The gene encoding the iron regulatory peptide hepcidin is regulated by anemia, hypoxia, and inflammation

Journal of Clinical Investigation

Volumn 110, Issue 7, 2002, Pages 1037-1044

  Nicolas, Gaël ^a   Chauvet, Caroline ^b   Viatte, Lydie ^a   Danan, Jean Louis ^b   Bigard, Xavier ^c   Devaux, Isabelle ^d   Beaumont, Carole ^d   Kahn, Axel ^a   Vaulont, Sophie ^a  

^a INSTITUT COCHIN   (France)

^b CNRS   (France)

^c CENTRE DE RECHERCHES   (France)

^d INSERM   (France)

Author keywords

[No Author keywords available]

Indexed keywords

HEPCIDIN; IRON REGULATORY FACTOR; MESSENGER RNA; UNCLASSIFIED DRUG;

ANEMIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLEEDING; CONTROLLED STUDY; GENE EXPRESSION; HEMOLYSIS; HEMOSTASIS; HUMAN; HUMAN CELL; HYPOXIA; INFLAMMATION; IRON ABSORPTION; IRON DEFICIENCY; IRON OVERLOAD; MOUSE; NONHUMAN; PATHOGENESIS; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN ANALYSIS; REGULATORY MECHANISM;

EID: 0036791486     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI0215686     Document Type: Article

References (18)

1. Finch, C. 1994. Regulators of iron balance in humans. Blood. 84:1697-1702.
2. Raja, K.B., Duane, P., and Peters, T.J. 1990. Effects of turpentine-induced inflammation on the hypoxic stimulation of intestinal Fe3+ absorption in mice. Int. J. Exp. Pathol. 71:785-789.
3. Park, C.H., Valore, E.V., Waring, A.J., and Ganz, T. 2001. Hepcidin: a urinary antimicrobial peptide synthesized in the liver. J. Biol. Chem. 276:7806-7810.
4. Krause, A., et al. 2000. LEAP-1, a novel highly disulfide-bonded human peptide, exhibits antimicrobial activity. FEBS Lett. 480:147-150.
5. Pigeon, C., et al. 2001. A new mouse liver specific gene, encoding a protein homologous to human antimicrobial peptide hepcidin, is overexpressed during iron overload. J. Biol. Chem. 276:7811-7819.
6. Nicolas, G., et al. 2001. Lack of hepcidin gene expression and severe tissue iron overload in upstream stimulatory factor 2 (USF2) knockout mice. Proc. Natl. Acad. Sci. USA. 98:8780-8785.
7. Nicolas, G., et al. 2002. Severe iron deficiency anemia in transgenic mice expressing liver hepcidin. Proc. Natl. Acad. Sci. USA. 99:4596-4601.
8. Mazure, N.M., et al. 2002. Repression of alpha-fetoprotein gene expression under hypoxic conditions in human hepatoma cells: characterization of a negative hypoxia response element that mediates opposite effects ofhypoxia inducible factor-1 and c-Myc. Cancer Res. 62:1158-1165.
9. Bigard, A.X., Sanchez, H., Birot, O., and Serrurier, B. 2000. Myosin heavy chain composition of skeletal muscles in young rats growing under hypobaric hypoxia conditions. J. Appl. Physiol. 88:479-486.
10. Milanini, J., Vinals, F., Pouyssegur, J., and Pages, G. 1998. p42/p44 MAP kinase module plays a key role in the transcriptional regulation of the vascular endothelial growth factor gene in fibroblasts. J. Biol. Chem. 273:18165-18172.
11. Torrance, J.D., and Bothwell, T.H. 1980. Tissue iron stores. Meth. Hematol. 1:90-115.
12. Ferrali, M., et al. 1997. Release of free, redox-active iron in the liver and DNA oxidative damage following phenylhydrazine intoxication. Biochem. Pharmacol. 53:1743-1751.
13. Kondo, H., Saito, K., Grasso, J.P., and Aisen, P. 1988. Iron metabolism in the erythrophagocytosing Kupffer cell. Hepatology. 8:32-38.
14. O'Riordan, D.K., et al. 1995. Cellular mechanisms underlying the increased duodenal iron absorption in rats in response to phenylhydrazine-induced haemolytic anaemia. Eur. J. Clin. Invest. 25:722-727.
15. Weinstein, D.A., et al. 2002. Inappropriate expression of hepcidin is associated with iron refractory anemia: implications for the anemia of chronic disease. Blood. In press.
16. Raja, K.B., Simpson, R.J., Pippard, M.J., and Peters, T.J. 1988. In vivo studies on the relationship between intestinal iron (Fe3+) absorption, hypoxia and erythropoiesis in the mouse. Br. J. Haematol. 68:373-378.
17. Raja, K.B., et al. 1997. Iron metabolism in transgenic mice with hypoplastic anaemia due to incomplete deficiency of erythropoietin. Br. J. Haematol. 96:248-253.
18. Kelley-Loughnane, N., Sabla, G.E., Ley-Ebert, C., Aronow, B.J., and Bezerra, J.A. 2002. Independent and overlapping transcriptional activation during liver development and regeneration in mice. Hepatology. 35:525-534.