Mediation by membrane protein kinase C of zinc-induced oxidative neuronal injury in mouse cortical cultures

Journal of Neurochemistry

Volumn 72, Issue 4, 1999, Pages 1609-1616

  Noh, Kyung Min ^a   Kim, Yang Hee ^a,b   Koh, Jae Young ^a  

^a University of Ulsan College of Medicine   (South Korea)

^b Seoul National University   (South Korea)

Author keywords

Excitotoxicity; Free radicals; Ischemia; Neuronal death; Phorbol ester

Indexed keywords

2 [1 (3 DIMETHYLAMINOPROPYL) 3 INDOLYL] 3 (3 INDOLYL)MALEIMIDE; PROTEIN KINASE C; TROLOX C; ZINC;

ANIMAL CELL; ARTICLE; BRAIN CORTEX; CALCIUM MOBILIZATION; ENZYME ACTIVATION; ENZYME ACTIVITY; FETUS; LIPID PEROXIDATION; MOUSE; NERVE CELL CULTURE; NERVE INJURY; NEUROTOXICITY; NONHUMAN; OXIDATIVE STRESS; PATHOPHYSIOLOGY; PRIORITY JOURNAL;

ANIMALS; ANTIOXIDANTS; BRAIN ISCHEMIA; CELL DEATH; CELLS, CULTURED; CHROMANS; ENZYME INHIBITORS; INDOLES; LIPID PEROXIDATION; MALEIMIDES; MICE; NERVE DEGENERATION; NEUROGLIA; NEURONS; NEUROTOXINS; OXIDATIVE STRESS; PHORBOLS; PROTEIN KINASE C; THIOBARBITURIC ACID REACTIVE SUBSTANCES; ZINC;

ANIMALIA; TRIXIS;

EID: 0344820731     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.1999.721609.x     Document Type: Article

References (41)

