-
1
-
-
58349122490
-
Melanoma antigen-11 inhibits the hypoxia-inducible factor prolyl hydroxylase 2 and activates hypoxic response
-
O. Aprelikova, S. Pandolfi, S. Tackett, M. Ferreira, K. Salnikow, Y. Ward, J.I. Risinger, J.C. Barrett, and J. Niederhuber Melanoma antigen-11 inhibits the hypoxia-inducible factor prolyl hydroxylase 2 and activates hypoxic response Cancer Res. 69 2009 616 624
-
(2009)
Cancer Res.
, vol.69
, pp. 616-624
-
-
Aprelikova, O.1
Pandolfi, S.2
Tackett, S.3
Ferreira, M.4
Salnikow, K.5
Ward, Y.6
Risinger, J.I.7
Barrett, J.C.8
Niederhuber, J.9
-
2
-
-
0041465022
-
HIF prolyl-hydroxylase 2 is the key oxygen sensor setting low steady-state levels of HIF-1α in normoxia
-
DOI 10.1093/emboj/cdg392
-
E. Berra, E. Benizri, A. Ginouvs, V. Volmat, D. Roux, and J. Pouysségur HIF prolyl-hydroxylase 2 is the key oxygen sensor setting low steady-state levels of HIF-1alpha in normoxia EMBO J. 22 2003 4082 4090 (Pubitemid 37021737)
-
(2003)
EMBO Journal
, vol.22
, Issue.16
, pp. 4082-4090
-
-
Berra, E.1
Benizri, E.2
Ginouves, A.3
Volmat, V.4
Roux, D.5
Pouyssegur, J.6
-
3
-
-
0035834409
-
A conserved family of prolyl-4-hydroxylases that modify HIF
-
DOI 10.1126/science.1066373
-
R.K. Bruick, and S.L. McKnight A conserved family of prolyl-4- hydroxylases that modify HIF Science 294 2001 1337 1340 (Pubitemid 33063099)
-
(2001)
Science
, vol.294
, Issue.5545
, pp. 1337-1340
-
-
Bruick, R.K.1
McKnight, S.L.2
-
4
-
-
77955110561
-
Heterogeneous nuclear ribonucleoproteins (hnRNPs) in cellular processes: Focus on hnRNP E1's multifunctional regulatory roles
-
A. Chaudhury, P. Chander, and P.H. Howe Heterogeneous nuclear ribonucleoproteins (hnRNPs) in cellular processes: Focus on hnRNP E1's multifunctional regulatory roles RNA 16 2010 1449 1462
-
(2010)
RNA
, vol.16
, pp. 1449-1462
-
-
Chaudhury, A.1
Chander, P.2
Howe, P.H.3
-
6
-
-
77953778296
-
History of biological metal utilization inferred through phylogenomic analysis of protein structures
-
C.L. Dupont, A. Butcher, R.E. Valas, P.E. Bourne, and G. Caetano-Anollés History of biological metal utilization inferred through phylogenomic analysis of protein structures Proc. Natl. Acad. Sci. USA 107 2010 10567 10572
-
(2010)
Proc. Natl. Acad. Sci. USA
, vol.107
, pp. 10567-10572
-
-
Dupont, C.L.1
Butcher, A.2
Valas, R.E.3
Bourne, P.E.4
Caetano-Anollés, G.5
-
7
-
-
17944375360
-
C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation
-
DOI 10.1016/S0092-8674(01)00507-4
-
A.C. Epstein, J.M. Gleadle, L.A. McNeill, K.S. Hewitson, J. O'Rourke, D.R. Mole, M. Mukherji, E. Metzen, M.I. Wilson, and A. Dhanda C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation Cell 107 2001 43 54 (Pubitemid 32972036)
-
(2001)
Cell
, vol.107
, Issue.1
, pp. 43-54
-
-
Epstein, A.C.R.1
Gleadle, J.M.2
McNeill, L.A.3
Hewitson, K.S.4
O'Rourke, J.5
Mole, D.R.6
Mukherji, M.7
Metzen, E.8
Wilson, M.I.9
Dhanda, A.10
Tian, Y.-M.11
Masson, N.12
Hamilton, D.L.13
Jaakkola, P.14
Barstead, R.15
Hodgkin, J.16
Maxwell, P.H.17
Pugh, C.W.18
Schofield, C.J.19
Ratcliffe, P.J.20
more..
