Positional cloning of zebrafish ferroportin1 identifies a conserved vertebrate iron exporter

Nature

Volumn 403, Issue 6771, 2000, Pages 776-781

  Donovan, Adriana ^a   Brownlie, Alison ^a   Zhou, Yi ^a   Shepard, Jennifer ^a   Pratt, Stephen J ^b   Moynihan, John ^a   Paw, Barry H ^a   Drejer, Anna ^a   Barut, Bruce ^a   Zapata, Agustin ^c   Law, Terence C ^a   Brugnara, Carlo ^a   Lux, Samuel E ^a   Pinkus, Geraldine S ^d   Pinkus, Jack L ^d   Kingsley, Paul D ^e   Palls, James ^e   Fleming, Mark D ^a,d   Andrews, Nancy C ^a   Leonard I, Zon ^a  

^a BOSTON CHILDREN S HOSPITAL   (United States)

^b WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSIDAD COMPLUTENSE DE MADRID   (Spain)

^d BRIGHAM AND WOMEN S HOSPITAL   (United States)

^e UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

IRON; MEMBRANE PROTEIN;

ANIMAL CELL; ARTICLE; BASOLATERAL MEMBRANE; CONTROLLED STUDY; INTESTINE CELL; IRON ABSORPTION; IRON TRANSPORT; MOLECULAR CLONING; NONHUMAN; NUCLEOTIDE SEQUENCE; PLACENTAL TRANSFER; PRIORITY JOURNAL; PROTEIN EXPRESSION; ZEBRA FISH;

AMINO ACID SEQUENCE; ANIMALS; CARRIER PROTEINS; CATION TRANSPORT PROTEINS; CHROMOSOME WALKING; CLONING, MOLECULAR; EMBRYO, NONMAMMALIAN; ENTEROCYTES; ERYTHROCYTES; EVOLUTION, MOLECULAR; HEMOGLOBINS; HUMANS; INTESTINES; IRON; MICE; MOLECULAR SEQUENCE DATA; MUTATION; OPEN READING FRAMES; PHENOTYPE; PLACENTA; SEQUENCE HOMOLOGY, AMINO ACID; TISSUE DISTRIBUTION; XENOPUS; YOLK SAC; ZEBRAFISH;

EID: 0034677467     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/35001596     Document Type: Article

References (29)

1. Fleming, M. D. et al. Microcytic anemia mice have a mutation in Nramp2, a candidate iron transporter gene. Nature Genet. 16, 383-386 (1997).
2. Gunshin, H. et al. Cloning and characterization of a mammalian proton-coupled metal-ion transporter. Nature 388, 482-488 (1997).
3. Andrews, N. C. Disorders of iron metabolism. N. Engl. J. Med. 341, 1986-1993 (1999).
4. Haffter, P. et al. The identification of genes with unique and essential functions in the development of the zebrafish, Danio rerio. Development 123, 1-36 (1996).
5. Ransom, D. G. et al. Characterization of zebrafish mutants with defects in embryonic hematopoiesis. Development 123, 311-319 (1996).
6. Ransom, D. G. & Zon, L. I. in The Zebrafish: Genetics and Genomics (eds Detrich, H. W. I., Westerfield, M. & Zon, L. I.) 195-210 (Academic, San Diego, 1999).
7. Vos, P. et al. AFLP: a new technique for DNA fingerprinting. Nucleic Acids Res. 23, 4407-4414 (1995).
8. Postlethwait, J. H. et al. Vertebrate genome evolution and the zebrafish gene map. Nature Genet. 18, 345-349 (1998).
9. Eisenstein, R. S. & Blemings, K. P. Iron regulatory proteins, iron responsive elements and iron homeostasis. J. Nutr. 128, 2295-2298 (1998).
10. Kimmel, C. B., Ballard, W. W., Kimmel, S. R., Ullmann, B. & Schilling, T. F. Stages of embryonic development of the zebrafish. Dev. Dyn. 203, 253-310 (1995).
11. Richards, M. P. Trace mineral metabolism in the avian embryo. Poult. Sci. 76, 152-164 (1997).
12. Dumont, J. N. Oogenesis in Xenopus laevis (Daudin). VI. The route of injected tracer transport in the follicle and developing oocyte. J. Exp. Zool. 204, 193-217 (1978).
13. Craik, J. C. Levels of calcium and iron in the ovaries and eggs of cod Gadus morhua L. and plaice Pleuronectes platessa L. Comp. Biochem. Physiol. A. 83, 515-517 (1986).
14. Al-Adhami, M. A. & Kunz, Y. W. Ontogenesis of haematopoietic sites in brachydanio rerio (Hamilton-Buchanan) (Teleostei). Develop. Growth Differ. 19, 171-179 (1977).
15. Rieb, J.-P. La circulation sangunie chez l'embryon de Brachydanio rerio. Annales d'Embryologie et de Morphogenese 6, 43-54 (1973).
16. Bannerman, R. M. Genetic defects of iron transport. Fed. Proc. 35, 2281-2285 (1976).
17. Kingston, P. J., Bannerman, C. E. & Bannerman, R. M. Iron deficiency anaemia in newborn sla mice: a genetic defect of placental iron transport. Br. J. Haematol. 40, 265-276 (1978).
18. Vulpe, C. D. et al. Hephaestin, a ceruloplasmin homologue implicated in intestinal iron transport, is defective in the sla mouse. Nature Genet. 21, 195-199 (1999).
19. Askwith, C. et al. The FET3 gene of S. cerevisiae encodes a multicopper oxidase required for ferrous iron uptake. Cell 76, 403-410 (1994).
20. Stearman, R., Yuan, D. S., Yamaguchi-Iwai, Y., Klausner, R. D. & Dancis, A. A permease-oxidase complex involved in high-affinity iron uptake in yeast. Science 271, 1552-1557 (1996).
21. Westerfield, M. The Zebrafish Book (Univ. Oregon Press, Eugene, 1993).
22. Thompson, M. A. et al. The cloche and spadetail genes differentially affect hematopoiesis and vasculogenesis. Dev. Biol. 197, 248-269 (1998).
23. Knapik, E. W. et al. A microsatellite genetic linkage map for zebrafish. Nature Genet. 18, 338-343 (1998).
24. Johnson, S. L., Africa, D., Horne, S. & Postlethwait, J. H. Half-tetrad analysis in zebrafish: mapping the ros mutation and the centromere of linkage group I. Genetics 139, 1727-1735 (1995).
25. Shimoda, N. et al. Zebrafish genetic map with 2000 microsatellite markers. Genomics 58, 219-232 (1999).
26. Farr, C. J., Saiki, R. K., Erlich, H. A., McCormick, F. & Marshall, C. J. Analysis of RAS gene mutations in acute myeloid leukemia by polymerase chain reaction and oligonucleotide probes. Proc. Natl Acad. Sci. USA 85, 1629-1633 (1988).
27. Wood, W. I., Gitschier, J., Lasky, L. A. & Lawn, R. M. Base composition-independent hybridization in tetramethylammonium chloride: a method for oligonucleotide screening of highly complex gene libraries. Proc. Natl Acad. Sci. USA 82, 1585-1588 (1985).
28. Palis, J. & Kingsley, P. D. Differential gene expression during early murine yolk sac development. Mol. Reprod. Dev. 42, 19-27 (1995).
29. Brownlie, A. et al. Positional cloning of the zebrafish sauternes gene: a model for congenital sideroblastic anaemia. Nature Genet. 20, 244-250 (1998).