ATOX1: A novel copper-responsive transcription factor in mammals?

International Journal of Biochemistry and Cell Biology

Volumn 41, Issue 6, 2009, Pages 1233-1236

  Muller, Patricia A J ^a   Klomp, Leo W J ^a  

^a UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

Author keywords

ATOX1; CABE; CCND1; Copper; Transcription

Indexed keywords

ANTIOXIDANT 1; BINDING PROTEIN; COPPER; COPPER RESPONSIVE ATOX1 BINDING ELEMENT; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

ATOX1 GENE; BINDING SITE; CCND1 GENE; DIMERIZATION; GENE EXPRESSION; GENE SEQUENCE; GENETIC ANALYSIS; GENOME; HUMAN; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN STRUCTURE; SHORT SURVEY;

ANIMALS; BASE SEQUENCE; CATION TRANSPORT PROTEINS; COPPER; HUMANS; MOLECULAR CHAPERONES; MOLECULAR SEQUENCE DATA;

MAMMALIA;

EID: 60349088851     PISSN: 13572725     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biocel.2008.08.001     Document Type: Short Survey

References (20)

1. Anastassopoulou I., Banci L., Bertini I., Cantini F., Katsari E., and Rosato A. Solution structure of the apo and copper(I)-loaded human metallochaperone HAH1. Biochemistry 43 (2004) 13046-13053
2. Fantl V., Stamp G., Andrews A., Rosewell I., and Dickson C. Mice lacking cyclin D1 are small and show defects in eye and mammary gland development. Genes Dev 9 (1995) 2364-2372
3. Hamza I., Faisst A., Prohaska J., Chen J., Gruss P., and Gitlin J.D. The metallochaperone Atox1 plays a critical role in perinatal copper homeostasis. Proc Natl Acad Sci USA 98 (2001) 6848-6852
4. Heuchel R., Radtke F., Georgiev O., Stark G., Aguet M., and Schaffner W. The transcription factor MTF-1 is essential for basal and heavy metal-induced metallothionein gene expression. EMBO J 13 (1994) 2870-2875
5. Huster D., Purnat T.D., Burkhead J.L., Ralle M., Fiehn O., Stuckert F., et al. High copper selectively alters lipid metabolism and cell cycle machinery in the mouse model of Wilson disease. J Biol Chem 282 (2007) 8343-8355
6. Itoh S., Kim H.W., Nakagawa O., Ozumi K., Lessner S.M., Aoki H., et al. Novel role of antioxidant-1 (Atox1) as a copper-dependent transcription factor involved in cell proliferation. J Biol Chem 283 (2008) 9157-9167
7. Kita Y., Masaki T., Funakoshi F., Yoshida S., Tanaka M., Kurokohchi K., et al. Expression of G1 phase-related cell cycle molecules in naturally developing hepatocellular carcinoma of Long-Evans Cinnamon rats. Int J Oncol 24 (2004) 1205-1211
8. Klomp L.W., Lin S.J., Yuan D.S., Klausner R.D., Culotta V.C., and Gitlin J.D. Identification and functional expression of HAH1, a novel human gene involved in copper homeostasis. J Biol Chem 272 (1997) 9221-9226
9. Lin S.J., and Culotta V.C. The ATX1 gene of Saccharomyces cerevisiae encodes a small metal homeostasis factor that protects cells against reactive oxygen toxicity. Proc Natl Acad Sci USA 92 (1995) 3784-3788
10. Muller P., van Bakel H., van de Sluis B., Holstege F., Wijmenga C., and Klomp L.W. Gene expression profiling of liver cells after copper overload in vivo and in vitro reveals new copper-regulated genes. J Biol Inorg Chem 12 (2007) 495-507
11. Pena M.M., Lee J., and Thiele D.J. A delicate balance: homeostatic control of copper uptake and distribution. J Nutr 129 (1999) 1251-1260
12. Prohaska J.R. Changes in tissue growth, concentrations of copper, iron, cytochrome oxidase and superoxide dismutase subsequent to dietary or genetic copper deficiency in mice. J Nutr 113 (1983) 2048-2058
13. Ralle M., Lutsenko S., and Blackburn N.J. X-ray absorption spectroscopy of the copper chaperone HAH1 reveals a linear two-coordinate Cu(I) center capable of adduct formation with exogenous thiols and phosphines. J Biol Chem 278 (2003) 23163-23170
14. Sicinski P., Donaher J.L., Parker S.B., Li T., Fazeli A., Gardner H., et al. Cyclin D1 provides a link between development and oncogenesis in the retina and breast. Cell 82 (1995) 621-630
15. Strausak D., Howie M.K., Firth S.D., Schlicksupp A., Pipkorn R., Multhaup G., et al. Kinetic analysis of the interaction of the copper chaperone Atox1 with the metal binding sites of the Menkes protein. J Biol Chem 278 (2003) 20821-20827
16. van den Berghe P.V., Folmer D.E., Malingre H.E., van Beurden E., Klomp A.E., van de Sluis B., et al. Human copper transporter 2 is localized in late endosomes and lysosomes and facilitates cellular copper uptake. Biochem J 407 (2007) 49-59
17. van Dongen E.M., Dekkers L.M., Spijker K., Meijer E.W., Klomp L.W., and Merkx M. Ratiometric fluorescent sensor proteins with subnanomolar affinity for Zn(II) based on copper chaperone domains. J Am Chem Soc 128 (2006) 10754-10762
18. van Dongen E.M., Klomp L.W., and Merkx M. Copper-dependent protein-protein interactions studied by yeast two-hybrid analysis. Biochem Biophys Res Commun 323 (2004) 789-795
19. Wernimont A.K., Huffman D.L., Lamb A.L., O'Halloran T.V., and Rosenzweig A.C. Structural basis for copper transfer by the metallochaperone for the Menkes/Wilson disease proteins. Nat Struct Biol 7 (2000) 766-771
20. Zhou B., and Gitschier J. hCTR1: a human gene for copper uptake identified by complementation in yeast. Proc Natl Acad Sci USA 94 (1997) 7481-7486