Activation of macrophage cytostatic effector mechanisms during acute graft-versus-host disease: Release of intracellular iron and nitric oxide-mediated cytostasis

Blood

Volumn 96, Issue 5, 2000, Pages 1836-1843

  Nestel, F P ^a   Greene, R N ^a   Kichian, K ^a   Ponka, P ^a   Lapp, W S ^a  

^a MCGILL UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIUM LIPOPOLYSACCHARIDE; GAMMA INTERFERON; IRON; N(G) METHYLARGININE; NITRIC OXIDE;

ANIMAL MODEL; ARTICLE; CELL PROLIFERATION; CYTOSTASIS; DISEASE ASSOCIATION; GRAFT VERSUS HOST REACTION; IRON KINETICS; MACROPHAGE ACTIVATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

EID: 0034284314     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v96.5.1836     Document Type: Article

References (60)

1. The functional and histological basis for graft-versus-host induced immunosuppression
2. Histological correlates of immune functional deficits in graft-vs-host disease
3. Graft-versus-host disease
4. Macrophage priming and lipopolysaccharide-triggered release of tumor necrosis factor-alpha during graft-versus-host disease
5. IL-12 p40 messenger RNA expression in target organs during acute graft-versus-host disease: Possible involvement of IFN-γ
6. Cytokine cascades in acute graft-versus-host disease
7. The role of endotoxin in the pathogenesis of acute graft-versus-host disease
8. Release of reactive nitrogen intermediates and reactive oxygen intermediates from mouse peritoneal macrophages: Comparison of activating cytokines and evidence for independent production
9. Gamma interferon priming of mouse and human macrophages for induction of tumor necrosis factor production by bacterial lipopolysaccharide
10. Endogenous IFN-gamma during human bone marrow transplantation: Analysis of serum levels of interferon and interferon-dependent secondary messages
11. Increased bactericidal macrophage activity induced by immunological stimuli is dependent on interferon (IFN)-γ: Interference of anti-IFN-γ but not anti-IFN-α/β with modulation of macrophage activity caused by lymphocytic choriomeningitis infection or systemic graft-vs-host reactions
12. An experimental model of idiopathic pneumonia syndrome after bone marrow transplantation. I. The roles of minor H antigens and endotoxin
13. Progressive accumulation of bacterial lipopolysaccharide in vivo during murine acute graft-versus-host disease
14. Total body irradiation and acute graft-versus-host disease. The role of gastrointestinal damage and inflammatory cytokines
15. Does graft-versus-host disease attack epithelial stem cells?
16. Parafollicular hair bulge in human GVHD. A stem cell-rich primary target
17. Parafollicular bulges, but not hair bulb keratinocytes, are attacked in graft-versus-host disease of human skin
18. Denuded bowel after recovery from graft-versus-host disease
19. Recognition and destruction of target cells by tumoricidal macrophages
20. Discrimination between neoplastic and non-neoplastic cells in vitro by activated macrophages
21. Nitric oxide: A macrophage product responsible for cytostasis and respiratory inhibition in tumor target cells
22. Inhibition of tumor cell ribonucleotide reductase by macrophage-derived nitric oxide
23. Quenching of the tyrosyl free radical of ribonucleotide reductase by nitric oxide: Relationship to cytostasis induced in tumor cells by cytotoxic macrophages
24. Inactivation of ribonucleotide reductase by nitric oxide
25. Iron depletion: Possible cause of tumor cell cytotoxicity induced by activated macrophages
26. Murine cytotoxic activated macrophages inhibit aconitase in tumor cells: Inhibition involves the iron-sulphur prosthetic group and is reversible
27. Mitochondrial iron loss from leukemia cells injured by macrophages: A possible mechanism for electron transport chain defects
28. Nitric oxide mediates intestinal pathology in graft-vs-host disease
29. Characterization of the immunosuppressive effects of nitric oxide in graft-vs-host disease
30. Interferon-γ suppresses T-cell proliferation to mitogen via the nitric oxide pathway during experimental graft-versus-host disease
31. The kinetics of iron and transferrin incorporation into rabbit erythroid cells and the nature of stromal-bound iron
32. 15N]nitrate in biological fluids
33. Alterations in sensitivity to nonspecific cell-mediated lysis associated with tumor progression: Characterization of activated macrophage and natural killer cell resistant tumor variants
34. Cytolytic mechanisms of activated macrophages: Tumor necrosis factor and L-arginine-dependent mechanisms act synergistically as the major cytolyric mechanisms of activated macrophages
35. The regulation of thymidine secretion by macrophages
36. Macrophage oxidation of L-arginine to nitrite and nitrate: Nitric oxide is an intermediate
37. Sites of inhibition of mitochondrial electron transport in macrophage-injured neoplastic cells
38. Nitric oxide: A cytotoxic activated macrophage effector molecule
39. IL-1 is a critical effector molecule during cytokine dysregulation in GVHD to minor histocompatibility antigens
40. Nitric oxide mediation of active immunosuppression associated with graft-versus-host disease
41. Nitric oxide production in host-versus-graft and graft-versus-host reactions in the rat
42. Nitric oxide formation as predictive parameter for acute GVHD after human allogeneic bone marrow transplantation
43. Oxidation, tyrosine nitration and cytostasis induction in the absence of inducible nitric oxide synthase
44. Lymphokine production by T-cell clones after human bone marrow transplantation
45. Nitric oxide production and nitric oxide synthase type 2 expression by human mononuclear phagocytes: A review
46. Enumeration of lymphokine mRNA-containing cells in vivo in a murine graft-versus-host reaction using the PCR
47. Murine graft-versus-host disease in an F1-hybrid model using IFN-γ gene knockout donors
48. Cells of Th2 cytokine phenotype prevent LPS-induced lethality during murine GVHR
49. Donor CD4-enriched cells of Th2 cytokine phenotype regulate graft-versus-host disease without impairing allogeneic engraftment in sublethally irradiated mice
50. Neutralizing IL-12 during induction of murine acute graft-versus-host disease polarizes the cytokine profile toward a Th2-type alloimmune response and confers long term protection from disease
51. Generation of EPR-detectable nitrosyl-iron complexes in tumor target cells cocultured with activated macrophages
52. Monokine mediated release of intracellular iron in tumor target cells in vitro
53. Bleomycin-detectable iron in plasma of bone-marrow transplant patients: Its correlation with liver injury
54. Biologically relevant metal ion-dependent hydroxyl radical generation - An update
55. The mononuclear phagocyte system of the mouse defined by immunohistochemical localization of antigen F4/80: Relationship between macrophages, Langerhans cells, reticular cells, and dendritic cells in lymphoid and hematopoeltic organs
56. Quantitative analysis of total macrophage content in adult mouse tissues: Immunocytochemical studies with monoclonal antibody F4/80
57. Antibodies to IFN-γ prevent immunologically mediated intestinal damage in murine graft-versus-host reaction
58. IFN-γ modulation of epithelial barrier function: Time course, reversibility, and site of cytokine binding
59. Graft-versus-host reactions in the beige mouse: An investigation of the role of natural killer cells in the pathogenesis of GVH disease
60. + graft-versus-host effector cells of donor origin