A heme export protein is required for red blood cell differentiation and iron homeostasis

Science

Volumn 319, Issue 5864, 2008, Pages 825-828

  Keel, Siobán B ^a   Doty, Raymond T ^a   Yang, Zhantao ^a   Quigley, John G ^a,e   Chen, Jing ^a   Knoblaugh, Sue ^b   Kingsley, Paul D ^c   De Domenico, Ivana ^d   Vaughn, Michael B ^d   Kaplan, Jerry ^d   Palis, James ^c   Abkowitz, Janis L ^a  

^a UNIVERSITY OF WASHINGTON   (United States)

^b Fred Hutchinson Cancer Research Center   (United States)

^c UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

^d UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

^e UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HEME; HEMOPROTEIN; IRON; PROTEIN FLVCR; RECEPTOR PROTEIN; UNCLASSIFIED DRUG;

ANEMIA; BLOOD; HOMEOSTASIS; IRON; PROTEIN; RODENT; VIRUS;

ARTICLE; BLACKFAN DIAMOND ANEMIA; CELL DIFFERENTIATION; CELL MATURATION; CELL SURVIVAL; CRANIOFACIAL MALFORMATION; ERYTHROBLAST; ERYTHROCYTE; ERYTHROID PRECURSOR CELL; ERYTHROPOIESIS; FELINE LEUKEMIA VIRUS; GENE DELETION; HOMEOSTASIS; LIMB MALFORMATION; MACROCYTIC ANEMIA; MACROPHAGE; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION;

ANEMIA, DIAMOND-BLACKFAN; ANIMALS; ANTIMICROBIAL CATIONIC PEPTIDES; EMBRYO LOSS; EMBRYONIC DEVELOPMENT; ERYTHROBLASTS; ERYTHROPOIESIS; HEME; HEPATOCYTES; HOMEOSTASIS; IRON; MACROPHAGES; MEMBRANE TRANSPORT PROTEINS; MICE; RECEPTORS, VIRUS; RED-CELL APLASIA, PURE;

FELINE LEUKEMIA VIRUS; MUS; SUBGROUP C;

EID: 38949097546     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1151133     Document Type: Article

References (25)

1. T. Tahara et al., J. Biol. Chem. 279, 5480 (2004).
2. M. Rafie-Kolpin et al., J. Biol. Chem. 275, 5171 (2000).
3. J. G. Quigley et al., Cell 118, 757 (2004).
4. N. G. Testa, D. Onions, O. Jarrett, F. Frassoni, J. F. Eliason, Leuk. Res. 7, 103 (1983).
5. J. L. Abkowitz, Blood 77, 1442 (1991).
6. N. Riedel, E. A. Hoover, R. E. Domsife, J. I. Mullins, Proc. Natl. Acad. Sci. U.S.A. 85, 2758 (1988).
7. M. A. Rigby et al., J. Gen. Virol. 73, 2839 (1992).
8. J. L. Abkowitz, R. D. Holly, C. K. Grant, J. Clin. Invest. 80, 1056 (1987).
9. Materials and methods are available as supporting material on Science Online.
10. S. Watanabe, R. Akagi, M. Mori, T. Tsuchiya, S. Sassa, Placenta 25, 387 (2004).
11. H. Wu, X. Liu, R. Jaenisch, H. F. Lodish, Cell 83, 59 (1995).
12. J. Zhang, M. Socolovsky, A. W. Gross, H. F. Lodish, Blood 102, 3938 (2003).
13. I. A. Cathie, Arch. Dis. Child. 25, 313 (1950).
14. T. N. Willig et al., Pediatr. Res. 46, 553 (1999).
15. V. E. Wang, T. Schmidt, J. Chen, P. A. Sharp, D. Tantin, Mol. Cell. Biol. 24, 1022 (2004).
16. A. Wickrema, S. B. Krantz, J. C. Winkelmann, M. C. Bondurant, Blood 80, 1940 (1992).
17. M. W. Hentze, M. U. Muckenthaler, N. C. Andrews, Cell 117, 285 (2004).
18. E. Nemeth et al., Science 306, 2090 (2004).
19. M. D. Knutson, M. Oukka, L. M. Koss, F. Aydemir, M. Wessling-Resnick, Proc. Natl. Acad. Sci. U.S.A. 102, 1324 (2005).
20. G. Papanikolaou et al., Blood 105, 4103 (2005).
21. M. Vokurka, J. Krijt, K. Sulc, E. Necas, Physiol. Res. 55, 667 (2006).
22. M. Pak, M. A. Lopez, V. Gabayan, T. Ganz, S. Rivera, Blood 108, 3730 (2006).
23. T. Tanno et al., Nat. Med. 13, 1096 (2007).
24. C. S. Tailor, B. J. Willett, D. Kabat, J. Virol. 73, 6500 (1999).
25. We thank J. Hicks (technical support), Fred Hutchinson Cancer Research Center Experimental Histopathology and University of Washington Medical Center, Clinical Research Center. This work is supported by NIH grants and the Henigson Research Fund.