-
8
-
-
18544386401
-
Hypoxia-inducible factor (HIF) asparagine hydroxylase is identical to factor inhibiting HIF (FIH) and is related to the cupin structural family
-
DOI 10.1074/jbc.C200273200
-
K.S. Hewitson, L.A. McNeill, M.V. Riordan, Y.M. Tian, A.N. Bullock, R.W. Welford, J.M. Elkins, N.J. Oldham, S. Bhattacharya, and J.M. Gleadle Hypoxia-inducible factor (HIF) asparagine hydroxylase is identical to factor inhibiting HIF (FIH) and is related to the cupin structural family J. Biol. Chem. 277 2002 26351 26355 (Pubitemid 34967127)
-
(2002)
Journal of Biological Chemistry
, vol.277
, Issue.29
, pp. 26351-26355
-
-
Hewitson, K.S.1
McNeill, L.A.2
Riordan, M.V.3
Tian, Y.-M.4
Bullock, A.N.5
Welford, R.W.6
Elkins, J.M.7
Oldham, N.J.8
Bhattacharya, S.9
Gleadle, J.M.10
Ratcliffe, P.J.11
Pugh, C.W.12
Schofield, C.J.13
-
9
-
-
33645048994
-
Cellular regulation and molecular interactions of the ferritins
-
K.J. Hintze, and E.C. Theil Cellular regulation and molecular interactions of the ferritins Cell. Mol. Life Sci. 63 2006 591 600
-
(2006)
Cell. Mol. Life Sci.
, vol.63
, pp. 591-600
-
-
Hintze, K.J.1
Theil, E.C.2
-
10
-
-
0035917313
-
2 sensing
-
M. Ivan, K. Kondo, H. Yang, W. Kim, J. Valiando, M. Ohh, A. Salic, J.M. Asara, W.S. Lane, and W.G. Kaelin Jr. HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing Science 292 2001 464 468 (Pubitemid 32335941)
-
(2001)
Science
, vol.292
, Issue.5516
, pp. 464-468
-
-
Ivan, M.1
Kondo, K.2
Yang, H.3
Kim, W.4
Valiando, J.5
Ohh, M.6
Salic, A.7
Asara, J.M.8
Lane, W.S.9
Kaelin Jr., W.G.10
-
11
-
-
0035917808
-
2-regulated prolyl hydroxylation
-
P. Jaakkola, D.R. Mole, Y.M. Tian, M.I. Wilson, J. Gielbert, S.J. Gaskell, Kriegsheim Av, H.F. Hebestreit, M. Mukherji, and C.J. Schofield Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation Science 292 2001 468 472 (Pubitemid 32335942)
-
(2001)
Science
, vol.292
, Issue.5516
, pp. 468-472
-
-
Jaakkola, P.1
Mole, D.R.2
Tian, Y.-M.3
Wilson, M.I.4
Gielbert, J.5
Gaskell, S.J.6
Von Kriegsheim, A.7
Hebestreit, H.F.8
Mukherji, M.9
Schofield, C.J.10
Maxwell, P.H.11
Pugh, C.W.12
Ratcliffe, P.J.13
-
12
-
-
43649093915
-
Oxygen Sensing by Metazoans: The Central Role of the HIF Hydroxylase Pathway
-
DOI 10.1016/j.molcel.2008.04.009, PII S109727650800292X
-
W.G. Kaelin Jr., and P.J. Ratcliffe Oxygen sensing by metazoans: the central role of the HIF hydroxylase pathway Mol. Cell 30 2008 393 402 (Pubitemid 351681994)
-
(2008)
Molecular Cell
, vol.30
, Issue.4
, pp. 393-402
-
-
Kaelin Jr., W.G.1
Ratcliffe, P.J.2
-
13
-
-
0037097861
-
FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor
-
DOI 10.1101/gad.991402
-
D. Lando, D.J. Peet, J.J. Gorman, D.A. Whelan, M.L. Whitelaw, and R.K. Bruick FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor Genes Dev. 16 2002 1466 1471 (Pubitemid 34686328)
-
(2002)
Genes and Development
, vol.16
, Issue.12
, pp. 1466-1471
-
-
Lando, D.1
Peet, D.J.2
Gorman, J.J.3
Whelan, D.A.4
Whitelaw, M.L.5
Bruick, R.K.6
-
14
-
-
0036469038
-
Asparagine hydroxylation of the HIF transactivation domain: A hypoxic switch
-
DOI 10.1126/science.1068592
-
