Iron activates NF-κB in Kupffer cells

American Journal of Physiology - Gastrointestinal and Liver Physiology

Volumn 283, Issue 3 46-3, 2002, Pages

  She, Hongyun ^a,b,c   Xiong, Shigang ^a,b,c   Lin, Min ^a,b,c   Zandi, Ebrahim ^a,b,c   Giulivi, Cecilia ^a,b,c   Tsukamoto, Hidekazu ^a,b,c  

^a Departments of Pathology   (United States)

^b UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^c UNIVERSITY OF MINNESOTA DULUTH   (United States)

Author keywords

Electron paramagnetic resonance; Free radical; Inhibitor B kinase; Nuclear factor B; Promoter; Tumor necrosis factor

Indexed keywords

FREE RADICAL; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ARTICLE; ELECTRON SPIN RESONANCE; GENE EXPRESSION REGULATION; IRON METABOLISM; KUPFFER CELL; LIVER INJURY; MACROPHAGE ACTIVATION; MEDIATOR RELEASE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DNA BINDING; RAT; TISSUE INJURY;

EID: 0036720960     PISSN: 01931857     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpgi.00108.2002     Document Type: Article

References (46)

1. Separation of oxidant-initiated and redox-regulated steps in the NF-kappa B signal transduction pathway
2. Phorbol esterinducible genes contain a common cis element recognized by a TPA-modulated trans-acting factor
3. A 65-kappaD subunit of active NF-kappaB is required for inhibition of NF-kappaB by I kappaB
4. Effects of iron loading on pathogenicity in hepatitis C virus-infected chimpanzees
5. Non-alcoholic steatohepatitis and iron: Increased prevalence of mutations of the HFE gene in non-alcoholic steatohepatitis
6. Induction of ferritin synthesis by oxidative stress. Transcriptional and post-transcriptional regulation by expansion of the "free" iron pool
7. Reactive oxygen species facilitate the in vitro and in vivo lipopolysaccharide-induced release of tumor necrosis factor
8. Regulation of tumor necrosis factor alpha transcription in macrophages: Involvement of four kappa B-like motifs and of constitutive and inducible forms of NF-kappa B
9. Desferal attenuates TNF release following hepatic ischemia/reperfusion
10. Iron reduction as an adjuvant to interferon therapy in patients with chronic hepatitis C who have previously not responded to interferon: A multicenter, prospective, randomized, controlled trial
11. Murine cytotoxic activated macrophages inhibit aconitase in tumor cells. Inhibition involves the iron-sulfur prosthetic group and is reversible
12. Differentiation of murine macrophages to express nonspecific cytotoxicity for tumor cells results in L-arginine-dependent inhibition of mitochondrial ironsulfur enzymes in the macrophage effector cells
13. Biosynthesis of nitric oxide activates iron regulatory factor in macrophages
14. Iron induces lipid peroxidation in cultured macrophages, increases their ability to oxidatively modify LDL, and affects their secretory properties
15. Interactive effects of the tumor necrosis factor promoter and 3′-untranslated regions
16. Inhibition of NFkappaB in activated rat hepatic stellate cells by proteasome inhibitors and an IkappaB super-repressor
17. Iron depletion: Possible cause of tumor cell cytotoxicity induced by activated macrophages
18. Iron augments macrophage-mediated killing of Brucella abortus alone and in conjunction with interferon-gamma
19. Effects of iron overload and lindane intoxication in relation to oxidative stress, Kupffer cell function, and liver injury in the rat
20. Iron metabolism in the erythrophagocytosing Kupffer cell
21. EPR demonstration of iron-nitrosyl complex formation by cytotoxic activated macrophages
22. Role of iron in NF-kappa B activation and cytokine gene expression by rat hepatic macrophages
23. Activation of apoptosis signal-regulating kinase I (ASK1) by tumor necrosis factor receptor -associated factor 2 requires prior dissociation of the ASK1 inhibitor thioredoxin
24. Macrophage dysfunction following the phagocytosis of IgG-coated erythrocytes: Production of lipid peroxidation products
25. Insulin resistance-associated hepatic iron overload
26. Iron overload impairs pro-inflammatory cytokine responses by Kupffer cells
27. HNE interacts directly with JNK isoforms in human hepatic stellate cells
28. The role of alcoholism in hepatic iron storage disease
29. IKK-gamma is an essential regulatory subunit of the IkappaB kinase complex
30. The oral iron chelator, 1,2-dimethyl-3-hydroxypyrid-4-one reduces hepatic-free iron, lipid peroxidation and fat accumulation in chronically ethanol-fed rats
31. Mammalian thioredoxin is a direct inhibitor of apoptosis signal-regulating kinase (ASK) 1
32. Protection against acetaminophen-induced liver injury in vivo by an iron chelator, deferoxamine
33. Oxidative stress interference with the nuclear factor-kappa B activation pathways
34. Assessing oxygen radicals as mediators in activation of inducible eukaryotic transcription factor NF-kappa B
35. Rapid detection of octamer binding proteins with "mini-extracts," prepared from a small number of cells
36. Depletion of the mitochondrial electron transport abrogates the cytotoxic and gene-inductive effects of TNF
37. The role of hydroxyl radical as a messenger in the activation of nuclear transcription factor NF-kappaB
38. Inhibition by N-acetylL-cysteine of interleukin-6 mRNA induction and activation of NF kappa B by tumor necrosis factor alpha in a mouse fibroblastic cell line, Balb/3T3
39. Induction of ferritin synthesis in ischemic-reperfused rat liver: Analysis of the molecular mechanisms
40. Time course study of the influence of acute iron overload on Kupffer cell functioning and hepatotoxicity assessed in the isolated perfused rat liver
41. Experimental liver cirrhosis induced by alcohol and iron
42. Iron primes hepatic macrophages for NF-kappaB activation in alcoholic liver injury
43. Role of inflammation in liver fibrogenesis
44. Activation of stress signaling pathways by the end product of lipid peroxidation. 4-hydroxy-2-nonenal is a potential inducer of intracellular peroxide production
45. Functional defects in phagocytic cells from patients with iron overload
46. The role of iron in the cytotoxicity of tumor necrosis factor