Q. Zhu, J.P. Julien, S. David Ceruloplasmin regulates iron levels in the CNS and prevents free radical injury J Neurosci 22 2002 6578 6586
14. J. Iacovelli, C. Zhao, N. Wolkow, P. Veldman, K. Gollomp, P. Ojha, N. Lukinova, A. King, L. Feiner, N. Esumi, D.J. Zack, E.A. Pierce, D. Vollrath, J.L. Dunaief Generation of Cre transgenic mice with postnatal RPE-specific ocular expression Invest Ophthalmol Vis Sci 52 2011 1378 1383
15. Y.Z. Le, L. Zheng, W. Zheng, J.D. Ash, M.P. Agbaga, M. Zhu, R.E. Anderson Mouse opsin promoter-directed Cre recombinase expression in transgenic mice Mol Vis 12 2006 389 398
16. Z.L. Harris, A.P. Durley, T.K. Man, J.D. Gitlin Targeted gene disruption reveals an essential role for ceruloplasmin in cellular iron efflux Proc Natl Acad Sci U S A 96 1999 10812 10817
17. M. Hadziahmetovic, Y. Song, N. Wolkow, J. Iacovelli, L. Kautz, M.P. Roth, J.L. Dunaief Bmp6 regulates retinal iron homeostasis and has altered expression in age-related macular degeneration Am J Pathol 179 2011 335 348
18. M. Hadziahmetovic, Y. Song, P. Ponnuru, J. Iacovelli, A. Hunter, N. Haddad, J. Beard, J.R. Connor, S. Vaulont, J.L. Dunaief Age-dependent retinal iron accumulation and degeneration in hepcidin knockout mice Invest Ophthalmol Vis Sci 52 2011 109 118
19. A.A. Davis, R.C. Hunt Transferrin is made and bound by photoreceptor cells J Cell Physiol 156 1993 280 285
20. W. Chen, H. Lu, K. Dutt, A. Smith, D.M. Hunt, R.C. Hunt Expression of the protective proteins hemopexin and haptoglobin by cells of the neural retina Exp Eye Res 67 1998 83 93
21. X. Du, E. She, T. Gelbart, J. Truksa, P. Lee, Y. Xia, K. Khovananth, S. Mudd, N. Mann, E.M. Moresco, E. Beutler, B. Beutler The serine protease TMPRSS6 is required to sense iron deficiency Science 320 2008 1088 1092
22. A.R. Folgueras, F.M. de Lara, A.M. Pendas, C. Garabaya, F. Rodriguez, A. Astudillo, T. Bernal, R. Cabanillas, C. Lopez-Otin, G. Velasco Membrane-bound serine protease matriptase-2 (Tmprss6) is an essential regulator of iron homeostasis Blood 112 2008 2539 2545
23. M. Hadziahmetovic, T. Dentchev, Y. Song, N. Haddad, X. He, P. Hahn, D. Pratico, R. Wen, Z.L. Harris, J.D. Lambris, J. Beard, J.L. Dunaief Ceruloplasmin/hephaestin knockout mice model morphologic and molecular features of AMD Invest Ophthalmol Vis Sci 49 2008 2728 2736
24. P.M. Harrison, P. Arosio The ferritins: molecular properties, iron storage function and cellular regulation Biochim Biophys Acta 1275 1996 161 203
25. I. Solovei, M. Kreysing, C. Lanctot, S. Kosem, L. Peichl, T. Cremer, J. Guck, B. Joffe Nuclear architecture of rod photoreceptor cells adapts to vision in mammalian evolution Cell 137 2009 356 368
26. K. Franze, J. Grosche, S.N. Skatchkov, S. Schinkinger, C. Foja, D. Schild, O. Uckermann, K. Travis, A. Reichenbach, J. Guck Muller cells are living optical fibers in the vertebrate retina Proc Natl Acad Sci U S A 104 2007 8287 8292
27. J.P. Gnana-Prakasam, P.M. Martin, B.A. Mysona, P. Roon, S.B. Smith, V. Ganapathy Hepcidin expression in mouse retina and its regulation via lipopolysaccharide/Toll-like receptor-4 pathway independent of Hfe Biochem J 411 2008 79 88
28. M.J. Hogan, J.A. Alvarado, J.E. Weddell Histology of the Human Eye: An Atlas and Textbook 1971 Saunders Philadelphia
29. S. Sisak, E. Banin, E.Z. Blumenthal A two-compartment model of the human retina Med Hypotheses 62 2004 808 816
30. T. Moos, N. Bernth, Y. Courtois, E.H. Morgan Developmental iron uptake and axonal transport in the retina of the rat Mol Cell Neurosci 46 2011 607 613
31. H. Chen, Z.K. Attieh, T. Su, B.A. Syed, H. Gao, R.M. Alaeddine, T.C. Fox, J. Usta, C.E. Naylor, R.W. Evans, A.T. McKie, G.J. Anderson, C.D. Vulpe Hephaestin is a ferroxidase that maintains partial activity in sex-linked anemia mice Blood 103 2004 3933 3939
32. J.R. Burdo, D.A. Antonetti, E.B. Wolpert, J.R. Connor Mechanisms and regulation of transferrin and iron transport in a model blood-brain barrier system Neuroscience 121 2003 883 890
33. J. Fisher, K. Devraj, J. Ingram, B. Slagle-Webb, A.B. Madhankumar, X. Liu, M. Klinger, I.A. Simpson, J.R. Connor Ferritin: a novel mechanism for delivery of iron to the brain and other organs Am J Physiol Cell Physiol 293 2007 C641 C649
34. S.T. Chen, A.J. Patel, L.J. Garey, L.S. Jen Expression of beta-amyloid precursor protein immunoreactivity in the retina of the rat during normal development and after neonatal optic tract lesion Neuroreport 8 1997 713 717
35. M.G. Yefimova, J.C. Jeanny, N. Keller, C. Sergeant, X. Guillonneau, C. Beaumont, Y. Courtois Impaired retinal iron homeostasis associated with defective phagocytosis in Royal College of Surgeons rats Invest Ophthalmol Vis Sci 43 2002 537 545
36. M.G. Yefimova, J.C. Jeanny, X. Guillonneau, N. Keller, J. Nguyen-Legros, C. Sergeant, F. Guillou, Y. Courtois Iron, ferritin, transferrin, and transferrin receptor in the adult rat retina Invest Ophthalmol Vis Sci 41 2000 2343 2351
37. K. Sugasawa, J. Deguchi, T. Okami, A. Yamamoto, K. Omori, M. Uyama, Y. Tashiro Immunocytochemical analyses of distributions of Na, K-ATPase and GLUT1, insulin and transferrin receptors in the developing retinal pigment epithelial cells Cell Struct Funct 19 1994 21 28
38. R.C. Hunt, A. Dewey, A.A. Davis Transferrin receptors on the surfaces of retinal pigment epithelial cells are associated with the cytoskeleton J Cell Sci 92 Pt 4 1989 655 666
39. R.C. Hunt, A.A. Davis Release of iron by human retinal pigment epithelial cells J Cell Physiol 152 1992 102 110