The complex interplay of iron metabolism, reactive oxygen species, and reactive nitrogen species: Insights into the potential of various iron therapies to induce oxidative and nitrosative stress

Free Radical Biology and Medicine

Volumn 65, Issue , 2013, Pages 1174-1194

  Koskenkorva Frank, Taija S ^a   Weiss, Günter ^b   Koppenol, Willem H ^c   Burckhardt, Susanna ^a,c  

^a Preclinical Research   (Switzerland)

^b INNSBRUCK MEDICAL UNIVERSITY   (Austria)

^c ETH ZURICH   (Switzerland)

Author keywords

Free radicals; Intravenous iron; Nitrosative stress; Oral iron; Oxidative stress; Reactive nitrogen species; Reactive oxygen species

Indexed keywords

C REACTIVE PROTEIN; CATALASE; COPPER ZINC SUPEROXIDE DISMUTASE; DEXTRAN; DEXTRAN SULFATE; FERROPORTIN; FERROUS FUMARATE; FERROUS SULFATE; HEPCIDIN; HYDROGEN PEROXIDE; HYDROXYL RADICAL; HYPOXIA INDUCIBLE FACTOR 1ALPHA; HYPOXIA INDUCIBLE FACTOR 2ALPHA; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 6; IRON; IRON COMPLEX; IRON DEXTRAN; MALONALDEHYDE; MESSENGER RNA; NATURAL RESISTANCE ASSOCIATED MACROPHAGE PROTEIN 2; NITRIC OXIDE; PEROXIREDOXIN 2; PEROXYNITRITE; REACTIVE NITROGEN SPECIES; REACTIVE OXYGEN METABOLITE; STAT3 PROTEIN; TRANSFERRIN;

ARTICLE; BINDING AFFINITY; CELL FUNCTION; DISEASE ACTIVITY; DNA FRAGMENTATION; ENZYME ACTIVITY; FENTON REACTION; GENE EXPRESSION; HEMOCHROMATOSIS; HOMEOSTASIS; HUMAN; HYDROXYLATION; IRON ABSORPTION; IRON DEFICIENCY; IRON DEFICIENCY ANEMIA; IRON METABOLISM; IRON OVERLOAD; IRON THERAPY; LIPID PEROXIDATION; METABOLIC REGULATION; NITRATION; NITROSATIVE STRESS; NONHUMAN; OXIDATIVE STRESS; PHAGOCYTOSIS; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; TREATMENT DURATION; UBIQUITINATION; UPREGULATION;

ABSOLUTE IRON DEFICIENCY; ACD; AID; ANEMIA OF CHRONIC DISEASE; ANTIOXIDANT-RESPONSIVE ELEMENTS; ARE; ASC; ASCORBIC ACID; DIVALENT METAL TRANSPORTER 1; DMT1; ENDOTHELIAL NITRIC OXIDE SYNTHASE; ENOS; EPO; ERYTHROPOIETIN; F-BOX AND LEUCINE-RICH REPEAT PROTEIN 5; FBXL5; FCM; FE-EDTA; FERRIC CARBOXYMALTOSE; FERRIC GLUCONATE; FERROPORTIN; FERUMOXYTOL; FG; FID; FMX; FPN; FREE RADICALS; FUNCTIONAL IRON DEFICIENCY; GASTROINTESTINAL; GI; GLUTATHIONE; GLUTATHIONE PEROXIDASE; GPX; GSH; HB; HEME OXYGENASE 1; HEMOGLOBIN; HIF; HO-1; HYPOXIA-INDUCIBLE FACTOR; ID(A); IIM; IL; INDUCIBLE NITRIC OXIDE SYNTHASE; INOS; INTERLEUKIN; INTRAVENOUS; INTRAVENOUS IRON; IPC; IPCS; IRE; IRON DEFICIENCY (ANEMIA); IRON ISOMALTOSIDE 1000; IRON POLYMALTOSE COMPLEX; IRON POLYMALTOSE COMPLEX SIMILAR; IRON SUCROSE; IRON SUCROSE SIMILAR; IRON-REGULATORY ELEMENT; IRON-REGULATORY PROTEIN; IRP; IS; ISS; IV; LABILE IRON POOL; LIP; LMWID; LOW-MOLECULAR-WEIGHT IRON DEXTRAN; MALONDIALDEHYDE, MPS, MONONUCLEAR PHAGOCYTE SYSTEM, NF-ΚB, NUCLEAR FACTOR-ΚB; MDA; NATURAL RESISTANCE-ASSOCIATED MACROPHAGE PROTEIN 1; NEURONAL NITRIC OXIDE SYNTHASE; NF-E2-RELATED FACTOR 2; NITROSATIVE STRESS; NNOS; NON-TRANSFERRIN-BOUND IRON; NRAMP1; NRF2; NTBI; ORAL IRON; OXIDATIVE STRESS; PHD; POLYGLUCOSE SORBITOL CARBOXYMETHYL ETHER; PROLYL HYDROXYLASE; PSC; REACTIVE NITROGEN SPECIES; REACTIVE OXYGEN SPECIES; RNS; ROS; SIX-TRANSMEMBRANE EPITHELIAL ANTIGEN OF THE PROSTATE 3; SOD; SODIUM FE(III) ETHYLENEDIAMINETETRAACETIC ACID; STEAP3; SUPEROXIDE DISMUTASE; TFR; TNF-Α; TRANSFERRIN RECEPTOR; TRANSFERRRIN SATURATION; TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL, MUCOLIPIN SUBFAMILY, MEMBER 1; TRPML1; TSAT; TUMOR NECROSIS FACTOR Α; UNTRANSLATED REGION; UTR; VHL; VON HIPPEL-LINDAU;

ANEMIA, IRON-DEFICIENCY; ANTIOXIDANTS; HEMOGLOBINS; HUMANS; HYDROGEN PEROXIDE; IRON; NITRIC OXIDE; OXIDATIVE STRESS; REACTIVE NITROGEN SPECIES; SUPEROXIDES;

EID: 84884950378     PISSN: 08915849     EISSN: 18734596     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2013.09.001     Document Type: Review

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