D. Lando, D.J. Peet, D.A. Whelan, J.J. Gorman, and M.L. Whitelaw Asparagine hydroxylation of the HIF transactivation domain a hypoxic switch Science 295 2002 858 861 (Pubitemid 34118367)
-
(2002)
Science
, vol.295
, Issue.5556
, pp. 858-861
-
-
Lando, D.1
Peet, D.J.2
Whelan, D.A.3
Gorman, J.J.4
Whitelaw, M.L.5
-
15
-
-
39349105090
-
Expanding chemical biology of 2-oxoglutarate oxygenases
-
DOI 10.1038/nchembio0308-152, PII NCHEMBIO0308152
-
C. Loenarz, and C.J. Schofield Expanding chemical biology of 2-oxoglutarate oxygenases Nat. Chem. Biol. 4 2008 152 156 (Pubitemid 351264133)
-
(2008)
Nature Chemical Biology
, vol.4
, Issue.3
, pp. 152-156
-
-
Loenarz, C.1
Schofield, C.J.2
-
16
-
-
0036223676
-
The poly(C)-binding proteins: A multiplicity of functions and a search for mechanisms
-
DOI 10.1017/S1355838202024627
-
A.V. Makeyev, and S.A. Liebhaber The poly(C)-binding proteins: a multiplicity of functions and a search for mechanisms RNA 8 2002 265 278 (Pubitemid 34311177)
-
(2002)
RNA
, vol.8
, Issue.3
, pp. 265-278
-
-
Makeyev, A.V.1
Liebhaber, S.A.2
-
17
-
-
77957674907
-
Cytosolic monothiol glutaredoxins function in intracellular iron sensing and trafficking via their bound iron-sulfur cluster
-
U. Mühlenhoff, S. Molik, J.R. Godoy, M.A. Uzarska, N. Richter, A. Seubert, Y. Zhang, J. Stubbe, F. Pierrel, and E. Herrero Cytosolic monothiol glutaredoxins function in intracellular iron sensing and trafficking via their bound iron-sulfur cluster Cell Metab. 12 2010 373 385
-
(2010)
Cell Metab.
, vol.12
, pp. 373-385
-
-
Mühlenhoff, U.1
Molik, S.2
Godoy, J.R.3
Uzarska, M.A.4
Richter, N.5
Seubert, A.6
Zhang, Y.7
Stubbe, J.8
Pierrel, F.9
Herrero, E.10
-
18
-
-
4344575965
-
Control of mRNA translation and stability in haematopoietic cells: The function of hnRNPs K and E1/E2
-
DOI 10.1016/j.biolcel.2004.03.010, PII S0248490004000851
-
A. Ostareck-Lederer, and D.H. Ostareck Control of mRNA translation and stability in haematopoietic cells: the function of hnRNPs K and E1/E2 Biol. Cell 96 2004 407 411 (Pubitemid 39157944)
-
(2004)
Biology of the Cell
, vol.96
, Issue.6
, pp. 407-411
-
-
Ostareck-Lederer, A.1
Ostareck, D.H.2
-
19
-
-
0035968001
-
Femtomolar sensitivity of metalloregulatory proteins controlling zinc homeostasis
-
DOI 10.1126/science.1060331
-
C.E. Outten, and T.V. O'Halloran Femtomolar sensitivity of metalloregulatory proteins controlling zinc homeostasis Science 292 2001 2488 2492 (Pubitemid 32605687)
-
(2001)
Science
, vol.292
, Issue.5526
, pp. 2488-2492
-
-
Outten, C.E.1
O'Halloran, T.V.2
-
20
-
-
33847050240
-
Non-heme dioxygenases: Cellular sensors and regulators jelly rolled into one?
-
A. Ozer, and R.K. Bruick Non-heme dioxygenases: cellular sensors and regulators jelly rolled into one? Nat. Chem. Biol. 3 2007 144 153
-
(2007)
Nat. Chem. Biol.
, vol.3
, pp. 144-153
-
-
Ozer, A.1
Bruick, R.K.2
-
21
-
-
17344392308
-
A new mathematical model for relative quantification in real-time RT-PCR
-
M.W. Pfaffl A new mathematical model for relative quantification in real-time RT-PCR Nucleic Acids Res. 29 2001 e45
-
(2001)
Nucleic Acids Res.
