Control of iron homeostasis by an iron-regulated ubiquitin ligase

Science

Volumn 326, Issue 5953, 2009, Pages 718-721

  Vashisht, Ajay A ^a   Zumbrennen, Kimberly B ^b   Huang, Xinhua ^a   Powers, David N ^a   Durazo, Armando ^c   Sun, Dahui ^d   Bhaskaran, Nimesh ^e   Persson, Anja ^f   Uhlen, Mathias ^f   Sangfeit, Olle ^e   Spruck, Charles ^d   Leibold, Elizabeth A ^b   Wohlschlegel, James A ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d SIDNEY KIMMEL CANCER CENTER   (United States)

^e KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^f ROYAL INSTITUTE OF TECHNOLOGY   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

F BOX PROTEIN; HEMERYTHRIN; IRON; IRON REGULATORY PROTEIN 2; PROTEIN FBXL5; UBIQUITIN PROTEIN LIGASE E3; UNCLASSIFIED DRUG;

DEGRADATION; ENZYME ACTIVITY; EUKARYOTE; HOMEOSTASIS; IRON; PROTEIN;

ARTICLE; ENZYME DEGRADATION; ENZYME REGULATION; EUKARYOTIC CELL; HOMEOSTASIS; HUMAN; IRON BINDING CAPACITY; IRON DEPLETION; PRIORITY JOURNAL; PROTEIN DEGRADATION; UBIQUITINATION;

CELL LINE; CULLIN PROTEINS; F-BOX PROTEINS; HEMERYTHRIN; HOMEOSTASIS; HUMANS; IRON; IRON REGULATORY PROTEIN 1; IRON REGULATORY PROTEIN 2; OXYGEN; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT PROTEINS; SKP CULLIN F-BOX PROTEIN LIGASES; UBIQUITIN-PROTEIN LIGASES;

EUKARYOTA;

EID: 70350613915     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1176333     Document Type: Article

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23. This work was supported by grants from NIH (GM45201 to E.A.L), the Swedish Cancer Society (N.B. and O.S.), the Swedish Children Cancer Foundation (O.S.), the Swedish Research Council (O.S.), the Cancer Society in Stockholm (O.S.), the Knut and Alice Wallenberg Foundation (A.P. and M.U.), the Stein-Oppenheimer Foundation (J.A.W.), and the Jonsson Comprehensive Cancer Center (J.A.W.). We thank D. Lim for graphic support.