Serum transferrin receptor and its ratio to serum ferritin in the diagnosis of iron deficiency

Blood

Volumn 89, Issue 3, 1997, Pages 1052-1057

  Punnonen, Kari ^a   Irjala, Kerttu ^a   Rajamäki, Allan ^a  

^a TURKU UNIVERSITY HOSPITAL   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

FERRITIN; TRANSFERRIN; TRANSFERRIN RECEPTOR;

ANEMIA; ARTICLE; BONE MARROW EXAMINATION; ERYTHROPOIESIS; FEMALE; HUMAN; HUMAN TISSUE; IRON DEFICIENCY; IRON DEFICIENCY ANEMIA; IRON STORAGE; LABORATORY TEST; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; TRANSFERRIN BLOOD LEVEL;

EID: 0030976033     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v89.3.1052     Document Type: Article

References (27)

1. Rockey DC, Cello JP: Evaluation of the gastrointestinal tract in patients with iron-deficiency anemia. N Engl J Med 329:1691, 1993
2. Ferguson BJ, Skikne BS, Simpson KM, Baynes RD, Cook JD: Serum transferrin receptor distinguishes the anemia of chronic disease from iron deficiency anemia. J Lab Clin Med 119:385, 1992
3. Cazzola M, Beguin Y: New tools for clinical evaluation of erythron function in man. Br J Haematol 80:278, 1992
4. Harju E, Pakarinen A, Larmi T: A comparison between serum ferritin concentration and the amount of bone marrow stainable iron. Scand J Clin Lab Invest 44:555, 1984
5. Burns ER, Goldberg SN, Lawrence C, Wenz B: Clinical utility of serum tests for iron deficiency in hospitalized patients. Am J Clin Pathol 93:240, 1990
6. Kohgo Y, Niitsu Y, Kondo H, Kato I, Tsushima N, Sasaki K, Hirayama M, Numata T, Nishisato T, Urushizaki I: Serum transferrin receptor as a new index of erythropoiesis. Blood 70:1955, 1987
7. Skikne BS, Flowers CH, Cook JD: Serum transferrin receptor: A quantitative measure of tissue iron deficiency. Blood 75:1870, 1990
8. Flowers CH, Skikne BS, Covell AM, Cook JD: The clinical measurement of serum transferrin receptor. J Lab Clin Med 114:368, 1989
9. Thorstensen K, Egeberg K, Romslo I, Dalhoj J, Wiggers P: Variations in serum erythropoietin and transferrin receptor during phlebotomy therapy of hereditary hemochromatosis: A case report. Eur J Haematol 47:219, 1991
10. Thorstensen K, Romslo I: The transferrin receptor: Its diagnostic value and its potential as therapeutic target. Scand J Clin Lab Invest 53:113, 1993
11. Cook JD, Skikne BS, Baynes RD: Serum transferrin receptor. Annu Rev Med 44:63, 1993
12. Huebers HA, Finch CA: The physiology of transferrin and transferrin receptors. Physiol Rev 67:520, 1987
13. Ahn J, Johnstone RM: Origin of a soluble truncated transferrin receptor. Blood 81:2442, 1993
14. Huebers HA, Beguin Y, Pootrakul P, Einspahr D, Finch CA: Intact transferrin receptors in human plasma and their relation to erythropoiesis. Blood 75:102, 1990
15. Shih YJ, Baynes RD, Hudson BG, Flowers CH, Skikne BS, Cook JD: Serum transferrin receptor is a truncated form of tissue receptor. J Biol Chem 265:19077, 1990
16. Rao KK, Shapiro D, Mattia E, Bridges K, Klausner RD: Effects of alterations in cellular iron on biosynthesis of the transferrin receptor in K562 cells. Mol Cell Biol 5:595, 1985
17. Beguin Y, Lampertz S, De Groote D, Igot D, Malaise M, Fillet G: Soluble CD23 and other receptors (CD4, CD8, CD25, CD71) in serum of patients with chronic lymphocytic leukemia. Leukemia 7:2019, 1993
18. Carmel R, Skikne BS: Serum transferrin receptor in the megaloblastic anemia of cobalamin deficiency. Eur J Haematol 49:246, 1992
19. Punnonen K, Irjala K, Rajamäki A: Iron deficiency anemia is associated with high serum levels of transferrin receptor. Clin Chem 40:774, 1994
20. Rajamäki A, Irjala K, Aitio A: Immunochemical determination of serum transferrin. Scand J Haematol 23:227, 1979
21. Beilby J, Olynyk J, Ching S, Prins A, Swanson N, Reed W, Harley H, Garcia-Webb P: Transferrin index: An alternative method for calculating the iron saturation of transferrin. Clin Chem 38:2078, 1992
22. Kairisto V, Poola A: Software for illustrative presentation of basic clinical characteristics of laboratory tests - GraphROC for Windows. Scand J Clin Lab Invest 222:43, 1995 (suppl 55)
23. Hanley JA, McNeil BJ: The meaning and use of the area under a receiver operating characteristics (ROC) curve. Radiology 143:29, 1982
24. . Beck JR, Schultz EK: The use of relative operating characteristic (ROC) curves in test performance evaluation. Arch Pathol Lab Med 110:13, 1986
25. Forsström J: Machine learning in clinical medicine by knowledge acquisition from patient databases (Dissertation). University of Turku, Turku, Finland, Departments of Medicine and Clinical Chemistry, 1992
26. Guyatt GH, Oxman AD, Ali M, Willan A, Mcllroy W, Patterson C: Laboratory diagnosis of iron-deficiency anemia: An overview. J Gen Intern Med 7:145, 1992
27. Fahmy M, Young SP: Modulation of iron metabolism in monocyte cell line U937 by inflammatory cytokines: Changes in transferrin uptake, iron handling and ferritin mRNA. Biochem J 296:175, 1993