Iron-induced mucosal pathology of the upper gastrointestinal tract: A common finding in patients on oral iron therapy

Histopathology

Volumn 53, Issue 3, 2008, Pages 311-317

  Kaye, P ^a,b   Abdulla, K ^b   Wood, J ^b   James, P ^b   Foley, S ^b   Ragunath, K ^b   Atherton, J ^b  

^a QUEEN S MEDICAL CENTRE   (United Kingdom)

^b NOTTINGHAM UNIVERSITY HOSPITALS NHS TRUST   (United Kingdom)

Author keywords

Anaemia; Erosions; Haemosiderin; Iron; Ulcer

Indexed keywords

IRON;

AGED; CLINICAL TRIAL; DIGESTIVE SYSTEM INJURY; DISEASE ASSOCIATION; ESOPHAGUS DISEASE; ESOPHAGUS EROSION; FEMALE; GASTRITIS; HISTOPATHOLOGY; HUMAN; IRON DEFICIENCY ANEMIA; IRON THERAPY; MAJOR CLINICAL STUDY; MALE; PATHOLOGY; PRIORITY JOURNAL; PROSPECTIVE STUDY; RETROSPECTIVE STUDY; REVIEW; TABLET; UPPER GASTROINTESTINAL TRACT INJURY;

GASTRIC MUCOSA; GASTROINTESTINAL DISEASES; HUMANS; IMMUNOHISTOCHEMISTRY; IRON; PROSPECTIVE STUDIES; UPPER GASTROINTESTINAL TRACT;

EID: 50049084034     PISSN: 03090167     EISSN: 13652559     Source Type: Journal    
DOI: 10.1111/j.1365-2559.2008.03081.x     Document Type: Review

References (19)

1. Banner W, Tong TG. Iron poisoning. Pediatr. Clin. North Am. 1986 33 393 409.
2. Tennenbein M, Littman C, Stimpson RE. Gastrointestinal pathology in adult iron overdose. Clin. Toxicol. 1990 28 311 320.
3. Hillman RS. Haemopoeitic agents: growth factors, minerals, and vitamins. In Hardman JG, Goodman Gilman A, Limbird LE eds. Goodman & Gilman's the pharmacologic basis of therapeutic. New York : Mcgraw-Hill, 1996 1311 1340.
4. Coplin M, Schuette S, Leichtmann G, Lashner B. Tolerability of iron: a comparison of bis-glycino iron II and ferrous sulphate. Clin. Ther. 1991 13 606 612.
5. Brock C, Curry H, Hanna C, Knipfer M, Taylor L. Adverse effects of iron supplementation: a comparative trial of a wax-matrix iron preparation and conventional ferrous sulphate tablets. Clin. Ther. 1985 7 568 573.
6. Abraham SC, Yardley JH, Wu T. Erosive injury to the upper gastrointestinal tract in patients receiving iron medication. Am. J. Surg. Pathol. 1999 23 1241 1247.
7. Haig A, Driman DK. Iron-induced mucosal injury to the upper gastrointestinal tract. Histopathology 2006 48 808 812.
8. Marginean EC, Bennick M, Cyczk J, Robert ME, Jain D. Gastric siderosis patterns and significance. Am. J. Surg. Pathol. 2006 30 514 520.
9. Roberts RJ, Nayfield S, Soper R, Kent TH. Acute iron intoxication with intestinal infarction managed in part by small bowel resection. Clin. Toxicol. 1975 8 3 12.
10. Bianchini F, Caderni G, Dolara P, Tanganelli E. Nuclear aberrations and micronuclei induction in the digestive tract of mice treated with different iron salts. J. Appl. Toxicol. 1988 8 179 183.
11. Murray MJ. Iron absorption. Clin. Toxicol. 1971 4 545 558.
12. Abbarah TR, Fredell JE, Ellenz GB. Ulceration by oral ferrous sulphate. JAMA 1976 236 2320 2321.
13. Alaily AB. Gangrene of Meckel's diverticulum in pregnancy due to iron tablet. BMJ 1974 1 103.
14. Ingoldby CJH. Perforated jejunal diverticulum due to local iron toxicity. BMJ 1977 1 949 950.
15. Eckstein RP, Symons P. Iron tablets cause histopathologically distinctive lesions in mucosal biopsies of the stomach and esophagus. Pathology 1996 28 142 145.
16. Laine LA, Bently E, Chandrasoma P. Effect of oral iron therapy on the upper gastrointestinal tract. Dig. Dis. Sci. 1988 33 172 177.
17. Kang JY, Wu AY, Chia JL, Wee A, Sutherland IH, Hori R. Clinical and ultrastructural studies in duodenal pseudomelanosis. Gut 1987 28 1673 1681.
18. Rimon E, Kagansky N, Kagansky M et al. Are we giving too much iron? Low-dose iron therapy is effective in octogenarians Am. J. Med. 2005 118 1142 1147.
19. Casparis D, Del Carlo P, Branconi F, Grossi A, Meranti D, Gafforio L. Effectiveness and tolerability of oral liquid ferrous gluconate in iron deficiency anaemia in pregnancy and in the immediate post-partum period: comparison with other liquid or solid formulation containing bivalent or trivalent iron (in Italian). Minerva Ginecol. 1996 48 511 518.