, vol.29
, pp. 45
-
-
Pfaffl, M.W.1
-
22
-
-
0035986679
-
Metallochaperones: Bind and deliver
-
DOI 10.1016/S1074-5521(02)00156-4, PII S1074552102001564
-
A.C. Rosenzweig Metallochaperones: bind and deliver Chem. Biol. 9 2002 673 677 (Pubitemid 34653061)
-
(2002)
Chemistry and Biology
, vol.9
, Issue.6
, pp. 673-677
-
-
Rosenzweig, A.C.1
-
23
-
-
58749094789
-
Intestinal hypoxia-inducible transcription factors are essential for iron absorption following iron deficiency
-
Y.M. Shah, T. Matsubara, S. Ito, S.H. Yim, and F.J. Gonzalez Intestinal hypoxia-inducible transcription factors are essential for iron absorption following iron deficiency Cell Metab. 9 2009 152 164
-
(2009)
Cell Metab.
, vol.9
, pp. 152-164
-
-
Shah, Y.M.1
Matsubara, T.2
Ito, S.3
Yim, S.H.4
Gonzalez, F.J.5
-
24
-
-
67650517831
-
Desaturases: Emerging models for understanding functional diversification of diiron-containing enzymes
-
J. Shanklin, J.E. Guy, G. Mishra, and Y. Lindqvist Desaturases: emerging models for understanding functional diversification of diiron-containing enzymes J. Biol. Chem. 284 2009 18559 18563
-
(2009)
J. Biol. Chem.
, vol.284
, pp. 18559-18563
-
-
Shanklin, J.1
Guy, J.E.2
Mishra, G.3
Lindqvist, Y.4
-
25
-
-
45849123222
-
A cytosolic iron chaperone that delivers iron to ferritin
-
DOI 10.1126/science.1157643
-
H. Shi, K.Z. Bencze, T.L. Stemmler, and C.C. Philpott A cytosolic iron chaperone that delivers iron to ferritin Science 320 2008 1207 1210 (Pubitemid 351929507)
-
(2008)
Science
, vol.320
, Issue.5880
, pp. 1207-1210
-
-
Shi, H.1
Bencze, K.Z.2
Stemmler, T.L.3
Philpott, C.C.4
-
27
-
-
0031020884
-
Endothelial PAS domain protein 1 (EPAS1), a transcription factor selectively expressed in endothelial cells
-
H. Tian, S.L. McKnight, and D.W. Russell Endothelial PAS domain protein 1 (EPAS1), a transcription factor selectively expressed in endothelial cells Genes Dev. 11 1997 72 82 (Pubitemid 27043825)
-
(1997)
Genes and Development
, vol.11
, Issue.1
, pp. 72-82
-
-
Tian, H.1
McKnight, S.L.2
Russell, D.W.3
-
28
-
-
4944223879
-
Determination and comparison of specific activity of the HIF-prolyl hydroxylases
-
DOI 10.1016/j.febslet.2004.09.005, PII S0014579304011135
-
J.R. Tuckerman, Y. Zhao, K.S. Hewitson, Y.M. Tian, C.W. Pugh, P.J. Ratcliffe, and D.R. Mole Determination and comparison of specific activity of the HIF-prolyl hydroxylases FEBS Lett. 576 2004 145 150 (Pubitemid 39330473)
-
(2004)
FEBS Letters
, vol.576
, Issue.1-2
, pp. 145-150
-
-
Tuckerman, J.R.1
Zhao, Y.2
Hewitson, K.S.3
Tian, Y.-M.4
Pugh, C.W.5
Ratcliffe, P.J.6
Mole, D.R.7
-
30
-
-
77955284188
-
The asparaginyl hydroxylase factor inhibiting HIF-1alpha is an essential regulator of metabolism
-
N. Zhang, Z. Fu, S. Linke, J. Chicher, J.J. Gorman, D. Visk, G.G. Haddad, L. Poellinger, D.J. Peet, F. Powell, and R.S. Johnson The asparaginyl hydroxylase factor inhibiting HIF-1alpha is an essential regulator of metabolism Cell Metab. 11 2010 364 378
-
(2010)
Cell Metab.
, vol.11
, pp. 364-378
-
-
Zhang, N.1
Fu, Z.2
Linke, S.3
Chicher, J.4
Gorman, J.J.5
Visk, D.6
Haddad, G.G.7
Poellinger, L.8
Peet, D.J.9
Powell, F.10
Johnson, R.S.11
|