Zn2+ Induces Permeability Transition Pore Opening and Release of Pro-apoptotic Peptides from Neuronal Mitochondria

Journal of Biological Chemistry

Volumn 276, Issue 50, 2001, Pages 47524-47529

  Jiang, Dongmei ^a   Sullivan, Patrick G ^a,b   Sensi, Stefano L ^a,c   Steward, Oswald ^a,b   Weiss, John H ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF CHIETI   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ATTENUATION; CELLS; POSITIVE IONS; SWELLING; TOXICITY; ZINC;

CONFOCAL IMAGING;

NEUROLOGY;

6 NITRO 7 SULFAMOYLBENZO[F]QUINOXALINE 2,3 DIONE; APOPTOSIS INDUCING FACTOR; BONGKREKIC ACID; CALCIUM ION; CYCLOSPORIN A; CYTOCHROME C; MITOCHONDRIAL PERMEABILITY TRANSITION PORE; PEPTIDE; STAUROSPORINE; ZINC; ANTIBIOTIC AGENT; CALCIUM; CATION; CYCLOSPORIN; ENZYME INHIBITOR; FLAVOPROTEIN; MEMBRANE PROTEIN; TRYPAN BLUE;

ANIMAL CELL; ANTIBODY LABELING; APOPTOSIS; ARTICLE; BINDING SITE; BRAIN CORTEX; CALCIUM TRANSPORT; CELL DEATH; CELL KILLING; CHANNEL GATING; CONFOCAL LASER MICROSCOPY; CONTROLLED STUDY; CYTOSOL; DOSE TIME EFFECT RELATION; MALE; MEMBRANE PERMEABILITY; MEMBRANE STRUCTURE; MITOCHONDRIAL MEMBRANE; MITOCHONDRION SWELLING; NERVE CELL; NONHUMAN; PEPTIDE ANALYSIS; PRIORITY JOURNAL; PROTEIN INDUCTION; RAT; SIGNAL TRANSDUCTION; STAINING; ZINC METABOLISM; ANIMAL; BRAIN; CONFOCAL MICROSCOPY; CYTOPLASM; DOSE RESPONSE; HUMAN; IMMUNOHISTOCHEMISTRY; METABOLISM; MITOCHONDRION; NECROSIS; RAT STRAIN; TIME;

ANIMALIA;

ANIMAL; ANTIBIOTICS; APOPTOSIS; BONGKREKIC ACID; BRAIN; CALCIUM; CATIONS; CYCLOSPORINE; CYTOCHROME C; CYTOPLASM; CYTOSOL; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; FLAVOPROTEINS; HUMAN; IMMUNOHISTOCHEMISTRY; MALE; MEMBRANE PROTEINS; MICROSCOPY, CONFOCAL; MITOCHONDRIA; NECROSIS; NEURONS; RATS; RATS, SPRAGUE-DAWLEY; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.; TIME FACTORS; TRYPAN BLUE; ZINC;

EID: 0035861677     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M108834200     Document Type: Article

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