1. Baraban J. M., Snyder S. H., and Alger B. E. (1985) Protein kinase C regulates ionic conductance in hippocampal pyramidal neurons: electrophysiological effects of phorbol esters. Proc. Natl. Acad. Sci. USA 82, 2538-2542.
2. Berg J. M. (1991) Zinc fingers and other metal-binding domains: elements for interactions between macromolecules. J. Biol. Chem. 265, 6513-6516.
3. Carvalho A. L., Duarte C. B., Faro C. J., Carvalho A. P., and Pires E. V. (1998) Calcium influx through AMPA receptors and through calcium channels is regulated by protein kinase C in cultured retina amacrine-like cells. J. Neurochem. 70, 2112-2119.
4. Chakravarthy B., Bussey A., Whifield J. F., Sikorska M., Williams R. E., and Durkin J. P. (1991) The direct measurement of protein kinase C in isolated membrane using a selective peptide substrate. Anal. Biochem. 196, 144-150.
5. Chen S. J., Klann E., Gower M. C., Powell C. M., Sessoms J. S., and Sweatt J. D. (1993) Studies with synthetic peptide substrates derived from the neuronal protein neurogranin reveal structure determinations of potency and selective for protein kinase C. Biochemistry 32, 1032-1039.
6. Choi D. W. and Koh J. Y. (1998) Zinc and brain injury. Annu. Rev. Neurosci. 21, 347-375.
7. Choi D. W., Maulucci-Gedde M., and Kriegstein A. R. (1987) Glutamate neurotoxicity in cortical cell culture. J. Neurosci. 7, 357-
8. Csermely P., Szmamel M., Resch K., and Somogyi J. (1988) Zinc can increase the activity of protein kinase C and contributes to its binding to plasma membranes in T lymphocytes. J. Biol. Chem. 263, 6487-6499.
9. Danscher G., Howell G., Peter-Clausell J., and Hertel N. (1985) The dithizone, Timm's sulphide silver and the selenium methods demonstrate a chelatable pool of zinc in CNS. Histochemistry 83, 419-422.
10. Felipo V., Minana M. D., and Grisolia S. (1993) Inhibitions of protein kinase C prevent the toxicity of glutamate in primary neuronal cultures. Brain Res. 604, 192-196.
11. Frederickson C. J., Kasarskis E. J., Ringo D., and Frederickson R. E. (1987) A quinolic fluorescence method for visualizing and assaying (he histochemically reactive zinc (bouton zinc) in the brain. J. Neurosci. Methods 20, 91-103.
12. Greenlund L. J. S., Deckwerth T. L., and Johnson E. M. Jr. (1995) Superoxide dismutase delays neuronal apoptosis: a role for reactive oxygen species in programmed neuronal death. Neuron 14, 303-315.
13. Gwag B. J., Koh J. Y., Demaro J., Ying H. S., Jacquin M. F., and Choi D. W. (1997) Slowly-triggered excitotoxicity occurs by necrosis in cortical cultures. Neuroscience 77, 393-401.
14. Hauss P., Mazerolles F., Hivros C, Lecomte O., Barbat C., and Fischer A. (1993) GF109203X, a specific PKC inhibitor, abrogates anti-CD3 antibody-induced CD4+ T cell adhesion to B cells. Cell. Immunol. 150, 439-446.
15. Hemmings H. C., Nairn A. C., McGuiness T. L., Huganir R. L., and Greengard P. (1989) Role of protein phosphorylation in neuronal signal transduction. FASEB J. 3, 1583-1592.
16. Joo F. A., Tosari Z. O., and Koltai M. (1989) Inhibition by H-7 of the protein kinase C prevents formation of brain edema in Sprague-Dawley DFY rats. Brain Res. 490, 141-143.
17. Kim Y. H., Kim E. Y., Gwag B. J., Sohn S., and Koh J. Y. (1999) Zinc-induced cortical neuronal death with features of apoptosis and necrosis: mediation by free-radicals. Neuroscience (in press).
18. Kirino T. (1982) Delayed neuronal death in the gerbil hippocampus following ischemia. Brain Res. 239, 57-69.
19. Koh J. Y. and Choi D. W. (1987) Quantitative determination of glutamate-mediated cortical neuronal injury in cell culture by lactate dehydrogenase efflux assay. J. Neurosci. Methods 20, 83-90.
20. Koh J. Y. and Choi D. W. (1994) Zinc toxicity on cultured cortical neurons: involvement of N-methyl-D-aspartate receptors. Neuroscience 60, 1049-1057.
21. Koh J. Y., Suh S. W., Gwag B. J., He Y. Y., Hsu C. Y., and Choi D. W. (1996) The role of zinc in selective neuronal death after transient global cerebral ischemia. Science 272, 1013-1016.
22. Lobner D., Gottron F., Ying H., Tian M., and Dugan L. L. (1997) Zinc-induced neuronal apoptosis or necrosis in cortical cell culture. Soc. Neurosci. Abstr. 23, 2255.
23. Louis J. C., Magal E., and Yavin E. (1988) Protein kinase C alteration in fetal rat brain after global ischemia. J. Biol. Chem. 263, 19282-19285.
24. Louis J. C., Magal E., Gerdes W., and Seifert W. (1993) Survival-promoting and protein kinase C regulating roles of basic FGF for hippocampal neurons exposed to phorbol ester, glutamate and ischemia-like conditions. Eur. J. Neurosci. 5, 1610-1621.
25. Manev H., Kharlamov E., Uz T., Mason R. P., and Cagnoli C. M. (1997) Characterization of zinc-induced neuronal death in primary cultures of rat cerebellar granule cells. Exp. Neurol. 146, 171-178.
26. Mattson M. P. (1991) Evidence for the involvement of protein kinase C in neurodegenerative changes in cultured human cortical neurons. Exp. Neurol. 112, 95-103.
27. 2+. J. Biol. Chem. 262, 13902-13906.
28. Nishizuka Y. (1989) The family of protein kinase C for signal transduction. JAMA 262, 1826-1833.
29. Nishizuka Y., Shearman M. S., Oda T., Berry N., Shinomura T., Asaoka Y., Ogita K., Kode H., Kikkawa U., and Kishimoto A. (1991) Protein kinase C family and nervous function. Prog. Brain Res. 89, 125-141.
30. Ohkawa H., Ohishi N., and Yagi K. (1979) Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal. Biochem. 95, 351-358.
31. Orrenius S., McConkey D. J., and Nicotera P. (1991) Role of calcium in toxic and programmed cell death. Adv. Exp. Med. Biol. 283, 419-425.
32. Padmaperuma B., Mark R., Dhillon H. S., Mattson M. P., and Prasad M. R. (1996) Alteration in brain protein kinase C after experimental brain injury. Brain Res. 714, 19-26.
33. Park J. W., Hoyal C. R., Benna J. E., and Babior B. M. (1997) Kinase-dependent activation of the leukocyte NADPH oxidase in a cell-free system. J. Biol. Chem. 272, 11035-11043.
34. Parker P. J., Coussens L., Totty N., Rhee L., Young S., Chen E., Stabel S., Waterfield M. D., and Ullrich A. (1986) Multiple, distinct forms of bovine and human protein kinase C suggest diversity in cellular signaling pathways. Science 233, 853-859.
35. Pelech S. L., Charest D. L., Howard S. L., Paddon H. B., and Salari H. (1990) Protein kinase C activation by platelet-activating factor is independent of enzyme translocation. Biochim. Biophys. Acta 1051, 100-107.
36. Pulsinelli W. A. (1985) Selective neuronal vulnerability: morphological and molecular characteristics. Prog. Brain Res. 63, 29-37.
37. Shearman M. S., Sekiguchi K., and Nishizuka Y. (1989) Modulation of ion channel activity: a key function of the protein kinase C enzyme family. Pharmacol. Rev. 41, 211-237.
38. Siesjö B. K. (1990) Calcium in the brain under physiological condition. Eur. Neurol. 2, 3-9.
39. Suh S. W., Koh J. Y., and Choi D. W. (1996) Extracellular zinc mediates selective neuronal death in hippocampus and amygdala following kainate-induced seizure. Soc. Neurosci. Abstr. 22, 2101.
40. 2+ in cell injury, necrosis and apoptosis. Curr. Opin. Cell Biol. 4, 227-232.
41. Weiss J. H., Hartley D. M., Koh J. Y., and Choi D. W. (1993) AMPA receptor activation potentiates zinc neurotoxicity. Neuron 10, 43-49.